A programmable Cas9-serine recombinase fusion protein that operates on DNA sequences in mammalian cells

Directed evolution of a recombinase that excises the provirus of most HIV-1 primary isolates with high specificity

(2016) Janet Karpinski et al.   NATURE BIOTECHNOLOGY

Editing Plant Genomes: a new era of crop improvement

(2016) Joseph F. Petolino et al.   PLANT BIOTECHNOLOGY JOURNAL

Cpf1 Is a Single RNA-Guided Endonuclease of a Class 2 CRISPR-Cas System

(2015) Bernd Zetsche et al.   CELL

Target-specific variants of Flp recombinase mediate genome engineering reactions in mammalian cells

(2015) Riddhi Shah et al.   FEBS Journal

Long-term and efficient expression of human β-globin gene in a hematopoietic cell line using a new site-specific integrating non-viral system

(2015) K Dormiani et al.   GENE THERAPY

Sequence determinants of improved CRISPR sgRNA design

(2015) Han Xu et al.   GENOME RESEARCH

Engineered CRISPR-Cas9 nucleases with altered PAM specificities

(2015) Benjamin P. Kleinstiver et al.   NATURE

Increasing the efficiency of precise genome editing with CRISPR-Cas9 by inhibition of nonhomologous end joining

(2015) Takeshi Maruyama et al.   NATURE BIOTECHNOLOGY

Broadening the targeting range of Staphylococcus aureus CRISPR-Cas9 by modifying PAM recognition

(2015) Benjamin P Kleinstiver et al.   NATURE BIOTECHNOLOGY

Increasing the efficiency of homology-directed repair for CRISPR-Cas9-induced precise gene editing in mammalian cells

(2015) Van Trung Chu et al.   NATURE BIOTECHNOLOGY

A novel frameshift mutation in FGF14 causes an autosomal dominant episodic ataxia

(2015) Karine Choquet et al.   NEUROGENETICS

Fidelity of end joining in mammalian episomes and the impact of Metnase on joint processing

(2014) Abhijit Rath et al.   BMC MOLECULAR BIOLOGY

Admixture Mapping Identifies a Quantitative Trait Locus Associated with FEV1/FVC in the COPDGene Study

(2014) Margaret M. Parker et al.   GENETIC EPIDEMIOLOGY

Enhancing the Specificity of Recombinase-Mediated Genome Engineering through Dimer Interface Redesign

(2014) Thomas Gaj et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Dimeric CRISPR RNA-guided FokI nucleases for highly specific genome editing

(2014) Shengdar Q Tsai et al.   NATURE BIOTECHNOLOGY

Fusion of catalytically inactive Cas9 to FokI nuclease improves the specificity of genome modification

(2014) John P Guilinger et al.   NATURE BIOTECHNOLOGY

Expanding the zinc-finger recombinase repertoire: directed evolution and mutational analysis of serine recombinase specificity determinants

(2014) Shannon J. Sirk et al.   NUCLEIC ACIDS RESEARCH

Ensembl 2015

(2014) Fiona Cunningham et al.   NUCLEIC ACIDS RESEARCH

The new frontier of genome engineering with CRISPR-Cas9

(2014) J. A. Doudna et al.   SCIENCE

Enhanced homology-directed human genome engineering by controlled timing of CRISPR/Cas9 delivery

(2014) Steven Lin et al.   eLife

Expanding the scope of site-specific recombinases for genetic and metabolic engineering

(2013) Thomas Gaj et al.   BIOTECHNOLOGY AND BIOENGINEERING

A new variable phenotype in spinocerebellar ataxia 27 (SCA 27) caused by a deletion in the FGF14 gene

(2013) J.A. Coebergh et al.   EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY

High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells

(2013) Yanfang Fu et al.   NATURE BIOTECHNOLOGY

Orthogonal Cas9 proteins for RNA-guided gene regulation and editing

(2013) Kevin M Esvelt et al.   NATURE METHODS

A comprehensive approach to zinc-finger recombinase customization enables genomic targeting in human cells

(2013) Thomas Gaj et al.   NUCLEIC ACIDS RESEARCH

RNA-Guided Human Genome Engineering via Cas9

(2013) P. Mali et al.   SCIENCE

Multiplex Genome Engineering Using CRISPR/Cas Systems

(2013) L. Cong et al.   SCIENCE

Recombinase-mediated cassette exchange (RMCE) — A rapidly-expanding toolbox for targeted genomic modifications

(2012) Soeren Turan et al.   GENE

A transcription activator-like effector toolbox for genome engineering

(2012) Neville E Sanjana et al.   Nature Protocols

Therapeutic opportunities for manipulating TReg cells in autoimmunity and cancer

(2012) Harald von Boehmer et al.   NATURE REVIEWS DRUG DISCOVERY

TALENs: a widely applicable technology for targeted genome editing

(2012) J. Keith Joung et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Chimeric TALE recombinases with programmable DNA sequence specificity

(2012) Andrew C. Mercer et al.   NUCLEIC ACIDS RESEARCH

Spinocerebellar ataxias type 27 derived from a disruption of the fibroblast growth factor 14 gene with mimicking phenotype of paroxysmal non-kinesigenic dyskinesia

(2011) Keiko Shimojima et al.   BRAIN & DEVELOPMENT

Recombinase-Mediated Cassette Exchange (RMCE): Traditional Concepts and Current Challenges

(2011) Soeren Turan et al.   JOURNAL OF MOLECULAR BIOLOGY

Zinc-finger recombinase activities in vitro

(2011) Marko M. Prorocic et al.   NUCLEIC ACIDS RESEARCH

Targeted plasmid integration into the human genome by an engineered zinc-finger recombinase

(2011) C. A. Gersbach et al.   NUCLEIC ACIDS RESEARCH

Repair at Single Targeted DNA Double-Strand Breaks in Pluripotent and Differentiated Human Cells

(2011) Hua Fung et al.   PLoS One

j5 DNA Assembly Design Automation Software

(2011) Nathan J. Hillson et al.   ACS Synthetic Biology

Regulation of Homologous Recombination in Eukaryotes

(2010) Wolf-Dietrich Heyer et al.   Annual Review of Genetics

A TALE nuclease architecture for efficient genome editing

(2010) Jeffrey C Miller et al.   NATURE BIOTECHNOLOGY

Directed evolution of recombinase specificity by split gene reassembly

(2010) Charles A. Gersbach et al.   NUCLEIC ACIDS RESEARCH

Structure-guided reprogramming of serine recombinase DNA sequence specificity

(2010) T. Gaj et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Circular Polymerase Extension Cloning of Complex Gene Libraries and Pathways

(2009) Jiayuan Quan et al.   PLoS One

Synthesis of programmable integrases

(2009) R. M. Gordley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Progress and prospects: Zinc-finger nucleases as gene therapy agents

(2008) D Carroll   GENE THERAPY

Regulation of DNA repair throughout the cell cycle

(2008) Dana Branzei et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Managing meiotic recombination in plant breeding

(2008) E WIJNKER et al.   TRENDS IN PLANT SCIENCE