Broad Spectrum Pro-Quorum-Sensing Molecules as Inhibitors of Virulence in Vibrios

Quorum-sensing non-coding small RNAs use unique pairing regions to differentially control mRNA targets

(2012) Yi Shao et al.   MOLECULAR MICROBIOLOGY

Mechanism of Vibrio cholerae Autoinducer-1 Biosynthesis

(2011) Yunzhou Wei et al.   ACS Chemical Biology

Design, synthesis, and biological evaluation of abiotic, non-lactone modulators of LuxR-type quorum sensing

(2011) Christine E. McInnis et al.   BIOORGANIC & MEDICINAL CHEMISTRY

AphA and LuxR/HapR reciprocally control quorum sensing in vibrios

(2011) S. T. Rutherford et al.   GENES & DEVELOPMENT

Quorum Sensing and Silencing in Vibrio parahaemolyticus

(2011) C. J. Gode-Potratz et al.   JOURNAL OF BACTERIOLOGY

Regulation of Cytotoxicity by Quorum-Sensing Signaling in Vibrio vulnificus Is Mediated by SmcR, a Repressor of hlyU

(2011) C.-P. Shao et al.   JOURNAL OF BACTERIOLOGY

A Strategy for Antagonizing Quorum Sensing

(2011) Guozhou Chen et al.   MOLECULAR CELL

Signal production and detection specificity in Vibrio CqsA/CqsS quorum-sensing systems

(2011) Wai-Leung Ng et al.   MOLECULAR MICROBIOLOGY

Reversible inhibitor of p97, DBeQ, impairs both ubiquitin-dependent and autophagic protein clearance pathways

(2011) T.-F. Chou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Two-component signal transduction as potential drug targets in pathogenic bacteria

(2010) Yasuhiro Gotoh et al.   CURRENT OPINION IN MICROBIOLOGY

Novel antibacterial compounds specifically targeting the essential WalR response regulator

(2010) Yasuhiro Gotoh et al.   JOURNAL OF ANTIBIOTICS

Negative Feedback Loops Involving Small Regulatory RNAs Precisely Control the Vibrio harveyi Quorum-Sensing Response

(2010) Kimberly C. Tu et al.   MOLECULAR CELL

Anti-virulence strategies to combat bacteria-mediated disease

(2010) David A. Rasko et al.   NATURE REVIEWS DRUG DISCOVERY

Probing bacterial transmembrane histidine kinase receptor-ligand interactions with natural and synthetic molecules

(2010) W.-L. Ng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Engagement of Arginine Finger to ATP Triggers Large Conformational Changes in NtrC1 AAA+ ATPase for Remodeling Bacterial RNA Polymerase

(2010) Baoyu Chen et al.   STRUCTURE

Bacterial Quorum-Sensing Network Architectures

(2009) Wai-Leung Ng et al.   Annual Review of Genetics

Jamming bacterial communication: New approaches for the treatment of infectious diseases

(2009) Jacqueline Njoroge et al.   EMBO Molecular Medicine

Structure-Based Design of DevR Inhibitor Active against NonreplicatingMycobacterium tuberculosis

(2009) Rajesh Kumar Gupta et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Quorum-Sensing Antagonist Targets Both Membrane-Bound and Cytoplasmic Receptors and Controls Bacterial Pathogenicity

(2009) Lee R. Swem et al.   MOLECULAR CELL

The Vibrio cholerae quorum-sensing autoinducer CAI-1: analysis of the biosynthetic enzyme CqsA

(2009) Robert C Kelly et al.   Nature Chemical Biology

Quorum Sensing in Staphylococci

(2008) Richard P. Novick et al.   Annual Review of Genetics

Effects of luxCDABEG induction in Vibrio fischeri: enhancement of symbiotic colonization and conditional attenuation of growth in culture

(2008) Jeffrey L. Bose et al.   ARCHIVES OF MICROBIOLOGY

InterruptingVibrio choleraeinfection of human epithelial cells with engineered commensal bacterial signaling

(2008) Faping Duan et al.   BIOTECHNOLOGY AND BIOENGINEERING

Expanding dialogues: from natural autoinducers to non-natural analogues that modulate quorum sensing in Gram-negative bacteria

(2008) Grant D. Geske et al.   CHEMICAL SOCIETY REVIEWS

The Vibrio harveyi master quorum-sensing regulator, LuxR, a TetR-type protein is both an activator and a repressor: DNA recognition and binding specificity at target promoters

(2008) Audra J. Pompeani et al.   MOLECULAR MICROBIOLOGY

Mucosal penetration primes Vibrio cholerae for host colonization by repressing quorum sensing

(2008) Z. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting QseC Signaling and Virulence for Antibiotic Development

(2008) D. A. Rasko et al.   SCIENCE

The Evolution of Quorum Sensing in Bacterial Biofilms

(2008) Carey D Nadell et al.   PLOS BIOLOGY

Synthetic ligands that activate and inhibit a quorum-sensing regulator in Pseudomonas aeruginosa

(2007) Margrith E. Mattmann et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The biology and future prospects of antivirulence therapies

(2007) Lynette Cegelski et al.   NATURE REVIEWS MICROBIOLOGY