Ex vivo gene therapy for HIV-1 treatment

The expanding universe of transposon technologies for gene and cell engineering

(2011) Zoltán Ivics et al.   Mobile DNA

Selection of genetically modified hematopoietic cells in vitro and in vivo using alkylating agent lysomustine

(2010) F.N. Rozov et al.   ANALYTICAL BIOCHEMISTRY

The challenge of obtaining therapeutic levels of genetically modified hematopoietic stem cells in β-thalassemia patients

(2010) Derek A. Persons   Annals of the New York Academy of Sciences

Lentiviral Vectors in Gene Therapy: Their Current Status and Future Potential

(2010) David Escors et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Hybrids of Nonviral Vectors for Gene Delivery

(2010) Shubiao Zhang et al.   BIOCONJUGATE CHEMISTRY

Translating Sleeping Beauty transposition into cellular therapies: Victories and challenges

(2010) Zsuzsanna Izsvák et al.   BIOESSAYS

Chim3 confers survival advantage to CD4+ T cells upon HIV-1 infection by preventing HIV-1 DNA integration and HIV-1-induced G2 cell-cycle delay

(2010) S. Porcellini et al.   BLOOD

Evidence for the cure of HIV infection by CCR5 32/ 32 stem cell transplantation

(2010) K. Allers et al.   BLOOD

Structural Basis of HIV-1 Tethering to Membranes by the BST-2/Tetherin Ectodomain

(2010) Andreas Hinz et al.   Cell Host & Microbe

Interactions of host APOBEC3 restriction factors with HIV-1 in vivo: implications for therapeutics

(2010) John S. Albin et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Improvement of lentiviral vector-mediated gene transduction by genetic engineering of the structural protein Pr55Gag

(2010) T Aoki et al.   GENE THERAPY

Generation of human TRIM5α mutants with high HIV-1 restriction activity

(2010) Q T Pham et al.   GENE THERAPY

Human immunodeficiency virus (HIV)-1 infects human hepatic stellate cells and promotes collagen I and monocyte chemoattractant protein-1 expression: Implications for the pathogenesis of HIV/hepatitis C virus-induced liver fibrosis

(2010) Ana C. Tuyama et al.   HEPATOLOGY

Unexpectedly High Copy Number of Random Integration but Low Frequency of Persistent Expression of the Sleeping Beauty Transposase After Trans Delivery in Primary Human T Cells

(2010) Xin Huang et al.   HUMAN GENE THERAPY

The use of cell-delivered gene therapy for the treatment of HIV/AIDS

(2010) Geoff P. Symonds et al.   IMMUNOLOGIC RESEARCH

Lentiviral vectors for immune cells targeting

(2010) Steven Froelich et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

An HIV-1 Resistance Polymorphism in TRIM5α Gene Among Chinese Intravenous Drug Users

(2010) Feng-Liang Liu et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Cytoplasmic Body Component TRIM5α Requires Lipid-enriched Microdomains for Efficient HIV-1 Restriction

(2010) Seiga Ohmine et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Absence of DICER in Monocytes and Its Regulation by HIV-1

(2010) William Coley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of HIV-1 infection by a unique short hairpin RNA to chemokine receptor 5 delivered into macrophages through hematopoietic progenitor cell transduction

(2010) Min Liang et al.   JOURNAL OF GENE MEDICINE

Host Genes Associated with HIV-1 Replication in Lymphatic Tissue

(2010) A. J. Smith et al.   JOURNAL OF IMMUNOLOGY

High Natural Permissivity of Primary Rabbit Cells for HIV-1, with a Virion Infectivity Defect in Macrophages as the Final Replication Barrier

(2010) H.-M. Tervo et al.   JOURNAL OF VIROLOGY

The HIV-1 Central Polypurine Tract Functions as a Second Line of Defense against APOBEC3G/F

(2010) C. Hu et al.   JOURNAL OF VIROLOGY

Productive Replication of vif-Chimeric HIV-1 in Feline Cells

(2010) M. A. Stern et al.   JOURNAL OF VIROLOGY

TRIM5  Disrupts the Structure of Assembled HIV-1 Capsid Complexes In Vitro

(2010) L. R. Black et al.   JOURNAL OF VIROLOGY

Antagonism of CD317 Restriction of Human Immunodeficiency Virus Type 1 (HIV-1) Particle Release and Depletion of CD317 Are Separable Activities of HIV-1 Vpu

(2010) C. Goffinet et al.   JOURNAL OF VIROLOGY

Endogenous CD317/Tetherin Limits Replication of HIV-1 and Murine Leukemia Virus in Rodent Cells and Is Resistant to Antagonists from Primate Viruses

(2010) C. Goffinet et al.   JOURNAL OF VIROLOGY

JNK1 Is Required for Lentivirus Entry and Gene Transfer

(2010) M.-H. Lee et al.   JOURNAL OF VIROLOGY

Moderate Influence of Human APOBEC3F on HIV-1 Replication in Primary Lymphocytes

(2010) L. C. F. Mulder et al.   JOURNAL OF VIROLOGY

APOBEC3G Contributes to HIV-1 Variation through Sublethal Mutagenesis

(2010) H. A. Sadler et al.   JOURNAL OF VIROLOGY

Ebola Virus Glycoprotein Counteracts BST-2/Tetherin Restriction in a Sequence-Independent Manner That Does Not Require Tetherin Surface Removal

(2010) L. A. Lopez et al.   JOURNAL OF VIROLOGY

Serine-Threonine Ubiquitination Mediates Downregulation of BST-2/Tetherin and Relief of Restricted Virion Release by HIV-1 Vpu

(2010) A. A. Tokarev et al.   JOURNAL OF VIROLOGY

P Body-Associated Protein Mov10 Inhibits HIV-1 Replication at Multiple Stages

(2010) R. Burdick et al.   JOURNAL OF VIROLOGY

Human APOBEC3G-Mediated Editing Can Promote HIV-1 Sequence Diversification and Accelerate Adaptation to Selective Pressure

(2010) E.-Y. Kim et al.   JOURNAL OF VIROLOGY

APOBEC3F and APOBEC3G Inhibit HIV-1 DNA Integration by Different Mechanisms

(2010) J. L. Mbisa et al.   JOURNAL OF VIROLOGY

HIV-1 Vif versus the APOBEC3 cytidine deaminases: An intracellular duel between pathogen and host restriction factors

(2010) Silke Wissing et al.   MOLECULAR ASPECTS OF MEDICINE

Hybrid Lentiviral Vectors

(2010) Waseem Qasim et al.   MOLECULAR THERAPY

Recent Advances in Lentiviral Vector Development and Applications

(2010) Janka Mátrai et al.   MOLECULAR THERAPY

Comparative Analysis of Transposable Element Vector Systems in Human Cells

(2010) Ivana Grabundzija et al.   MOLECULAR THERAPY

Gene Transfer Efficiency and Genome-Wide Integration Profiling of Sleeping Beauty, Tol2, and PiggyBac Transposons in Human Primary T Cells

(2010) Xin Huang et al.   MOLECULAR THERAPY

A Transposon and Transposase System for Human Application

(2010) Perry B Hackett et al.   MOLECULAR THERAPY

Human hematopoietic stem/progenitor cells modified by zinc-finger nucleases targeted to CCR5 control HIV-1 in vivo

(2010) Nathalia Holt et al.   NATURE BIOTECHNOLOGY

HIV-1 infects multipotent progenitor cells causing cell death and establishing latent cellular reservoirs

(2010) Christoph C Carter et al.   NATURE MEDICINE

Quantitative profiling of the full APOBEC3 mRNA repertoire in lymphocytes and tissues: implications for HIV-1 restriction

(2010) Eric W. Refsland et al.   NUCLEIC ACIDS RESEARCH

Survival of the Fittest: Positive Selection of CD4+ T Cells Expressing a Membrane-Bound Fusion Inhibitor Following HIV-1 Infection

(2010) Janine Kimpel et al.   PLoS One

Targeting HIV-1 DNA integration by swapping tethers

(2010) R. Craigie   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lens epithelium-derived growth factor fusion proteins redirect HIV-1 DNA integration

(2010) A. L. Ferris et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hexagonal assembly of a restricting TRIM5  protein

(2010) B. K. Ganser-Pornillos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Specific insertions of zinc finger domains into Gag-Pol yield engineered retroviral vectors with selective integration properties

(2010) Kwang-il Lim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A single amino acid substitution of the human immunodeficiency virus type 1 capsid protein affects viral sensitivity to TRIM5α

(2010) Ayumu Kuroishi et al.   Retrovirology

In silico modeling indicates the development of HIV-1 resistance to multiple shRNA gene therapy differs to standard antiretroviral therapy

(2010) Tanya Applegate et al.   Retrovirology

Anticipating and blocking HIV-1 escape by second generation antiviral shRNAs

(2010) Nick CT Schopman et al.   Retrovirology

Vpu serine 52 dependent counteraction of tetherin is required for HIV-1 replication in macrophages, but not in ex vivo human lymphoid tissue

(2010) Michael Schindler et al.   Retrovirology

Vpu-dependent block to incorporation of GaLV Env into lentiviral vectors

(2010) Ilias Christodoulopoulos et al.   Retrovirology

Anti-tetherin activities in Vpu-expressing primate lentiviruses

(2010) Su Yang et al.   Retrovirology

HIV-1 Vpu and HIV-2 Env counteract BST-2/tetherin by sequestration in a perinuclear compartment

(2010) Heiko Hauser et al.   Retrovirology

Anti-retroviral activity of TRIM5α

(2010) Emi E. Nakayama et al.   REVIEWS IN MEDICAL VIROLOGY

RNA-Based Gene Therapy for HIV with Lentiviral Vector-Modified CD34+ Cells in Patients Undergoing Transplantation for AIDS-Related Lymphoma

(2010) D. L. DiGiusto et al.   Science Translational Medicine

Adaptation of HIV-1 to cells expressing rhesus monkey TRIM5α

(2010) Beatriz Pacheco et al.   VIROLOGY

Computational Models of HIV-1 Resistance to Gene Therapy Elucidate Therapy Design Principles

(2010) Sharon Aviran et al.   PLoS Computational Biology

Antagonism of Tetherin Restriction of HIV-1 Release by Vpu Involves Binding and Sequestration of the Restriction Factor in a Perinuclear Compartment

(2010) Mathieu Dubé et al.   PLoS Pathogens

Immunoelectron Microscopic Evidence for Tetherin/BST2 as the Physical Bridge between HIV-1 Virions and the Plasma Membrane

(2010) Jason Hammonds et al.   PLoS Pathogens

Direct Restriction of Virus Release and Incorporation of the Interferon-Induced Protein BST-2 into HIV-1 Particles

(2010) Kathleen Fitzpatrick et al.   PLoS Pathogens

Tetherin Restricts Productive HIV-1 Cell-to-Cell Transmission

(2010) Nicoletta Casartelli et al.   PLoS Pathogens

High-Level Genomic Integration, Epigenetic Changes, and Expression ofSleeping BeautyTransgene

(2009) Jianhui Zhu et al.   BIOCHEMISTRY

Foamy virus vectors for gene transfer

(2009) Grant D Trobridge   EXPERT OPINION ON BIOLOGICAL THERAPY

Foamy combinatorial anti-HIV vectors with MGMTP140K potently inhibit HIV-1 and SHIV replication and mediate selection in vivo

(2009) H-P Kiem et al.   GENE THERAPY

Foamy and Lentiviral Vectors Transduce Canine Long-Term Repopulating Cells at Similar Efficiency

(2009) Grant D. Trobridge et al.   HUMAN GENE THERAPY

Modification of Integration Site Preferences of an HIV-1-Based Vector by Expression of a Novel Synthetic Protein

(2009) Robert M. Silvers et al.   HUMAN GENE THERAPY

Specific Transduction of HIV-Susceptible Cells for CCR5 Knockdown and Resistance to HIV Infection: A Novel Method for Targeted Gene Therapy and Intracellular Immunization

(2009) Joseph S Anderson et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Determinants for the Rhesus Monkey TRIM5α-mediated Block of the Late Phase of HIV-1 Replication

(2009) Ryuta Sakuma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Potent inhibition of HIV-1 by TRIM5-cyclophilin fusion proteins engineered from human components

(2009) Martha R. Neagu et al.   JOURNAL OF CLINICAL INVESTIGATION

Site-specific integration of retroviral DNA in human cells using fusion proteins consisting of human immunodeficiency virus type 1 integrase and the designed polydactyl zinc-finger protein E2C

(2009) Kunkai Su et al.   METHODS

Preintegration HIV-1 Inhibition by a Combination Lentiviral Vector Containing a Chimeric TRIM5α Protein, a CCR5 shRNA, and a TAR Decoy

(2009) Joseph S Anderson et al.   MOLECULAR THERAPY

RNAi-mediated CCR5 Silencing by LFA-1-targeted Nanoparticles Prevents HIV Infection in BLT Mice

(2009) Sang-Soo Kim et al.   MOLECULAR THERAPY

Long-Term Control of HIV byCCR5Delta32/Delta32 Stem-Cell Transplantation

(2009) Gero Hütter et al.   NEW ENGLAND JOURNAL OF MEDICINE

Definition of the interacting interfaces of Apobec3G and HIV-1 Vif using MAPPIT mutagenesis analysis

(2009) Delphine Lavens et al.   NUCLEIC ACIDS RESEARCH

Protection of Stem Cell-Derived Lymphocytes in a Primate AIDS Gene Therapy Model after In Vivo Selection

(2009) Grant D. Trobridge et al.   PLoS One

Multiple ways of targeting APOBEC3–virion infectivity factor interactions for anti-HIV-1 drug development

(2009) Jessica L. Smith et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Cassette deletion in multiple shRNA lentiviral vectors for HIV-1 and its impact on treatment success

(2009) Glen J Mcintyre et al.   Virology Journal

BCA2/Rabring7 Promotes Tetherin-Dependent HIV-1 Restriction

(2009) Kei Miyakawa et al.   PLoS Pathogens

HIV-1 Vpu Neutralizes the Antiviral Factor Tetherin/BST-2 by Binding It and Directing Its Beta-TrCP2-Dependent Degradation

(2009) Bastien Mangeat et al.   PLoS Pathogens

Vpu Antagonizes BST-2–Mediated Restriction of HIV-1 Release via β-TrCP and Endo-Lysosomal Trafficking

(2009) Richard S. Mitchell et al.   PLoS Pathogens