Transgenic approach to increase artemisinin content in Artemisia annua L.
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Title
Transgenic approach to increase artemisinin content in Artemisia annua L.
Authors
Keywords
Artemisinin, Artemisinin biosynthetic pathway, <em class=EmphasisTypeItalic >Artemisia annua</em> L., Metabolic regulation, Secondary metabolism
Journal
PLANT CELL REPORTS
Volume 33, Issue 4, Pages 605-615
Publisher
Springer Nature
Online
2014-01-11
DOI
10.1007/s00299-014-1566-y
References
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Note: Only part of the references are listed.- Promotion of artemisinin biosynthesis in transgenic Artemisia annua by overexpressing ADS, CYP71AV1 and CPR genes
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- (2013) C. J. Paddon et al. NATURE
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- Overexpression of the cytochrome P450 monooxygenase (cyp71av1) and cytochrome P450 reductase (cpr) genes increased artemisinin content in Artemisia annua (Asteraceae)
- (2012) Q. Shen et al. GENETICS AND MOLECULAR RESEARCH
- A Concise Synthesis of (+)-Artemisinin
- (2012) Chunyin Zhu et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- The stacked over-expression of FPS, CYP71AV1 and CPR genes leads to the increase of artemisinin level in Artemisia annua L.
- (2012) Yunfei Chen et al. Plant Biotechnology Reports
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- (2012) Qifang Pan et al. PLoS One
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- (2011) Linda Olofsson et al. BMC PLANT BIOLOGY
- Searching for Artemisinin Production Improvement in Plants and Microorganisms
- (2011) Katarzyna Barbacka et al. CURRENT PHARMACEUTICAL BIOTECHNOLOGY
- Trichomes + roots + ROS = artemisinin: regulating artemisinin biosynthesis in Artemisia annua L.
- (2011) Khanhvan T. Nguyen et al. IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-PLANT
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- (2010) Tazyeen Nafis et al. Plant Biotechnology Reports
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- (2010) Waleerat Banyai et al. PLANT CELL TISSUE AND ORGAN CULTURE
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- (2010) Waleerat Banyai et al. PLANT GROWTH REGULATION
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- (2010) P. R. Arsenault et al. PLANT PHYSIOLOGY
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- (2010) I. A. Graham et al. SCIENCE
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- Abscisic acid (ABA) treatment increases artemisinin content in Artemisia annua by enhancing the expression of genes in artemisinin biosynthetic pathway
- (2009) Fuyuan Jing et al. BIOLOGIA
- Molecular cloning of an aldehyde dehydrogenase implicated in artemisinin biosynthesis in Artemisia annuaThis paper is one of a selection of papers published in a Special Issue from the National Research Council of Canada – Plant Biotechnology Institute.
- (2009) Keat H. Teoh et al. Botany
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- (2009) Andrea Chini et al. FEBS Journal
- Effects of exogenous methyl jasmonate on artemisinin biosynthesis and secondary metabolites in Artemisia annua L.
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- (2008) Jennifer R. Anthony et al. METABOLIC ENGINEERING
- Molecular mechanisms underlying plant memory in JA-mediated defence responses
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