GLANDULAR TRICHOME-SPECIFIC WRKY 1 promotes artemisinin biosynthesis in Artemisia annua

Jasmonate-responsive transcription factors regulating plant secondary metabolism

(2016) Meiliang Zhou et al.   BIOTECHNOLOGY ADVANCES

Synthetic biology’s first malaria drug meets market resistance

(2016) Mark Peplow   NATURE

The jasmonate-responsive AaMYC2 transcription factor positively regulates artemisinin biosynthesis inArtemisia annua

(2016) Qian Shen et al.   NEW PHYTOLOGIST

Overexpression ofAaWRKY1Leads to an Enhanced Content of Artemisinin inArtemisia annua

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WRKY Transcription Factors: Molecular Regulation and Stress Responses in Plants

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Transcriptional regulation of artemisinin biosynthesis in Artemisia annua L.

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TRICHOME AND ARTEMISININ REGULATOR 1 Is Required for Trichome Development and Artemisinin Biosynthesis in Artemisia annua

(2015) Hexin Tan et al.   Molecular Plant

A Basic Leucine Zipper Transcription Factor, AabZIP1, Connects Abscisic Acid Signaling with Artemisinin Biosynthesis in Artemisia annua

(2015) Fangyuan Zhang et al.   Molecular Plant

The Pfam protein families database: towards a more sustainable future

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Dried whole-plantArtemisia annuaslows evolution of malaria drug resistance and overcomes resistance to artemisinin

(2015) Mostafa A. Elfawal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of MKK9-MPK3/MPK6 enhances phosphate acquisition inArabidopsis thaliana

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Effects of overexpression of AaWRKY1 on artemisinin biosynthesis in transgenic Artemisia annua plants

(2014) Junli Han et al.   PHYTOCHEMISTRY

Cloning and Characterization of AabHLH1, a bHLH Transcription Factor that Positively Regulates Artemisinin Biosynthesis in Artemisia annua

(2014) Yunpeng Ji et al.   PLANT AND CELL PHYSIOLOGY

Transgenic approach to increase artemisinin content in Artemisia annua L.

(2014) Kexuan Tang et al.   PLANT CELL REPORTS

Regulation of Specialized Metabolism by WRKY Transcription Factors

(2014) Craig Schluttenhofer et al.   PLANT PHYSIOLOGY

Non-Cell-Autonomous Regulation of Root Hair Patterning Genes by WRKY75 in Arabidopsis

(2014) L. Rishmawi et al.   PLANT PHYSIOLOGY

Simulated digestion of dried leaves of Artemisia annua consumed as a treatment (pACT) for malaria

(2013) Pamela J. Weathers et al.   JOURNAL OF ETHNOPHARMACOLOGY

High-level semi-synthetic production of the potent antimalarial artemisinin

(2013) C. J. Paddon et al.   NATURE

AaORA, a trichome-specific AP2/ERF transcription factor ofArtemisia annua, is a positive regulator in the artemisinin biosynthetic pathway and in disease resistance toBotrytis cinerea

(2013) Xu Lu et al.   NEW PHYTOLOGIST

Overexpression of AtWRKY28 and AtWRKY75 in Arabidopsis enhances resistance to oxalic acid and Sclerotinia sclerotiorum

(2013) Xiaoting Chen et al.   PLANT CELL REPORTS

Molecular Cloning and Characterization of a Trichome-Specific Promoter of Artemisinic Aldehyde Δ11(13) Reductase (DBR2) in Artemisia annua

(2013) Weimin Jiang et al.   PLANT MOLECULAR BIOLOGY REPORTER

Gene Network Analysis and Functional Studies of Senescence-associated Genes Reveal Novel Regulators of Arabidopsis Leaf SenescenceF

(2012) Zhonghai Li et al.   Journal of Integrative Plant Biology

Trichome-specific expression of the amorpha-4,11-diene 12-hydroxylase (cyp71av1) gene, encoding a key enzyme of artemisinin biosynthesis in Artemisia annua, as reported by a promoter-GUS fusion

(2012) Hongzhen Wang et al.   PLANT MOLECULAR BIOLOGY

Dried Whole Plant Artemisia annua as an Antimalarial Therapy

(2012) Mostafa A. Elfawal et al.   PLoS One

The Jasmonate-Responsive AP2/ERF Transcription Factors AaERF1 and AaERF2 Positively Regulate Artemisinin Biosynthesis in Artemisia annua L.

(2011) Zong-Xia Yu et al.   Molecular Plant

Trichome isolation with and without fixation using laser microdissection and pressure catapulting followed by RNA amplification: Expression of genes of terpene metabolism in apical and sub-apical trichome cells of Artemisia annua L.

(2011) Linda Olofsson et al.   PLANT SCIENCE

Accelerated Profile HMM Searches

(2011) Sean R. Eddy   PLoS Computational Biology

The Genetic Map of Artemisia annua L. Identifies Loci Affecting Yield of the Antimalarial Drug Artemisinin

(2010) I. A. Graham et al.   SCIENCE

WRKY transcription factors

(2010) Paul J. Rushton et al.   TRENDS IN PLANT SCIENCE

Molecular cloning of an aldehyde dehydrogenase implicated in artemisinin biosynthesis in Artemisia annuaThis paper is one of a selection of papers published in a Special Issue from the National Research Council of Canada – Plant Biotechnology Institute.

(2009) Keat H. Teoh et al.   Botany

Evidence for a positive regulatory role of strawberry (Fragaria×ananassa) Fa WRKY1 and Arabidopsis At WRKY75 proteins in resistance

(2009) Sonia Encinas-Villarejo et al.   JOURNAL OF EXPERIMENTAL BOTANY

Artemisinin biosynthesis in growing plants of Artemisia annua. A 13CO2 study

(2009) Nicholas Schramek et al.   PHYTOCHEMISTRY

Isolation and Characterization of AaWRKY1, an Artemisia annua Transcription Factor that Regulates the Amorpha-4,11-diene Synthase Gene, a Key Gene of Artemisinin Biosynthesis

(2009) Dongming Ma et al.   PLANT AND CELL PHYSIOLOGY

Development of transgenic Artemisia annua (Chinese wormwood) plants with an enhanced content of artemisinin, an effective anti-malarial drug, by hairpin-RNA-mediated gene silencing

(2008) Ling Zhang et al.   BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY

The Molecular Cloning of Artemisinic Aldehyde Δ11(13) Reductase and Its Role in Glandular Trichome-dependent Biosynthesis of Artemisinin inArtemisia annua

(2008) Yansheng Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY