Directly induced human retinal ganglion cells mimic fetal RGCs and are neuroprotective after transplantation in vivo

Transplantation of miPSC/mESC-derived Retinal Ganglion Cells into healthy and glaucomatous retinas

(2021) Julia Oswald et al.   Molecular Therapy-Methods & Clinical Development

Human brain organoids assemble functionally integrated bilateral optic vesicles

(2021) Elke Gabriel et al.   Cell Stem Cell

Physiologic maturation is both extrinsically and intrinsically regulated in progenitor-derived neurons

(2020) Praseeda Venugopalan et al.   Scientific Reports

Single-Cell Transcriptomic Comparison of Human Fetal Retina, hPSC-Derived Retinal Organoids, and Long-Term Retinal Cultures

(2020) Akshayalakshmi Sridhar et al.   Cell Reports

Single-Cell Analysis of Human Retina Identifies Evolutionarily Conserved and Species-Specific Mechanisms Controlling Development

(2020) Yufeng Lu et al.   DEVELOPMENTAL CELL

Role of the Internal Limiting Membrane in Structural Engraftment and Topographic Spacing of Transplanted Human Stem Cell-Derived Retinal Ganglion Cells

(2020) Kevin Y. Zhang et al.   Stem Cell Reports

Opposing Effects of Growth and Differentiation Factors in Cell-Fate Specification

(2019) Kun-Che Chang et al.   CURRENT BIOLOGY

Islet1 and Brn3 Expression Pattern Study in Human Retina and hiPSC-Derived Retinal Organoid

(2019) Ziming Luo et al.   Stem Cells International

An Optimized System for Effective Derivation of Three-dimensional Retinal Tissue via Wnt Signaling Regulation

(2018) Ziming Luo et al.   STEM CELLS

Rbpj direct regulation of Atoh7 transcription in the embryonic mouse retina

(2018) Joel B. Miesfeld et al.   Scientific Reports

Dimensionality reduction for visualizing single-cell data using UMAP

(2018) Etienne Becht et al.   NATURE BIOTECHNOLOGY

Medium- to long-term survival and functional examination of human iPSC-derived retinas in rat and primate models of retinal degeneration

(2018) Hung-Ya Tu et al.   EBioMedicine

Microglial dynamics after axotomy-induced retinal ganglion cell death

(2017) Francisco M. Nadal-Nicolás et al.   Journal of Neuroinflammation

Novel Regulatory Mechanisms for the SoxC Transcriptional Network Required for Visual Pathway Development

(2017) Kun-Che Chang et al.   JOURNAL OF NEUROSCIENCE

Math5 (Atoh7) gene dosage limits retinal ganglion cell genesis

(2017) Lev Prasov et al.   NEUROREPORT

Transplanted neurons integrate into adult retinas and respond to light

(2016) Praseeda Venugopalan et al.   Nature Communications

Donor and host photoreceptors engage in material transfer following transplantation of post-mitotic photoreceptor precursors

(2016) R. A. Pearson et al.   Nature Communications

Small Molecules Modulate Chromatin Accessibility to Promote NEUROG2-Mediated Fibroblast-to-Neuron Reprogramming

(2016) Derek K. Smith et al.   Stem Cell Reports

Differentiation of human ESCs to retinal ganglion cells using a CRISPR engineered reporter cell line

(2015) Valentin M. Sluch et al.   Scientific Reports

Notch signaling differentially regulates Atoh7 and Neurog2 in the distal mouse retina

(2014) K. A. Maurer et al.   DEVELOPMENT

Inhibition of adenosine kinase attenuates inflammation and neurotoxicity in traumatic optic neuropathy

(2014) Saif Ahmad et al.   JOURNAL OF NEUROIMMUNOLOGY

Differentiation of Retinal Ganglion Cells and Photoreceptor Precursors from Mouse Induced Pluripotent Stem Cells Carrying an Atoh7/Math5 Lineage Reporter

(2014) Bin-Bin Xie et al.   PLoS One

Generation of three-dimensional retinal tissue with functional photoreceptors from human iPSCs

(2014) Xiufeng Zhong et al.   Nature Communications

Survival and Integration of Developing and Progenitor-Derived Retinal Ganglion Cells following Transplantation

(2013) Jonathan Hertz et al.   CELL TRANSPLANTATION

Rapid Single-Step Induction of Functional Neurons from Human Pluripotent Stem Cells

(2013) Yingsha Zhang et al.   NEURON

Long-Distance Growth and Connectivity of Neural Stem Cells after Severe Spinal Cord Injury

(2012) Paul Lu et al.   CELL

Math5 defines the ganglion cell competence state in a subpopulation of retinal progenitor cells exiting the cell cycle

(2012) Joseph A. Brzezinski et al.   DEVELOPMENTAL BIOLOGY

Neurog2 controls the leading edge of neurogenesis in the mammalian retina

(2010) Robert B. Hufnagel et al.   DEVELOPMENTAL BIOLOGY

Conserved regulatory sequences in Atoh7 mediate non-conserved regulatory responses in retina ontogenesis

(2009) D. Skowronska-Krawczyk et al.   DEVELOPMENT