An Evolutionary Model Encompassing Substrate Specificity and Reactivity of Type I Polyketide Synthase Thioesterases

Assembly Line Polyketide Synthases: Mechanistic Insights and Unsolved Problems

(2014) Chaitan Khosla et al.   BIOCHEMISTRY

Investigating the reactivities of a polyketide synthase module through fluorescent click chemistry

(2013) Amanda Jane Hughes et al.   CHEMICAL COMMUNICATIONS

Habitat-specific type I polyketide synthases in soils and street sediments

(2013) Patrick Hill et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Elucidation of Gephyronic Acid Biosynthetic Pathway Revealed Unexpected SAM-Dependent Methylations

(2013) Jeanette Young et al.   JOURNAL OF NATURAL PRODUCTS

A genomic approach to the cryptic secondary metabolome of the anaerobic world

(2012) Anne-Catrin Letzel et al.   NATURAL PRODUCT REPORTS

6-Deoxyerythronolide B Synthase Thioesterase-Catalyzed Macrocyclization Is Highly Stereoselective

(2012) Atahualpa Pinto et al.   ORGANIC LETTERS

Structural Basis for Phosphopantetheinyl Carrier Domain Interactions in the Terminal Module of Nonribosomal Peptide Synthetases

(2011) Ye Liu et al.   CHEMISTRY & BIOLOGY

Biochemical and Structural Characterization of the Tautomycetin Thioesterase: Analysis of a Stereoselective Polyketide Hydrolase

(2010) Jamie B. Scaglione et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Genome Mining Reveals trans-AT Polyketide Synthase Directed Antibiotic Biosynthesis in the Bacterial Phylum Bacteroidetes

(2010) Roberta Teta  et al.   CHEMBIOCHEM

A Thioesterase from an Iterative Fungal Polyketide Synthase Shows Macrocyclization and Cross Coupling Activity and May Play a Role in Controlling Iterative Cycling through Product Offloading

(2009) Meng Wang et al.   BIOCHEMISTRY

Polyketide synthase thioesterases catalyze rapid hydrolysis of peptidyl thioesters

(2009) Meng Wang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A Darwinian view of metabolism: molecular properties determine fitness

(2009) R. D. Firn et al.   JOURNAL OF EXPERIMENTAL BOTANY

Examining the Role of Hydrogen Bonding Interactions in the Substrate Specificity for the Loading Step of Polyketide Synthase Thioesterase Domains†

(2008) Meng Wang et al.   BIOCHEMISTRY

Exploiting the mosaic structure of trans-acyltransferase polyketide synthases for natural product discovery and pathway dissection

(2008) TuAnh Nguyen et al.   NATURE BIOTECHNOLOGY

Evolution of polyketide synthases in bacteria

(2008) C. P. Ridley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA