ARQiv-HTS, a versatile whole-organism screening platform enabling in vivo drug discovery at high-throughput rates

15 years of zebrafish chemical screening

(2015) Andrew J Rennekamp et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

The fickle P value generates irreproducible results

(2015) Lewis G Halsey et al.   NATURE METHODS

Zebrafish as tools for drug discovery

(2015) Calum A. MacRae et al.   NATURE REVIEWS DRUG DISCOVERY

RGtk2: A Graphical User Interface Toolkit forR

(2015) Michael Lawrence et al.   Journal of Statistical Software

Effects of proarrhythmic drugs on relaxation time and beating pattern in rat engineered heart tissue

(2014) Alexandra Eder et al.   BASIC RESEARCH IN CARDIOLOGY

Robust adaptive phase-shifting demodulation for testing moving wavefronts

(2013) Orlando Medina et al.   OPTICS EXPRESS

An Ultra High-Throughput, Whole-Animal Screen for Small Molecule Modulators of a Specific Genetic Pathway in Caenorhabditis elegans

(2013) Chi K. Leung et al.   PLoS One

Interference with xenobiotic metabolic activity by the commonly used vehicle solvents dimethylsulfoxide and methanol in zebrafish (Danio rerio) larvae but not Daphnia magna

(2012) Rhiannon M. David et al.   CHEMOSPHERE

Advances in zebrafish chemical screening technologies

(2012) Jonathan R Mathias et al.   Future Medicinal Chemistry

Diagnosing the decline in pharmaceutical R&D efficiency

(2012) Jack W. Scannell et al.   NATURE REVIEWS DRUG DISCOVERY

Automated Reporter Quantification In Vivo: High-Throughput Screening Method for Reporter-Based Assays in Zebrafish

(2012) Steven L. Walker et al.   PLoS One

How were new medicines discovered?

(2011) David C. Swinney et al.   NATURE REVIEWS DRUG DISCOVERY

A New System for the Rapid Collection of Large Numbers of Developmentally Staged Zebrafish Embryos

(2011) Isaac Adatto et al.   PLoS One

Large-Scale Assessment of the Zebrafish Embryo as a Possible Predictive Model in Toxicity Testing

(2011) Shaukat Ali et al.   PLoS One

Chemical screen identifies FDA-approved drugs and target pathways that induce precocious pancreatic endocrine differentiation

(2011) M. Rovira et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of Histone Deacetylase Expands the Renal Progenitor Cell Population

(2010) E. D. de Groh et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Rapid behavior-based identification of neuroactive small molecules in the zebrafish

(2010) David Kokel et al.   Nature Chemical Biology

Zebrafish Behavioral Profiling Links Drugs to Biological Targets and Rest/Wake Regulation

(2010) J. Rihel et al.   SCIENCE

A Chemical Genetic Screen in Zebrafish for Pathways Interacting with cdx4 in Primitive Hematopoiesis

(2010) Elizabeth J. Paik et al.   Zebrafish

Chemical Screening for Hair Cell Loss and Protection in the Zebrafish Lateral Line

(2010) Allison B. Coffin et al.   Zebrafish

Ha-ras Oncogene–Induced Stat3 Phosphorylation Enhances Oncogenicity of the Cell

(2009) Hsuan-Heng Yeh et al.   DNA AND CELL BIOLOGY

Notch-responsive cells initiate the secondary transition in larval zebrafish pancreas

(2009) Michael J. Parsons et al.   MECHANISMS OF DEVELOPMENT

Zebrafish chemical screening reveals an inhibitor of Dusp6 that expands cardiac cell lineages

(2009) Gabriela Molina et al.   Nature Chemical Biology

Chemical modifier screen identifies HDAC inhibitors as suppressors of PKD models

(2009) Y. Cao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of Genetic and Chemical Modulators of Zebrafish Mechanosensory Hair Cell Death

(2008) Kelly N. Owens et al.   PLoS Genetics