Immune Deregulation in Sepsis and Septic Shock: Reversing Immune Paralysis by Targeting PD-1/PD-L1 Pathway

Sepsis Induces Deregulation of IL-13 Production and PD-1 Expression in Lung Group 2 Innate Lymphoid Cells

(2020) Yuichi Akama et al.   SHOCK

The Role of Innate Lymphoid Cells in the Regulation of Immune Homeostasis in Sepsis-Mediated Lung Inflammation

(2020) Yuichi Akama et al.   Diagnostics

Supervised machine learning for the early prediction of acute respiratory distress syndrome (ARDS)

(2020) Sidney Le et al.   JOURNAL OF CRITICAL CARE

Machine learning for patient risk stratification for acute respiratory distress syndrome

(2019) Daniel Zeiberg et al.   PLoS One

Immune Checkpoint Inhibition in Sepsis

(2019) Richard S. Hotchkiss et al.   CRITICAL CARE MEDICINE

Suppression of Exosomal PD-L1 Induces Systemic Anti-tumor Immunity and Memory

(2019) Mauro Poggio et al.   CELL

Derivation, Validation, and Potential Treatment Implications of Novel Clinical Phenotypes for Sepsis

(2019) Christopher W. Seymour et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Effect of a Recombinant Human Soluble Thrombomodulin on Mortality in Patients With Sepsis-Associated Coagulopathy

(2019) Jean-Louis Vincent et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

A clinically applicable approach to continuous prediction of future acute kidney injury

(2019) Nenad Tomašev et al.   NATURE

Exosomes in Sepsis and Inflammatory Tissue Injury.

(2019) Eun Jeong Park et al.   CURRENT PHARMACEUTICAL DESIGN

Immune checkpoint inhibition in sepsis: a Phase 1b randomized study to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of nivolumab

(2019) Richard S. Hotchkiss et al.   INTENSIVE CARE MEDICINE

Early Prediction of Sepsis From Clinical Data

(2019) Matthew A. Reyna et al.   CRITICAL CARE MEDICINE

Fc Effector Function Contributes to the Activity of Human Anti-CTLA-4 Antibodies

(2018) Frederick Arce Vargas et al.   CANCER CELL

The Surviving Sepsis Campaign Bundle

(2018) Mitchell M. Levy et al.   CRITICAL CARE MEDICINE

Big Data and Machine Learning in Health Care

(2018) Andrew L. Beam et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Adjunctive Glucocorticoid Therapy in Patients with Septic Shock

(2018) Balasubramanian Venkatesh et al.   NEW ENGLAND JOURNAL OF MEDICINE

Hydrocortisone plus Fludrocortisone for Adults with Septic Shock

(2018) Djillali Annane et al.   NEW ENGLAND JOURNAL OF MEDICINE

Integrin and PD-1 Ligand Expression on Circulating Extracellular Vesicles in Systemic Inflammatory Response Syndrome and Sepsis

(2018) Eiji Kawamoto et al.   SHOCK

Innate Lymphoid Cells: 10 Years On

(2018) Eric Vivier et al.   CELL

Immune Effects of Corticosteroids in Sepsis

(2018) Nicholas Heming et al.   Frontiers in Immunology

Oxygen Saturation on Admission Is a Predictive Biomarker for PD-L1 Expression on Circulating Monocytes and Impaired Immune Response in Patients With Sepsis

(2018) José Avendaño-Ortiz et al.   Frontiers in Immunology

The Artificial Intelligence Clinician learns optimal treatment strategies for sepsis in intensive care

(2018) Matthieu Komorowski et al.   NATURE MEDICINE

Guidelines for the diagnosis and management of critical illness-related corticosteroid insufficiency (CIRCI) in critically ill patients (Part I): Society of Critical Care Medicine (SCCM) and European Society of Intensive Care Medicine (ESICM) 2017

(2017) Djillali Annane et al.   INTENSIVE CARE MEDICINE

SUMO proteins: Guardians of immune system

(2017) Sabrina Adorisio et al.   JOURNAL OF AUTOIMMUNITY

Activated protein C inhibits neutrophil extracellular trap formationin vitroand activationin vivo

(2017) Laura D. Healy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activated Protein C Attenuates Severe Inflammation by Targeting VLA-3highNeutrophil Subpopulation in Mice

(2017) Pranita P. Sarangi et al.   JOURNAL OF IMMUNOLOGY

IL-7 Restores T Lymphocyte Immunometabolic Failure in Septic Shock Patients through mTOR Activation

(2017) Fabienne Venet et al.   JOURNAL OF IMMUNOLOGY

Advances in the understanding and treatment of sepsis-induced immunosuppression

(2017) Fabienne Venet et al.   Nature Reviews Nephrology

Recognizing Sepsis as a Global Health Priority — A WHO Resolution

(2017) Konrad Reinhart et al.   NEW ENGLAND JOURNAL OF MEDICINE

Monocyte-Dependent Suppression of T-Cell Function in Postoperative Patients and Abdominal Sepsis

(2017) Markus Albertsmeier et al.   SHOCK

IL-33 contributes to sepsis-induced long-term immunosuppression by expanding the regulatory T cell population

(2017) Daniele C. Nascimento et al.   Nature Communications

Myeloid-Derived Suppressor Cells

(2017) Dmitry I. Gabrilovich   Cancer Immunology Research

Keratinocyte growth factor for the treatment of the acute respiratory distress syndrome (KARE): a randomised, double-blind, placebo-controlled phase 2 trial

(2017) Daniel F McAuley et al.   Lancet Respiratory Medicine

LFA-1 and Mac-1 integrins bind to the serine/threonine-rich domain of thrombomodulin

(2016) Eiji Kawamoto et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Biomarkers for the Early Detection and Prognosis of Acute Kidney Injury

(2016) Rakesh Malhotra et al.   Clinical Journal of the American Society of Nephrology

CD4+T-cell subsets in inflammatory diseases: beyond the Th1/Th2 paradigm

(2016) Kiyoshi Hirahara et al.   INTERNATIONAL IMMUNOLOGY

The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

(2016) Mervyn Singer et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Interleukin 7 immunotherapy improves host immunity and survival in a two-hit model of Pseudomonas aeruginosa pneumonia

(2016) Yuichiro Shindo et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Emerging therapies for the treatment of sepsis

(2015) Jean-Louis Vincent   Current Opinion in Anesthesiology

Complement System Part II: Role in Immunity

(2015) Nicolas S. Merle et al.   Frontiers in Immunology

The PD-1/PD-Ls pathway and autoimmune diseases

(2014) Suya Dai et al.   CELLULAR IMMUNOLOGY

Mortality Related to Severe Sepsis and Septic Shock Among Critically Ill Patients in Australia and New Zealand, 2000-2012

(2014) Kirsi-Maija Kaukonen et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Parallels between Cancer and Infectious Disease

(2014) Richard S. Hotchkiss et al.   NEW ENGLAND JOURNAL OF MEDICINE

The role of platelets in sepsis

(2014) Cornelis van ’t Veer et al.   THROMBOSIS AND HAEMOSTASIS

Assessment of the worldwide burden of critical illness: the Intensive Care Over Nations (ICON) audit

(2014) Jean-Louis Vincent et al.   Lancet Respiratory Medicine

NETosis: how vital is it?

(2013) B. G. Yipp et al.   BLOOD

Dynamic regulation of innate immunity by ubiquitin and ubiquitin-like proteins

(2013) Xing Liu et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Nivolumab plus Ipilimumab in Advanced Melanoma

(2013) Jedd D. Wolchok et al.   NEW ENGLAND JOURNAL OF MEDICINE

Apoptosome Structure, Assembly, and Procaspase Activation

(2013) Shujun Yuan et al.   STRUCTURE

Epidemiology of severe sepsis

(2013) Florian B Mayr et al.   Virulence

PAMPs and DAMPs: signal 0s that spur autophagy and immunity

(2012) Daolin Tang et al.   IMMUNOLOGICAL REVIEWS

Alarmins: awaiting a clinical response

(2012) James K. Chan et al.   JOURNAL OF CLINICAL INVESTIGATION

The Small Ubiquitin-like Modifier-Deconjugating Enzyme Sentrin-Specific Peptidase 1 Switches IFN Regulatory Factor 8 from a Repressor to an Activator during Macrophage Activation

(2012) T.-H. Chang et al.   JOURNAL OF IMMUNOLOGY

Interleukin-7 Ameliorates Immune Dysfunction and Improves Survival in a 2-Hit Model of Fungal Sepsis

(2012) Jacqueline Unsinger et al.   JOURNAL OF INFECTIOUS DISEASES

Persistent inflammation and immunosuppression

(2012) Lori F. Gentile et al.   Journal of Trauma and Acute Care Surgery

The potential of biologics for the treatment of asthma

(2012) Girolamo Pelaia et al.   NATURE REVIEWS DRUG DISCOVERY

Drotrecogin Alfa (Activated) in Adults with Septic Shock

(2012) V. Marco Ranieri et al.   NEW ENGLAND JOURNAL OF MEDICINE

Safety, Activity, and Immune Correlates of Anti–PD-1 Antibody in Cancer

(2012) Suzanne L. Topalian et al.   NEW ENGLAND JOURNAL OF MEDICINE

Immunosuppression in Patients Who Die of Sepsis and Multiple Organ Failure

(2011) Jonathan S. Boomer et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

A genomic storm in critically injured humans

(2011) Wenzhong Xiao et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Unknown

(2011) Alex Cuenca et al.   MOLECULAR MEDICINE

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

The PD-1 pathway in tolerance and autoimmunity

(2010) Loise M. Francisco et al.   IMMUNOLOGICAL REVIEWS

Delayed administration of anti-PD-1 antibody reverses immune dysfunction and improves survival during sepsis

(2010) P. Brahmamdam et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Development of Ipilimumab: Contribution to a New Paradigm for Cancer Immunotherapy

(2010) Axel Hoos et al.   SEMINARS IN ONCOLOGY

Caspase-7 deficiency protects from endotoxin-induced lymphocyte apoptosis and improves survival

(2009) M. Lamkanfi et al.   BLOOD

PD-L1 regulates the development, maintenance, and function of induced regulatory T cells

(2009) Loise M. Francisco et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Thrombomodulin Mutations in Atypical Hemolytic–Uremic Syndrome

(2009) Mieke Delvaeye et al.   NEW ENGLAND JOURNAL OF MEDICINE

PD-1 expression by macrophages plays a pathologic role in altering microbial clearance and the innate inflammatory response to sepsis

(2009) X. Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA