Article
Endocrinology & Metabolism
Borbala Szabo, Kinga Nemeth, Katalin Meszaros, Lilla Krokker, Istvan Liko, Eva Saskoi, Krisztina Nemeth, Pal Tamas Szabo, Nikolette Szucs, Sandor Czirjak, Gabor Szaloki, Attila Patocs, Henriett Butz
Summary: This study revealed that aspirin can induce global DNA demethylation and consequential transcriptome changes in pituitary cells, leading to decreased cell proliferation and migration. Aspirin also regulates the activity of Tp53 and the expression of Pttg1, which are involved in cell cycle control. The findings suggest that aspirin may have potential beneficial effects in PitNET.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Oncology
Jinxiang Huang, Fenglin Zhang, Guohan Hu, Yuan Pan, Wei Sun, Lei Jiang, Peng Wang, Jiting Qiu, Xuehua Ding
Summary: The role of SIRT1 in pituitary tumors was investigated, and it was found that the SIRT1/H3K9ac/PTTG1 axis plays a crucial role in the formation of pituitary tumors. This discovery may provide a new therapeutic strategy for the treatment of pituitary tumors.
Article
Biochemistry & Molecular Biology
Haibo Zhang, Ziqing He, Li Qiu, Jinfen Wei, Xiaocheng Gong, Mingjian Xian, Zixi Chen, Ying Cui, Shuying Fu, Zihao Zhang, Bowen Hu, Xiquan Zhang, Shudai Lin, Hongli Du
Summary: The upregulated PRR11 in various cancers is associated with poor prognosis and can promote cell proliferation and migration by regulating the expression of PTTG1, thus influencing cell cycle progression.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Xuewen Zhang, Nianping Wu, Huili Huang, Shi Li, Shicheng Liu, Rui Zhang, Yuan Huang, Hao Lyu, Shuai Xiao, Declan William Ali, Marek Michalak, Xing-Zhen Chen, Cefan Zhou, Jingfeng Tang
Summary: PTTG1 is a bona fide β-catenin binding protein that positively regulates Wnt/β-catenin signaling by inhibiting the destruction complex assembly and promoting β-catenin stabilization and nuclear localization. PTTG1's subcellular distribution is regulated by its phosphorylation status. It is highly expressed in hepatocellular carcinoma (HCC) and associated with poor patient prognosis, as it promotes the proliferation and metastasis of HCC cells.
Article
Multidisciplinary Sciences
Linshan Liu, Bin Xiao, Alison Hirukawa, Harvey W. Smith, Dongmei Zuo, Virginie Sanguin-Gendreau, Luke McCaffrey, Alice Jisoo Nam, William J. Muller
Summary: The regulation of gene expression through histone posttranslational modifications is crucial in breast cancer progression. Ezh2 integrates mTORC1 and Wnt signaling pathways in the early stages of mammary tumor progression, suggesting that targeting Ezh2 could be a potential treatment for early-stage luminal B breast cancer.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Medicine, Research & Experimental
Anke Zhang, Yuanzhi Xu, Houshi Xu, Jie Ren, Tong Meng, Yunjia Ni, Qingwei Zhu, Wen-Bo Zhang, Yuan-Bo Pan, Jiali Jin, Yunke Bi, Zhe Bao Wu, Shaojian Lin, Meiqing Lou
Summary: The study found a positive association between lactate and PA invasion. Invasive PAs were found to have high infiltration of M2-like TAMs. Lactate secreted by PA cells promoted M2 polarization via mTORC2 and ERK signaling pathways, while activated TAMs secreted CCL17 to promote PA invasion through the CCL17/CCR4/mTORC1 axis. High CCL17 expression was associated with larger tumor size, greater invasion, and higher susceptibility to postoperative recurrence in human PAs.
Article
Cell Biology
Xiaowei Liu, Yuanxia Cai, Cheng Cheng, Yaoyao Gu, Xiaoxiao Hu, Kai Chen, Yeming Wu, Zhixiang Wu
Summary: PCLAF is overexpressed in neuroblastoma and is associated with poor prognosis. Knocking down PCLAF restricts neuroblastoma cell proliferation and affects cell cycle-related pathways. PCLAF accelerates the G1/S transition of neuroblastoma cell cycle by activating the E2F1/PTTG1 signaling pathway.
CELL DEATH & DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Jiahuang Qiu, Yifan Guo, Shunhao Wang, Quanzhong Ren, Zheng Dong, Ming Gao, Juan Ma, Shuguang Chen, Sijin Liu
Summary: In this study, the transcriptome profiles of lncRNAs were compared between primary breast cancer 4T1 cells and highly metastatic 4T1-LG12 cells. It was found that many differentially expressed lncRNAs were strongly correlated with the metastatic propensity of 4T1-LG12 cells. Among them, lncRNA-45, a newly identified lncRNA, was the most upregulated lncRNA transcribed by an internal region within the Rptor gene. Functional investigation revealed that lncRNA-45 played a regulatory role in the epithelial-to-mesenchymal transition process of breast cancer cells and its knockdown significantly suppressed the invasive capability of 4T1-LG12 cells.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Oncology
Qi Zhou, Leijia Li, Feifei Sha, Yiming Lei, Xuan Tian, Lingjun Chen, Yan Chen, Huiling Liu, Yunwei Guo
Summary: PTTG1 is highly expressed in hepatocellular carcinoma and plays a crucial role in its development. PTTG1 promotes asparagine synthetase transcription, leading to increased levels of asparagine and activation of the mTOR pathway, facilitating HCC progression.
Article
Oncology
Emanuela Teveroni, Fiorella Di Nicuolo, Giada Bianchetti, Alan L. Epstein, Giuseppe Grande, Giuseppe Maulucci, Marco De Spirito, Alfredo Pontecorvi, Domenico Milardi, Francesca Mancini
Summary: The study found that nuclear PTTG1 promotes the invasiveness of seminoma cell lines, which was supported by the analysis results from the Atlas database. These data suggest that nuclear PTTG1 may be an eligible prognostic factor in seminomas.
Article
Oncology
Shengquan Huang, Qianjin Liao, Weibing Li, Guoxian Deng, Ming Jia, Qiang Fang, Huixiang Ji, Mingsen Meng
Summary: In this study, overexpression of PTTG3P in CRPC cells was found to promote resistance to androgen-deprivation therapy by upregulating PTTG1 through a competitive mechanism. This suggests that PTTG3P may serve as a potential target for therapy of CRPC.
BULLETIN DU CANCER
(2021)
Article
Biotechnology & Applied Microbiology
Linhang Mei
Summary: This study elucidated the relationship between PTTG1 and miRNAs in breast cancer, successfully identified several potential upstream ncRNAs, and found that the PTTG1-miR-186-5p/miR-655-3p axis is associated with TGF-beta and MAPK signaling pathways, further revealing the importance of AURKA.
Article
Gastroenterology & Hepatology
Mar Coll, Silvia Arino, Celia Martinez-Sanchez, Ester Garcia-Pras, Javier Gallego, Anna Moles, Beatriz Aguilar-Bravo, Delia Blaya, Julia Vallverdu, Teresa Rubio-Tomas, Juan Jose Lozano, Elisa Pose, Isabel Graupera, Andrea Fernandez-Vidal, Albert Pol, Ramon Bataller, Jian-Guo Geng, Pere Gines, Mercedes Fernandez, Pau Sancho-Bru
Summary: The study found that ductular reaction cells promote angiogenesis in chronic liver disease through the Slit2-Robo1 pathway and play a key role in the liver wound-healing response.
Article
Biochemistry & Molecular Biology
Jirong Wang, Chengyun Xu, Jing Zhang, Yizhong Bao, Ying Tang, Xiaoling Lv, Bo Ma, Ximei Wu, Genxiang Mao
Summary: RhoA protein plays a crucial role in regulating the cytoskeletal architecture of osteoclasts and bone resorption activity. Deletion of RhoA leads to severe osteopetrosis phenotype and suppression of bone resorption, which is mediated by inhibiting Akt-mTOR-NFATc1 signaling during osteoclast differentiation. Activation of RhoA is associated with enhanced osteoclast activity and the development of osteoporotic bone phenotype. The absence of RhoA in osteoclast precursors in mice prevents OVX-induced bone loss.
MOLECULAR MEDICINE
(2023)
Article
Medicine, Research & Experimental
Guoyin Li, Zewen Song, Changjing Wu, XiaoYan Li, Liping Zhao, Binghua Tong, Zhenni Guo, Meiqing Sun, Jin Zhao, Huina Zhang, Lintao Jia, Shengqing Li, Lei Wang
Summary: Cumulative evidence suggests that abnormal regulation of the NEDD4 family is involved in tumorigenesis and cancer development. This study found that NEDD4L is associated with overall survival in lung adenocarcinoma (LUAD) patients and may regulate the mTORC1 pathway. Experimental results demonstrate that NEDD4L inhibits mTOR signaling activity and significantly inhibits LUAD cell proliferation. Additionally, the expression of NEDD4L is regulated by EGFR signaling.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)