Research Progress on Quercetin's Biological Activity and Structural Modification Based on Its Antitumor Effects

SAR-guided development of indole-matrine hybrids as potential anticancer agents via mitochondrial stress/cytochrome c/caspase 3 signaling pathway

(2023) Lingyu Li et al.   BIOORGANIC CHEMISTRY

Design, syntheses and biological evaluation of natural product aiphanol derivatives and analogues: Discovery of potent anticancer agents

(2023) Licheng Yao et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Apoptotic Mechanisms of Quercetin in Liver Cancer: Recent Trends and Advancements

(2023) Gautam Sethi et al.   Pharmaceutics

Dysregulated miRNAs modulate tumor microenvironment associated signaling networks in pancreatic ductal adenocarcinoma

(2023) Tiantian Liu et al.   Precision Clinical Medicine

A Pharmacokinetic Study of Different Quercetin Formulations in Healthy Participants: A Diet-Controlled, Crossover, Single- and Multiple-Dose Pilot Study

(2023) Julia Solnier et al.   Evidence-based Complementary and Alternative Medicine

Delivery of quercetin for breast cancer and targeting potentiation via hyaluronic nano-micelles

(2023) Jiao Sun et al.   International Journal of Biological Macromolecules

Combined and targeted drugs delivery system for colorectal cancer treatment: Conatumumab decorated, reactive oxygen species sensitive irinotecan prodrug and quercetin co-loaded nanostructured lipid carriers

(2022) Youqiang Liu et al.   DRUG DELIVERY

O-substituted quercetin derivatives: Structural classification, drug design, development, and biological activities, a review

(2022) Seyedeh Roya Alizadeh et al.   JOURNAL OF MOLECULAR STRUCTURE

Dietary proteins as excipient ingredients for improving the solubility, stability, and bioaccessibility of quercetin: Role of intermolecular interactions

(2022) Li Liao et al.   FOOD RESEARCH INTERNATIONAL

Preclinical evidence for quercetin against inflammatory bowel disease: a meta-analysis and systematic review

(2022) Shuangyuan Hu et al.   INFLAMMOPHARMACOLOGY

Antioxidative Properties and Chemical Changes of Quercetin in Fish Oil: Quercetin Reacts with Free Fatty Acids to Form Its Ester Derivatives

(2021) Shaojun Liu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Senolytic combination of Dasatinib and Quercetin alleviates intestinal senescence and inflammation and modulates the gut microbiome in aged mice

(2021) Tatiana Dandolini Saccon et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Potential Therapeutic Targets of Quercetin, a Plant Flavonol, and Its Role in the Therapy of Various Types of Cancer through the Modulation of Various Cell Signaling Pathways

(2021) Saleh A. Almatroodi et al.   MOLECULES

Induction of NUPR1 and AP‑1 contributes to the carcinogenic potential of nickel

(2021) Anthony Murphy et al.   ONCOLOGY REPORTS

Quercetin induces pro‐apoptotic autophagy via SIRT1 / AMPK signaling pathway in human lung cancer cell lines A549 and H1299 in vitro

(2021) Hengjuan Guo et al.   Thoracic Cancer

Synthesis, Antiproliferative Activity and Radical Scavenging Ability of 5-O-Acyl Derivatives of Quercetin

(2021) Stephen Lo et al.   MOLECULES

Quercetin modified electrospun PHBV fibrous scaffold enhances cartilage regeneration

(2021) Wei Chen et al.   JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE

Long-term treatment with senolytic drugs Dasatinib and Quercetin ameliorates age-dependent intervertebral disc degeneration in mice

(2021) Emanuel J. Novais et al.   Nature Communications

Quercetin derivatives: Drug design, development, and biological activities, a review

(2021) Seyedeh Roya Alizadeh et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Encapsulating quercetin in cyclodextrin metal–organic frameworks improved its solubility and bioavailability

(2021) Zhenjiong Wang et al.   JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE

Suppression of glomerular damage and apoptosis and biomarkers of acute kidney injury induced by acetaminophen toxicity using a combination of resveratrol and quercetin

(2020) Mohammad Dallak et al.   DRUG AND CHEMICAL TOXICOLOGY

A Review on Structure, Modifications and Structure-Activity Relation of Quercetin and Its Derivatives

(2020) Rubin Thapa Magar et al.   JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY

NVP-BSK805, an Inhibitor of JAK2 Kinase, Significantly Enhances the Radiosensitivity of Esophageal Squamous Cell Carcinoma in vitro and in vivo

(2020) Yuhui Hua et al.   Drug Design Development and Therapy

Testing of the Survivin Suppressant YM155 in a Large Panel of Drug-Resistant Neuroblastoma Cell Lines

(2020) Martin Michaelis et al.   Cancers

Novel Five- and Six-Membered Rings of Phosphorus–Selenium Heterocycles from Selenation of Amido-Schiff Bases

(2020) Guoxiong Hua et al.   ACS Omega

Autophagy negative-regulating Wnt signaling enhanced inflammatory osteoclastogenesis from Pre-OCs in vitro

(2020) Lili Chen et al.   BIOMEDICINE & PHARMACOTHERAPY

Delayed recanalization after MCAO ameliorates ischemic stroke by inhibiting apoptosis via HGF/c-Met/STAT3/Bcl-2 pathway in rats

(2020) Hong Tang et al.   EXPERIMENTAL NEUROLOGY

The role of TLR4/NF-κB signaling pathway in activated microglia of rats with chronic high intraocular pressure and vitro scratch injury-induced microglia

(2020) Hongjun Wang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

BML-111 inhibits EMT, migration and metastasis of TAMs-stimulated triple-negative breast cancer cells via ILK pathway

(2020) Lan Lin et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Cefepime/sulbactam as an enhanced antimicrobial combination therapy for the treatment of MDR Gram-negative infections—authors’ response

(2020) David W Wareham et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Elevated tumor-to-liver standardized uptake value ratio (TLR) from preoperative 18F-FDG PET/CT predicts poor prognosis of patients with clear cell renal cell carcinoma after nephrectomy

(2020) Caixia Wu et al.   EUROPEAN JOURNAL OF RADIOLOGY

Mitochondrial Fission Factor (MFF) Inhibits Mitochondrial Metabolism and Reduces Breast Cancer Stem Cell (CSC) Activity

(2020) Rosa Sánchez-Alvarez et al.   Frontiers in Oncology

Quercetin inhibits cell viability, migration and invasion by regulating miR-16/HOXA10 axis in oral cancer

(2019) Junfang Zhao et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Quercetin inhibits human metastatic ovarian cancer cell growth and modulates components of the intrinsic apoptotic pathway in PA-1 cell line

(2019) Dhanaraj Teekaraman et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Quercetin-Modified Metal–Organic Frameworks for Dual Sensitization of Radiotherapy in Tumor Tissues by Inhibiting the Carbonic Anhydrase IX

(2019) Tengchuang Ma et al.   ACS Nano

Quercetin suppresses the tumorigenesis of oral squamous cell carcinoma by regulating microRNA-22/WNT1/β-catenin axis

(2019) Chunping Zhang et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Quercetin suppresses the proliferation and metastasis of metastatic osteosarcoma cells by inhibiting parathyroid hormone receptor 1

(2019) Shenglong Li et al.   BIOMEDICINE & PHARMACOTHERAPY

Nitrogen-containing derivatives of O-tetramethylquercetin: Synthesis and biological profiles in prostate cancer cell models

(2019) Pravien Rajaram et al.   BIOORGANIC CHEMISTRY

Semisynthetic Quercetin Derivatives with Potent Antitumor Activity in Colon Carcinoma

(2019) Ayan Mukherjee et al.   ACS Omega

The Association Between Thyroid Injury and Apoptosis, and Alterations of Bax, Bcl-2, and Caspase-3 mRNA/Protein Expression Induced by Nickel Sulfate in Wistar Rats

(2019) Yahong Liu et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease

(2019) LaTonya J. Hickson et al.   EBioMedicine

A minireview of quercetin: from its metabolism to possible mechanisms of its biological activities

(2019) Hande Gül Ulusoy et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Antitumor and apoptotic effects of quercetin on human melanoma cells involving JNK/P38 MAPK signaling activation

(2019) Sung-Hyun Kim et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Quercetin facilitates cell death and chemosensitivity through RAGE/PI3K/AKT/mTOR axis in human pancreatic cancer cells

(2019) Chieh-Yu Lan et al.   JOURNAL OF FOOD AND DRUG ANALYSIS

The inhibitory effect of carboxyl-terminated polyamidoamine dendrimers on dentine host-derived matrix metalloproteinases in vitro in an etch-and-rinse adhesive system

(2019) Qian Wu et al.   Royal Society Open Science

Using CETSA assay and a mathematical model to reveal dual Bcl-2/Mcl-1 inhibition and on-target mechanism for ABT-199 and S1

(2019) Zongwei Guo et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Methyl lucidone induces apoptosis and G2/M phase arrest via the PI3K/Akt/NF-κB pathway in ovarian cancer cells

(2019) Jae-Hwan Yoon et al.   PHARMACEUTICAL BIOLOGY

Quercetin conjugated with silica nanoparticles inhibits tumor growth in MCF-7 breast cancer cell lines

(2018) Fahimeh Aghapour et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Double emulsions as potential fat replacers with gallic acid and quercetin nanoemulsions in the aqueous phases

(2018) Wladimir Silva et al.   FOOD CHEMISTRY

Formulation and evaluation of mixed polymeric micelles of quercetin for treatment of breast, ovarian, and multidrug resistant cancers

(2018) Arjun Patra et al.   International Journal of Nanomedicine

Notch1 signaling in melanoma cells promoted tumor-induced immunosuppression via upregulation of TGF-β1

(2018) Zike Yang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Quercetin suppresses breast cancer stem cells (CD44 + /CD24 − ) by inhibiting the PI3K/Akt/mTOR-signaling pathway

(2018) Xiuli Li et al.   LIFE SCIENCES

Reversal effect of quercetin on multidrug resistance via FZD7/β-catenin pathway in hepatocellular carcinoma cells

(2018) Zhaolin Chen et al.   PHYTOMEDICINE

Inhibition of EGF expression and NF-κB activity by treatment with quercetin leads to suppression of angiogenesis in nasopharyngeal carcinoma

(2018) Dong-Yan Huang et al.   SAUDI JOURNAL OF BIOLOGICAL SCIENCES

Midkine downregulation increases the efficacy of quercetin on prostate cancer stem cell survival and migration through PI3K/AKT and MAPK/ERK pathway

(2018) Suat Erdogan et al.   BIOMEDICINE & PHARMACOTHERAPY

Different roles of Nrf2 and NFKB in the antioxidant imbalance produced by esculetin or quercetin on NB4 leukemia cells

(2018) Virginia Rubio et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Quercetin induced cell apoptosis and altered gene expression in AGS human gastric cancer cells

(2018) Hung-Sheng Shang et al.   ENVIRONMENTAL TOXICOLOGY

Curcumin and Quercetin Synergistically Inhibit Cancer Cell Proliferation in Multiple Cancer Cells and Modulate Wnt/β-catenin Signaling and Apoptotic Pathways in A375 Cells

(2018) Nishtha S Srivastava et al.   PHYTOMEDICINE

ERCC6L that is up-regulated in high grade of renal cell carcinoma enhances cell viability in vitro and promotes tumor growth in vivo potentially through modulating MAPK signalling pathway

(2018) Gejun Zhang et al.   CANCER GENE THERAPY

Quercetin induces apoptosis and autophagy in primary effusion lymphoma cells by inhibiting PI3K/AKT/mTOR and STAT3 signaling pathways

(2017) Marisa Granato et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Rational design and structure–activity relationship studies of quercetin–amino acid hybrids targeting the anti-apoptotic protein Bcl-xL

(2017) Tahsin F. Kellici et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

The effect of quercetin nanoparticle on cervical cancer progression by inducing apoptosis, autophagy and anti-proliferation via JAK2 suppression

(2016) Cheng-lin Luo et al.   BIOMEDICINE & PHARMACOTHERAPY

Development and evaluation of PLGA polymer based nanoparticles of quercetin

(2016) Md. Khalid Anwer et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Cubosome formulations stabilized by a dansyl-conjugated block copolymer for possible nanomedicine applications

(2015) Sergio Murgia et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Dual drug delivery of tamoxifen and quercetin: Regulated metabolism for anticancer treatment with nanosponges

(2015) Jacob N. Lockhart et al.   JOURNAL OF CONTROLLED RELEASE

Selenium-Containing Chrysin and Quercetin Derivatives: Attractive Scaffolds for Cancer Therapy

(2015) Inês L. Martins et al.   JOURNAL OF MEDICINAL CHEMISTRY

Endogenous and exogenous mediators of quercetin bioavailability

(2015) Yi Guo et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Quercetin–POM (pivaloxymethyl) conjugates: Modulatory activity for P-glycoprotein-based multidrug resistance

(2015) Mi Kyoung Kim et al.   PHYTOMEDICINE

The endocannabinoid anandamide induces apoptosis in cytotrophoblast cells: Involvement of both mitochondrial and death receptor pathways

(2015) M.A. Costa et al.   PLACENTA

Water-Soluble and Cleavable Quercetin–Amino Acid Conjugates as Safe Modulators for P-Glycoprotein-Based Multidrug Resistance

(2014) Mi Kyoung Kim et al.   JOURNAL OF MEDICINAL CHEMISTRY

Quercetin-Containing Self-Nanoemulsifying Drug Delivery System for Improving Oral Bioavailability

(2014) Thanh Huyen Tran et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Pinocembrin protects against β-amyloid-induced toxicity in neurons through inhibiting receptor for advanced glycation end products (RAGE)-independent signaling pathways and regulating mitochondrion-mediated apoptosis

(2012) Rui Liu et al.   BMC Medicine

Synthesis of methylated quercetin derivatives and their reversal activities on P-gp- and BCRP-mediated multidrug resistance tumour cells

(2012) Jian Yuan et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Development of a Quercetin-loaded nanostructured lipid carrier formulation for topical delivery

(2012) Guo Chen-yu et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Lung cancer risk in the electroplating industry in Lombardy, Italy, using the Italian occupational cancer monitoring (OCCAM) information system

(2011) Celestino Panizza et al.   AMERICAN JOURNAL OF INDUSTRIAL MEDICINE

Enhanced Stability and Intracellular Accumulation of Quercetin by Protection of the Chemically or Metabolically Susceptible Hydroxyl Groups with a Pivaloxymethyl (POM) Promoiety

(2010) Mi Kyoung Kim et al.   JOURNAL OF MEDICINAL CHEMISTRY

In vitro solubility, stability and permeability of novel quercetin–amino acid conjugates

(2008) Mi Kyoung Kim et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Discovering novel quercetin-3-O-amino acid-esters as a new class of Src tyrosine kinase inhibitors

(2008) He Huang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY