The lyophilized chloroplasts store synthetic DARPin G3 as bioactive encapsulated organelles

Phase I trial of 99mTc-(HE)3-G3, a DARPin-based probe for imaging of HER2 expression in breast cancer

(2021) Olga Bragina et al.   JOURNAL OF NUCLEAR MEDICINE

Affordable oral health care: dental biofilm disruption using chloroplast made enzymes with chewing gum delivery

(2021) Rahul Singh et al.   PLANT BIOTECHNOLOGY JOURNAL

Mass Production of Virus-Like Particles Using Chloroplast Genetic Engineering for Highly Immunogenic Oral Vaccine Against Fish Disease

(2021) Yoichi Nakahira et al.   Frontiers in Plant Science

Comparative Evaluation of Engineered Polypeptide Scaffolds in HER2-Targeting Magnetic Nanocarrier Delivery

(2021) Victoria O. Shipunova et al.   ACS Omega

Plant Molecular Farming: A Viable Platform for Recombinant Biopharmaceutical Production

(2020) Balamurugan Shanmugaraj et al.   Plants-Basel

Unravelling hidden components of the chloroplast envelope proteome: opportunities and limits of better MS sensitivity

(2019) Imen Bouchnak et al.   MOLECULAR & CELLULAR PROTEOMICS

Human Epidermal Growth Factor Receptor 2 Testing in Breast Cancer: American Society of Clinical Oncology/College of American Pathologists Clinical Practice Guideline Focused Update

(2018) Antonio C. Wolff et al.   ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE

Cold chain and virus-free oral polio booster vaccine made in lettuce chloroplasts confers protection against all three poliovirus serotypes

(2018) Henry Daniell et al.   PLANT BIOTECHNOLOGY JOURNAL

HER2-positive breast cancer

(2017) Sibylle Loibl et al.   LANCET

Expression and assembly of largest foreign protein in chloroplasts: oral delivery of human FVIII made in lettuce chloroplasts robustly suppresses inhibitor formation in haemophilia A mice

(2017) Kwang-Chul Kwon et al.   PLANT BIOTECHNOLOGY JOURNAL

Recent achievements obtained by chloroplast transformation

(2017) Muhamed Adem et al.   Plant Methods

Low cost industrial production of coagulation factor IX bioencapsulated in lettuce cells for oral tolerance induction in hemophilia B

(2015) Jin Su et al.   BIOMATERIALS

Protein expression in Pichia pastoris: recent achievements and perspectives for heterologous protein production

(2014) Mudassar Ahmad et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Engineered proteins with desired specificity: DARPins, other alternative scaffolds and bispecific IgGs

(2014) Christian Jost et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Development of the designed ankyrin repeat protein (DARPin) G3 for HER2 molecular imaging

(2014) Robert Goldstein et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Recombinant protein expression in Escherichia coli: advances and challenges

(2014) Germán L. Rosano et al.   Frontiers in Microbiology

Optimizing the Yield of Recombinant Pharmaceutical Proteins in Plants

(2013) Richard Twyman et al.   CURRENT PHARMACEUTICAL DESIGN

Low Cost Tuberculosis Vaccine Antigens in Capsules: Expression in Chloroplasts, Bio-Encapsulation, Stability and Functional Evaluation In Vitro

(2013) Priya Saikumar Lakshmi et al.   PLoS One

Oral delivery of human biopharmaceuticals, autoantigens and vaccine antigens bioencapsulated in plant cells

(2012) Kwang-Chul Kwon et al.   ADVANCED DRUG DELIVERY REVIEWS

Oral delivery of bioencapsulated exendin-4 expressed in chloroplasts lowers blood glucose level in mice and stimulates insulin secretion in beta-TC6 cells

(2012) Kwang-Chul Kwon et al.   PLANT BIOTECHNOLOGY JOURNAL

Towards high-yield production of pharmaceutical proteins with plant cell suspension cultures

(2011) Jianfeng Xu et al.   BIOTECHNOLOGY ADVANCES

DARPins and other repeat protein scaffolds: advances in engineering and applications

(2011) Ykelien L Boersma et al.   CURRENT OPINION IN BIOTECHNOLOGY

Advances in plant molecular farming

(2010) Olawole O. Obembe et al.   BIOTECHNOLOGY ADVANCES

Anti-HER2 vaccines: new prospects for breast cancer therapy

(2010) Maha Zohra Ladjemi et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Efficient Tumor Targeting with High-Affinity Designed Ankyrin Repeat Proteins: Effects of Affinity and Molecular Size

(2010) C. Zahnd et al.   CANCER RESEARCH

Plant-specific glycosylation patterns in the context of therapeutic protein production

(2010) Véronique Gomord et al.   PLANT BIOTECHNOLOGY JOURNAL

Production of pharmaceutical-grade recombinant aprotinin and a monoclonal antibody product using plant-based transient expression systems

(2010) Gregory P. Pogue et al.   PLANT BIOTECHNOLOGY JOURNAL

Success stories in molecular farming-a brief overview

(2010) Loïc Faye et al.   PLANT BIOTECHNOLOGY JOURNAL

Plants as bioreactors: Recent developments and emerging opportunities

(2009) Arun K. Sharma et al.   BIOTECHNOLOGY ADVANCES

Pharmaceutical industry financial performance

(2009) Michael Goodman   NATURE REVIEWS DRUG DISCOVERY

The HER-2 Receptor and Breast Cancer: Ten Years of Targeted Anti-HER-2 Therapy and Personalized Medicine

(2009) J. S. Ross et al.   ONCOLOGIST

Plant-made vaccine antigens and biopharmaceuticals

(2009) Henry Daniell et al.   TRENDS IN PLANT SCIENCE