Biallelic loss-of-function mutation in NIK causes a primary immunodeficiency with multifaceted aberrant lymphoid immunity

Early-onset inflammatory bowel disease and common variable immunodeficiency–like disease caused by IL-21 deficiency

(2014) Elisabeth Salzer et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Human CD19 and CD40L deficiencies impair antibody selection and differentially affect somatic hypermutation

(2014) Menno C. van Zelm et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

A common single nucleotide polymorphism impairs B-cell activating factor receptor's multimerization, contributing to common variable immunodeficiency

(2014) Kathrin Pieper et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Germline Mutations in NFKB2 Implicate the Noncanonical NF-κB Pathway in the Pathogenesis of Common Variable Immunodeficiency

(2013) Karin Chen et al.   AMERICAN JOURNAL OF HUMAN GENETICS

B-cell deficiency and severe autoimmunity caused by deficiency of protein kinase C  

(2013) E. Salzer et al.   BLOOD

Inhibition of human B-cell development into plasmablasts by histone deacetylase inhibitor valproic acid

(2013) Anne-Kathrin Kienzler et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

B-cell biology and development

(2013) Kathrin Pieper et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Natural killer cell deficiency

(2013) Jordan S. Orange   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Loss-of-function mutations in the IL-21 receptor gene cause a primary immunodeficiency syndrome

(2013) Daniel Kotlarz et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CD62L Is Critical for Maturation and Accumulation of Murine Hepatic NK Cells in Response to Viral Infection

(2013) H. Peng et al.   JOURNAL OF IMMUNOLOGY

A Cell-Intrinsic Requirement for NF- B-Inducing Kinase in CD4 and CD8 T Cell Memory

(2013) A. M. Rowe et al.   JOURNAL OF IMMUNOLOGY

Dominant-activating germline mutations in the gene encoding the PI(3)K catalytic subunit p110δ result in T cell senescence and human immunodeficiency

(2013) Carrie L Lucas et al.   NATURE IMMUNOLOGY

Deficiency of Innate and Acquired Immunity Caused by an IKBKB Mutation

(2013) Ulrich Pannicke et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cell-Intrinsic Role for NF-kappa B-Inducing Kinase in Peripheral Maintenance but Not Thymic Development of Foxp3+ Regulatory T Cells in Mice

(2013) Susan E. Murray   PLoS One

Phosphoinositide 3-Kinase   Gene Mutation Predisposes to Respiratory Infection and Airway Damage

(2013) I. Angulo et al.   SCIENCE

Bilateral adrenal EBV-associated smooth muscle tumors in a child with a natural killer cell deficiency

(2012) R. K. Shaw et al.   BLOOD

Functional STAT3 deficiency compromises the generation of human T follicular helper cells

(2012) C. S. Ma et al.   BLOOD

Combined immunodeficiency with life-threatening EBV-associated lymphoproliferative disorder in patients lacking functional CD27

(2012) E. Salzer et al.   HAEMATOLOGICA

The noncanonical NF-κB pathway

(2012) Shao-Cong Sun   IMMUNOLOGICAL REVIEWS

Structure of the Nuclear Factor κB-inducing Kinase (NIK) Kinase Domain Reveals a Constitutively Active Conformation

(2012) Jinsong Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NIK Prevents the Development of Hypereosinophilic Syndrome-like Disease in Mice Independent of IKK  Activation

(2012) H. Hacker et al.   JOURNAL OF IMMUNOLOGY

Viral immune modulators perturb the human molecular network by common and unique strategies

(2012) Andreas Pichlmair et al.   NATURE

The kinase TBK1 controls IgA class switching by negatively regulating noncanonical NF-κB signaling

(2012) Jin Jin et al.   NATURE IMMUNOLOGY

The Crystal Structure of the Catalytic Domain of the NF-κB Inducing Kinase Reveals a Narrow but Flexible Active Site

(2012) Gladys de Leon-Boenig et al.   STRUCTURE

BCR-signalling synergizes with TLR-signalling for induction of AID and immunoglobulin class-switching through the non-canonical NF-κB pathway

(2012) Egest J. Pone et al.   Nature Communications

Human memory B cells originate from three distinct germinal center-dependent and -independent maturation pathways

(2011) M. A. Berkowska et al.   BLOOD

Genetic CD21 deficiency is associated with hypogammaglobulinemia

(2011) Jens Thiel et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Noncanonical NF- B regulates inducible costimulator (ICOS) ligand expression and T follicular helper cell development

(2011) H. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reference values for B cell subpopulations from infancy to adulthood

(2010) H. Morbach et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Two Newly Diagnosed HLA Class II-Deficient Patients Identified by Rapid Vector-Based Complementation Analysis Reveal Discoordinate Invariant Chain Expression Levels

(2010) Klaus G. Schmetterer et al.   INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

Roles of TRAF2 and TRAF3 in Epstein-Barr virus latent membrane protein 1-induced alternative NF-κB activation

(2010) Yoon-Jae Song et al.   VIRUS GENES

Regulation of Th17 cell differentiation and EAE induction by MAP3K NIK

(2009) W. Jin et al.   BLOOD

Impaired CD4 and CD8 Effector Function and Decreased Memory T Cell Populations in ICOS-Deficient Patients

(2009) N. Takahashi et al.   JOURNAL OF IMMUNOLOGY

B-cell activating factor receptor deficiency is associated with an adult-onset antibody deficiency syndrome in humans

(2009) K. Warnatz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A coarse-grained potential for fold recognition and molecular dynamics simulations of proteins

(2009) Peter Májek et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Flowcytometric phenotyping of common variable immunodeficiency

(2008) Klaus Warnatz et al.   CYTOMETRY PART B-CLINICAL CYTOMETRY

Age-matched lymphocyte subpopulation reference values in childhood and adolescence: application of exponential regression analysis

(2008) Sabine Huenecke et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

TRAF2 and TRAF3 Signal Adapters Act Cooperatively to Control the Maturation and Survival Signals Delivered to B Cells by the BAFF Receptor

(2008) Sandra Gardam et al.   IMMUNITY

NIK overexpression amplifies, whereas ablation of its TRAF3-binding domain replaces BAFF:BAFF-R-mediated survival signals in B cells

(2008) Y. Sasaki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA