A distinct sodium channel voltage-sensor locus determines insect selectivity of the spider toxin Dc1a

The insecticidal neurotoxin Aps III is an atypical knottin peptide that potently blocks insect voltage-gated sodium channels

(2013) Niraj S. Bende et al.   BIOCHEMICAL PHARMACOLOGY

Domain IV voltage-sensor movement is both sufficient and rate limiting for fast inactivation in sodium channels

(2013) Deborah L. Capes et al.   JOURNAL OF GENERAL PHYSIOLOGY

Production of Recombinant Disulfide-Rich Venom Peptides for Structural and Functional Analysis via Expression in the Periplasm of E. coli

(2013) Julie K. Klint et al.   PLoS One

Intron Retention in mRNA Encoding Ancillary Subunit of Insect Voltage-Gated Sodium Channel Modulates Channel Expression, Gating Regulation and Drug Sensitivity

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Spider-Venom Peptides: Structure, Pharmacology, and Potential for Control of Insect Pests

(2012) Glenn F. King et al.   Annual Review of Entomology

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(2012) Jérôme J. Lacroix et al.   JOURNAL OF GENERAL PHYSIOLOGY

China must provide education on HIV

(2012) Jian Zhang et al.   NATURE

Adaptive evolution of voltage-gated sodium channels: The first 800 million years

(2012) H. H. Zakon   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanism of Voltage Gating in Potassium Channels

(2012) M. O. Jensen et al.   SCIENCE

Spider-venom peptides that target voltage-gated sodium channels: Pharmacological tools and potential therapeutic leads

(2012) Julie K. Klint et al.   TOXICON

Molecular mechanisms of pyrethroid insecticide neurotoxicity: recent advances

(2011) David M. Soderlund   ARCHIVES OF TOXICOLOGY

Macromolecular NMR spectroscopy for the non-spectroscopist

(2011) Ann H. Kwan et al.   FEBS Journal

Substitutions in the Domain III Voltage-sensing Module Enhance the Sensitivity of an Insect Sodium Channel to a Scorpion β-Toxin

(2011) Weizhong Song et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Common Molecular Determinants of Tarantula Huwentoxin-IV Inhibition of Na+Channel Voltage Sensors in Domains II and IV

(2011) Yucheng Xiao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure-Function Map of the Receptor Site for β-Scorpion Toxins in Domain II of Voltage-gated Sodium Channels

(2011) Joel Z. Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional properties and toxin pharmacology of a dorsal root ganglion sodium channel viewed through its voltage sensors

(2011) Frank Bosmans et al.   JOURNAL OF GENERAL PHYSIOLOGY

The crystal structure of a voltage-gated sodium channel

(2011) Jian Payandeh et al.   NATURE

CLICK—topology-independent comparison of biomolecular 3D structures

(2011) M. N. Nguyen et al.   NUCLEIC ACIDS RESEARCH

Intermediate states of the Kv1.2 voltage sensor from atomistic molecular dynamics simulations

(2011) L. Delemotte et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Peptide toxins that selectively target insect NaVand CaVchannels

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A non-uniformly sampled 4D HCC(CO)NH-TOCSY experiment processed using maximum entropy for rapid protein sidechain assignment

(2010) Mehdi Mobli et al.   JOURNAL OF MAGNETIC RESONANCE

Dali server: conservation mapping in 3D

(2010) Liisa Holm et al.   NUCLEIC ACIDS RESEARCH

A Gating Charge Transfer Center in Voltage Sensors

(2010) X. Tao et al.   SCIENCE

Divergent actions of the pyrethroid insecticides S-bioallethrin, tefluthrin, and deltamethrin on rat Nav1.6 sodium channels

(2010) Jianguo Tan et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

NMR methods for determining disulfide-bond connectivities

(2010) Mehdi Mobli et al.   TOXICON

Targeting voltage sensors in sodium channels with spider toxins

(2010) Frank Bosmans et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Spider-Venom Peptides as Therapeutics

(2010) Natalie J. Saez et al.   Toxins

The Toxicogenomic Multiverse: Convergent Recruitment of Proteins Into Animal Venoms

(2009) Bryan G. Fry et al.   Annual Review of Genomics and Human Genetics

The discovery of a novel sodium channel in the cockroach Periplaneta americana: Evidence for an early duplication of the para-like gene

(2009) Bénédicte Moignot et al.   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

TALOS+: a hybrid method for predicting protein backbone torsion angles from NMR chemical shifts

(2009) Yang Shen et al.   JOURNAL OF BIOMOLECULAR NMR

A single charged voltage sensor is capable of gating theShakerK+channel

(2009) Dominique G. Gagnon et al.   JOURNAL OF GENERAL PHYSIOLOGY

Structure and hydration of membranes embedded with voltage-sensing domains

(2009) Dmitriy Krepkiy et al.   NATURE

Interactions between lipids and voltage sensor paddles detected with tarantula toxins

(2009) Mirela Milescu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Deconstructing voltage sensor function and pharmacology in sodium channels

(2008) Frank Bosmans et al.   NATURE

Neurotoxic and insecticidal properties of venom from the Australian theraphosid spider Selenotholus foelschei

(2008) Volker Herzig et al.   NEUROTOXICOLOGY

A rational nomenclature for naming peptide toxins from spiders and other venomous animals

(2008) Glenn F. King et al.   TOXICON