Recent advances in the biosynthesis of unusual polyketide synthase substrates

Divergent Mechanistic Routes for the Formation ofgem-Dimethyl Groups in the Biosynthesis of Complex Polyketides

(2015) Sean Poust et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Rational Control of Polyketide Extender Units by Structure-Based Engineering of a Crotonyl-CoA Carboxylase/Reductase in Antimycin Biosynthesis

(2015) Lihan Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Uncovering the Formation and Selection of Benzylmalonyl-CoA from the Biosynthesis of Splenocin and Enterocin Reveals a Versatile Way to Introduce Amino Acids into Polyketide Carbon Scaffolds

(2015) Chenchen Chang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Reinvigorating natural product combinatorial biosynthesis with synthetic biology

(2015) Eunji Kim et al.   Nature Chemical Biology

Decoding and reprogramming complex polyketide assembly lines: prospects for synthetic biology

(2015) Christian Hertweck   TRENDS IN BIOCHEMICAL SCIENCES

Insights into the Pamamycin Biosynthesis

(2014) Yuriy Rebets et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

An Unusual Dehydratase Acting on Glycerate and a Ketoreducatse Stereoselectively Reducing α-Ketone in Polyketide Starter Unit Biosynthesis

(2014) Hai-Yan He et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Predicted Incorporation of Non-native Substrates by a Polyketide Synthase Yields Bioactive Natural Product Derivatives

(2014) Kenny Bravo-Rodriguez et al.   CHEMBIOCHEM

Structure of a modular polyketide synthase

(2014) Somnath Dutta et al.   NATURE

Structural rearrangements of a polyketide synthase module during its catalytic cycle

(2014) Jonathan R. Whicher et al.   NATURE

De novo biosynthesis of terminal alkyne-labeled natural products

(2014) Xuejun Zhu et al.   Nature Chemical Biology

Lomaiviticin Biosynthesis Employs a New Strategy for Starter Unit Generation

(2014) Abraham J. Waldman et al.   ORGANIC LETTERS

A Polyketide Synthase Acyltransferase Domain Structure Suggests a Recognition Mechanism for Its Hydroxymalonyl-Acyl Carrier Protein Substrate

(2014) Hyunjun Park et al.   PLoS One

A Common Origin for Guanidinobutanoate Starter Units in Antifungal Natural Products

(2013) Hui Hong et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Multiplexing of Combinatorial Chemistry in Antimycin Biosynthesis: Expansion of Molecular Diversity and Utility

(2013) Yan Yan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Mechanism and Specificity of an Acyltransferase Domain from a Modular Polyketide Synthase

(2013) Briana J. Dunn et al.   BIOCHEMISTRY

Bioactivity-Guided Genome Mining Reveals the Lomaiviticin Biosynthetic Gene Cluster inSalinispora tropica

(2013) Roland D. Kersten et al.   CHEMBIOCHEM

Flavin-Linked Oxidase Catalyzes Pyrrolizine Formation of Dichloropyrrole-Containing Polyketide Extender Unit in Chlorizidine A

(2013) Simone M. Mantovani et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Engineering the acyltransferase substrate specificity of assembly line polyketide synthases

(2013) B. J. Dunn et al.   Journal of the Royal Society Interface

Direct evidence for a covalent ene adduct intermediate in NAD(P)H-dependent enzymes

(2013) Raoul G Rosenthal et al.   Nature Chemical Biology

Chlorizidine, a Cytotoxic 5H-Pyrrolo[2,1-a]isoindol-5-one-Containing Alkaloid from a Marine Streptomyces sp.

(2013) Xavier Alvarez-Mico et al.   ORGANIC LETTERS

Expanding the Fluorine Chemistry of Living Systems Using Engineered Polyketide Synthase Pathways

(2013) M. C. Walker et al.   SCIENCE

Enzymatic Synthesis of Dilactone Scaffold of Antimycins

(2012) Moriah Sandy et al.   ACS Chemical Biology

Enzyme-Directed Mutasynthesis: A Combined Experimental and Theoretical Approach to Substrate Recognition of a Polyketide Synthase

(2012) Uschi Sundermann et al.   ACS Chemical Biology

Flavoenzyme-Catalyzed Atropo-Selective N,C-Bipyrrole Homocoupling in Marinopyrrole Biosynthesis

(2012) Kazuya Yamanaka et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The structures of type I polyketide synthases

(2012) Adrian T. Keatinge-Clay   NATURAL PRODUCT REPORTS

Microbial engineering for the production of advanced biofuels

(2012) Pamela P. Peralta-Yahya et al.   NATURE

Structure guided design of improved anti-proliferative rapalogs through biosynthetic medicinal chemistry

(2012) Matthew A. Gregory et al.   Chemical Science

Characterization of 2-Octenoyl-CoA Carboxylase/Reductase UtilizingpteBfromStreptomyce avermitilis

(2011) Hye-Gyeong YOO et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Enzymatic Extender Unit Generation for In Vitro Polyketide Synthase Reactions: Structural and Func-tional Showcasing of Streptomyces coelicolor MatB

(2011) Amanda J. Hughes et al.   CHEMISTRY & BIOLOGY

Cloning and Elucidation of the FR901464 Gene Cluster Revealing a Complex Acyltransferase-less Polyketide Synthase Using Glycerate as Starter Units

(2011) Feng Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Beyond ethylmalonyl-CoA: The functional role of crotonyl-CoAcarboxylase/reductase homologs in expanding polyketide diversity

(2011) Micheal C. Wilson et al.   NATURAL PRODUCT REPORTS

Unusual carbon fixation gives rise to diverse polyketide extender units

(2011) Nick Quade et al.   Nature Chemical Biology

Bryostatins: biological context and biotechnological prospects

(2010) Amaro E Trindade-Silva et al.   CURRENT OPINION IN BIOTECHNOLOGY

Nonactin Biosynthesis: Unexpected Patterns of Label Incorporation from 4,6-Dioxoheptanoate Show Evidence of a Degradation Pathway for Levulinate through Propionate inStreptomyces griseus

(2010) Jian Rong et al.   JOURNAL OF NATURAL PRODUCTS

Biosynthesis of the Allylmalonyl-CoA Extender Unit for the FK506 Polyketide Synthase Proceeds through a Dedicated Polyketide Synthase and Facilitates the Mutasynthesis of Analogues

(2010) SangJoon Mo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Biosynthetic Logic of Polyketide Diversity

(2009) Christian Hertweck   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Protein−Protein Recognition between Acyltransferases and Acyl Carrier Proteins in Multimodular Polyketide Synthases

(2009) Fong T. Wong et al.   BIOCHEMISTRY

Biosynthesis of the salinosporamide A polyketide synthase substrate chloroethylmalonyl-coenzyme A from S-adenosyl-L-methionine

(2009) A. S. Eustaquio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Carboxylation mechanism and stereochemistry of crotonyl-CoA carboxylase/reductase, a carboxylating enoyl-thioester reductase

(2009) T. J. Erb et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In Vivo and In Vitro Trans-Acylation by BryP, the Putative Bryostatin Pathway Acyltransferase Derived from an Uncultured Marine Symbiont

(2008) Nicole B. Lopanik et al.   CHEMISTRY & BIOLOGY

Biosynthesis of polyketide synthase extender units

(2008) Yolande A. Chan et al.   NATURAL PRODUCT REPORTS

In vitro reconstitution and crystal structure of p-aminobenzoate N-oxygenase (AurF) involved in aureothin biosynthesis

(2008) Y. S. Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glyceryl-S-Acyl Carrier Protein as an Intermediate in the Biosynthesis of Tetronate Antibiotics

(2007) Yuhui Sun et al.   CHEMBIOCHEM