Article
Multidisciplinary Sciences
Bart R. J. van Dijken, Alfred O. Ankrah, Gilles N. Stormezand, Rudi A. J. O. Dierckx, Peter Jan van Laar, Anouk van der Hoorn
Summary: In this retrospective study, volume-based parameters MTV and TLMM were found to be inversely correlated with overall survival in IDH wild type glioblastoma patients, while SUV-based parameters did not show a correlation.
Article
Multidisciplinary Sciences
Kosuke Nakajo, Takehiro Uda, Toshiyuki Kawashima, Yuzo Terakawa, Kenichi Ishibashi, Naohiro Tsuyuguchi, Yuta Tanoue, Atsufumi Nagahama, Hiroshi Uda, Saya Koh, Tsuyoshi Sasaki, Kenji Ohata, Yonehiro Kanemura, Takeo Goto
Summary: This study aimed to investigate whether 11C-methionine PET can be used as an additional imaging biomarker to estimate the prognosis of glioma. The study found that LN max may serve as a prognostic marker for newly diagnosed and untreated WHO grade II-IV astrocytic glioma.
SCIENTIFIC REPORTS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Timo Schluermann, Birgit Waschulzik, Stephanie Combs, Jens Gempt, Benedikt Wiestler, Wolfgang Weber, Igor Yakushev
Summary: This study aimed to summarize the diagnostic utility of amino acid PET in recurrent brain metastases. The analysis of 12 studies with a total of 547 lesions in 397 patients showed that amino acid PET had good accuracy in the differential diagnosis of recurrent brain metastases, with a specificity of 84%, suggesting it can reduce the need for invasive procedures and overtreatment.
JOURNAL OF NUCLEAR MEDICINE
(2023)
Article
Neurosciences
Yihuan Lu, Takuya Toyonaga, Mika Naganawa, Jean-Dominique Gallezot, Ming-Kai Chen, Adam P. Mecca, Christopher H. van Dyck, Richard E. Carson
Summary: The purpose of the study is to reveal SV2A changes between Alzheimer's disease patients and cognitive normal participants using partial volume correction algorithms. In the hippocampus region, the IY algorithm increased the significance of group differences. MG algorithm may increase GM binding values to a greater extent. The results suggest that PVC is important for adjusting significant volume reduction.
Article
Engineering, Biomedical
Yansong Zhu, Murat Bilgel, Yuanyuan Gao, Olivier G. Rousset, Susan M. Resnick, Dean F. Wong, Arman Rahmim
Summary: The partial volume effect caused by limited spatial resolution of PET degrades image quality, but anatomical information from MR images can be used to improve partial volume correction methods. The proposed post-reconstruction PVC method utilizes deconvolution with PLS regularization to incorporate anatomical information without requiring MR segmentation or assuming uniform PET distributions within regions, showing promising results for clinical imaging scenarios.
PHYSICS IN MEDICINE AND BIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hosameldin Otman, Julien Farce, Pierre Meneret, Xavier Palard-Novello, Pierre-Jean Le Reste, Isabelle Lecouillard, Elodie Vauleon, Marion Chanchou, Beatrice Carsin Nicol, Marc Bertaux, Anne Devillers, Denis Mariano-Goulart, Florent Cachin, Antoine Girard, Florence Le Jeune
Summary: This study compared the diagnostic performance and interobserver agreement of [F-18]-FDG PET with delayed images, standard images, and dual-time-point images in differentiating brain metastasis recurrence from radiation necrosis after stereotactic radiotherapy. The results showed that [F-18]-FDG PET with delayed images had higher accuracy and better interobserver agreement.
CLINICAL NUCLEAR MEDICINE
(2022)
Article
Endocrinology & Metabolism
Matthew R. Scott, Natalie C. Edwards, Michael J. Properzi, Heidi I. L. Jacobs, Julie C. Price, Cristina Lois, Michelle E. Farrell, Bernard J. Hanseeuw, Emma G. Thibault, Dorene M. Rentz, Keith A. Johnson, Reisa A. Sperling, Aaron P. Schultz, Rachel F. Buckley
Summary: Clinically normal females exhibit higher 18F-flortaucipir (FTP)-PET signal than males across the cortex. However, these sex differences may be explained by neuroimaging idiosyncrasies such as off-target extracerebral tracer retention or partial volume effects (PVEs).
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Amirhossein Sanaat, Hossein Shooli, Andrew Stephen Bohringer, Maryam Sadeghi, Isaac Shiri, Yazdan Salimi, Nathalie Ginovart, Valentina Garibotto, Hossein Arabi, Habib Zaidi
Summary: A novel partial volume correction (PVC) technique using CycleGAN was proposed to overcome the adverse effects of partial volume effect on PET images. The technique directly maps non-PVC PET images to PVC PET images without the need for additional anatomical information or assumptions.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Oncology
Aidan M. Burke, Michael Carrasquilla, Walter C. Jean, Brian T. Collins, Amjad N. Anaizi, Michael B. Atkins, Geoffrey T. Gibney, Sean P. Collins
Summary: Combination therapy of anti-PD-1 and CTLA-4 with stereotactic radiosurgery has shown impressive results in the treatment of melanoma brain metastases, with good local control and overall survival rates. However, it is also associated with an increased risk of radiation necrosis compared to SRS alone.
FRONTIERS IN ONCOLOGY
(2022)
Article
Clinical Neurology
Kazufumi Ohmura, Yuka Ikegame, Hirohito Yano, Jun Shinoda, Toru Iwama
Summary: This study investigates the use of MET-PET in distinguishing brain lesions that are difficult to discriminate in conventional CT and MRI. By combining five diagnostic characteristics, significant differences were observed among the five brain lesions. MET-PET is an auxiliary diagnostic technique that could help in the differential diagnosis of these brain lesions.
JOURNAL OF NEUROIMAGING
(2023)
Article
Clinical Neurology
Jacob T. Hall, Charles F. Opalak, Matthew T. Carr, Timothy J. Harris, William C. Broaddus
Summary: This study found that meningiomas treated with radiation show a non-linear decrease in volume over time, with the greatest decrease occurring within the first year post-treatment. The volume reduction begins to plateau after 5 years.
WORLD NEUROSURGERY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Amarnath Jena, Sangeeta Taneja, Anna Ara Khan, Shanti K. Sogani
Summary: This study aims to distinguish between true recurrence and radiation necrosis of brain tumors using a combination of PET imaging and advanced MRI parameters, achieving high accuracy, sensitivity, and specificity. Further large-scale prospective studies with neuropathological validations are needed to confirm these findings.
CLINICAL NUCLEAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Silvia Campanioni, Jose A. Gonzalez-Novoa, Laura Busto, Roberto Carlos Agis-Balboa, Cesar Veiga
Summary: Alzheimer's disease (AD) is the most common form of dementia, with confirmed epigenetic changes. Positron Emission Tomography (PET) is used for quantifying amyloid deposition in the brain tissues. This study aims to develop a new methodology for analyzing cognitive scores and PET features to identify multiple AD phenotypes. Using computational methods and various imaging techniques, the study successfully identifies three phenotypes and analyzes them under epigenetic conditions.
Article
Health Care Sciences & Services
Tatjana Traub-Weidinger, Nina Poetsch, Adelheid Woehrer, Eva-Maria Klebermass, Tatjana Bachnik, Matthias Preusser, Mario Mischkulnig, Barbara Kiesel, Georg Widhalm, Markus Mitterhauser, Marcus Hacker, Oskar Koperek
Summary: PSMA expression in gliomas is associated with neovascularization, with higher expression in high-grade gliomas. Gliomas without IDH1-R132H mutation show significantly more vascular PSMA expression. Additionally, higher PSMA staining vessels are found in tumors with elevated amino acid metabolism, indicating a correlation with shorter survival.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Medicine, General & Internal
Ana Misir Krpan, Marina Hodolic, Anja Tea Golubic, Maja Baucic, Jakob Nemir, Goran Mrak, Marijan Zuvic, Drazen Hoic
Summary: This study aimed to investigate the diagnostic accuracy of F-18-FET and F-18-FCH PET-CT in patients with primary low-grade gliomas (LGG). The results showed that F-18-FET had better concordance with tumor histology compared to F-18-FCH and MRI, suggesting that F-18-FET is more accurate for diagnosing LGG.
CROATIAN MEDICAL JOURNAL
(2021)
Article
Oncology
Tsuyoshi Hayashi, Toru Nakamura, Yasutoshi Kimura, Makoto Yoshida, Masanori Someya, Hiroshi Kawakami, Yusuke Sakuhara, Norio Katoh, Kuniyuki Takahashi, Yoshiyasu Ambo, Katsutoshi Miura, Masayo Motoya, Eiichi Tanaka, Katsuhiko Murakawa, Takumi Yamabuki, Hajime Yamazaki, Akio Katanuma, Satoshi Hirano
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2019)
Article
Oncology
Anussara Prayongrat, Keiji Kobashi, Yoichi M. Ito, Norio Katoh, Masaya Tamura, Yasuhiro Dekura, Chie Toramatsu, Chonlakiet Khorprasert, Napapat Amornwichet, Petch Alisanant, Hiroki Shirato, Shinichi Shimizu
RADIOTHERAPY AND ONCOLOGY
(2019)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yusuke Uchinami, Ryusuke Suzuki, Norio Katoh, Hiroshi Taguchi, Koichi Yasuda, Naoki Miyamoto, Yoichi M. Ito, Shinichi Shimizu, Hiroki Shirato
JOURNAL OF APPLIED CLINICAL MEDICAL PHYSICS
(2019)
Article
Surgery
Ryo Morita, Daisuke Abo, Yusuke Sakuhara, Takeshi Soyama, Norio Katoh, Naoki Miyamoto, Yuusuke Uchinami, Shinichi Shimizu, Hiroki Shirato, Kohsuke Kudo
MINIMALLY INVASIVE THERAPY & ALLIED TECHNOLOGIES
(2020)
Article
Radiology, Nuclear Medicine & Medical Imaging
Naoki Miyamoto, Kenichiro Maeda, Daisuke Abo, Ryo Morita, Seishin Takao, Taeko Matsuura, Norio Katoh, Kikuo Umegaki, Shinichi Shimizu, Hiroki Shirato
PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS
(2019)
Article
Radiology, Nuclear Medicine & Medical Imaging
Takaaki Yoshimura, Shinichi Shimizu, Takayuki Hashimoto, Kentaro Nishioka, Norio Katoh, Tetsuya Inoue, Hiroshi Taguchi, Koichi Yasuda, Taeko Matsuura, Seishin Takao, Masaya Tamura, Yoichi M. Ito, Yuto Matsuo, Hiroshi Tamura, Kenji Horita, Kikuo Umegaki, Hiroki Shirato
JOURNAL OF APPLIED CLINICAL MEDICAL PHYSICS
(2020)
Article
Radiology, Nuclear Medicine & Medical Imaging
Shiro Watanabe, Tetsuya Inoue, Shozo Okamoto, Keiichi Magota, Ayumi Takayanagi, Jun Sakakibara-Konishi, Norio Katoh, Kenji Hirata, Osamu Manabe, Takuya Toyonaga, Yuji Kuge, Hiroki Shirato, Nagara Tamaki, Tohru Shiga
Article
Gastroenterology & Hepatology
Tomoki Kimura, Atsuya Takeda, Naoko Sanuki, Keisuke Ariyoshi, Takuhiro Yamaguchi, Toshiyuki Imagumbai, Norio Katoh, Takahisa Eriguchi, Yohei Oku, Shuichi Ozawa, Yuichiro Tsurugai, Masaki Kokubo, Shinichi Shimizu, Satoshi Ishikura
Summary: The study demonstrated low incidence of SBRT-related toxicities. Local control and overall survival after SBRT were comparable for previously untreated solitary HCC patients unfit for resection or radiofrequency ablation. Although a definitive conclusion cannot be drawn from this study, the promising results suggest that SBRT may be an alternative option in the management of early HCC.
HEPATOLOGY RESEARCH
(2021)
Article
Biology
Koichi Yasuda, Hideki Minatogawa, Yasuhiro Dekura, Seishin Takao, Masaya Tamura, Nayuta Tsushima, Takayoshi Suzuki, Satoshi Kano, Takatsugu Mizumachi, Takashi Mori, Kentaro Nishioka, Motoyasu Shido, Norio Katoh, Hiroshi Taguchi, Noriyuki Fujima, Rikiya Onimaru, Isao Yokota, Keiji Kobashi, Shinichi Shimizu, Akihiro Homma, Hiroki Shirato, Hidefumi Aoyama
Summary: Pharyngeal cancer patients treated with IMPT using a model-based approach showed lower acute toxicities compared to those treated with IMXT. Multivariate analysis revealed that IMPT was independently associated with lower rates of grade 2 or worse dysphagia and dysgeusia. IMPT may have clinical benefits for acute dysphagia.
JOURNAL OF RADIATION RESEARCH
(2021)
Article
Gastroenterology & Hepatology
Yusuke Uchinami, Norio Katoh, Daisuke Abo, Hiroshi Taguchi, Koichi Yasuda, Kentaro Nishioka, Takeshi Soyama, Ryo Morita, Naoki Miyamoto, Ryusuke Suzuki, Takuya Sho, Masato Nakai, Koji Ogawa, Tatsuhiko Kakisaka, Tatsuya Orimo, Toshiya Kamiyama, Shinichi Shimizu, Hidefumi Aoyama
Summary: This study reported the outcomes of stereotactic body radiotherapy using a real-time tumor-tracking radiotherapy system for hepatocellular carcinoma patients, showing favorable results with lower incidence of toxicities, especially in patients treated with BED10 >= 100 Gy to the reference point.
HEPATOLOGY RESEARCH
(2021)
Article
Biology
Takahiro Yamada, Seishin Takao, Hidenori Koyano, Hideaki Nihongi, Yusuke Fujii, Shusuke Hirayama, Naoki Miyamoto, Taeko Matsuura, Kikuo Umegaki, Norio Katoh, Isao Yokota, Hiroki Shirato, Shinichi Shimizu
Summary: The study aims to evaluate the reliability of dose distributions for liver tumors treated with real-time-image gated SSPT (RGPT). Results show that the accumulated dose distributions demonstrate a high level of accuracy, with average differences in maximum and minimum doses below 1.3%.
JOURNAL OF RADIATION RESEARCH
(2021)
Article
Biology
Anussara Prayongrat, Natchalee Srimaneekarn, Sira Sriswasdi, Yoichi M. Ito, Norio Katoh, Masaya Tamura, Yasuhiro Dekura, Chie Toramatsu, Chonlakiet Khorprasert, Napapat Amornwichet, Petch Alisanant, Yuichi Hirata, Anthony Hayter, Hiroki Shirato, Shinichi Shimizu, Keiji Kobashi
Summary: A multivariable NTCP model with confidence interval assessment was developed to predict radiation-induced liver disease in primary liver cancer patients. The model, based on clinical and dosimetric data, showed high predictive accuracy and potential for improving the selection of appropriate radiotherapy modalities for each patient.
JOURNAL OF RADIATION RESEARCH
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Risa Hayashi, Koichi Miyazaki, Seishin Takao, Kohei Yokokawa, Sodai Tanaka, Taeko Matsuura, Hiroshi Taguchi, Norio Katoh, Shinichi Shimizu, Kikuo Umegaki, Naoki Miyamoto
Summary: The study demonstrated the feasibility of real-time CT image generation technique utilizing internal fiducial markers for evaluating internal deformation. By monitoring marker displacement in real-time, a three-dimensional deformation vector field can be derived to synthesize the entire CT image.
Article
Oncology
Hideya Yamazaki, Takuya Kimoto, Motohisa Suzuki, Masao Murakami, Osamu Suzuki, Masaru Takagi, Norio Katoh, Takeshi Arimura, Takashi Ogino, Hiroyuki Ogino
Summary: This study examined the outcomes of patients with biliary duct carcinoma treated with particle beam therapy. The results showed that particle beam therapy has good efficacy for biliary duct carcinoma, with higher radiation doses improving overall survival. In particular, higher radiation doses were associated with better outcomes for patients with extrahepatic biliary duct carcinoma.
Article
Radiology, Nuclear Medicine & Medical Imaging
Takaaki Yoshimura, Shinichi Shimizu, Takayuki Hashimoto, Kentaro Nishioka, Norio Katoh, Hiroshi Taguchi, Koichi Yasuda, Taeko Matsuura, Seishin Takao, Masaya Tamura, Sodai Tanaka, Yoichi M. Ito, Yuto Matsuo, Hiroshi Tamura, Kenji Horita, Kikuo Umegaki, Hiroki Shirato
JOURNAL OF APPLIED CLINICAL MEDICAL PHYSICS
(2020)