Non-invasive metabolic imaging of brain tumours in the era of precision medicine

The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary

(2016) David N. Louis et al.   ACTA NEUROPATHOLOGICA

Inhibition of Dopamine Receptor D4 Impedes Autophagic Flux, Proliferation, and Survival of Glioblastoma Stem Cells

(2016) Sonam Dolma et al.   CANCER CELL

The Evolving Molecular Genetics of Low-grade Glioma

(2015) Sriram Venneti et al.   ADVANCES IN ANATOMIC PATHOLOGY

Acetyl-CoA Synthetase 2 Promotes Acetate Utilization and Maintains Cancer Cell Growth under Metabolic Stress

(2015) Zachary T. Schug et al.   CANCER CELL

Noninvasive Quantification of 2-Hydroxyglutarate in Human Gliomas with IDH1 and IDH2 Mutations

(2015) U. E. Emir et al.   CANCER RESEARCH

Late Pseudoprogression in Glioblastoma: Diagnostic Value of Dynamic O-(2-[18F]fluoroethyl)-L-Tyrosine PET

(2015) S. Kebir et al.   CLINICAL CANCER RESEARCH

PET, MRI, and simultaneous PET/MRI in the development of diagnostic and therapeutic strategies for glioma

(2015) Simon Puttick et al.   DRUG DISCOVERY TODAY

Compensatory glutamine metabolism promotes glioblastoma resistance to mTOR inhibitor treatment

(2015) Kazuhiro Tanaka et al.   JOURNAL OF CLINICAL INVESTIGATION

Vismodegib Exerts Targeted Efficacy Against Recurrent Sonic Hedgehog–Subgroup Medulloblastoma: Results From Phase II Pediatric Brain Tumor Consortium Studies PBTC-025B and PBTC-032

(2015) Giles W. Robinson et al.   JOURNAL OF CLINICAL ONCOLOGY

Glutamine synthetase activity fuels nucleotide biosynthesis and supports growth of glutamine-restricted glioblastoma

(2015) Saverio Tardito et al.   NATURE CELL BIOLOGY

p53 in survival, death and metabolic health: a lifeguard with a licence to kill

(2015) Flore Kruiswijk et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Integration of 2-hydroxyglutarate-proton magnetic resonance spectroscopy into clinical practice for disease monitoring in isocitrate dehydrogenase-mutant glioma

(2015) Macarena I. de la Fuente et al.   NEURO-ONCOLOGY

From the clinician's point of view - What is the status quo of positron emission tomography in patients with brain tumors?

(2015) Norbert Galldiks et al.   NEURO-ONCOLOGY

Molecular subgroups of medulloblastoma identification using noninvasive magnetic resonance spectroscopy

(2015) Stefan Blüml et al.   NEURO-ONCOLOGY

CBTRUS Statistical Report: Primary Brain and Central Nervous System Tumors Diagnosed in the United States in 2008-2012

(2015) Quinn T. Ostrom et al.   NEURO-ONCOLOGY

Biological tumor volume in 18FET-PET before radiochemotherapy correlates with survival in GBM

(2015) B. Suchorska et al.   NEUROLOGY

Drug repurposing: sulfasalazine sensitizes gliomas to gamma knife radiosurgery by blocking cystine uptake through system Xc−, leading to glutathione depletion

(2015) L Sleire et al.   ONCOGENE

Glucose-dependent acetylation of Rictor promotes targeted cancer therapy resistance

(2015) Kenta Masui et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PET imaging of tumor glycolysis downstream of hexokinase through noninvasive measurement of pyruvate kinase M2

(2015) Timothy H. Witney et al.   Science Translational Medicine

Glutamine-based PET imaging facilitates enhanced metabolic evaluation of gliomas in vivo

(2015) Sriram Venneti et al.   Science Translational Medicine

Perspectives of Ultra-High-Field MRI in Neuroradiology

(2015) E. R. Gizewski et al.   Clinical Neuroradiology

Metabolic Targeting of Lactate Efflux by Malignant Glioma Inhibits Invasiveness and Induces Necrosis: An In Vivo Study

(2015) Chaim B Colen et al.   NEOPLASIA

Complete clinical regression of a BRAF V600E-mutant pediatric glioblastoma multiforme after BRAF inhibitor therapy

(2014) Giles W Robinson et al.   BMC CANCER

Multimodal neuroimaging in humans at 9.4 T: a technological breakthrough towards an advanced metabolic imaging scanner

(2014) N. Jon Shah   Brain Structure & Function

Acetate Is a Bioenergetic Substrate for Human Glioblastoma and Brain Metastases

(2014) Tomoyuki Mashimo et al.   CELL

Acetate Dependence of Tumors

(2014) Sarah A. Comerford et al.   CELL

Druggable glycolytic requirement for Hedgehog-dependent neuronal and medulloblastoma growth

(2014) Laura Di Magno et al.   CELL CYCLE

Akt-Dependent Metabolic Reprogramming Regulates Tumor Cell Histone Acetylation

(2014) Joyce V. Lee et al.   Cell Metabolism

Noninvasive Detection of Glutamate Predicts Survival in Pediatric Medulloblastoma

(2014) M. Wilson et al.   CLINICAL CANCER RESEARCH

Diagnosis of pseudoprogression in patients with glioblastoma using O-(2-[18F]fluoroethyl)-l-tyrosine PET

(2014) Norbert Galldiks et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Dynamic18F-FET PET in suspected WHO grade II gliomas defines distinct biological subgroups with different clinical courses

(2014) Niklas Thon et al.   INTERNATIONAL JOURNAL OF CANCER

Medulloblastoma—translating discoveries from the bench to the bedside

(2014) Amar J. Gajjar et al.   Nature Reviews Clinical Oncology

Accuracy of 2-hydroxyglutarate quantification by short-echo proton-MRS at 3 T: A phantom study

(2014) Nicola Bertolino et al.   Physica Medica-European Journal of Medical Physics

In vivo chemical exchange saturation transfer imaging allows early detection of a therapeutic response in glioblastoma

(2014) K. Sagiyama et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immune evasion mediated by tumor-derived lactate dehydrogenase induction of NKG2D ligands on myeloid cells in glioblastoma patients

(2014) C. A. Crane et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypoxia, lipids, and cancer: surviving the harsh tumor microenvironment

(2014) Daniel Ackerman et al.   TRENDS IN CELL BIOLOGY

Response of BRAF-Mutant Melanoma to BRAF Inhibition Is Mediated by a Network of Transcriptional Regulators of Glycolysis

(2014) T. J. Parmenter et al.   Cancer Discovery

Accumulation of 2-hydroxyglutarate in gliomas correlates with survival: a study by 3.0-tesla magnetic resonance spectroscopy

(2014) Manabu Natsumeda et al.   Acta Neuropathologica Communications

Hexokinase 2 Is Required for Tumor Initiation and Maintenance and Its Systemic Deletion Is Therapeutic in Mouse Models of Cancer

(2013) Krushna C. Patra et al.   CANCER CELL

The mTORC1 Pathway Stimulates Glutamine Metabolism and Cell Proliferation by Repressing SIRT4

(2013) Alfred Csibi et al.   CELL

The Somatic Genomic Landscape of Glioblastoma

(2013) Cameron W. Brennan et al.   CELL

EGFR Mutation-Induced Alternative Splicing of Max Contributes to Growth of Glycolytic Tumors in Brain Cancer

(2013) Ivan Babic et al.   Cell Metabolism

Medulloblastoma molecular dissection

(2013) Marc Remke et al.   CURRENT OPINION IN ONCOLOGY

Brainstem Ganglioglioma Successfully Treated With Vemurafenib

(2013) Sarah Rush et al.   JOURNAL OF CLINICAL ONCOLOGY

Dynamic 18F-FET PET in Newly Diagnosed Astrocytic Low-Grade Glioma Identifies High-Risk Patients

(2013) N. L. Jansen et al.   JOURNAL OF NUCLEAR MEDICINE

Role of O-(2-18F-Fluoroethyl)-L-Tyrosine PET as a Diagnostic Tool for Detection of Malignant Progression in Patients with Low-Grade Glioma

(2013) N. Galldiks et al.   JOURNAL OF NUCLEAR MEDICINE

In vivo imaging of glucose uptake and metabolism in tumors

(2013) Simon Walker-Samuel et al.   NATURE MEDICINE

Comparison of visual and semiquantitative analysis of 18F-FDOPA-PET/CT for recurrence detection in glioblastoma patients

(2013) K. Herrmann et al.   NEURO-ONCOLOGY

Biopsy validation of 18F-DOPA PET and biodistribution in gliomas for neurosurgical planning and radiotherapy target delineation: results of a prospective pilot study

(2013) D. H. Pafundi et al.   NEURO-ONCOLOGY

Vemurafenib in pediatric patients withBRAFV600Emutated high-grade gliomas

(2013) Francisco Bautista et al.   PEDIATRIC BLOOD & CANCER

Pyruvate Kinase M2 Expression, but Not Pyruvate Kinase Activity, Is Up-Regulated in a Grade-Specific Manner in Human Glioma

(2013) Joydeep Mukherjee et al.   PLoS One

Limits of [18F]-FLT PET as a Biomarker of Proliferation in Oncology

(2013) Eliot T. McKinley et al.   PLoS One

(R)-2-Hydroxyglutarate Is Sufficient to Promote Leukemogenesis and Its Effects Are Reversible

(2013) J.-A. Losman et al.   SCIENCE

Mutational Analysis Reveals the Origin and Therapy-Driven Evolution of Recurrent Glioma

(2013) B. E. Johnson et al.   SCIENCE

An Inhibitor of Mutant IDH1 Delays Growth and Promotes Differentiation of Glioma Cells

(2013) D. Rohle et al.   SCIENCE

K27M mutation in histone H3.3 defines clinically and biologically distinct subgroups of pediatric diffuse intrinsic pontine gliomas

(2012) Dong-Anh Khuong-Quang et al.   ACTA NEUROPATHOLOGICA

Hotspot Mutations in H3F3A and IDH1 Define Distinct Epigenetic and Biological Subgroups of Glioblastoma

(2012) Dominik Sturm et al.   CANCER CELL

ATF4 Regulates MYC-Mediated Neuroblastoma Cell Death upon Glutamine Deprivation

(2012) Guoliang Qing et al.   CANCER CELL

Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate

(2012) Patrick S. Ward et al.   CANCER CELL

The Metabolic Profile of Tumors Depends on Both the Responsible Genetic Lesion and Tissue Type

(2012) Mariia O. Yuneva et al.   Cell Metabolism

Analysis of Tumor Metabolism Reveals Mitochondrial Glucose Oxidation in Genetically Diverse Human Glioblastomas in the Mouse Brain In Vivo

(2012) Isaac Marin-Valencia et al.   Cell Metabolism

Exploratory Clinical Trial of (4S)-4-(3-[18F]fluoropropyl)-L-glutamate for Imaging xC- Transporter Using Positron Emission Tomography in Patients with Non-Small Cell Lung or Breast Cancer

(2012) S. Baek et al.   CLINICAL CANCER RESEARCH

Quantitative volumetric analysis of gliomas with sequential MRI and 11C-methionine PET assessment: patterns of integration in therapy planning

(2012) Javier Arbizu et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Value of 11C-methionine PET in imaging brain tumours and metastases

(2012) Andor W. J. M. Glaudemans et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Impact of 3,4-Dihydroxy-6-18F-Fluoro-L-Phenylalanine PET/CT on Managing Patients with Brain Tumors: The Referring Physician's Perspective

(2012) F. Walter et al.   JOURNAL OF NUCLEAR MEDICINE

11C-Methionine PET for Grading and Prognostication in Gliomas: A Comparison Study with 18F-FDG PET and Contrast Enhancement on MRI

(2012) T. Singhal et al.   JOURNAL OF NUCLEAR MEDICINE

Performance of 18F-Fluoro-Ethyl-Tyrosine (18F-FET) PET for the Differential Diagnosis of Primary Brain Tumor: A Systematic Review and Metaanalysis

(2012) V. Dunet et al.   JOURNAL OF NUCLEAR MEDICINE

IDH mutation impairs histone demethylation and results in a block to cell differentiation

(2012) Chao Lu et al.   NATURE

Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation

(2012) Peppi Koivunen et al.   NATURE

IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype

(2012) Sevin Turcan et al.   NATURE

Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma

(2012) Jeremy Schwartzentruber et al.   NATURE

Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas

(2012) Gang Wu et al.   NATURE GENETICS

2-hydroxyglutarate detection by magnetic resonance spectroscopy in IDH-mutated patients with gliomas

(2012) Changho Choi et al.   NATURE MEDICINE

Prediction of oligodendroglial histology and LOH 1p/19q using dynamic [18F]FET-PET imaging in intracranial WHO grade II and III gliomas

(2012) N. L. Jansen et al.   NEURO-ONCOLOGY

The Impact of Gabapentin Administration on Brain GABA and Glutamate Concentrations: A 7T 1H-MRS Study

(2012) Kejia Cai et al.   NEUROPSYCHOPHARMACOLOGY

Increased xCT Expression Correlates With Tumor Invasion and Outcome in Patients With Glioblastomas

(2012) Satoru Takeuchi et al.   NEUROSURGERY

Metabolism of [U-13C]glucose in human brain tumorsin vivo

(2012) Elizabeth A. Maher et al.   NMR IN BIOMEDICINE

Detection of 2-Hydroxyglutarate in IDH-Mutated Glioma Patients by In Vivo Spectral-Editing and 2D Correlation Magnetic Resonance Spectroscopy

(2012) O. C. Andronesi et al.   Science Translational Medicine

Metabolic reprogramming in cancer: Unraveling the role of glutamine in tumorigenesis

(2012) Dania Daye et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Interactions between epigenetics and metabolism in cancers

(2012) Jihye Yun et al.   Frontiers in Oncology

Aerobic Glycolysis: Meeting the Metabolic Requirements of Cell Proliferation

(2011) Sophia Y. Lunt et al.   Annual Review of Cell and Developmental Biology

Serial Magnetic Resonance Spectroscopy Reveals a Direct Metabolic Effect of Cediranib in Glioblastoma

(2011) H. Kim et al.   CANCER RESEARCH

13C-Pyruvate Imaging Reveals Alterations in Glycolysis that Precede c-Myc-Induced Tumor Formation and Regression

(2011) Simon Hu et al.   Cell Metabolism

Specific PET Imaging of xC−Transporter Activity Using a18F-Labeled Glutamate Derivative Reveals a Dominant Pathway in Tumor Metabolism

(2011) Norman Koglin et al.   CLINICAL CANCER RESEARCH

Concurrent Temozolomide and Dose-Escalated Intensity-Modulated Radiation Therapy in Newly Diagnosed Glioblastoma

(2011) C. I. Tsien et al.   CLINICAL CANCER RESEARCH

Hexokinase 2 is a key mediator of aerobic glycolysis and promotes tumor growth in human glioblastoma multiforme

(2011) Amparo Wolf et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Independent prognostic value of pre-treatment 18-FDG-PET in high-grade gliomas

(2011) Cécile Colavolpe et al.   JOURNAL OF NEURO-ONCOLOGY

Chemical exchange saturation transfer (CEST): What is in a name and what isn't?

(2011) Peter C. M. van Zijl et al.   MAGNETIC RESONANCE IN MEDICINE

Hyperpolarized 13C magnetic resonance metabolic imaging: application to brain tumors

(2011) I. Park et al.   NEURO-ONCOLOGY

Bevacizumab impairs oxidative energy metabolism and shows antitumoral effects in recurrent glioblastomas: a 31P/1H MRSI and quantitative magnetic resonance imaging study

(2011) E. Hattingen et al.   NEURO-ONCOLOGY

Hot spots in dynamic18FET-PET delineate malignant tumor parts within suspected WHO grade II gliomas

(2011) M. Kunz et al.   NEURO-ONCOLOGY

Developmental profile and regulation of the glycolytic enzyme hexokinase 2 in normal brain and glioblastoma multiforme

(2011) Amparo Wolf et al.   NEUROBIOLOGY OF DISEASE

The future of ultra-high field MRI and fMRI for study of the human brain

(2011) Jeff H. Duyn   NEUROIMAGE

Metabolic Tumor Imaging Using Magnetic Resonance Spectroscopy

(2011) Kristine Glunde et al.   SEMINARS IN ONCOLOGY

Patients with IDH1 wild type anaplastic astrocytomas exhibit worse prognosis than IDH1-mutated glioblastomas, and IDH1 mutation status accounts for the unfavorable prognostic effect of higher age: implications for classification of gliomas

(2010) Christian Hartmann et al.   ACTA NEUROPATHOLOGICA

Semiquantitative analysis of C-11 methionine PET may distinguish brain tumor recurrence from radiation necrosis even in small lesions

(2010) Shozo Okamoto et al.   ANNALS OF NUCLEAR MEDICINE

1H nuclear magnetic resonance spectroscopy characterisation of metabolic phenotypes in the medulloblastoma of the SMO transgenic mice

(2010) S K Hekmatyar et al.   BRITISH JOURNAL OF CANCER

The Common Feature of Leukemia-Associated IDH1 and IDH2 Mutations Is a Neomorphic Enzyme Activity Converting α-Ketoglutarate to 2-Hydroxyglutarate

(2010) Patrick S. Ward et al.   CANCER CELL

Identification of a CpG Island Methylator Phenotype that Defines a Distinct Subgroup of Glioma

(2010) Houtan Noushmehr et al.   CANCER CELL

Recent Developments in PET Instrumentation

(2010) Hao Peng et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Positron emission tomography tracers for imaging angiogenesis

(2010) Roland Haubner et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Updated Response Assessment Criteria for High-Grade Gliomas: Response Assessment in Neuro-Oncology Working Group

(2010) Patrick Y. Wen et al.   JOURNAL OF CLINICAL ONCOLOGY

Erratum: Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

(2010) Lenny Dang et al.   NATURE

Pyruvate kinase M2 is a target of the tumor-suppressive microRNA-326 and regulates the survival of glioma cells

(2010) B. Kefas et al.   NEURO-ONCOLOGY

Imaging of Brain Tumors: MR Spectroscopy and Metabolic Imaging

(2010) Alena Horská et al.   NEUROIMAGING CLINICS OF NORTH AMERICA

Glutamine addiction: a new therapeutic target in cancer

(2010) David R. Wise et al.   TRENDS IN BIOCHEMICAL SCIENCES

MR Spectroscopy in Radiation Injury

(2009) P.C. Sundgren   AMERICAN JOURNAL OF NEURORADIOLOGY

Clinical impact of 11C-methionine PET on expected management of patients with brain neoplasm

(2009) Tomohiko Yamane et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Role of Proton Magnetic Resonance Spectroscopy in Differentiating Oligodendrogliomas from Astrocytomas

(2009) Sanjeev Chawla et al.   JOURNAL OF NEUROIMAGING

Methyl-L-11C-Methionine PET as a Diagnostic Marker for Malignant Progression in Patients with Glioma

(2009) R. T. Ullrich et al.   JOURNAL OF NUCLEAR MEDICINE

c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism

(2009) Ping Gao et al.   NATURE

Imaging of integrin αvβ3 expression in patients with malignant glioma by [18F] Galacto-RGD positron emission tomography

(2009) Oliver Schnell et al.   NEURO-ONCOLOGY

IDH1andIDH2Mutations in Gliomas

(2009) Hai Yan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

EGFR Signaling Through an Akt-SREBP-1-Dependent, Rapamycin-Resistant Pathway Sensitizes Glioblastomas to Antilipogenic Therapy

(2009) D. Guo et al.   Science Signaling

N -acetylaspartate synthesis in the brain: Mitochondria vs. microsomes

(2008) Prasanth S. Ariyannur et al.   BRAIN RESEARCH

18F-FDOPA PET/MRI fusion in patients with primary/recurrent gliomas: Initial experience

(2008) Carlos J. Ledezma et al.   EUROPEAN JOURNAL OF RADIOLOGY

Relationship of pre-surgery metabolic and physiological MR imaging parameters to survival for patients with untreated GBM

(2008) Forrest W. Crawford et al.   JOURNAL OF NEURO-ONCOLOGY

Evaluation of MR markers that predict survival in patients with newly diagnosed GBM prior to adjuvant therapy

(2008) Suja Saraswathy et al.   JOURNAL OF NEURO-ONCOLOGY

Glioma surgery using a multimodal navigation system with integrated metabolic images

(2008) Yoji Tanaka et al.   JOURNAL OF NEUROSURGERY

Imaging of Cell Proliferation: Status and Prospects

(2008) J. R. Bading et al.   JOURNAL OF NUCLEAR MEDICINE

Current and Potential Applications of Clinical 13C MR Spectroscopy

(2008) J. Kurhanewicz et al.   JOURNAL OF NUCLEAR MEDICINE

11C-Acetate PET in the Evaluation of Brain Glioma: Comparison with 11C-Methionine and 18F-FDG-PET

(2008) Y. Yamamoto et al.   MOLECULAR IMAGING AND BIOLOGY

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

(2008) Heather R. Christofk et al.   NATURE

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

(2008) Roger McLendon et al.   NATURE

Lactate promotes glioma migration by TGF-β2–dependent regulation of matrix metalloproteinase-2

(2008) Fusun Baumann et al.   NEURO-ONCOLOGY

Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction

(2008) D. R. Wise et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

FDG, MET or CHO? The quest for the optimal PET tracer for glioma imaging continues

(2008) Balázs Gulyás et al.   Nature clinical practice. Neurology