Structural analysis of leader peptide binding enables leader-free cyanobactin processing

An Efficient Method for the In Vitro Production of Azol(in)e-Based Cyclic Peptides

(2014) Wael E. Houssen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Improving on Nature: Making a Cyclic Heptapeptide Orally Bioavailable

(2014) Daniel S. Nielsen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

One-Pot Synthesis of Azoline-Containing Peptides in a Cell-free Translation System Integrated with a Posttranslational Cyclodehydratase

(2014) Yuki Goto et al.   CHEMISTRY & BIOLOGY

Marine natural products

(2014) John W. Blunt et al.   NATURAL PRODUCT REPORTS

Structure and mechanism of the tRNA-dependent lantibiotic dehydratase NisB

(2014) Manuel A. Ortega et al.   NATURE

Discovery of a new ATP-binding motif involved in peptidic azoline biosynthesis

(2014) Kyle L Dunbar et al.   Nature Chemical Biology

Assessing the Combinatorial Potential of the RiPP Cyanobactin tru Pathway

(2014) Duane E. Ruffner et al.   ACS Synthetic Biology

Structure of PatF fromProchloron didemni

(2013) Andrew F. Bent et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

The Cyanobactin Heterocyclase Enzyme: A Processive Adenylase That Operates with a Defined Order of Reaction

(2013) Jesko Koehnke et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Orchestration of Enzymatic Processing by Thiazole/Oxazole-Modified Microcin Dehydrogenases

(2013) Joel O. Melby et al.   BIOCHEMISTRY

An Enzymatic Route to Selenazolines

(2013) Jesko Koehnke et al.   CHEMBIOCHEM

Insights into the Mechanism of Peptide Cyclodehydrations Achieved through the Chemoenzymatic Generation of Amide Derivatives

(2013) Kyle L. Dunbar et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Marine Pharmacology in 2009–2011: Marine Compounds with Antibacterial, Antidiabetic, Antifungal, Anti-Inflammatory, Antiprotozoal, Antituberculosis, and Antiviral Activities; Affecting the Immune and Nervous Systems, and other Miscellaneous Mechanisms of Action

(2013) Alejandro Mayer et al.   Marine Drugs

The Discovery of New Cyanobactins fromCyanothecePCC 7425 Defines a New Signature for Processing of Patellamides

(2012) Wael E. Houssen et al.   CHEMBIOCHEM

Structures of Cyanobactin Maturation Enzymes Define a Family of Transamidating Proteases

(2012) Vinayak Agarwal et al.   CHEMISTRY & BIOLOGY

An Engineered Lantibiotic Synthetase That Does Not Require a Leader Peptide on Its Substrate

(2012) Trent J. Oman et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Selectivity, Directionality, and Promiscuity in Peptide Processing from a Bacillus sp. Al Hakam Cyclodehydratase

(2012) Joel O. Melby et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature

(2012) Paul G. Arnison et al.   NATURAL PRODUCT REPORTS

YcaO domains use ATP to activate amide backbones during peptide cyclodehydrations

(2012) Kyle L Dunbar et al.   Nature Chemical Biology

The mechanism of patellamide macrocyclization revealed by the characterization of the PatG macrocyclase domain

(2012) Jesko Koehnke et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

REFMAC5 for the refinement of macromolecular crystal structures

(2011) Garib N. Murshudov et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Pericyclic Prenylation: Peptide Modification through a Claisen Rearrangement

(2011) Jaimeen D. Majmudar et al.   CHEMBIOCHEM

Linking Chemistry and Genetics in the Growing Cyanobactin Natural Products Family

(2011) Mohamed S. Donia et al.   CHEMISTRY & BIOLOGY

Cyanobactins—ribosomal cyclic peptides produced by cyanobacteria

(2010) Kaarina Sivonen et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Marine Molecular Machines: Heterocyclization in Cyanobactin Biosynthesis

(2010) John A. McIntosh et al.   CHEMBIOCHEM

Insights into Heterocyclization from Two Highly Similar Enzymes

(2010) John A. McIntosh et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Highly Diverse Cyanobactins in Strains of the Genus Anabaena

(2009) N. Leikoski et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

How the MccB bacterial ancestor of ubiquitin E1 initiates biosynthesis of the microcin C7 antibiotic

(2009) Catherine A Regni et al.   EMBO JOURNAL

xia2: an expert system for macromolecular crystallography data reduction

(2009) G. Winter   JOURNAL OF APPLIED CRYSTALLOGRAPHY

Follow the leader: the use of leader peptides to guide natural product biosynthesis

(2009) Trent J Oman et al.   Nature Chemical Biology

The exploration of macrocycles for drug discovery — an underexploited structural class

(2008) Edward M. Driggers et al.   NATURE REVIEWS DRUG DISCOVERY