Expanding the scope of site-specific recombinases for genetic and metabolic engineering

A Population-Based Experimental Model for Protein Evolution: Effects of Mutation Rate and Selection Stringency on Evolutionary Outcomes

(2013) Aaron M. Leconte et al.   BIOCHEMISTRY

Synthetic circuits integrating logic and memory in living cells

(2013) Piro Siuti et al.   NATURE BIOTECHNOLOGY

A comprehensive approach to zinc-finger recombinase customization enables genomic targeting in human cells

(2013) Thomas Gaj et al.   NUCLEIC ACIDS RESEARCH

Attachment site recognition and regulation of directionality by the serine integrases

(2013) Karen Rutherford et al.   NUCLEIC ACIDS RESEARCH

Amplifying Genetic Logic Gates

(2013) J. Bonnet et al.   SCIENCE

ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering

(2013) Thomas Gaj et al.   TRENDS IN BIOTECHNOLOGY

Synthetic Biology: An Emerging Engineering Discipline

(2012) Allen A. Cheng et al.   Annual Review of Biomedical Engineering

Effects of DNA Binding of the Zinc Finger and Linkers for Domain Fusion on the Catalytic Activity of Sequence-Specific Chimeric Recombinases Determined by a Facile Fluorescent System

(2012) Wataru Nomura et al.   BIOCHEMISTRY

Zinc-finger Nuclease Editing of Human cxcr4 Promotes HIV-1 CD4+ T Cell Resistance and Enrichment

(2012) Jinyun Yuan et al.   MOLECULAR THERAPY

The expanding scope of DNA sequencing

(2012) Jay Shendure et al.   NATURE BIOTECHNOLOGY

Targeted gene knockout by direct delivery of zinc-finger nuclease proteins

(2012) Thomas Gaj et al.   NATURE METHODS

Chimeric TALE recombinases with programmable DNA sequence specificity

(2012) Andrew C. Mercer et al.   NUCLEIC ACIDS RESEARCH

Engineering of a target site-specific recombinase by a combined evolution- and structure-guided approach

(2012) Josephine Abi-Ghanem et al.   NUCLEIC ACIDS RESEARCH

Vika/vox, a novel efficient and specific Cre/loxP-like site-specific recombination system

(2012) Madina Karimova et al.   NUCLEIC ACIDS RESEARCH

Rewritable digital data storage in live cells via engineered control of recombination directionality

(2012) J. Bonnet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Crystal Structure of TAL Effector PthXo1 Bound to Its DNA Target

(2012) A. N.-S. Mak et al.   SCIENCE

Structural Basis for Sequence-Specific Recognition of DNA by TAL Effectors

(2012) D. Deng et al.   SCIENCE

Genome Engineering With Zinc-Finger Nucleases

(2011) Dana Carroll   GENETICS

A system for the continuous directed evolution of biomolecules

(2011) Kevin M. Esvelt et al.   NATURE

An unbiased genome-wide analysis of zinc-finger nuclease specificity

(2011) Richard Gabriel et al.   NATURE BIOTECHNOLOGY

Zinc-finger recombinase activities in vitro

(2011) Marko M. Prorocic et al.   NUCLEIC ACIDS RESEARCH

VCre/VloxP and SCre/SloxP: new site-specific recombination systems for genome engineering

(2011) Emiko Suzuki et al.   NUCLEIC ACIDS RESEARCH

Targeted plasmid integration into the human genome by an engineered zinc-finger recombinase

(2011) C. A. Gersbach et al.   NUCLEIC ACIDS RESEARCH

A Genome-Wide Analysis of FRT-Like Sequences in the Human Genome

(2011) Jeffry L. Shultz et al.   PLoS One

Zinc Finger Recombinases with Adaptable DNA Sequence Specificity

(2011) Chris Proudfoot et al.   PLoS One

Multiple new site-specific recombinases for use in manipulating animal genomes

(2011) A. Nern et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Critical Amino Acid Residues Within the ɸC31 Integrase DNA-Binding Domain Affect Recombination Activities in Mammalian Cells

(2010) Raphael Liesner et al.   HUMAN GENE THERAPY

Directed Evolution of an Enhanced and Highly Efficient FokI Cleavage Domain for Zinc Finger Nucleases

(2010) Jing Guo et al.   JOURNAL OF MOLECULAR BIOLOGY

Human hematopoietic stem/progenitor cells modified by zinc-finger nucleases targeted to CCR5 control HIV-1 in vivo

(2010) Nathalia Holt et al.   NATURE BIOTECHNOLOGY

A robust system for production of minicircle DNA vectors

(2010) Mark A Kay et al.   NATURE BIOTECHNOLOGY

Selection-free zinc-finger-nuclease engineering by context-dependent assembly (CoDA)

(2010) Jeffry D Sander et al.   NATURE METHODS

Directed evolution of recombinase specificity by split gene reassembly

(2010) Charles A. Gersbach et al.   NUCLEIC ACIDS RESEARCH

SeLOX—a locus of recombination site search tool for the detection and directed evolution of site-specific recombination systems

(2010) Vineeth Surendranath et al.   NUCLEIC ACIDS RESEARCH

Generation of induced pluripotent stem cells using site-specific integration with phage integrase

(2010) L. Ye et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure-guided reprogramming of serine recombinase DNA sequence specificity

(2010) T. Gaj et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Selection of bacteriophage λ integrases with altered recombination specificity by in vitro compartmentalization

(2009) Yvonne Tay et al.   NUCLEIC ACIDS RESEARCH

Synthesis of programmable integrases

(2009) R. M. Gordley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Breaking the Code of DNA Binding Specificity of TAL-Type III Effectors

(2009) J. Boch et al.   SCIENCE

A Simple Cipher Governs DNA Recognition by TAL Effectors

(2009) M. J. Moscou et al.   SCIENCE

Protein Design by Directed Evolution

(2008) Christian Jäckel et al.   Annual Review of Biophysics

Binding and Catalytic Contributions to Site Recognition by Flp Recombinase

(2008) Katrine L. Whiteson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deficient SUMO Attachment to Flp Recombinase Leads to Homologous Recombination-dependent Hyperamplification of the Yeast 2 μm Circle Plasmid

(2008) Ling Xiong et al.   MOLECULAR BIOLOGY OF THE CELL

Rapid “Open-Source” Engineering of Customized Zinc-Finger Nucleases for Highly Efficient Gene Modification

(2008) Morgan L. Maeder et al.   MOLECULAR CELL

Mutational Derivatives of PhiC31 Integrase With Increased Efficiency and Specificity

(2008) Annahita Keravala et al.   MOLECULAR THERAPY

Establishment of HIV-1 resistance in CD4+ T cells by genome editing using zinc-finger nucleases

(2008) Elena E Perez et al.   NATURE BIOTECHNOLOGY

Heritable targeted gene disruption in zebrafish using designed zinc-finger nucleases

(2008) Yannick Doyon et al.   NATURE BIOTECHNOLOGY

Combining metabolic engineering and metabolic evolution to develop nonrecombinant strains ofEscherichia coli C that produce succinate and malate

(2007) Kaemwich Jantama et al.   BIOTECHNOLOGY AND BIOENGINEERING

Creation of Engineered Human Embryonic Stem Cell Lines Using phiC31 Integrase

(2007) Bhaskar Thyagarajan et al.   STEM CELLS