Interferon-gamma and tumor necrosis factor-alpha synergistically enhance the immunosuppressive capacity of human umbilical-cord-derived mesenchymal stem cells by increasing PD-L1 expression

Cross talk between glucose metabolism and immunosuppression in IFN-γ–primed mesenchymal stem cells

(2022) Mengwei Yao et al.   Life Science Alliance

Comparative Proteomic Analysis of the Mesenchymal Stem Cells Secretome from Adipose, Bone Marrow, Placenta and Wharton’s Jelly

(2021) Sungho Shin et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Heterospheroid formation improves therapeutic efficacy of mesenchymal stem cells in murine colitis through immunomodulation and epithelial regeneration

(2021) Shobha Regmi et al.   BIOMATERIALS

Immune Deregulation in Sepsis and Septic Shock: Reversing Immune Paralysis by Targeting PD-1/PD-L1 Pathway

(2021) Yuki Nakamori et al.   Frontiers in Immunology

WJMSC‐derived small extracellular vesicle enhance T cell suppression through PD‐L1

(2021) Meizhang Li et al.   Journal of Extracellular Vesicles

PD-L1+ and XCR1+ dendritic cells are region-specific regulators of gut homeostasis

(2021) Thais G. Moreira et al.   Nature Communications

Mesenchymal Stem Cell‐Derived Extracellular Vesicles with High PD‐L1 Expression for Autoimmune Diseases Treatment

(2021) Fang Xu et al.   ADVANCED MATERIALS

Human Wharton’s Jelly-Derived Mesenchymal Stromal Cells Primed by Tumor Necrosis Factor-α and Interferon-γ Modulate the Innate and Adaptive Immune Cells of Type 1 Diabetic Patients

(2021) Mairvat Al- Mrahleh et al.   Frontiers in Immunology

Pathogenic Activation of Mesenchymal Stem Cells is induced by the Disease Microenvironment in Systemic Sclerosis

(2020) Zeinab Taki et al.   Arthritis & Rheumatology

Combination of human umbilical cord mesenchymal stem (stromal) cell transplantation with IFN-γ treatment synergistically improves the clinical outcomes of patients with rheumatoid arthritis

(2020) Xiao He et al.   ANNALS OF THE RHEUMATIC DISEASES

Regenerative potential of Wharton's jelly‐derived mesenchymal stem cells: A new horizon of stem cell therapy

(2020) Hossein Abbaszadeh et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Immunosuppressive Property of MSCs Mediated by Cell Surface Receptors

(2020) Siyu Liu et al.   Frontiers in Immunology

The Extrinsic and Intrinsic Roles of PD-L1 and Its Receptor PD-1: Implications for Immunotherapy Treatment

(2020) Katie Hudson et al.   Frontiers in Immunology

Ulcerative colitis

(2020) Taku Kobayashi et al.   Nature Reviews Disease Primers

Select animal models of colitis and their value in predicting clinical efficacy of biological therapies in ulcerative colitis

(2020) Janine Bilsborough et al.   Expert Opinion on Drug Discovery

Mesenchymal stem cells immunomodulation: The road to IFN-γ licensing and the path ahead

(2019) Amandda Évelin Silva- Carvalho et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Anti-αFR CAR-engineered NK-92 Cells Display Potent Cytotoxicity Against αFR-positive Ovarian Cancer

(2019) Xiang Ao et al.   JOURNAL OF IMMUNOTHERAPY

Characteristics and clinical applications of Wharton’s jelly-derived mesenchymal stromal cells

(2019) L.L. Liau et al.   Current Research in Translational Medicine

Mechanisms Controlling PD-L1 Expression in Cancer

(2019) Jong-Ho Cha et al.   MOLECULAR CELL

PD-1/PD-L1 Pathway Mediates the Alleviation of Pulmonary Fibrosis by Human Mesenchymal Stem Cells in Humanized Mice

(2018) Ke Ni et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Inducible indoleamine 2,3-dioxygenase 1 and programmed death ligand 1 expression as the potency marker for mesenchymal stromal cells

(2018) Qingdong Guan et al.   CYTOTHERAPY

Regulation and Function of the PD-L1 Checkpoint

(2018) Chong Sun et al.   IMMUNITY

Serum IFN-γ levels predict the therapeutic effect of mesenchymal stem cell transplantation in active rheumatoid arthritis

(2018) Yi Yang et al.   Journal of Translational Medicine

B7‑H1‑mediated immunosuppressive properties in human mesenchymal stem cells are mediated by STAT‑1 and not PI3K/Akt signaling

(2018) In Jang et al.   Molecular Medicine Reports

Expression of Programmed Death-Ligand 1 by Human Colonic CD90+ Stromal Cells Differs Between Ulcerative Colitis and Crohn’s Disease and Determines Their Capacity to Suppress Th1 Cells

(2018) Ellen J. Beswick et al.   Frontiers in Immunology

Bioactive factors secreted from mesenchymal stromal cells protect the intestines from experimental colitis in a three-dimensional culture

(2018) FABIANY DA COSTA GONÇALVES et al.   CYTOTHERAPY

IL-27 regulates the adherence, proliferation, and migration of MSCs and enhances their regulatory effects on Th1 and Th2 subset generations

(2017) Fenghuang Xu et al.   IMMUNOLOGIC RESEARCH

Tonsil-derived mesenchymal stem cells (T-MSCs) prevent Th17-mediated autoimmune response via regulation of the programmed death-1/programmed death ligand-1 (PD-1/PD-L1) pathway

(2017) Ji-Yon Kim et al.   Journal of Tissue Engineering and Regenerative Medicine

Interferon Receptor Signaling Pathways Regulating PD-L1 and PD-L2 Expression

(2017) Angel Garcia-Diaz et al.   Cell Reports

Safety and therapeutic effect of mesenchymal stem cell infusion on moderate to severe ulcerative colitis

(2016) Jianxia Hu et al.   Experimental and Therapeutic Medicine

Culture medium from TNF-α–stimulated mesenchymal stem cells attenuates allergic conjunctivitis through multiple antiallergic mechanisms

(2015) Wenru Su et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Interleukin-25 Mediates Transcriptional Control of PD-L1 via STAT3 in Multipotent Human Mesenchymal Stromal Cells (hMSCs) to Suppress Th17 Responses

(2015) Wei-Bei Wang et al.   Stem Cell Reports

Interferon-γ-induced activation of JAK1 and JAK2 suppresses tumor cell susceptibility to NK cells through upregulation of PD-L1 expression

(2015) Roberto Bellucci et al.   OncoImmunology

The PD-1/PD-Ls pathway and autoimmune diseases

(2014) Suya Dai et al.   CELLULAR IMMUNOLOGY

Protective effects of Fc-fused PD-L1 on two different animal models of colitis

(2014) Mi-Young Song et al.   GUT

Synergistic effects of IL-4 and TNFα on the induction of B7-H1 in renal cell carcinoma cells inhibiting allogeneic T cell proliferation

(2014) Dagmar Quandt et al.   Journal of Translational Medicine

Regulation of NF-κB by TNF family cytokines

(2014) Matthew S. Hayden et al.   SEMINARS IN IMMUNOLOGY

Concise Review: The Surface Markers and Identity of Human Mesenchymal Stem Cells

(2014) Feng-Juan Lv et al.   STEM CELLS

Human Umbilical Cord Blood Mesenchymal Stem Cells Reduce Colitis in Mice by Activating NOD2 Signaling to COX2

(2013) Hyung–Sik Kim et al.   GASTROENTEROLOGY