Mechanisms of genotoxicity. A review ofin vitroandin vivostudies with engineered nanoparticles

The automated FADU-assay, a potential high-throughput in vitro method for early screening of DNA breakage

(2014) María Moreno-Villanueva   ALTEX-Alternatives to Animal Experimentation

Zinc oxide nanoparticles induce oxidative DNA damage and ROS-triggered mitochondria mediated apoptosis in human liver cells (HepG2)

(2012) Vyom Sharma et al.   APOPTOSIS

Practical considerations for conducting ecotoxicity test methods with manufactured nanomaterials: what have we learnt so far?

(2012) Richard D. Handy et al.   ECOTOXICOLOGY

Gentiana asclepiadea exerts antioxidant activity and enhances DNA repair of hydrogen peroxide- and silver nanoparticles-induced DNA damage

(2012) Alexandra Hudecová et al.   FOOD AND CHEMICAL TOXICOLOGY

Impact of agglomeration and different dispersions of titanium dioxide nanoparticles on the human related in vitro cytotoxicity and genotoxicity

(2012) Zuzana Magdolenova et al.   JOURNAL OF ENVIRONMENTAL MONITORING

Silver nanoparticles induce premutagenic DNA oxidation that can be prevented by phytochemicals from Gentiana asclepiadea

(2012) A. Hudecova et al.   MUTAGENESIS

DNA damage induced by micro- and nanoparticles--interaction with FPG influences the detection of DNA oxidation in the comet assay

(2012) J. Kain et al.   MUTAGENESIS

Genotoxicity testing of PLGA–PEO nanoparticles in TK6 cells by the comet assay and the cytokinesis-block micronucleus assay

(2012) Alena Kazimirova et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Carbon black nanoparticle instillation induces sustained inflammation and genotoxicity in mouse lung and liver

(2012) Julie A Bourdon et al.   Particle and Fibre Toxicology

Genotoxicity evaluation of fullerene C60 nanoparticles in a comet assay using lung cells of intratracheally instilled rats

(2012) Makoto Ema et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Effects of Cobalt Nanoparticles on Human T Cells In Vitro

(2011) Haitao Jiang et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Genomic instability of gold nanoparticle treated human lung fibroblast cells

(2011) Jasmine J. Li et al.   BIOMATERIALS

The role of iron redox state in the genotoxicity of ultrafine superparamagnetic iron oxide nanoparticles

(2011) Neenu Singh et al.   BIOMATERIALS

Cytotoxicity and Genotoxicity of Size-Fractionated Iron Oxide (Magnetite) in A549 Human Lung Epithelial Cells: Role of ROS, JNK, and NF-κB

(2011) Mathias Könczöl et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Genotoxicity Evaluation of Nanomaterials: DNA Damage, Micronuclei, and 8-Hydroxy-2-deoxyguanosine Induced by Magnetic Doped CdSe Quantum Dots in Male Mice

(2011) W. K. B. Khalil et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Cellular uptake and mutagenic potential of metal oxide nanoparticles in bacterial cells

(2011) Ashutosh Kumar et al.   CHEMOSPHERE

Cytotoxicity and genotoxicity of titanium dioxide nanoparticles in UVA-irradiated normal peripheral blood lymphocytes

(2011) Su Jin Kang et al.   DRUG AND CHEMICAL TOXICOLOGY

Chronic exposure to nanosized, anatase titanium dioxide is not cyto- or genotoxic to Chinese hamster ovary cells

(2011) Shuguang Wang et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Repetitive exposure to zinc oxide nanoparticles induces dna damage in human nasal mucosa mini organ cultures

(2011) Stephan Hackenberg et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Genotoxicity of Colloidal Fullerene C60

(2011) Shun Matsuda et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Study of serum interaction with a cationic nanoparticle: Implications for in vitro endocytosis, cytotoxicity and genotoxicity

(2011) Maysaloun Merhi et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Differential genotoxicity of chemical properties and particle size of rare metal and metal oxide nanoparticles

(2011) Go Hasegawa et al.   JOURNAL OF APPLIED TOXICOLOGY

Interaction of C60 Fullerene with the Proteins Involved in DNA Mismatch Repair Pathway

(2011) Shishir Kumar Gupta et al.   Journal of Biomedical Nanotechnology

C60-Fullerene Binds with the ATP Binding Domain of Human DNA Topoiosmerase II Alpha

(2011) Lokesh Baweja et al.   Journal of Biomedical Nanotechnology

Gene Expression Profiles for Genotoxic Effects of Silica-Free and Silica-Coated Cobalt Ferrite Nanoparticles

(2011) D. W. Hwang et al.   JOURNAL OF NUCLEAR MEDICINE

Physical−Chemical Aspects of Protein Corona: Relevance toin Vitroandin VivoBiological Impacts of Nanoparticles

(2011) Marco P. Monopoli et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Influence ofBifidobacterium bifidumon Release of Minerals from Bread with Differing Bran Content

(2011) Beata Nalepa et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES

Cytotoxic and genotoxic effects of multi-wall carbon nanotubes on human umbilical vein endothelial cells in vitro

(2011) Yuan-Yuan Guo et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Genotoxic effects of silver nanoparticles stimulated by oxidative stress in human normal bronchial epithelial (BEAS-2B) cells

(2011) Ha Ryong Kim et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Investigation of genotoxic and cytotoxic effects of micro- and nanosized titanium dioxide in six organs of mice in vivo

(2011) Lyudmila P. Sycheva et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Titanium dioxide particles phosphorylate histone H2AX independent of ROS production

(2011) Tatsushi Toyooka et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Characterization of synthesized silver nanoparticles and assessment of its genotoxicity potentials using the alkaline comet assay

(2011) Natesan A.L. Flower et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Amorphous silica nanoparticles do not induce cytotoxicity, cell transformation or genotoxicity in Balb/3T3 mouse fibroblasts

(2011) Chiara Uboldi et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Investigation on the genotoxicity of different sizes of gold nanoparticles administered to the lungs of rats

(2011) Markus Schulz et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Genotoxicity of silver nanoparticles evaluated using the Ames test and in vitro micronucleus assay

(2011) Yan Li et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Carbon nanotube-mediated wireless cell permeabilization: drug and gene uptake

(2011) Vittoria Raffa et al.   Nanomedicine

Ameliorative Effects of Dimetylthiourea and N-Acetylcysteine on Nanoparticles Induced Cyto-Genotoxicity in Human Lung Cancer Cells-A549

(2011) Ritesh Kumar Srivastava et al.   PLoS One

In vivo genotoxicity study of titanium dioxide nanoparticles using comet assay following intratracheal instillation in rats

(2011) Masato Naya et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Cytotoxic and genotoxic effects of silver nanoparticles in testicular cells

(2011) Nana Asare et al.   TOXICOLOGY

Nanotoxicology and in vitro studies: The need of the hour

(2011) Sumit Arora et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Toxic effects of gold nanoparticles on Salmonella typhimurium bacteria

(2011) Shuguang Wang et al.   TOXICOLOGY AND INDUSTRIAL HEALTH

Cytotoxic, genotoxic and pro-inflammatory effects of zinc oxide nanoparticles in human nasal mucosa cells in vitro

(2011) Stephan Hackenberg et al.   TOXICOLOGY IN VITRO

Titanium dioxide nanoparticles induced cytotoxicity, oxidative stress and DNA damage in human amnion epithelial (WISH) cells

(2011) Quaiser Saquib et al.   TOXICOLOGY IN VITRO

The comet assay in nanotoxicology research

(2010) Hanna L. Karlsson   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Cytotoxicity and genotoxicity of silver nanoparticles in the human lung cancer cell line, A549

(2010) Rasmus Foldbjerg et al.   ARCHIVES OF TOXICOLOGY

DNA binding and aggregation by carbon nanoparticles

(2010) Hongjie An et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Genotoxicity of titanium dioxide (TiO2) nanoparticles at two trophic levels: Plant and human lymphocytes

(2010) Manosij Ghosh et al.   CHEMOSPHERE

Nanosized titanium dioxide particles do not induce DNA damage in human peripheral blood lymphocytes

(2010) Stephan Hackenberg et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

p38 MAPK Activation, DNA Damage, Cell Cycle Arrest and Apoptosis As Mechanisms of Toxicity of Silver Nanoparticles in Jurkat T Cells

(2010) Hyun-Jeong Eom et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Toxicological evaluation of pH-sensitive nanoparticles of curcumin: Acute, sub-acute and genotoxicity studies

(2010) Prajakta Dandekar et al.   FOOD AND CHEMICAL TOXICOLOGY

Bioeffects of CdTe Quantum Dots on Human Umbilical Vein Endothelial Cells

(2010) Liping Wang et al.   JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY

What the Cell “Sees” in Bionanoscience

(2010) Dorota Walczyk et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Biological safety of water-soluble fullerenes evaluated using tests for genotoxicity, phototoxicity, and pro-oxidant activity

(2010) Hisae Aoshima et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

Effects of Surface Chemistry on Cytotoxicity, Genotoxicity, and the Generation of Reactive Oxygen Species Induced by ZnO Nanoparticles

(2010) Hong Yin et al.   LANGMUIR

Adaptations of the in vitro MN assay for the genotoxicity assessment of nanomaterials

(2010) L. Gonzalez et al.   MUTAGENESIS

Molecular mechanisms of micronucleus, nucleoplasmic bridge and nuclear bud formation in mammalian and human cells

(2010) M. Fenech et al.   MUTAGENESIS

Protein−Nanoparticle Interaction: Identification of the Ubiquitin−Gold Nanoparticle Interaction Site

(2010) Luigi Calzolai et al.   NANO LETTERS

Intracellular synchrotron nanoimaging and DNA damage/genotoxicity screening of novel lanthanide-coated nanovectors

(2010) David J Lewis et al.   Nanomedicine

Genotoxicity and cytotoxicity of zinc oxide and titanium dioxide in HEp-2 cells

(2010) Ilham F Osman et al.   Nanomedicine

Possible genotoxic mechanisms of nanoparticles: Criteria for improved test strategies

(2010) Ken Donaldson et al.   Nanotoxicology

Rationale of genotoxicity testing of nanomaterials: Regulatory requirements and appropriateness of available OECD test guidelines

(2010) David B. Warheit et al.   Nanotoxicology

Exploring the aneugenic and clastogenic potential in the nanosize range: A549 human lung carcinoma cells and amorphous monodisperse silica nanoparticles as models

(2010) Laetitia Gonzalez et al.   Nanotoxicology

Oxidative stress and DNA damage responses in rat and mouse lung to inhaled carbon nanoparticles

(2010) Anton Wessels et al.   Nanotoxicology

DNA damage and alterations in expression of DNA damage responsive genes induced by TiO2nanoparticles in human hepatoma HepG2 cells

(2010) Jana PetkoviĆ et al.   Nanotoxicology

The Role of Surface Functionality on Acute Cytotoxicity, ROS Generation and DNA Damage by Cationic Gold Nanoparticles

(2010) Apiwat Chompoosor et al.   Small

In vitro mutagenicity assessment of aluminium oxide nanomaterials using the Salmonella/microsome assay

(2010) A. Balasubramanyam et al.   TOXICOLOGY IN VITRO

ROS-mediated genotoxicity induced by titanium dioxide nanoparticles in human epidermal cells

(2010) Ritesh K. Shukla et al.   TOXICOLOGY IN VITRO

In vitro evaluation of SiC nanoparticles impact on A549 pulmonary cells: Cyto-, genotoxicity and oxidative stress

(2010) S. Barillet et al.   TOXICOLOGY LETTERS

Intracellular localisation, geno- and cytotoxic response of polyN-isopropylacrylamide (PNIPAM) nanoparticles to human keratinocyte (HaCaT) and colon cells (SW 480)

(2010) Pratap C. Naha et al.   TOXICOLOGY LETTERS

Intracellular distribution, geno- and cytotoxic effects of nanosized titanium dioxide particles in the anatase crystal phase on human nasal mucosa cells

(2010) Stephan Hackenberg et al.   TOXICOLOGY LETTERS

Silver nanoparticles: Evaluation of DNA damage, toxicity and functional impairment in human mesenchymal stem cells

(2010) Stephan Hackenberg et al.   TOXICOLOGY LETTERS

Genotoxic potential of TiO2 on bottlenose dolphin leukocytes

(2009) Margherita Bernardeschi et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

NanoGenotoxicology: The DNA damaging potential of engineered nanomaterials

(2009) Neenu Singh et al.   BIOMATERIALS

In vitro cytotoxicity screening of water-dispersible metal oxide nanoparticles in human cell lines

(2009) Jong Young Choi et al.   BIOPROCESS AND BIOSYSTEMS ENGINEERING

Titanium Dioxide Nanoparticles Induce DNA Damage and Genetic Instability In vivo in Mice

(2009) B. Trouiller et al.   CANCER RESEARCH

A new approach for the in vitro identification of the cytotoxicity of superparamagnetic iron oxide nanoparticles

(2009) Morteza Mahmoudi et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Development ofin vitrosystems for nanotoxicology: methodological considerations

(2009) Vicki Stone et al.   CRITICAL REVIEWS IN TOXICOLOGY

Genotoxic effects of nanosized and fine TiO2

(2009) GCM Falck et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Changing the dose metric for inhalation toxicity studies: Short-term study in rats with engineered aerosolized amorphous silica nanoparticles

(2009) Christie M. Sayes et al.   INHALATION TOXICOLOGY

Comparative study of the cytotoxic and genotoxic effects of titanium oxide and aluminium oxide nanoparticles in Chinese hamster ovary (CHO-K1) cells

(2009) A.L. Di Virgilio et al.   JOURNAL OF HAZARDOUS MATERIALS

Evaluation of genotoxicity of amine-terminated water-dispersible FePt nanoparticles in the Ames test and in vitro chromosomal aberration test

(2009) Shinya Maenosono et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

Mutagenicity of water-soluble ZnO nanoparticles in Ames test

(2009) Rie Yoshida et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

Confounding experimental considerations in nanogenotoxicology

(2009) S.H. Doak et al.   MUTAGENESIS

Genotoxicity and morphological transformation induced by cobalt nanoparticles and cobalt chloride: an in vitro study in Balb/3T3 mouse fibroblasts

(2009) J. Ponti et al.   MUTAGENESIS

Testing strategies for the safety of nanoparticles used in medical applications

(2009) Maria Dusinska et al.   Nanomedicine

DNA damage and p53-mediated growth arrest in human cells treated with platinum nanoparticles

(2009) PV Asharani et al.   Nanomedicine

In vitroevaluation of the genotoxicity of a family of novel MeO-PEG-poly(D,L-lactic-co-glycolic acid)-PEG-OMe triblock copolymer and PLGA nanoparticles

(2009) Lili He et al.   NANOTECHNOLOGY

Nanomaterials: A challenge for toxicologists

(2009) Alok Dhawan et al.   Nanotoxicology

Titanium dioxide nanoparticles induce oxidative stress and DNA-adduct formation but not DNA-breakage in human lung cells

(2009) Kunal Bhattacharya et al.   Particle and Fibre Toxicology

Nanomaterials for environmental studies: Classification, reference material issues, and strategies for physico-chemical characterisation

(2009) Vicki Stone et al.   SCIENCE OF THE TOTAL ENVIRONMENT

The importance of life cycle concepts for the development of safe nanoproducts

(2009) Claudia Som et al.   TOXICOLOGY

Disturbed mitotic progression and genome segregation are involved in cell transformation mediated by nano-TiO2 long-term exposure

(2009) Shing Huang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

DNA damaging potential of zinc oxide nanoparticles in human epidermal cells

(2009) Vyom Sharma et al.   TOXICOLOGY LETTERS

BC nanofibres: In vitro study of genotoxicity and cell proliferation

(2009) Susana Moreira et al.   TOXICOLOGY LETTERS

In vitro and in vivo genotoxicity tests on fullerene C60 nanoparticles

(2009) Naohide Shinohara et al.   TOXICOLOGY LETTERS

Size-dependent toxicity of metal oxide particles—A comparison between nano- and micrometer size

(2009) Hanna L. Karlsson et al.   TOXICOLOGY LETTERS

Cytotoxicity and Genotoxicity of Silver Nanoparticles in Human Cells

(2008) P. V. AshaRani et al.   ACS Nano

Clinical toxicities of nanocarrier systems

(2008) Karina R. Vega-Villa et al.   ADVANCED DRUG DELIVERY REVIEWS

Clastogenic and aneugenic effects of multi-wall carbon nanotubes in epithelial cells

(2008) Julie Muller et al.   CARCINOGENESIS

Chromosomal aberration frequency in lymphocytes predicts the risk of cancer: results from a pooled cohort study of 22 358 subjects in 11 countries

(2008) S. Bonassi et al.   CARCINOGENESIS

Copper Oxide Nanoparticles Are Highly Toxic: A Comparison between Metal Oxide Nanoparticles and Carbon Nanotubes

(2008) Hanna L. Karlsson et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Biopharmaceutics and Therapeutic Potential of Engineered Nanomaterials

(2008) Xing-Jie Liang et al.   CURRENT DRUG METABOLISM

Genotoxic and cytotoxic potential of titanium dioxide (TiO2) nanoparticles on fish cells in vitro

(2008) William F. Vevers et al.   ECOTOXICOLOGY

The ecotoxicology of nanoparticles and nanomaterials: current status, knowledge gaps, challenges, and future needs

(2008) Richard D. Handy et al.   ECOTOXICOLOGY

Titanium dioxide nanoparticles trigger p53-mediated damage response in peripheral blood lymphocytes

(2008) Su Jin Kang et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Genotoxicity, cytotoxicity, and reactive oxygen species induced by single‐walled carbon nanotubes and C60fullerenes in the FE1‐Muta™Mouse lung epithelial cells

(2008) Nicklas Raun Jacobsen et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Oxidatively Damaged DNA in Rats Exposed by Oral Gavage to C 60 Fullerenes and Single-Walled Carbon Nanotubes

(2008) Janne K. Folkmann et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Twenty-Eight-Day Oral Toxicity, Genotoxicity, and Gender-Related Tissue Distribution of Silver Nanoparticles in Sprague-Dawley Rats

(2008) Yong Soon Kim et al.   INHALATION TOXICOLOGY

Comparative study of cytotoxicity, oxidative stress and genotoxicity induced by four typical nanomaterials: the role of particle size, shape and composition

(2008) Hui Yang et al.   JOURNAL OF APPLIED TOXICOLOGY

Toxicity of nano- and micro-sized ZnO particles in human lung epithelial cells

(2008) Weisheng Lin et al.   JOURNAL OF NANOPARTICLE RESEARCH

Ecotoxicological applications and significance of the comet assay

(2008) A. N. Jha   MUTAGENESIS

Comparative genotoxicity of cobalt nanoparticles and ions on human peripheral leukocytes in vitro

(2008) R. Colognato et al.   MUTAGENESIS

Hydroxyl radicals (OH) are associated with titanium dioxide (TiO2) nanoparticle-induced cytotoxicity and oxidative DNA damage in fish cells

(2008) James F. Reeves et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Flow-cytometric analysis of in vitro micronucleus formation: Comparative studies with WIL2-NS human lymphoblastoid and L5178Y mouse lymphoma cell lines

(2008) S. Laingam et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Genotoxicity investigations on nanomaterials: Methods, preparation and characterization of test material, potential artifacts and limitations—Many questions, some answers

(2008) Robert Landsiedel et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Reproducible Comet Assay of Amorphous Silica Nanoparticles Detects No Genotoxicity

(2008) Clifford A. Barnes et al.   NANO LETTERS

Genotoxicity of engineered nanomaterials: A critical review

(2008) Laetitia Gonzalez et al.   Nanotoxicology

Carbon nanotubes introduced into the abdominal cavity of mice show asbestos-like pathogenicity in a pilot study

(2008) Craig A. Poland et al.   Nature Nanotechnology

Nanotechnology, Cosmetics and the Skin: Is There a Health Risk?

(2008) G.J. Nohynek et al.   SKIN PHARMACOLOGY AND PHYSIOLOGY

A new strategy to probe the genotoxicity of silver nanoparticles combined with cetylpyridine bromide

(2008) Zhenxing Chi et al.   SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY

How Meaningful are the Results of Nanotoxicity Studies in the Absence of Adequate Material Characterization?

(2008) David B. Warheit   TOXICOLOGICAL SCIENCES

DNA damage response to different surface chemistry of silver nanoparticles in mammalian cells

(2008) Maqusood Ahamed et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Studies on the in vitro genotoxicity of baytubes®, agglomerates of engineered multi-walled carbon-nanotubes (MWCNT)

(2008) U. Wirnitzer et al.   TOXICOLOGY LETTERS

Multi-walled carbon nanotubes: Lack of mutagenic activity in the bacterial reverse mutation assay

(2008) Antonella Di Sotto et al.   TOXICOLOGY LETTERS

Nanoparticle-driven DNA damage mimics irradiation-related carcinogenesis pathways

(2007) R. M. Mroz et al.   EUROPEAN RESPIRATORY JOURNAL