Quantifying small molecule phenotypic effects using mitochondrial morpho-functional fingerprinting and machine learning

Machine learning in cell biology – teaching computers to recognize phenotypes

(2013) Christoph Sommer et al.   JOURNAL OF CELL SCIENCE

Review of Clinical Trials for Mitochondrial Disorders: 1997–2012

(2013) Douglas S. Kerr   Neurotherapeutics

A Randomized Trial of Glutamine and Antioxidants in Critically Ill Patients

(2013) Daren Heyland et al.   NEW ENGLAND JOURNAL OF MEDICINE

Ten misconceptions about antioxidants

(2013) Aalt Bast et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Computational classification of mitochondrial shapes reflects stress and redox state

(2013) T Ahmad et al.   Cell Death & Disease

Trolox-Sensitive Reactive Oxygen Species Regulate Mitochondrial Morphology, Oxidative Phosphorylation and Cytosolic Calcium Handling in Healthy Cells

(2012) Felix Distelmaier et al.   ANTIOXIDANTS & REDOX SIGNALING

Effects of cytoprotective antioxidants on lymphocytes from representative mitochondrial neurodegenerative diseases

(2012) Ruth Goldschmidt et al.   BIOORGANIC & MEDICINAL CHEMISTRY

OXPHOS mutations and neurodegeneration

(2012) Werner J H Koopman et al.   EMBO JOURNAL

Primary fibroblasts of NDUFS4−/− mice display increased ROS levels and aberrant mitochondrial morphology

(2012) Federica Valsecchi et al.   MITOCHONDRION

Physiological Roles of Mitochondrial Reactive Oxygen Species

(2012) Laura A. Sena et al.   MOLECULAR CELL

EPI-743 reverses the progression of the pediatric mitochondrial disease—Genetically defined Leigh Syndrome

(2012) Diego Martinelli et al.   MOLECULAR GENETICS AND METABOLISM

Mitochondrial disorders as windows into an ancient organelle

(2012) Scott B. Vafai et al.   NATURE

Monogenic Mitochondrial Disorders

(2012) Werner J.H. Koopman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Free radicals and antioxidants: updating a personal view

(2012) Barry Halliwell   NUTRITION REVIEWS

Multi-Parametric Analysis and Modeling of Relationships between Mitochondrial Morphology and Apoptosis

(2012) Yara Reis et al.   PLoS One

Plasma thiol status is altered in children with mitochondrial diseases

(2012) Heli Salmi et al.   SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION

Vitamins C and E: Beneficial effects from a mechanistic perspective

(2011) Maret G. Traber et al.   FREE RADICAL BIOLOGY AND MEDICINE

The mitochondria-targeted antioxidant MitoQ decreases features of the metabolic syndrome in ATM+/–/ApoE–/– mice

(2011) John R. Mercer et al.   FREE RADICAL BIOLOGY AND MEDICINE

Impaired mitochondrial biogenesis, defective axonal transport of mitochondria, abnormal mitochondrial dynamics and synaptic degeneration in a mouse model of Alzheimer's disease

(2011) M. J. Calkins et al.   HUMAN MOLECULAR GENETICS

Chemistry and biology of reactive oxygen species in signaling or stress responses

(2011) Bryan C Dickinson et al.   Nature Chemical Biology

Automatic Morphological Subtyping Reveals New Roles of Caspases in Mitochondrial Dynamics

(2011) Jyh-Ying Peng et al.   PLoS Computational Biology

Tuning of the Pro-oxidant and Antioxidant Activity of Trolox Through the Controlled Release from Biodegradable Poly(trolox ester) Polymers

(2010) Paritosh Wattamwar et al.   FREE RADICAL BIOLOGY AND MEDICINE

Biochemical diagnosis of mitochondrial disorders

(2010) Richard J. T. Rodenburg   JOURNAL OF INHERITED METABOLIC DISEASE

Mitochondrial complex I deficiency: from organelle dysfunction to clinical disease

(2009) F. Distelmaier et al.   BRAIN

Antioxidant Activity of Vitamin E and Trolox: Understanding of the Factors that Govern Lipid Peroxidation Studies In Vitro

(2009) Marlene Lúcio et al.   Food Biophysics

The antioxidant Trolox restores mitochondrial membrane potential and Ca2+-stimulated ATP production in human complex I deficiency

(2009) Felix Distelmaier et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Multi-parameter phenotypic profiling: using cellular effects to characterize small-molecule compounds

(2009) Yan Feng et al.   NATURE REVIEWS DRUG DISCOVERY

Mitigation of NADH: Ubiquinone oxidoreductase deficiency by chronic Trolox treatment

(2008) Werner J.H. Koopman et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Vitamin E: The shrew waiting to be tamed

(2008) Regina Brigelius-Flohé   FREE RADICAL BIOLOGY AND MEDICINE

Modulation of mitochondrial morphology by bioenergetics defects in primary human fibroblasts

(2008) O. Guillery et al.   NEUROMUSCULAR DISORDERS

Life cell quantification of mitochondrial membrane potential at the single organelle level

(2007) Felix Distelmaier et al.   CYTOMETRY PART A