Human retinal ganglion cell neurons generated by synchronous BMP inhibition and transcription factor mediated reprogramming

A Python library for probabilistic analysis of single-cell omics data

(2022) Adam Gayoso et al.   NATURE BIOTECHNOLOGY

A Critical Role for DLK and LZK in Axonal Repair in the Mammalian Spinal Cord

(2022) Junmi M. Saikia et al.   JOURNAL OF NEUROSCIENCE

Directly induced human retinal ganglion cells mimic fetal RGCs and are neuroprotective after transplantation in vivo

(2022) Ziming Luo et al.   Stem Cell Reports

Reprogramming Müller glia to regenerate ganglion-like cells in adult mouse retina with developmental transcription factors

(2022) Levi Todd et al.   Science Advances

Probabilistic harmonization and annotation of single‐cell transcriptomics data with deep generative models

(2021) Chenling Xu et al.   Molecular Systems Biology

Single Cell Transcriptomic Analyses Reveal the Impact of bHLH Factors on Human Retinal Organoid Development

(2021) Xiangmei Zhang et al.   Frontiers in Cell and Developmental Biology

Single Cell Sequencing of Induced Pluripotent Stem Cell Derived Retinal Ganglion Cells (iPSC-RGC) Reveals Distinct Molecular Signatures and RGC Subtypes

(2021) Harini V. Gudiseva et al.   Genes

CRISPR Generated SIX6 and POU4F2 Reporters Allow Identification of Brain and Optic Transcriptional Differences in Human PSC-Derived Organoids

(2021) Karl J. Wahlin et al.   Frontiers in Cell and Developmental Biology

Integration of eQTL and a Single-Cell Atlas in the Human Eye Identifies Causal Genes for Age-Related Macular Degeneration

(2020) Luz D. Orozco et al.   Cell Reports

Single-Cell Transcriptomic Comparison of Human Fetal Retina, hPSC-Derived Retinal Organoids, and Long-Term Retinal Cultures

(2020) Akshayalakshmi Sridhar et al.   Cell Reports

Glia-to-Neuron Conversion by CRISPR-CasRx Alleviates Symptoms of Neurological Disease in Mice

(2020) Haibo Zhou et al.   CELL

Single-Cell Analysis of Human Retina Identifies Evolutionarily Conserved and Species-Specific Mechanisms Controlling Development

(2020) Yufeng Lu et al.   DEVELOPMENTAL CELL

Cell Atlas of The Human Fovea and Peripheral Retina

(2020) Wenjun Yan et al.   Scientific Reports

Quick Commitment and Efficient Reprogramming Route of Direct Induction of Retinal Ganglion Cell-like Neurons

(2020) Jing Wang et al.   Stem Cell Reports

A comprehensive library of human transcription factors for cell fate engineering

(2020) Alex H. M. Ng et al.   NATURE BIOTECHNOLOGY

Inhibition of GCK-IV kinases dissociates cell death and axon regeneration in CNS neurons

(2020) Amit K. Patel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differentiation and maturation of oligodendrocytes in human three-dimensional neural cultures

(2019) Rebecca M. Marton et al.   NATURE NEUROSCIENCE

Engineered CRISPR–Cas12a variants with increased activities and improved targeting ranges for gene, epigenetic and base editing

(2019) Benjamin P. Kleinstiver et al.   NATURE BIOTECHNOLOGY

Efficient integration of heterogeneous single-cell transcriptomes using Scanorama

(2019) Brian Hie et al.   NATURE BIOTECHNOLOGY

Voltage- and calcium-gated ion channels of neurons in the vertebrate retina

(2019) Matthew J. Van Hook et al.   PROGRESS IN RETINAL AND EYE RESEARCH

DLK regulates a distinctive transcriptional regeneration program after peripheral nerve injury

(2019) Jung Eun Shin et al.   NEUROBIOLOGY OF DISEASE

Single-Cell Profiles of Retinal Ganglion Cells Differing in Resilience to Injury Reveal Neuroprotective Genes

(2019) Nicholas M. Tran et al.   NEURON

Islet1 and Brn3 Expression Pattern Study in Human Retina and hiPSC-Derived Retinal Organoid

(2019) Ziming Luo et al.   Stem Cells International

Elevated expression of human bHLH factor ATOH7 accelerates cell cycle progression of progenitors and enhances production of avian retinal ganglion cells

(2018) Xiang-Mei Zhang et al.   Scientific Reports

Combining NGN2 Programming with Developmental Patterning Generates Human Excitatory Neurons with NMDAR-Mediated Synaptic Transmission

(2018) Ralda Nehme et al.   Cell Reports

Retinal Ganglion Cell Diversity and Subtype Specification from Human Pluripotent Stem Cells

(2018) Kirstin B. Langer et al.   Stem Cell Reports

SoxC transcription factors in retinal development and regeneration

(2017) Kun-Che Chang et al.   Neural Regeneration Research

Enhanced Functional Genomic Screening Identifies Novel Mediators of Dual Leucine Zipper Kinase-Dependent Injury Signaling in Neurons

(2017) Derek S. Welsbie et al.   NEURON

Enhanced Stem Cell Differentiation and Immunopurification of Genome Engineered Human Retinal Ganglion Cells

(2017) Valentin M. Sluch et al.   Stem Cells Translational Medicine

Photoreceptor Outer Segment-like Structures in Long-Term 3D Retinas from Human Pluripotent Stem Cells

(2017) Karl J. Wahlin et al.   Scientific Reports

Lhx2 Is an Essential Factor for Retinal Gliogenesis and Notch Signaling

(2016) Jimmy de Melo et al.   JOURNAL OF NEUROSCIENCE

Multiplex gene editing by CRISPR–Cpf1 using a single crRNA array

(2016) Bernd Zetsche et al.   NATURE BIOTECHNOLOGY

Stepwise Differentiation of Retinal Ganglion Cells from Human Pluripotent Stem Cells Enables Analysis of Glaucomatous Neurodegeneration

(2016) Sarah K. Ohlemacher et al.   STEM CELLS

Generation of Functional Human Retinal Ganglion Cells with Target Specificity from Pluripotent Stem Cells by Chemically Defined Recapitulation of Developmental Mechanism

(2016) Pooja Teotia et al.   STEM CELLS

Neurosphere Based Differentiation of Human iPSC Improves Astrocyte Differentiation

(2016) Shuling Zhou et al.   Stem Cells International

The Types of Retinal Ganglion Cells: Current Status and Implications for Neuronal Classification

(2015) Joshua R. Sanes et al.   Annual Review of Neuroscience

Bmp4 from the optic vesicle specifies murine retina formation

(2015) Jie Huang et al.   DEVELOPMENTAL BIOLOGY

The LRR receptor Islr2 is required for retinal axon routing at the vertebrate optic chiasm

(2015) Paolo Panza et al.   Neural Development

Cytoskeletal disruption activates the DLK/JNK pathway, which promotes axonal regeneration and mimics a preconditioning injury

(2015) Vera Valakh et al.   NEUROBIOLOGY OF DISEASE

Neuronal medium that supports basic synaptic functions and activity of human neurons in vitro

(2015) Cedric Bardy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Two transcription factors, Pou4f2 and Isl1, are sufficient to specify the retinal ganglion cell fate

(2015) Fuguo Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Contributions of Retinal Ganglion Cells to Subcortical Visual Processing and Behaviors

(2015) Onkar S. Dhande et al.   Annual Review of Vision Science

Transcription Activator-Like Effector Nuclease (TALEN)-Mediated CLYBL Targeting Enables Enhanced Transgene Expression and One-Step Generation of Dual Reporter Human Induced Pluripotent Stem Cell (iPSC) and Neural Stem Cell (NSC) Lines

(2015) Trevor Cerbini et al.   PLoS One

Rapid neurogenesis through transcriptional activation in human stem cells

(2014) V. Busskamp et al.   Molecular Systems Biology

Transcription Factors SOX4 and SOX11 Function Redundantly to Regulate the Development of Mouse Retinal Ganglion Cells

(2013) Ying Jiang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Potassium ion channels in retinal ganglion cells (Review)

(2013) YI-SHENG ZHONG et al.   Molecular Medicine Reports

Induction of retinal ganglion-like cells from fibroblasts by adenoviral gene delivery

(2013) F. Meng et al.   NEUROSCIENCE

Functional genomic screening identifies dual leucine zipper kinase as a key mediator of retinal ganglion cell death

(2013) D. S. Welsbie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypoxia Increases the Yield of Photoreceptors Differentiating from Mouse Embryonic Stem Cells and Improves the Modeling of Retinogenesis In Vitro

(2013) Marcela Garita-HernÁndez et al.   STEM CELLS

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

Role of transmembrane semaphorin Sema6A in oligodendrocyte differentiation and myelination

(2012) Frédéric Bernard et al.   GLIA

The loss of interneuron functional diversity in the piriform cortex after induction of experimental epilepsy

(2012) Cezar Gavrilovici et al.   NEUROBIOLOGY OF DISEASE

Eye Development and Retinogenesis

(2012) W. Heavner et al.   Cold Spring Harbor Perspectives in Biology

Microtubule depolymerization in Caenorhabditis elegans touch receptor neurons reduces gene expression through a p38 MAPK pathway

(2011) A. Bounoutas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypoxia Enhances the Generation of Retinal Progenitor Cells from Human Induced Pluripotent and Embryonic Stem Cells

(2011) Daekyeong Bae et al.   STEM CELLS AND DEVELOPMENT

Neurog2 controls the leading edge of neurogenesis in the mammalian retina

(2010) Robert B. Hufnagel et al.   DEVELOPMENTAL BIOLOGY

Direct conversion of fibroblasts to functional neurons by defined factors

(2010) Thomas Vierbuchen et al.   NATURE

Distinct roles for Robo2 in the regulation of axon and dendrite growth by retinal ganglion cells

(2009) Jennifer C. Hocking et al.   MECHANISMS OF DEVELOPMENT

Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling

(2009) Stuart M Chambers et al.   NATURE BIOTECHNOLOGY

Embryonic stem cell–specific microRNAs promote induced pluripotency

(2009) Robert L Judson et al.   NATURE BIOTECHNOLOGY

A dual leucine kinase–dependent axon self-destruction program promotes Wallerian degeneration

(2009) Bradley R Miller et al.   NATURE NEUROSCIENCE

ISL1 and BRN3B co-regulate the differentiation of murine retinal ganglion cells

(2008) L. Pan et al.   DEVELOPMENT

Fast unfolding of communities in large networks

(2008) Vincent D Blondel et al.   JOURNAL OF STATISTICAL MECHANICS-THEORY AND EXPERIMENT

Gene-regulation logic in retinal ganglion cell development: Isl1 defines a critical branch distinct from but overlapping with Pou4f2

(2008) X. Mu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA