Article
Biochemistry & Molecular Biology
Md Habban Akhter, Sarwar Beg, Mohammed Tarique, Arshi Malik, Sarah Afaq, Hani Choudhry, Salman Hosawi
Summary: Although nanomedicines fabricated from biocompatible nanocarriers have reduced targeting potential for clinical benefits, over expression of receptors on tumor cells offers opportunity to design functional nanomedicines for specific delivery of therapeutics, alleviating bio-toxicity and unwanted effects.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2021)
Article
Engineering, Biomedical
Jiaul Hoque, Yu-Ru V. Shih, Yuze Zeng, Hunter Newman, Nivedita Sangaj, Neha Arjunji, Shyni Varghese
Summary: Extracellular adenosine plays a key role in maintaining bone health and could be used to treat bone loss, but challenges remain in systemic administration due to short half-life and ubiquitous receptors. Bone-targeting nanocarriers demonstrated higher accumulation in vertebrae and attenuated bone loss in mice, suggesting potential for treating bone degenerative diseases like osteoporosis.
Review
Biochemical Research Methods
Neeraj Kulkarni, Suchita Dattatray Shinde, Govinda Shivaji Jadhav, Diksha Ramesh Adsare, Kamya Rao, Mihir Kachhia, Mohit Maingle, Shubham Prakash Patil, Neha Arya, Bichismita Sahu
Summary: Peptides and chitosan are important biomolecules with potential for a wide range of biomedical applications. Hybridizing peptides and chitosan into new biomaterials can enhance their biosignaling properties and cell adhesion properties for use in drug delivery, tissue engineering, and other fields.
BIOCONJUGATE CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Xiangru Feng, Weiguo Xu, Xiaoru Xu, Gao Li, Jianxun Ding, Xuesi Chen
Summary: The physicochemical characteristics of nanoparticles play a crucial role in determining their drug delivery performance, and altering the amino acid composition can adjust the drug release profile and antitumor efficacy of nanogels.
SCIENCE CHINA-CHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Sibgha Batool, Saba Sohail, Fakhar Ud Din, Ali H. Alamri, Ahmad S. Alqahtani, Mohammad A. Alshahrani, Mohammed A. Alshehri, Han Gon Choi
Summary: Nanotechnology has revolutionized cancer treatment by improving drug delivery systems and enhancing the therapeutic efficacy of anticancer drugs. Nanocarriers have overcome the limitations of conventional delivery systems, leading to targeted drug accumulation, sustained release, improved bioavailability, and enhanced apoptosis of cancer cells. This review discusses cancer targeting techniques, surface modification on nanoparticles, and the potential challenges and opportunities in this field.
Article
Chemistry, Multidisciplinary
Qun Wang, Yifan Yang, Dingkang Liu, Yue Ji, Xiangdong Gao, Jun Yin, Wenbing Yao
Summary: The study presents a novel and efficient intracellular protein delivery platform, capable of delivering proteins directly into the cytosol of living cells with high efficacy and safety. This system offers new possibilities for targeting intracellular undruggable targets and expanding the use of protein-based therapeutics, especially for antibodies.
Article
Chemistry, Multidisciplinary
Woan-Ruoh Lee, Wei-Ling Chou, Zih-Chan Lin, Chien-Yu Lin, Calvin T. Sung, Jaiyouy Fang
Summary: This study developed a siRNA delivery system based on nanoparticles and combined it with ablative laser technology for treating psoriasis. The results showed that the system effectively enhanced siRNA absorption, reduced the expression of IL-6, and alleviated psoriasiform dermatitis in mice.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Chemistry, Multidisciplinary
Cheng Lv, Jian Ao, Ji Wang, Man Tang, An-An Liu, Dai-Wen Pang
Summary: A host-cell-assisted strategy is proposed to construct folate-engineered nanocarriers with maintained biofunctions, which can be further multi-functionalized for tumor real-time imaging and therapy. This cell-based strategy facilitates the development and widespread application of bio-nanocarriers in targeted cancer therapy and promotes interdisciplinary studies of nanotechnology, chemistry, and virology.
Article
Chemistry, Multidisciplinary
Yuqiang Li, Yitong Jiang, Ziyan Zheng, Nan Du, Shuli Guan, Wenxuan Guo, Xiaohu Tang, Jiajunzi Cui, Lanqiong Zhang, Kunpeng Liu, Qingsong Yu, Zhihua Gan
Summary: The limited availability of anticancer drugs and drug resistance have made monotherapy-based cancer therapy challenging. Combination therapy using currently available drugs is a potential alternative, but the barrier between in vitro screening and in vivo delivery hinders its application. This study proposes a precise drug delivery strategy using engineered nanomedicine to overcome this limitation and facilitate individualized combination therapy.
ADVANCED MATERIALS
(2022)
Review
Pharmacology & Pharmacy
Aiguo Jiang, Xinqiang Guan, Lianping He, Xingang Guan
Summary: Drug delivery systems (DDSs) based on elastin-like polypeptides (ELPs) have gained attention for their potential in improving drug loading and delivery efficiency in cancer treatment. ELPs possess excellent biocompatibility, degradability, temperature-responsiveness, and controllable sequence and structure, making them suitable for various applications in tissue engineering and cancer therapy. ELPs-based DDSs can enhance the pharmacokinetics and biodistribution of therapeutic agents, leading to improved antitumor efficacy. This review focuses on the recent advancements in using ELPs for delivering functional peptides, therapeutic proteins, small molecule drugs, and photosensitizers in cancer treatment.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Nanoscience & Nanotechnology
Jie Yang, Rui-Mei Jin, Shen-Yan Wang, Xiao-Ting Xie, Wei Hu, Hong-Feng Tang, Bo Liu
Summary: Simultaneous delivery of different functional drugs to tumor sites for chemotherapy remains challenging. In this study, nanogels formed by an engineered coiled-coil polypeptide PC(10)A were designed and prepared as a carrier for co-delivery of paclitaxel and doxorubicin. The results showed that PC(10)A/PTX/DOX nanogels had good biocompatibility, exhibited synergistic therapy effect of tumors, and had lower side effects compared with free PTX/DOX.
Article
Multidisciplinary Sciences
Amit Kumar Sharma, Rohit Sharma, Kusum Vats, Haladhar Dev Sarma, Archana Mukherjee, Tapas Das, Drishty Satpati
Summary: In this study, DOTA-A9 peptide and its pegylated variant were constructed and radiolabeled. [Lu-177]DOTA-PEG(4)-A9 showed higher binding affinity and tumor uptake in SKBR3 breast cancer cells, indicating its potential as a HER2-targeting probe.
SCIENTIFIC REPORTS
(2022)
Article
Biophysics
Ning Liu, Meiying Cui, Nannan Hu, Fuxu Yang, Yeteng Mu, Chong Guo, Xingang Guan, Zhigang Xie
Summary: This study demonstrates the great potential of ELPs-based nanocarriers for targeted delivery of antitumor peptides or proteins in cancer therapy. The multifunctional nanoparticles can significantly suppress tumor growth and increase apoptotic cell death.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Engineering, Biomedical
Yonggang Zhang, Jiaping Li, Pamela Habibovic
Summary: In this study, a sandwich-structured magnetically responsive three-dimensional scaffold has been developed. The scaffold exhibits multimodal motion under external magnetic field and can be used as a smart carrier for remote-controlled compound delivery. It also shows good biocompatibility, making it a potential smart biomaterial for various biomedical applications.
BIOACTIVE MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Chung-Sung Lee, Jiabing Fan, Hee Sook Hwang, Soyon Kim, Chen Chen, Minjee Kang, Tara Aghaloo, Aaron W. James, Min Lee
Summary: Extracellular vesicles, particularly exosome mimetics (EMs) with hydroxyapatite-binding moieties, have demonstrated potential as biocarriers for targeted bone regeneration. The introduction of a Smoothened agonist (SAG) greatly enhanced the osteogenic capacity of the EMs through hedgehog signaling activation. The integration of EM/SAG into a scaffold significantly improved in vivo reossification, and biodistribution studies confirmed the accumulation of systemically administered EMs in bone tissue.
Article
Biochemistry & Molecular Biology
Tianqi Xu, Alexey Schulga, Elena Konovalova, Sara S. Rinne, Hongchao Zhang, Olga Vorontsova, Anna Orlova, Sergey M. Deyev, Vladimir Tolmachev, Anzhelika Vorobyeva
Summary: Pancreatic cancer (PC) is an aggressive malignancy, and targeted therapies could improve its treatment. Overexpression of HER3 and EpCAM in PC is associated with poor prognosis. The study investigated whether co-targeting HER3 with MM-121 and EpCAM with Ec1-LoPE could enhance therapeutic efficacy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Anastasiia S. Obozina, Elena N. Komedchikova, Olga A. Kolesnikova, Anna M. Iureva, Vera L. Kovalenko, Fedor A. Zavalko, Tatiana V. Rozhnikova, Ekaterina D. Tereshina, Elizaveta N. Mochalova, Victoria O. Shipunova
Summary: Targeted nanoparticles from various origins have potential as diagnostic and therapeutic tools, but currently no FDA-approved targeted drug formulations exist due to effectiveness and production challenges. Self-assembling protein nanoparticles offer a solution by encoding proteins in DNA and allowing for standardized production. This review focuses on targeted self-assembling protein nanoparticles based on various proteins, discussing their applications in targeted delivery and providing a critical assessment of their efficacy in biomedicine.
Article
Pharmacology & Pharmacy
Elena N. Komedchikova, Olga A. Kolesnikova, Ekaterina D. Tereshina, Polina A. Kotelnikova, Anna S. Sogomonyan, Alexey V. Stepanov, Sergey M. Deyev, Maxim P. Nikitin, Victoria O. Shipunova
Summary: Nanoparticle-based chemotherapy is an effective approach to cancer diagnostics and therapy, but efficient tumor targeting remains a challenge. A two-step targeted drug delivery strategy (DDS) using non-toxic and toxic modules can lower dose and systemic toxicity. In this study, we compared one-step and two-step DDS using chemotherapy loaded PLGA nanoparticles and barnase*barstar interface. We found that the two-step DDS significantly improved the performance of chemotherapy-loaded nanocarriers, making it a promising strategy for targeted anti-cancer drugs.
Article
Pharmacology & Pharmacy
Vera L. Kovalenko, Elena N. Komedchikova, Anna S. Sogomonyan, Ekaterina D. Tereshina, Olga A. Kolesnikova, Aziz B. Mirkasymov, Anna M. Iureva, Andrei V. Zvyagin, Petr I. Nikitin, Victoria O. Shipunova
Summary: This article presents a new strategy for the treatment of aggressive tumors using lectin-equipped polymer nanoparticles for targeted delivery and photodynamic therapy. The experiments showed that this treatment method achieved high tumor growth inhibition even for large solid tumors.
Article
Pharmacology & Pharmacy
Victoria O. Shipunova, Elena N. Komedchikova, Polina A. Kotelnikova, Maxim P. Nikitin, Sergey M. Deyev
Summary: Therapy for aggressive metastatic breast cancer remains a challenge, but researchers are exploring the development of chemotherapeutic nanoagents targeting cancer cell receptors. A two-step targeted delivery approach using HER2 protein and chemotherapy nanoparticles has shown to be more effective than a one-step strategy.
Article
Chemistry, Multidisciplinary
Gleb I. Tselikov, Artem Danilov, Victoria O. Shipunova, Sergey M. Deyev, Andrei V. Kabashin, Alexander N. Grigorenko
Summary: Optical biosensors have great potential in biomedical diagnostics, security, environmental, and food safety applications. However, the sensitivity of current plasmonic biosensors is limited. In this study, we propose a scissor effect in topologically dark metamaterials to achieve ultrahigh-amplitude sensitivity in biosensing events, solving the sensitivity limitation problem. By designing topologically dark metamaterials and fabricating them, we demonstrate the detection of folic acid with greatly improved sensitivity compared to previous optical counterparts.
Article
Biochemistry & Molecular Biology
Elizaveta N. Mochalova, Elena A. Egorova, Kristina S. Komarova, Victoria O. Shipunova, Nelli F. Khabibullina, Petr I. Nikitin, Maxim P. Nikitin
Summary: Recent developments in nanomedicine have introduced nanomaterials capable of recognizing and killing tumor cells with higher specificity. However, their clinical application is limited by their fast clearance from the bloodstream. MPS-cytoblockade shows promise in prolonging the circulation of nanoagents, but concerns have been raised about its potential health risks. This study suggests that the MPS-cytoblockade may be less harmful than liposomal anti-cancer drugs while significantly improving the efficacy of nanoagents.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Irina N. Zavestovskaya, Anton L. Popov, Danil D. Kolmanovich, Gleb V. Tikhonowski, Andrei I. Pastukhov, Maxim S. Savinov, Pavel V. Shakhov, Julia S. Babkova, Anton A. A. Popov, Ivan V. Zelepukin, Maria S. Grigoryeva, Alexander E. Shemyakov, Sergey M. Klimentov, Vladimir A. Ryabov, Paras N. Prasad, Sergey M. Deyev, Andrei V. V. Kabashin
Summary: Proton therapy is a promising radiotherapy modality for deep-seated and unresectable tumors, and its efficiency can be enhanced by using boron-containing substances. In this study, elemental boron nanoparticles (B NPs) were explored as sensitizers for proton therapy enhancement. These B NPs were efficiently absorbed by cancer cells and showed no remarkable toxicity effects. Proton beam irradiation of B NPs also led to the generation of reactive oxygen species, suggesting a possible non-nuclear mechanism of cancer cell death. Overall, this study offers a new approach with potential clinical applications for proton beam-based cancer treatment.
Article
Biochemistry & Molecular Biology
Daniel V. Kalinovsky, Irina V. Kholodenko, Elena V. Svirshchevskaya, Alexey V. Kibardin, Dmitry Yu. Ryazantsev, Fedor N. Rozov, Sergey S. Larin, Sergey M. Deyev, Roman V. Kholodenko
Summary: Pegylation can alter the function and properties of antibody fragments, leading to multivalent interaction with target antigens. In this study, pegylated monomers and multimers of GD2-specific scFv fragments were generated using maleimide-thiol chemistry. Multimerization enhanced the antigen-binding properties and showed more efficient tumor uptake in a mouse cancer model. This provides a rationale for improving the therapeutic characteristics of GD2-specific antibody fragments.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
Article
Chemistry, Analytical
Alexey M. Yashchenok, Vasiliy S. Chernyshev, Elena V. Konovalova, Roman Kholodenko, Ekaterina Tsydenzhapova, Victoria O. Shipunova, Alexey A. Schulga, Sergey M. Deyev, Dmitry A. Gorin
Summary: In this study, we propose a method for the isolation and detection of sEVs based on anti-CD63 aptamer conjugated magnetic beads and the presence of membrane proteins. We compare the surface markers of EpCAM and HER2 in sEVs derived from different cell lines and blood plasma. The results show high specificity and a shorter assay time.
ANALYSIS & SENSING
(2023)