Muscle-bone crosstalk via endocrine signals and potential targets for osteosarcopenia-related fracture

Irisin Modulates Inflammatory, Angiogenic, and Osteogenic Factors during Fracture Healing

(2023) Angela Oranger et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Exosomes Derived from Adipose Stem Cells Enhance Bone Fracture Healing via the Activation of the Wnt3a/β-Catenin Signaling Pathway in Rats with Type 2 Diabetes Mellitus

(2023) Dong Zhang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The role of Meteorin‐like in skeletal development and bone fracture healing

(2022) Rong Huang et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Serum irisin concentrations and osteoporotic vertebral fractures in women with rheumatoid arthritis

(2022) Jorge Ivan Gamez-Nava et al.   MEDICINE

Screening for Sarcopenia among Elderly Arab Females: Influence of Body Composition, Lifestyle, Irisin, and Vitamin D

(2022) Tafany A. Alsaawi et al.   Nutrients

Meteorin-like is an injectable peptide that can enhance regeneration in aged muscle through immune-driven fibro/adipogenic progenitor signaling

(2022) David E. Lee et al.   Nature Communications

The muscle to bone axis (and viceversa): An encrypted language affecting tissues and organs and yet to be codified?

(2021) Francesca Bosco et al.   PHARMACOLOGICAL RESEARCH

The analysis of osteosarcopenia as a risk factor for fractures, mortality, and falls

(2021) Z. Teng et al.   OSTEOPOROSIS INTERNATIONAL

FGF-2–dependent signaling activated in aged human skeletal muscle promotes intramuscular adipogenesis

(2021) Sebastian Mathes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Testing the efficacy of a human full-length OPG-Fc analog in a severe model of cardiotoxin-induced skeletal muscle injury and repair

(2021) Zineb Bouredji et al.   Molecular Therapy-Methods & Clinical Development

Serum levels of irisin in postmenopausal women with osteoporotic hip fractures

(2021) Kai Liu et al.   CYTOKINE

Systemic Administration of Recombinant Irisin Accelerates Fracture Healing in Mice

(2021) Silvia Concetta Colucci et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Muscle weakness and selective muscle atrophy in osteoprotegerin-deficient mice

(2020) Dounia Hamoudi et al.   HUMAN MOLECULAR GENETICS

RANKL/RANK/OPG Pathway: A Mechanism Involved in Exercise-Induced Bone Remodeling

(2020) Mohammad Tobeiha et al.   Biomed Research International

Vibration and β‐hydroxy‐β‐methylbutyrate treatment suppresses intramuscular fat infiltration and adipogenic differentiation in sarcopenic mice

(2020) Jinyu Wang et al.   Journal of Cachexia Sarcopenia and Muscle

RANKL inhibition improves muscle strength and insulin sensitivity and restores bone mass

(2020) Nicolas Bonnet et al.   JOURNAL OF CLINICAL INVESTIGATION

Osteocalcin promotes bone mineralization but is not a hormone

(2020) Stavros C. Manolagas   PLoS Genetics

Osteosarcopenia: epidemiology, diagnosis, and treatment—facts and numbers

(2020) Ben Kirk et al.   Journal of Cachexia Sarcopenia and Muscle

Circulating Irisin Levels as a Marker of Osteosarcopenic-Obesity in Cushing’s Disease

(2020) Valentina Guarnotta et al.   Diabetes Metabolic Syndrome and Obesity-Targets and Therapy

A Review of the Potential Application of Osteocyte-Related Biomarkers, Fibroblast Growth Factor-23, Sclerostin, and Dickkopf-1 in Predicting Osteoporosis and Fractures

(2020) Fitri Fareez Ramli et al.   Diagnostics

Irisin deficiency disturbs bone metabolism

(2020) Xiaofang Zhu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Myokines and Osteokines in the Pathogenesis of Muscle and Bone Diseases

(2020) G. Colaianni et al.   Current Osteoporosis Reports

Muscle, Bone, and Fat Crosstalk: the Biological Role of Myokines, Osteokines, and Adipokines

(2020) Ben Kirk et al.   Current Osteoporosis Reports

The association of the serum levels of myostatin, follistatin, and interleukin-6 with sarcopenia, and their impacts on survival in patients with hepatocellular carcinoma

(2020) Kanghyug Choi et al.   Clinical and Molecular Hepatology

Evaluation of myostatin as a possible regulator and marker of skeletal muscle–cortical bone interaction in adults

(2020) Nagato Kuriyama et al.   JOURNAL OF BONE AND MINERAL METABOLISM

Targeting myostatin/activin A protects against skeletal muscle and bone loss during spaceflight

(2020) Se-Jin Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The effect of short‐term exercise prehabilitation on skeletal muscle protein synthesis and atrophy during bed rest in older men

(2020) Benoit Smeuninx et al.   Journal of Cachexia Sarcopenia and Muscle

Bone and Muscle Crosstalk in Aging

(2020) Chen He et al.   Frontiers in Cell and Developmental Biology

Prospective associations of osteosarcopenia and osteodynapenia with incident fracture and mortality over 10 years in community-dwelling older adults

(2019) Saliu Balogun et al.   ARCHIVES OF GERONTOLOGY AND GERIATRICS

Muscle‐bone crosstalk and potential therapies for sarco‐osteoporosis

(2019) GuoBin Li et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Sarcopenia

(2019) Alfonso J Cruz-Jentoft et al.   LANCET

FGF-2 targets sclerostin in bone and myostatin in skeletal muscle to mitigate the deleterious effects of glucocorticoid on musculoskeletal degradation

(2019) Sulekha Adhikary et al.   LIFE SCIENCES

WNT3A accelerates delayed alveolar bone repair in ovariectomized mice

(2019) Y. Liu et al.   OSTEOPOROSIS INTERNATIONAL

Effect of a Multicomponent Home-Based Physical Therapy Intervention on Ambulation After Hip Fracture in Older Adults

(2019) Jay Magaziner et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Inhibition of myostatin signal pathway may be involved in low-intensity pulsed ultrasound promoting bone healing

(2019) Lijun Sun et al.   Journal of Medical Ultrasonics

The effects of myokines on osteoclasts and osteoblasts

(2019) Jin Young Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Oral delivery of novel human IGF-1 bioencapsulated in lettuce cells promotes musculoskeletal cell proliferation, differentiation and diabetic fracture healing

(2019) J. Park et al.   BIOMATERIALS

Association of serum sclerostin levels with low skeletal muscle mass: The Korean Sarcopenic Obesity Study (KSOS)

(2019) Jung A. Kim et al.   BONE

Impaired Fracture Healing in Sarco‐Osteoporotic Mice Can Be Rescued by Vibration Treatment Through Myostatin Suppression

(2019) Ning Zhang et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Distinct Effects of IL-6 Classic and Trans -Signaling in Bone Fracture Healing

(2018) Katja Prystaz et al.   AMERICAN JOURNAL OF PATHOLOGY

Does combined osteopenia/osteoporosis and sarcopenia confer greater risk of falls and fracture than either condition alone in older men? The Concord Health and Ageing in Men Project

(2018) David Scott et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Pharmacological inhibition of IL-6 trans-signaling improves compromised fracture healing after severe trauma

(2018) Kathrin Kaiser et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Effect of Brain-Derived Neurotrophic Factor on the Neurogenesis and Osteogenesis in Bone Engineering

(2018) Qing Liu et al.   TISSUE ENGINEERING PART A

β-aminoisobutyric Acid, l -BAIBA, Is a Muscle-Derived Osteocyte Survival Factor

(2018) Yukiko Kitase et al.   Cell Reports

Healthy community-living older men differ from women in associations between myostatin levels and skeletal muscle mass

(2018) Li-Ning Peng et al.   Journal of Cachexia Sarcopenia and Muscle

An animal model of co-existing sarcopenia and osteoporotic fracture in senescence accelerated mouse prone 8 (SAMP8)

(2017) Ning Zhang et al.   EXPERIMENTAL GERONTOLOGY

Circulating irisin levels as a predictive biomarker for sarcopenia: A cross-sectional community-based study

(2017) Jae Seung Chang et al.   Geriatrics & Gerontology International

Myostatin inhibits osteoblastic differentiation by suppressing osteocyte-derived exosomal microRNA-218: A novel mechanism in muscle-bone communication

(2017) Yiwen Qin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Treatment of Sarcopenia with Bimagrumab: Results from a Phase II, Randomized, Controlled, Proof-of-Concept Study

(2017) Daniel Rooks et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

BDNF regulates the expression and secretion of VEGF from osteoblasts via the TrkB/ERK1/2 signaling pathway during fracture healing

(2017) Zitao Zhang et al.   Molecular Medicine Reports

Osteosarcopenia: where bone, muscle, and fat collide

(2017) H. P. Hirschfeld et al.   OSTEOPOROSIS INTERNATIONAL

Prostaglandin E2 is essential for efficacious skeletal muscle stem-cell function, augmenting regeneration and strength

(2017) Andrew T. V. Ho et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sclerostin influences body composition by regulating catabolic and anabolic metabolism in adipocytes

(2017) Soohyun P. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Irisin treatment improves healing of dystrophic skeletal muscle

(2017) Musarrat Maisha Reza et al.   Oncotarget

Corrigendum to “Osteocalcin is necessary and sufficient to maintain muscle mass in older mice” [Mol Metabol 5 (2017) 1042–1047]

(2017) Paula Mera et al.   Molecular Metabolism

Irisin prevents and restores bone loss and muscle atrophy in hind-limb suspended mice

(2017) Graziana Colaianni et al.   Scientific Reports

Muscle RANK is a key regulator of Ca2+ storage, SERCA activity, and function of fast-twitch skeletal muscles

(2016) Sébastien S. Dufresne et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Systemic Nutrient and Stress Signaling via Myokines and Myometabolites

(2016) Mamta Rai et al.   Annual Review of Physiology

Combination therapy with BMP-2 and a systemic RANKL inhibitor enhances bone healing in a mouse critical-sized femoral defect

(2016) Sofia Bougioukli et al.   BONE

Sclerostin antibody treatment improves fracture outcomes in a Type I diabetic mouse model

(2016) Cristal S. Yee et al.   BONE

Serum myostatin levels are independently associated with skeletal muscle wasting in patients with heart failure

(2016) Takaaki Furihata et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Gut microbiota induce IGF-1 and promote bone formation and growth

(2016) Jing Yan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Welcome to the ICD-10 code for sarcopenia

(2016) Stefan D. Anker et al.   Journal of Cachexia Sarcopenia and Muscle

Skeletal muscle wasting and renewal: a pivotal role of myokine IL-6

(2016) José E. Belizário et al.   SpringerPlus

Myostatin in relation to physical activity and dysglycaemia and its effect on energy metabolism in human skeletal muscle cells

(2015) M. Hjorth et al.   Acta Physiologica

Muscle and bone, two interconnected tissues

(2015) Camille Tagliaferri et al.   AGEING RESEARCH REVIEWS

Endochondral fracture healing with external fixation in the Sost knockout mouse results in earlier fibrocartilage callus removal and increased bone volume fraction and strength

(2015) A. Morse et al.   BONE

Irisin is associated with osteoporotic fractures independently of bone mineral density, body composition or daily physical activity

(2015) Andrea Palermo et al.   CLINICAL ENDOCRINOLOGY

Does Sclerostin Depletion Stimulate Fracture Healing in a Mouse Model?

(2015) Mohammad M. Alzahrani et al.   CLINICAL ORTHOPAEDICS AND RELATED RESEARCH

Bone morphogenetic protein 2 and decorin expression in old fracture fragments and surrounding tissues

(2015) X.G. Han et al.   GENETICS AND MOLECULAR RESEARCH

Muscle Wasting in Fasting Requires Activation of NF-κB and Inhibition of AKT/Mechanistic Target of Rapamycin (mTOR) by the Protein Acetylase, GCN5

(2015) Donghoon Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Randomized, Double-Blind Phase 2 Clinical Trial of Blosozumab, a Sclerostin Antibody, in Postmenopausal Women with Low Bone Mineral Density

(2015) Robert R. Recker et al.   JOURNAL OF BONE AND MINERAL RESEARCH

The myokine irisin increases cortical bone mass

(2015) Graziana Colaianni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Myostatin antibody (LY2495655) in older weak fallers: a proof-of-concept, randomised, phase 2 trial

(2015) Clemens Becker et al.   Lancet Diabetes & Endocrinology

Myostatin as a mediator of sarcopenia versus homeostatic regulator of muscle mass: insights using a new mass spectrometry-based assay

(2015) H. Robert Bergen et al.   Skeletal Muscle

Myostatin and Sarcopenia: Opportunities and Challenges - A Mini-Review

(2014) Thomas A. White et al.   GERONTOLOGY

Irisin, a Link among Fatty Liver Disease, Physical Inactivity and Insulin Resistance

(2014) María Arias-Loste et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Irisin stimulates muscle growth-related genes and regulates adipocyte differentiation and metabolism in humans

(2014) J Y Huh et al.   INTERNATIONAL JOURNAL OF OBESITY

Effect of a Home-Based Exercise Program on Functional Recovery Following Rehabilitation After Hip Fracture

(2014) Nancy K. Latham et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Are OPG and RANKL involved in human fracture healing?

(2014) Julia Köttstorfer et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Sclerostin monoclonal antibody enhanced bone fracture healing in an open osteotomy model in rats

(2014) Pui Kit Suen et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Circulating irisin is associated with osteoporotic fractures in postmenopausal women with low bone mass but is not affected by either teriparatide or denosumab treatment for 3 months

(2014) A. D. Anastasilakis et al.   OSTEOPOROSIS INTERNATIONAL

WNT3A promotes myogenesis of human embryonic stem cells and enhances in vivo engraftment

(2014) Yongsung Hwang et al.   Scientific Reports

Sclerostin deficient mice rapidly heal bone defects by activating β-catenin and increasing intramembranous ossification

(2013) Meghan E. McGee-Lawrence et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A myostatin and activin decoy receptor enhances bone formation in mice

(2013) P. Bialek et al.   BONE

The role of the serum RANKL/OPG ratio in the healing of intertrochanteric fractures in elderly patients

(2013) XUE-FEI WANG et al.   Molecular Medicine Reports

High serum sclerostin predicts the occurrence of osteoporotic fractures in postmenopausal women: The center of excellence for osteoporosis research study

(2012) Mohammed-Salleh M Ardawi et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Serum Sclerostin Increases in Healthy Adult Men during Bed Rest

(2012) J. M. Spatz et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Strongly enhanced levels of sclerostin during human fracture healing

(2012) Kambiz Sarahrudi et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

FNDC5 and irisin in humans: I. Predictors of circulating concentrations in serum and plasma and II. mRNA expression and circulating concentrations in response to weight loss and exercise

(2012) Joo Young Huh et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

(2012) Pontus Boström et al.   NATURE

Bench to bedside: elucidation of the OPG–RANK–RANKL pathway and the development of denosumab

(2012) David L. Lacey et al.   NATURE REVIEWS DRUG DISCOVERY

Follistatin Improves Skeletal Muscle Healing after Injury and Disease through an Interaction with Muscle Regeneration, Angiogenesis, and Fibrosis

(2011) Jinhong Zhu et al.   AMERICAN JOURNAL OF PATHOLOGY

Expression of RANKL/OPG during bone remodeling in vivo

(2011) H. Tanaka et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Increased callus mass and enhanced strength during fracture healing in mice lacking the sclerostin gene

(2011) Chaoyang Li et al.   BONE

Serum sclerostin levels were positively correlated with fat mass and bone mineral density in Central South Chinese postmenopausal women

(2011) Zhifeng Sheng et al.   CLINICAL ENDOCRINOLOGY

Immunolocalization of Myostatin (GDF-8) Following Musculoskeletal Injury and the Effects of Exogenous Myostatin on Muscle and Bone Healing

(2011) Moataz Elkasrawy et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Bone fracture and bone fracture repair

(2011) N. L. Fazzalari   OSTEOPOROSIS INTERNATIONAL

Upregulation of Inflammatory Genes and Downregulation of Sclerostin Gene Expression Are Key Elements in the Early Phase of Fragility Fracture Healing

(2011) Joana Caetano-Lopes et al.   PLoS One

Serum myostatin levels and skeletal muscle wasting in chronic obstructive pulmonary disease

(2011) Chun-Rong Ju et al.   RESPIRATORY MEDICINE

Osteoprotegerin and RANKL in the pathogenesis of rheumatoid arthritis-induced osteoporosis

(2011) Shengqian Xu et al.   RHEUMATOLOGY INTERNATIONAL

Sclerostin antibody treatment enhances metaphyseal bone healing in rats

(2010) Fredrik Agholme et al.   JOURNAL OF BONE AND MINERAL RESEARCH

A local application of recombinant human fibroblast growth factor 2 for tibial shaft fractures: A randomized, placebo-controlled trial

(2010) Hiroshi Kawaguchi et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Brain-derived Neurotrophic Factor Regulates Satellite Cell Differentiation and Skeltal Muscle Regeneration

(2010) Charlene Clow et al.   MOLECULAR BIOLOGY OF THE CELL

The influence of osteoporosis in femoral fracture healing time

(2009) Vassilios S. Nikolaou et al.   INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED

Theoretical investigation of the role of the RANK–RANKL–OPG system in bone remodeling

(2009) Peter Pivonka et al.   JOURNAL OF THEORETICAL BIOLOGY

Myostatin, activin receptor IIb, and follistatin-like-3 gene expression are altered in adipose tissue and skeletal muscle of obese mice

(2008) David L. Allen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Myostatin (GDF-8) deficiency increases fracture callus size, Sox-5 expression, and callus bone volume

(2008) Ethan Kellum et al.   BONE

The dual role of IL-6-type cytokines on bone remodeling and bone tumors

(2008) Frédéric Blanchard et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Comparison of Effects of the Bisphosphonate Alendronate Versus the RANKL Inhibitor Denosumab on Murine Fracture Healing

(2008) Louis C Gerstenfeld et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Imbalance of RANK, RANKL and OPG expression during tibial fracture repair in diabetic rats

(2008) Fernanda Penna Lima Guedes de Amorim et al.   JOURNAL OF MOLECULAR HISTOLOGY

The effects of RANKL inhibition on fracture healing and bone strength in a mouse model of osteogenesis imperfecta

(2007) Demetris Delos et al.   JOURNAL OF ORTHOPAEDIC RESEARCH