WJMSC‐derived small extracellular vesicle enhance T cell suppression through PD‐L1

A Phase 3, Single-Arm, Prospective Study of Remestemcel-L, Ex Vivo Culture-Expanded Adult Human Mesenchymal Stromal Cells for the Treatment of Pediatric Patients Who Failed to Respond to Steroid Treatment for Acute Graft-versus-Host Disease

(2020) Joanne Kurtzberg et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Assessment of ST2 for risk of death following graft-versus-host disease in the pediatric and adult age groups

(2020) Courtney Rowan et al.   BLOOD

Extracellular vesicles from human liver stem cells inhibit renal cancer stem cell‐derived tumor growth in vitro and in vivo

(2020) Alessia Brossa et al.   INTERNATIONAL JOURNAL OF CANCER

Mesenchymal Stem/Stromal Cell-Derived Exosomes for Immunomodulatory Therapeutics and Skin Regeneration

(2020) Dae Hyun Ha et al.   Cells

IL-1β enhances human placenta-derived mesenchymal stromal cells ability to mediate Th1/Th2 and Th1/CD4+IL-10+ T cell balance and regulates its adhesion, proliferation and migration via PD-L1

(2020) Aiping Zhang et al.   CELLULAR IMMUNOLOGY

Suppression of Exosomal PD-L1 Induces Systemic Anti-tumor Immunity and Memory

(2019) Mauro Poggio et al.   CELL

Mesenchymal stem cells immunomodulation: The road to IFN-γ licensing and the path ahead

(2019) Amandda Évelin Silva- Carvalho et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Mesenchymal stem cells: Cell therapy and regeneration potential

(2019) Christina Brown et al.   Journal of Tissue Engineering and Regenerative Medicine

A Phase 3 Randomized Study of Remestemcel-L versus Placebo Added to Second-Line Therapy in Patients with Steroid-Refractory Acute Graft-versus-Host Disease

(2019) Partow Kebriaei et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Therapeutic Application of Mesenchymal Stem Cells Derived Extracellular Vesicles for Immunomodulation

(2019) Marina O. Gomzikova et al.   Frontiers in Immunology

Mesenchymal Stromal Cells: Clinical Challenges and Therapeutic Opportunities

(2018) Jacques Galipeau et al.   Cell Stem Cell

Inducible indoleamine 2,3-dioxygenase 1 and programmed death ligand 1 expression as the potency marker for mesenchymal stromal cells

(2018) Qingdong Guan et al.   CYTOTHERAPY

Mesenchymal stromal cell exosome–enhanced regulatory T-cell production through an antigen-presenting cell–mediated pathway

(2018) Bin Zhang et al.   CYTOTHERAPY

Exosomes originating from MSCs stimulated with TGF-β and IFN-γ promote Treg differentiation

(2018) Qingyi Zhang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Shedding light on the cell biology of extracellular vesicles

(2018) Guillaume van Niel et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Immunoregulatory mechanisms of mesenchymal stem and stromal cells in inflammatory diseases

(2018) Yufang Shi et al.   Nature Reviews Nephrology

Immune evasion mediated by PD-L1 on glioblastoma-derived extracellular vesicles

(2018) Franz L. Ricklefs et al.   Science Advances

Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response

(2018) Gang Chen et al.   NATURE

Xenogeneic Graft-Versus-Host Disease in Humanized NSG and NSG-HLA-A2/HHD Mice

(2018) Grégory Ehx et al.   Frontiers in Immunology

A potent immunomodulatory role of exosomes derived from mesenchymal stromal cells in preventing cGVHD

(2018) Peilong Lai et al.   Journal of Hematology & Oncology

Regulation of GVHD and GVL Activity via PD-L1 Interaction With PD-1 and CD80

(2018) Kaniel Cassady et al.   Frontiers in Immunology

PD-L1 interacts with CD80 to regulate graft-versus-leukemia activity of donor CD8+ T cells

(2017) Xiong Ni et al.   JOURNAL OF CLINICAL INVESTIGATION

Acute Graft-versus-Host Disease — Biologic Process, Prevention, and Therapy

(2017) Robert Zeiser et al.   NEW ENGLAND JOURNAL OF MEDICINE

Exosomes: Therapy delivery tools and biomarkers of diseases

(2017) Lucio Barile et al.   PHARMACOLOGY & THERAPEUTICS

Graft-Versus-Host Disease Amelioration by Human Bone Marrow Mesenchymal Stromal/Stem Cell-Derived Extracellular Vesicles Is Associated with Peripheral Preservation of Naive T Cell Populations

(2017) Sumie Fujii et al.   STEM CELLS

Immunomodulatory effects of mesenchymal stromal cells-derived exosome

(2016) Wancheng Chen et al.   IMMUNOLOGIC RESEARCH

Programmed death ligand-1 expression on donor T cells drives graft-versus-host disease lethality

(2016) Asim Saha et al.   JOURNAL OF CLINICAL INVESTIGATION

Molecular and Biochemical Aspects of the PD-1 Checkpoint Pathway

(2016) Vassiliki A. Boussiotis   NEW ENGLAND JOURNAL OF MEDICINE

Mesenchymal Stromal Cell Secretion of Programmed Death-1 Ligands Regulates T Cell Mediated Immunosuppression

(2016) Lindsay C. Davies et al.   STEM CELLS

Single and Multiple Dose MultiStem (Multipotent Adult Progenitor Cell) Therapy Prophylaxis of Acute Graft-versus-Host Disease in Myeloablative Allogeneic Hematopoietic Cell Transplantation: A Phase 1 Trial

(2015) Richard T. Maziarz et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Bone marrow-derived mesenchymal stem cells (JR-031) for steroid-refractory grade III or IV acute graft-versus-host disease: a phase II/III study

(2015) Kazuo Muroi et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Biomarker profiling of steroid-resistant acute GVHD in patients after infusion of mesenchymal stromal cells

(2015) L C J te Boome et al.   LEUKEMIA

High day 28 ST2 levels predict for acute graft-versus-host disease and transplant-related mortality after cord blood transplantation

(2014) Doris M. Ponce et al.   BLOOD

Programmed Death-1 Pathway in Host Tissues Ameliorates Th17/Th1-Mediated Experimental Chronic Graft-versus-Host Disease

(2014) Hideaki Fujiwara et al.   JOURNAL OF IMMUNOLOGY

MSC-derived exosomes: a novel tool to treat therapy-refractory graft-versus-host disease

(2014) L Kordelas et al.   LEUKEMIA

Mesenchymal stem cells: immune evasive, not immune privileged

(2014) James A Ankrum et al.   NATURE BIOTECHNOLOGY

Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells

(2013) Ophir Shalem et al.   SCIENCE

Multiplex Genome Engineering Using CRISPR/Cas Systems

(2013) L. Cong et al.   SCIENCE

The role of B7 family molecules in hematologic malignancy

(2012) P. Greaves et al.   BLOOD

Acute graft-versus-host disease biomarkers measured during therapy can predict treatment outcomes: a Blood and Marrow Transplant Clinical Trials Network study

(2012) J. E. Levine et al.   BLOOD

Mesenchymal stem cells are short-lived and do not migrate beyond the lungs after intravenous infusion

(2012) E. Eggenhofer et al.   Frontiers in Immunology

Mesenchymal stromal cell ‘licensing’: a multistep process

(2011) M Krampera   LEUKEMIA

PD-L1 regulates the development, maintenance, and function of induced regulatory T cells

(2009) Loise M. Francisco et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Interaction of human PD-L1 and B7-1

(2008) Manish J. Butte et al.   MOLECULAR IMMUNOLOGY