Select animal models of colitis and their value in predicting clinical efficacy of biological therapies in ulcerative colitis

The microbiome and inflammatory bowel disease

(2020) Kerri L. Glassner et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Retinoic Acid Is Elevated in the Mucosa of Patients With Active Ulcerative Colitis and Displays a Proinflammatory Role by Augmenting IL-17 and IFNγ Production

(2020) Ritika Rampal et al.   INFLAMMATORY BOWEL DISEASES

Colonic microbiota is associated with inflammation and host epigenomic alterations in inflammatory bowel disease

(2020) F. J. Ryan et al.   Nature Communications

Neutrophil Extracellular Traps Sustain Inflammatory Signals in Ulcerative Colitis

(2019) Vincenzo Dinallo et al.   Journal of Crohns & Colitis

Histologic Healing Rates of Medical Therapies for Ulcerative Colitis

(2019) Robert Battat et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Temporally Distinct Functions of the Cytokines IL-12 and IL-23 Drive Chronic Colon Inflammation in Response to Intestinal Barrier Impairment

(2019) Christina Eftychi et al.   IMMUNITY

Fibrogenesis in Chronic DSS Colitis is Not Influenced by Neutralisation of Regulatory T Cells, of Major T Helper Cytokines or Absence of IL-13

(2019) Brecht Creyns et al.   Scientific Reports

Efficacy and Safety of Mirikizumab in a Randomized Phase 2 Study of Patients With Ulcerative Colitis

(2019) William J. Sandborn et al.   GASTROENTEROLOGY

Ustekinumab as Induction and Maintenance Therapy for Ulcerative Colitis

(2019) Bruce E. Sands et al.   NEW ENGLAND JOURNAL OF MEDICINE

Anti-interleukin-23 agents for the treatment of ulcerative colitis

(2019) Jurij Hanžel et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Comparison of the fecal, cecal, and mucus microbiome in male and female mice after TNBS-induced colitis

(2019) Ariangela J. Kozik et al.   PLoS One

Histological Remission in Ulcerative Colitis

(2019) Thomas Chateau et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Complete Resolution of Mucosal Neutrophils Associates With Improved Long-Term Clinical Outcomes of Patients With Ulcerative Colitis

(2019) Rish K. Pai et al.   Clinical Gastroenterology and Hepatology

Histological Markers of Clinical Relapse in Endoscopically Quiescent Ulcerative Colitis

(2019) David Kevans et al.   INFLAMMATORY BOWEL DISEASES

The global, regional, and national burden of inflammatory bowel disease in 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017

(2019) Sudabeh Alatab et al.   Lancet Gastroenterology & Hepatology

Differential Susceptibility to T Cell-Induced Colitis in Mice: Role of the Intestinal Microbiota

(2018) Cynthia Reinoso Webb et al.   INFLAMMATORY BOWEL DISEASES

Relationship between intestinal microbiota and ulcerative colitis: Mechanisms and clinical application of probiotics and fecal microbiota transplantation

(2018) Zhao-Hua Shen et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Reproducibility of preclinical animal research improves with heterogeneity of study samples

(2018) Bernhard Voelkl et al.   PLOS BIOLOGY

A Versatile New Model of Chemically Induced Chronic Colitis Using an Outbred Murine Strain

(2018) Monica Barone et al.   Frontiers in Microbiology

IL-12, IL-23 and IL-17 in IBD: immunobiology and therapeutic targeting

(2018) Alexander R. Moschen et al.   Nature Reviews Gastroenterology & Hepatology

Compositional Changes in the Gut Mucus Microbiota Precede the Onset of Colitis-Induced Inflammation

(2017) Maria Glymenaki et al.   INFLAMMATORY BOWEL DISEASES

Tricellulin is regulated via interleukin-13-receptor α2, affects macromolecule uptake, and is decreased in ulcerative colitis

(2017) S M Krug et al.   Mucosal Immunology

Distinct Microbial Communities Trigger Colitis Development upon Intestinal Barrier Damage via Innate or Adaptive Immune Cells

(2017) Urmi Roy et al.   Cell Reports

A Randomized, Double-Blind, Placebo-Controlled Phase 2 Study of Brodalumab in Patients With Moderate-to-Severe Crohn’s Disease

(2016) Stephan R Targan et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

A mouse model for ulcerative colitis based on NOD-scidIL2R γnullmice reconstituted with peripheral blood mononuclear cells from affected individuals

(2016) Pia Palamides et al.   Disease Models & Mechanisms

Neutrophil interactions with epithelial-expressed ICAM-1 enhances intestinal mucosal wound healing

(2016) R Sumagin et al.   Mucosal Immunology

Treatment with a Monoclonal Anti-IL-12p40 Antibody Induces Substantial Gut Microbiota Changes in an Experimental Colitis Model

(2016) Josué Castro-Mejía et al.   Gastroenterology Research and Practice

IL-13Rα2 uses TMEM219 in chitinase 3-like-1-induced signalling and effector responses

(2016) Chang-Min Lee et al.   Nature Communications

The Dual Role of Neutrophils in Inflammatory Bowel Diseases

(2016) Odile Wéra et al.   Journal of Clinical Medicine

Anrukinzumab, an anti-interleukin 13 monoclonal antibody, in active UC: efficacy and safety from a phase IIa randomised multicentre study

(2015) Walter Reinisch et al.   GUT

Differential Roles for Interleukin-23 and Interleukin-17 in Intestinal Immunoregulation

(2015) Joseph R. Maxwell et al.   IMMUNITY

A Multihit Model

(2015) Lydia M. Keubler et al.   INFLAMMATORY BOWEL DISEASES

Gut biogeography of the bacterial microbiota

(2015) Gregory P. Donaldson et al.   NATURE REVIEWS MICROBIOLOGY

Lebrikizumab in moderate-to-severe asthma: pooled data from two randomised placebo-controlled studies

(2015) Nicola A Hanania et al.   THORAX

Overexpression of GATA-3 in T Cells Accelerates Dextran Sulfate Sodium-Induced Colitis

(2014) Midori Okamura et al.   EXPERIMENTAL ANIMALS

Tralokinumab for moderate-to-severe UC: a randomised, double-blind, placebo-controlled, phase IIa study

(2014) Silvio Danese et al.   GUT

IL-13Rα2-bearing, type II NKT cells reactive to sulfatide self-antigen populate the mucosa of ulcerative colitis

(2014) Ivan J Fuss et al.   GUT

IL-13 Orchestrates Resolution of Chronic Intestinal Inflammation via Phosphorylation of Glycogen Synthase Kinase-3 

(2014) S. Fichtner-Feigl et al.   JOURNAL OF IMMUNOLOGY

Histological evaluation in ulcerative colitis

(2014) T. C. DeRoche et al.   Gastroenterology Report

Correlation Between the Endoscopic and Histologic Score in Assessing the Activity of Ulcerative Colitis

(2013) Bart Lemmens et al.   INFLAMMATORY BOWEL DISEASES

Unique Gene Expression and MR T2 Relaxometry Patterns Define Chronic Murine Dextran Sodium Sulphate Colitis as a Model for Connective Tissue Changes in Human Crohn’s Disease

(2013) Christine Breynaert et al.   PLoS One

Dextran Sodium Sulphate Colitis Mouse Model: Traps and Tricks

(2012) Martina Perše et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Effect of α4β7 blockade on intestinal lymphocyte subsets and lymphoid tissue development

(2010) Caihong Wang et al.   INFLAMMATORY BOWEL DISEASES

Molecular Basis for Shared Cytokine Recognition Revealed in the Structure of an Unusually High Affinity Complex between IL-13 and IL-13Rα2

(2010) Patrick J. Lupardus et al.   STRUCTURE

Differential regulation of interleukin 17 and interferon   production in inflammatory bowel disease

(2009) L. Rovedatti et al.   GUT

IL-13R 2 Membrane and Soluble Isoforms Differ in Humans and Mice

(2009) W. Chen et al.   JOURNAL OF IMMUNOLOGY

T cell transfer model of chronic colitis: concepts, considerations, and tricks of the trade

(2008) Dmitry V. Ostanin et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Distinct Cytokine Patterns Identified from Multiplex Profiles of Murine DSS and TNBS-Induced Colitis

(2008) Philip Alex et al.   INFLAMMATORY BOWEL DISEASES

Attenuation of inflammation and cytokine production in rat colitis by a novel selective inhibitor of leukotriene A4 hydrolase

(2007) B J R Whittle et al.   BRITISH JOURNAL OF PHARMACOLOGY