CD73 Protein as a Source of Extracellular Precursors for Sustained NAD+Biosynthesis in FK866-treated Tumor Cells

Inhibition of Nicotinamide Phosphoribosyltransferase Reduces Neutrophil-Mediated Injury in Myocardial Infarction

(2012) Fabrizio Montecucco et al.   ANTIOXIDANTS & REDOX SIGNALING

Targeting NAD+ salvage pathway induces autophagy in multiple myeloma cells via mTORC1 and extracellular signal-regulated kinase (ERK1/2) inhibition

(2012) M. Cea et al.   BLOOD

Synthetic lethality of PARP and NAMPT inhibition in triple-negative breast cancer cells

(2012) Ilirjana Bajrami et al.   EMBO Molecular Medicine

Cyclic ADP-ribose and Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) as Messengers for Calcium Mobilization

(2012) Hon Cheung Lee   JOURNAL OF BIOLOGICAL CHEMISTRY

Exploring the therapeutic space around NAD+

(2012) Riekelt H. Houtkooper et al.   JOURNAL OF CELL BIOLOGY

Inhibition of CD73 Improves B Cell-Mediated Anti-Tumor Immunity in a Mouse Model of Melanoma

(2012) G. Forte et al.   JOURNAL OF IMMUNOLOGY

The dynamic regulation of NAD metabolism in mitochondria

(2012) Liana Roberts Stein et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

CD73: a potent suppressor of antitumor immune responses

(2012) Paul. A. Beavis et al.   TRENDS IN IMMUNOLOGY

CD73 promotes tumor growth and metastasis

(2012) Bin Zhang   OncoImmunology

Nicotinamide phosphoribosyltransferase protects against ischemic stroke through SIRT1-dependent adenosine monophosphate-activated kinase pathway

(2011) Pei Wang et al.   ANNALS OF NEUROLOGY

The high-resolution crystal structure of periplasmicHaemophilus influenzaeNAD nucleotidase reveals a novel enzymatic function of human CD73 related to NAD metabolism

(2011) Silvia Garavaglia et al.   BIOCHEMICAL JOURNAL

Nicotinamide Mononucleotide, a Key NAD+ Intermediate, Treats the Pathophysiology of Diet- and Age-Induced Diabetes in Mice

(2011) Jun Yoshino et al.   Cell Metabolism

Homing-associated molecules CD73 and VAP-1 as targets to prevent harmful inflammations and cancer spread

(2011) Marko Salmi et al.   FEBS LETTERS

Pathways and Subcellular Compartmentation of NAD Biosynthesis in Human Cells

(2011) Andrey Nikiforov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nicotinamide Phosphoribosyltransferase/Visfatin Does Not Catalyze Nicotinamide Mononucleotide Formation in Blood Plasma

(2011) Nobumasa Hara et al.   PLoS One

Synergistic Interactions between HDAC and Sirtuin Inhibitors in Human Leukemia Cells

(2011) Michele Cea et al.   PLoS One

CD73: A Novel Target for Cancer Immunotherapy

(2010) B. Zhang   CANCER RESEARCH

Chemical Proteomics Identifies Nampt as the Target of CB30865, An Orphan Cytotoxic Compound

(2010) Tracey C. Fleischer et al.   CHEMISTRY & BIOLOGY

Potent synergistic interaction between the Nampt inhibitor APO866 and the apoptosis activator TRAIL in human leukemia cells

(2010) Gabriele Zoppoli et al.   EXPERIMENTAL HEMATOLOGY

Analogues of 4-[(7-Bromo-2-methyl-4-oxo-3H-quinazolin-6-yl)methylprop-2-ynylamino]-N-(3-pyridylmethyl)benzamide (CB-30865) as Potent Inhibitors of Nicotinamide Phosphoribosyltransferase (Nampt)

(2010) Jeffrey W. Lockman et al.   JOURNAL OF MEDICINAL CHEMISTRY

Anti-CD73 antibody therapy inhibits breast tumor growth and metastasis

(2010) J. Stagg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Preclinical development of the nicotinamide phosphoribosyl transferase inhibitor prodrug GMX1777

(2009) Pierre Beauparlant et al.   ANTI-CANCER DRUGS

Safety and efficacy of NAD depleting cancer drugs: results of a phase I clinical trial of CHS 828 and overview of published data

(2009) Anne von Heideman et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

The NAD World: A New Systemic Regulatory Network for Metabolism and Aging—Sirt1, Systemic NAD Biosynthesis, and Their Importance

(2009) Shin-ichiro Imai   CELL BIOCHEMISTRY AND BIOPHYSICS

The NMN/NaMN adenylyltransferase (NMNAT) protein family

(2009) Corinna Lau   Frontiers in Bioscience-Landmark

The Small Molecule GMX1778 Is a Potent Inhibitor of NAD+ Biosynthesis: Strategy for Enhanced Therapy in Nicotinic Acid Phosphoribosyltransferase 1-Deficient Tumors

(2009) M. Watson et al.   MOLECULAR AND CELLULAR BIOLOGY

Catastrophic NAD+ Depletion in Activated T Lymphocytes through Nampt Inhibition Reduces Demyelination and Disability in EAE

(2009) Santina Bruzzone et al.   PLoS One

Emerging Roles of NAD+ and Its Metabolites in Cell Signaling

(2009) F. Koch-Nolte et al.   Science Signaling

Nicotinic Acid, Nicotinamide, and Nicotinamide Riboside: A Molecular Evaluation of NAD+ Precursor Vitamins in Human Nutrition

(2008) Katrina L Bogan et al.   Annual Review of Nutrition

Perivascular adipose tissue-derived visfatin is a vascular smooth muscle cell growth factor: role of nicotinamide mononucleotide

(2008) Pei Wang et al.   CARDIOVASCULAR RESEARCH