Understanding How Minerals Contribute to Optimal Immune Function

A SWOT Analysis of Pharmacy Students’ Perspectives on e-Learning Based on a Narrative Review

(2023) Carla Pires   Pharmacy

The Role of Minerals in the Optimal Functioning of the Immune System

(2022) Christopher Weyh et al.   Nutrients

Editorial of Special Issue “Magnesium in Human Health and Disease”

(2021) Sara Castiglioni   Nutrients

Zinc and respiratory tract infections: Perspectives for COVID‑19 (Review)

(2020) Anatoly Skalny et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Optimal Nutritional Status for a Well-Functioning Immune System Is an Important Factor to Protect against Viral Infections

(2020) Philip C. Calder et al.   Nutrients

Inadequacy of Immune Health Nutrients: Intakes in US Adults, the 2005–2016 NHANES

(2020) Carroll A. Reider et al.   Nutrients

Is copper beneficial for COVID-19 patients?

(2020) Syamal Raha et al.   MEDICAL HYPOTHESES

Copper(II) generates ROS and RNS, impairs antioxidant system and damages membrane and DNA in human blood cells

(2019) Nazim Husain et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

The Role of Zinc in Antiviral Immunity

(2019) Scott A Read et al.   Advances in Nutrition

Selenium Deficiency Induces Inflammation via the iNOS/NF-κB Pathway in the Brain of Pigs

(2019) Yilei Zhang et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Effect of magnesium supplements on serum C-reactive protein: a systematic review and meta-analysis

(2018) Mohsen Mazidi et al.   Archives of Medical Science

Bone resorption: supporting immunometabolism

(2018) Gustav van Niekerk et al.   Biology Letters

Role of divalent metals in infectious disease susceptibility and outcome

(2018) G. Weiss et al.   CLINICAL MICROBIOLOGY AND INFECTION

Iron and innate antimicrobial immunity—Depriving the pathogen, defending the host

(2018) Manfred Nairz et al.   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

Immune Function and Micronutrient Requirements Change over the Life Course

(2018) Silvia Maggini et al.   Nutrients

The role of insufficient copper in lipid synthesis and fatty-liver disease

(2017) Austin Morrell et al.   IUBMB LIFE

Bacterial Siderophores Hijack Neutrophil Functions

(2017) Piu Saha et al.   JOURNAL OF IMMUNOLOGY

An Iron-Rich Diet Decreases the Mycobacterial Burden and Correlates With Hepcidin Upregulation, Lower Levels of Proinflammatory Mediators, and Increased T-Cell Recruitment in a Model of Mycobacterium bovis Bacille Calmette-Guerin Infection

(2017) Rafiou Agoro et al.   JOURNAL OF INFECTIOUS DISEASES

Multiple Nutritional Factors and the Risk of Hashimoto's Thyroiditis

(2017) Shiqian Hu et al.   THYROID

Zinc in Infection and Inflammation

(2017) et al.   Nutrients

Genetic and Dietary Iron Overload Differentially Affect the Course of Salmonella Typhimurium Infection

(2017) Manfred Nairz et al.   Frontiers in Cellular and Infection Microbiology

Iron- and Hepcidin-Independent Downregulation of the Iron Exporter Ferroportin in Macrophages during Salmonella Infection

(2017) Alexandra Willemetz et al.   Frontiers in Immunology

Antioxidant and anti-inflammatory effects of zinc. Zinc-dependent NF-κB signaling

(2017) Magdalena Jarosz et al.   INFLAMMOPHARMACOLOGY

Lipocalin 2 Protects from Inflammation and Tumorigenesis Associated with Gut Microbiota Alterations

(2016) Alexander R. Moschen et al.   Cell Host & Microbe

The Yin and Yang of copper during infection

(2016) Angelique N. Besold et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Myeloid Cell–Derived HIF-1α Promotes Control ofLeishmania major

(2016) Valentin Schatz et al.   JOURNAL OF IMMUNOLOGY

Induction of regulatory T cells in Th1-/Th17-driven experimental autoimmune encephalomyelitis by zinc administration

(2016) Eva Rosenkranz et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Dietary copper and human health: Current evidence and unresolved issues

(2016) Muriel Bost et al.   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

Siderophores: More than Stealing Iron

(2016) Judith Behnsen et al.   mBio

Zinc and its role in immunity and inflammation

(2015) Paola Bonaventura et al.   AUTOIMMUNITY REVIEWS

Hepcidin-Induced Hypoferremia Is a Critical Host Defense Mechanism against the Siderophilic Bacterium Vibrio vulnificus

(2015) João Arezes et al.   Cell Host & Microbe

The Iron age of host-microbe interactions

(2015) M. P. Soares et al.   EMBO REPORTS

Lipocalin-2 ensures host defense againstSalmonellaTyphimurium by controlling macrophage iron homeostasis and immune response

(2015) Manfred Nairz et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Zinc enhances the number of regulatory T cells in allergen-stimulated cells from atopic subjects

(2015) Eva Rosenkranz et al.   EUROPEAN JOURNAL OF NUTRITION

Genetic variants of SLC11A1 are associated with both autoimmune and infectious diseases: systematic review and meta-analysis

(2015) N S Archer et al.   GENES AND IMMUNITY

Increased Ferroportin-1 Expression and Rapid Splenic Iron Loss Occur with Anemia Caused by Salmonella enterica Serovar Typhimurium Infection in Mice

(2015) Diane E. Brown et al.   INFECTION AND IMMUNITY

The influence of the trace element zinc on the immune system

(2015) Claudia Schubert et al.   LaboratoriumsMedizin-Journal of Laboratory Medicine

Serum copper to zinc ratio: Relationship with aging and health status

(2015) Marco Malavolta et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Diverging roles of bacterial siderophores during infection

(2015) Victoria I. Holden et al.   Metallomics

Contrasting regulation of macrophage iron homeostasis in response to infection with Listeria monocytogenes depending on localization of bacteria

(2015) David Haschka et al.   Metallomics

Zinc deficiency enhanced inflammatory response by increasing immune cell activation and inducing IL6 promoter demethylation

(2015) Carmen P. Wong et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Anaemia in kidney disease: harnessing hypoxia responses for therapy

(2015) Mark J. Koury et al.   Nature Reviews Nephrology

Interplay between enterobactin, myeloperoxidase and lipocalin 2 regulates E. coli survival in the inflamed gut

(2015) Vishal Singh et al.   Nature Communications

Magnesium in Prevention and Therapy

(2015) Uwe Gröber et al.   Nutrients

Dietary Selenium in Adjuvant Therapy of Viral and Bacterial Infections

(2015) Holger Steinbrenner et al.   Advances in Nutrition

Ferritin-Mediated Iron Sequestration Stabilizes Hypoxia-Inducible Factor-1α upon LPS Activation in the Presence of Ample Oxygen

(2015) Isabel Siegert et al.   Cell Reports

HIF-1α restricts NF-κB-dependent gene expression to control innate immunity signals

(2014) Daniel Bandarra et al.   Disease Models & Mechanisms

Attenuated Inflammatory Responses in Hemochromatosis Reveal a Role for Iron in the Regulation of Macrophage Cytokine Translation

(2014) L. Wang et al.   JOURNAL OF IMMUNOLOGY

Differential impact of zinc deficiency on phagocytosis, oxidative burst, and production of pro-inflammatory cytokines by human monocytes

(2014) Lena S. Mayer et al.   Metallomics

Multiple impacts of zinc on immune function

(2014) Hajo Haase et al.   Metallomics

Iron at the interface of immunity and infection

(2014) Manfred Nairz et al.   Frontiers in Pharmacology

The structure and regulation of magnesium selective ion channels

(2013) Jian Payandeh et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Zinc signals and immune function

(2013) Hajo Haase et al.   BIOFACTORS

Seven Dietary Minerals (Ca, P, Mg, Fe, Zn, Cu, and Mn) and Their Relationship with Blood Pressure and Blood Lipids in Healthy Adults with Self-Selected Diet

(2013) Mi-Hyun Kim et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Magnesium deficit - overlooked cause of low vitamin D status?

(2013) Armin Zittermann   BMC Medicine

Iron in Infection and Immunity

(2013) James E. Cassat et al.   Cell Host & Microbe

Probiotic Bacteria Reduce Salmonella Typhimurium Intestinal Colonization by Competing for Iron

(2013) Elisa Deriu et al.   Cell Host & Microbe

Lipocalin 2 deactivates macrophages and worsens pneumococcal pneumonia outcomes

(2013) Joanna M. Warszawska et al.   JOURNAL OF CLINICAL INVESTIGATION

Nitric oxide–mediated regulation of ferroportin-1 controls macrophage iron homeostasis and immune function in Salmonella infection

(2013) Manfred Nairz et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Impaired Neutrophil Function in 24p3 Null Mice Contributes to Enhanced Susceptibility to Bacterial Infections

(2013) Z. Liu et al.   JOURNAL OF IMMUNOLOGY

Nutrition, diet and immunosenescence

(2013) Mònica Maijó et al.   MECHANISMS OF AGEING AND DEVELOPMENT

The SLC30 family of zinc transporters – A review of current understanding of their biological and pathophysiological roles

(2013) Liping Huang et al.   MOLECULAR ASPECTS OF MEDICINE

Lipocalin-2 Expressed in Innate Immune Cells Is an Endogenous Inhibitor of Inflammation in Murine Nephrotoxic Serum Nephritis

(2013) Kathrin Eller et al.   PLoS One

Selenium Supplementation Restores Innate and Humoral Immune Responses in Footrot-Affected Sheep

(2013) Jean A. Hall et al.   PLoS One

Metallothioneins negatively regulate IL-27-induced type 1 regulatory T-cell differentiation

(2013) C. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pirin is an iron-dependent redox regulator of NF- B

(2013) F. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Magnesium in Disease Prevention and Overall Health

(2013) Stella Lucia Volpe   Advances in Nutrition

Discovery of Human Zinc Deficiency: Its Impact on Human Health and Disease

(2013) Ananda S. Prasad   Advances in Nutrition

Lipocalin 2 Bolsters Innate and Adaptive Immune Responses to Blood-Stage Malaria Infection by Reinforcing Host Iron Metabolism

(2012) Hong Zhao et al.   Cell Host & Microbe

Identification of Ser/Thr phosphorylation sites in the C2-domain of phospholipase C γ2 (PLCγ2) using TRPM7-kinase

(2012) Francina Deason-Towne et al.   CELLULAR SIGNALLING

MRI-Based Liver Iron Content Predicts for Nonrelapse Mortality in MDS and AML Patients Undergoing Allogeneic Stem Cell Transplantation

(2012) M. Wermke et al.   CLINICAL CANCER RESEARCH

Lipocalin-2 ameliorates granulocyte functionality

(2012) Andrea Schroll et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Neutrophil gelatinase-associated lipocalin and interleukin-10 regulate intramacrophage Chlamydia pneumoniae replication by modulating intracellular iron homeostasis

(2012) Rosa Bellmann-Weiler et al.   IMMUNOBIOLOGY

Magnesium Decreases Inflammatory Cytokine Production: A Novel Innate Immunomodulatory Mechanism

(2012) J. Sugimoto et al.   JOURNAL OF IMMUNOLOGY

Hereditary Hemochromatosis Restores the Virulence of Plague Vaccine Strains

(2012) L. E. Quenee et al.   JOURNAL OF INFECTIOUS DISEASES

Slc11a1 (Nramp1) impairs growth of Salmonella enterica serovar typhimurium in macrophages via stimulation of lipocalin-2 expression

(2012) Gernot Fritsche et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Selenium and human health

(2012) Margaret P Rayman   LANCET

Post-natal anaemia and iron deficiency in HIV-infected women and the health and survival of their children

(2012) Sheila Isanaka et al.   Maternal and Child Nutrition

Estimating the Global Prevalence of Zinc Deficiency: Results Based on Zinc Availability in National Food Supplies and the Prevalence of Stunting

(2012) K. Ryan Wessells et al.   PLoS One

Mechanism of zinc-mediated inhibition of caspase-9

(2012) Kristen L. Huber et al.   PROTEIN SCIENCE

Hepcidin and the Iron-Infection Axis

(2012) H. Drakesmith et al.   SCIENCE

Interaction of Lipocalin 2, Transferrin, and Siderophores Determines the Replicative Niche of Klebsiella pneumoniae during Pneumonia

(2012) M. A. Bachman et al.   mBio

Heme Uptake by Leishmania amazonensis Is Mediated by the Transmembrane Protein LHR1

(2012) Chau Huynh et al.   PLoS Pathogens

The Role of Selenium in Inflammation and Immunity: From Molecular Mechanisms to Therapeutic Opportunities

(2011) Zhi Huang et al.   ANTIOXIDANTS & REDOX SIGNALING

Nrf2 regulates ferroportin 1-mediated iron efflux and counteracts lipopolysaccharide-induced ferroportin 1 mRNA suppression in macrophages

(2011) Nobuhiko Harada et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Zinc and human health: an update

(2011) Christos T. Chasapis et al.   ARCHIVES OF TOXICOLOGY

Ferroportin1 deficiency in mouse macrophages impairs iron homeostasis and inflammatory responses

(2011) Z. Zhang et al.   BLOOD

Low hepcidin accounts for the proinflammatory status associated with iron deficiency

(2011) A. Pagani et al.   BLOOD

Hepcidin regulation by innate immune and infectious stimuli

(2011) A. E. Armitage et al.   BLOOD

Nitric oxide activates an Nrf2/sulfiredoxin antioxidant pathway in macrophages

(2011) Kahina Abbas et al.   FREE RADICAL BIOLOGY AND MEDICINE

Klebsiella pneumoniae Yersiniabactin Promotes Respiratory Tract Infection through Evasion of Lipocalin 2

(2011) Michael A. Bachman et al.   INFECTION AND IMMUNITY

Nifedipine Affects the Course of Salmonella enterica Serovar Typhimurium Infection by Modulating Macrophage Iron Homeostasis

(2011) Sabine M. Mair et al.   JOURNAL OF INFECTIOUS DISEASES

A possible role for secreted ferritin in tissue iron distribution

(2011) Esther G. Meyron-Holtz et al.   JOURNAL OF NEURAL TRANSMISSION

Zinc differentially regulates mitogen-activated protein kinases in human T cells

(2011) Andrea Hönscheid et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Heme controls ferroportin1 (FPN1) transcription involving Bach1, Nrf2 and a MARE/ARE sequence motif at position -7007 of the FPN1 promoter

(2010) S. Marro et al.   HAEMATOLOGICA

Role of Ferroportin in Macrophage-Mediated Immunity

(2010) E. E. Johnson et al.   INFECTION AND IMMUNITY

Zinc suppresses Th17 development via inhibition of STAT3 activation

(2010) Chika Kitabayashi et al.   INTERNATIONAL IMMUNOLOGY

Hepcidin mediates transcriptional changes that modulate acute cytokine-induced inflammatory responses in mice

(2010) Ivana De Domenico et al.   JOURNAL OF CLINICAL INVESTIGATION

Zinc Influences Innate Immune Responses in Children with Enterotoxigenic Escherichia coli-Induced Diarrhea

(2010) Alaullah Sheikh et al.   JOURNAL OF NUTRITION

Changes in Intestinal Bifidobacteria Levels Are Associated with the Inflammatory Response in Magnesium-Deficient Mice

(2010) Barbara D. Pachikian et al.   JOURNAL OF NUTRITION

Development of a Copper Database for Exposure-Response Analysis

(2010) Daniel Krewski et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES

An Exposure-Response Curve for Copper Excess and Deficiency

(2010) Andrea Chambers et al.   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS

Long-term selenium supplementation of humans: Selenium status and relationships between selenium concentrations in skeletal muscle and indicator materials

(2010) Dietrich Behne et al.   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

Impact of iron treatment on immune effector function and cellular iron status of circulating monocytes in dialysis patients

(2010) T. Sonnweber et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Neutropenia Caused by Copper Deficiency: Possible Mechanisms of Action

(2010) Susan S. Percival   NUTRITION REVIEWS

Is Low Copper Status Immunosuppressive?

(2010) Mark L. Failla et al.   NUTRITION REVIEWS

Zn2+ Inhibits Coronavirus and Arterivirus RNA Polymerase Activity In Vitro and Zinc Ionophores Block the Replication of These Viruses in Cell Culture

(2010) Aartjan J. W. te Velthuis et al.   PLoS Pathogens

Methods of assessment of selenium status in humans: a systematic review

(2009) Kate Ashton et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Neurogenic Inflammation and Cardiac Dysfunction Due to Hypomagnesemia

(2009) Jay H. Kramer et al.   AMERICAN JOURNAL OF THE MEDICAL SCIENCES

Selenium and the Selenoprotein Thioredoxin Reductase in the Prevention, Treatment and Diagnostics of Cancer

(2009) Markus Selenius et al.   ANTIOXIDANTS & REDOX SIGNALING

Toll-like receptors mediate induction of hepcidin in mice infected with Borrelia burgdorferi

(2009) C. L. Koening et al.   BLOOD

Absence of functional Hfe protects mice from invasive Salmonella enterica Serovar Typhimurium infection via induction of lipocalin-2

(2009) M. Nairz et al.   BLOOD

The human selenoproteome: recent insights into functions and regulation

(2009) M. A. Reeves et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Selenium and selenium-antagonistic elements in nutritional cancer prevention

(2009) G. N. Schrauzer   CRITICAL REVIEWS IN BIOTECHNOLOGY

Zinc: role in immunity, oxidative stress and chronic inflammation

(2009) Ananda S Prasad   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Selenium and Inflammation: Underlying Anti-inflammatory Mechanisms

(2009) L. H. Duntas   HORMONE AND METABOLIC RESEARCH

Bone morphogenetic protein-6 induces the expression of inducible nitric oxide synthase in macrophages

(2009) Seok J. Kwon et al.   IMMUNOLOGY

Innate immunity

(2009) Stuart E. Turvey et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

A Role for the ATP7A Copper-transporting ATPase in Macrophage Bactericidal Activity

(2009) Carine White et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The transplant iron score as a predictor of stem cell transplant survival

(2009) Jonathan A Storey et al.   Journal of Hematology & Oncology

Nramp1 promotes efficient macrophage recycling of iron following erythrophagocytosis in vivo

(2009) S. Soe-Lin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mucosal Lipocalin 2 Has Pro-Inflammatory and Iron-Sequestering Effects in Response to Bacterial Enterobactin

(2009) Michael A. Bachman et al.   PLoS Pathogens

Iron availability and infection

(2008) Eugene D. Weinberg   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Iron depletion limits intracellular bacterial growth in macrophages

(2008) P. N. Paradkar et al.   BLOOD

Leishmania donovanidepletes labile iron pool to exploit iron uptake capacity of macrophage for its intracellular growth

(2008) Nupur Kanti Das et al.   CELLULAR MICROBIOLOGY

The Interaction between Nutrition and Infection

(2008) Peter Katona et al.   CLINICAL INFECTIOUS DISEASES

Nramp1-functionality increases iNOS expressionviarepression of IL-10 formation

(2008) Gernot Fritsche et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Ferritin functions as a proinflammatory cytokine via iron-independent protein kinase C zeta/nuclear factor kappaB-regulated signaling in rat hepatic stellate cells

(2008) Richard G. Ruddell et al.   HEPATOLOGY

Effects of the Aspergillus fumigatus siderophore systems on the regulation of macrophage immune effector pathways and iron homeostasis

(2008) M. Seifert et al.   IMMUNOBIOLOGY

Role of iron homeostasis in trypanosomiasis-associated anemia

(2008) Benoît Stijlemans et al.   IMMUNOBIOLOGY

Nrf1 and Nrf2 Play Distinct Roles in Activation of Antioxidant Response Element-dependent Genes

(2008) Makiko Ohtsuji et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Unknown

(2008) Ananda Prasad   MOLECULAR MEDICINE

Biosynthesis and IroC-dependent export of the siderophore salmochelin are essential for virulence of Salmonella enterica serovar Typhimurium

(2008) Marie-Laure V. Crouch et al.   MOLECULAR MICROBIOLOGY

NF-κB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1α

(2008) Jordi Rius et al.   NATURE

Worldwide prevalence of anaemia, WHO Vitamin and Mineral Nutrition Information System, 1993–2005

(2008) Erin McLean et al.   PUBLIC HEALTH NUTRITION

Modulation of macrophage iron transport by Nramp1 (Slc11a1)

(2007) Gernot Fritsche et al.   IMMUNOBIOLOGY