ApoE4 and Connectivity-Mediated Spreading of Tau Pathology at Lower Amyloid Levels

APOE effects on regional tau in preclinical Alzheimer’s disease

(2023) Christina B. Young et al.   Molecular Neurodegeneration

Astrocyte reactivity influences amyloid-β effects on tau pathology in preclinical Alzheimer’s disease

(2023) Bruna Bellaver et al.   NATURE MEDICINE

Comparison of Group-Level and Individualized Brain Regions for Measuring Change in Longitudinal Tau Positron Emission Tomography in Alzheimer Disease

(2023) Antoine Leuzy et al.   JAMA Neurology

Don’t forget about tau: the effects of ApoE4 genotype on Alzheimer’s disease cerebrospinal fluid biomarkers in subjects with mild cognitive impairment—data from the Dementia Competence Network

(2022) Gloria S. Benson et al.   JOURNAL OF NEURAL TRANSMISSION

Regional Aβ-tau interactions promote onset and acceleration of Alzheimer’s disease tau spreading

(2022) Wha Jin Lee et al.   NEURON

Network Tau spreading is vulnerable to the expression gradients of APOE and glutamatergic-related genes

(2022) Victor Montal et al.   Science Translational Medicine

Global and local ancestry modulate APOE association with Alzheimer’s neuropathology and cognitive outcomes in an admixed sample

(2022) Michel Satya Naslavsky et al.   MOLECULAR PSYCHIATRY

Correlations between APOE4 allele and regional amyloid and tau burdens in cognitively normal older individuals

(2022) Yun Jeong Hong et al.   Scientific Reports

Lecanemab in Early Alzheimer’s Disease

(2022) Christopher H. van Dyck et al.   NEW ENGLAND JOURNAL OF MEDICINE

Amyloid-associated increases in soluble tau relate to tau aggregation rates and cognitive decline in early Alzheimer’s disease

(2022) Alexa Pichet Binette et al.   Nature Communications

Combining tau-PET and fMRI meta-analyses for patient-centered prediction of cognitive decline in Alzheimer’s disease

(2022) Davina Biel et al.   Alzheimers Research & Therapy

Differential associations of APOE-ε2 and APOE-ε4 alleles with PET-measured amyloid-β and tau deposition in older individuals without dementia

(2021) Gemma Salvadó et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Segregation of functional networks is associated with cognitive resilience in Alzheimer’s disease

(2021) Michael Ewers et al.   BRAIN

Tau-PET and in vivo Braak-staging as prognostic markers of future cognitive decline in cognitively normal to demented individuals

(2021) Davina Biel et al.   Alzheimers Research & Therapy

Accuracy of Tau Positron Emission Tomography as a Prognostic Marker in Preclinical and Prodromal Alzheimer Disease

(2021) Rik Ossenkoppele et al.   JAMA Neurology

In vivo rate-determining steps of tau seed accumulation in Alzheimer’s disease

(2021) Georg Meisl et al.   Science Advances

Prospective longitudinal atrophy in Alzheimer’s disease correlates with the intensity and topography of baseline tau-PET

(2020) Renaud La Joie et al.   Science Translational Medicine

Functional brain architecture is associated with the rate of tau accumulation in Alzheimer’s disease

(2020) Nicolai Franzmeier et al.   Nature Communications

Comparison of amyloid PET measured in Centiloid units with neuropathological findings in Alzheimer’s disease

(2020) Sanka Amadoru et al.   Alzheimers Research & Therapy

APOEε4 potentiates the relationship between amyloid-β and tau pathologies

(2020) Joseph Therriault et al.   MOLECULAR PSYCHIATRY

Spread of pathological tau proteins through communicating neurons in human Alzheimer's disease

(2020) Jacob W. Vogel et al.   Nature Communications

Sex Differences in the Association of Global Amyloid and Regional Tau Deposition Measured By Positron Emission Tomography in Clinically Normal Older Adults

(2019) Rachel F. Buckley et al.   JAMA Neurology

The BIN1 rs744373 SNP is associated with increased tau-PET levels and impaired memory

(2019) Nicolai Franzmeier et al.   Nature Communications

Oscillatory hyperactivity and hyperconnectivity in young APOE-ɛ4 carriers and hypoconnectivity in Alzheimer’s disease

(2019) Loes Koelewijn et al.   eLife

APOE genotype and sex affect microglial interactions with plaques in Alzheimer’s disease mice

(2019) T. L. Stephen et al.   Acta Neuropathologica Communications

Cortical tau deposition follows patterns of entorhinal functional connectivity in aging

(2019) Jenna N Adams et al.   eLife

Association of Apolipoprotein E ε4 With Medial Temporal Tau Independent of Amyloid-β

(2019) Joseph Therriault et al.   JAMA Neurology

Standardization of amyloid quantitation with florbetapir standardized uptake value ratios to the Centiloid scale

(2018) Michael Navitsky et al.   Alzheimers & Dementia

NIA-AA Research Framework: Toward a biological definition of Alzheimer's disease

(2018) Clifford R. Jack et al.   Alzheimers & Dementia

Tau burden and the functional connectome in Alzheimer’s disease and progressive supranuclear palsy

(2018) Thomas E Cope et al.   BRAIN

Subthreshold Amyloid Predicts Tau Deposition in Aging

(2018) Stephanie L. Leal et al.   JOURNAL OF NEUROSCIENCE

The nonlinear relationship between cerebrospinal fluid Aβ42 and tau in preclinical Alzheimer’s disease

(2018) Mony J. de Leon et al.   PLoS One

Multisite study of the relationships between antemortem [11C]PIB-PET Centiloid values and postmortem measures of Alzheimer's disease neuropathology

(2018) Renaud La Joie et al.   Alzheimers & Dementia

Structural Basis of Large-Scale Functional Connectivity in the Mouse

(2017) Joanes Grandjean et al.   JOURNAL OF NEUROSCIENCE

Comparison of multiple tau-PET measures as biomarkers in aging and Alzheimer's disease

(2017) Anne Maass et al.   NEUROIMAGE

ApoE4 Accelerates Early Seeding of Amyloid Pathology

(2017) Chia-Chen Liu et al.   NEURON

Risk factors associated with the onset and progression of Alzheimer’s disease: A systematic review of the evidence

(2017) Mona Hersi et al.   NEUROTOXICOLOGY

Association of APOE with tau-tangle pathology with and without β-amyloid

(2016) Jose M. Farfel et al.   NEUROBIOLOGY OF AGING

PET Imaging of Tau Deposition in the Aging Human Brain

(2016) Michael Schöll et al.   NEURON

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(2016)   OPHTHALMIC AND PHYSIOLOGICAL OPTICS

Primary age-related tauopathy (PART): a common pathology associated with human aging

(2014) John F. Crary et al.   ACTA NEUROPATHOLOGICA

Functional MRI Assessment of Task-Induced Deactivation of the Default Mode Network in Alzheimer’s Disease and At-Risk Older Individuals

(2014) Maija Pihlajamäki et al.   BEHAVIOURAL NEUROLOGY

Advanced diffusion MRI fiber tracking in neurosurgical and neurodegenerative disorders and neuroanatomical studies: A review

(2014) Kumar Abhinav et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Human APOE4 increases microglia reactivity at Aβ plaques in a mouse model of Aβ deposition

(2014) Gustavo A Rodriguez et al.   Journal of Neuroinflammation

Apolipoprotein E ε4 and age effects on florbetapir positron emission tomography in healthy aging and Alzheimer disease

(2012) Adam S. Fleisher et al.   NEUROBIOLOGY OF AGING

The diagnosis of mild cognitive impairment due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Marilyn S. Albert et al.   Alzheimers & Dementia

Amyloid-Dependent and Amyloid-Independent Stages of Alzheimer Disease

(2011) Bradley T. Hyman   ARCHIVES OF NEUROLOGY

Adult hippocampal neurogenesis and its role in Alzheimer's disease

(2011) Yangling Mu et al.   Molecular Neurodegeneration

Prevalence of Apolipoprotein E4 Genotype and Homozygotes (APOE e4/4) among Patients Diagnosed with Alzheimer’s Disease: A Systematic Review and Meta-Analysis

(2011) Alex Ward et al.   NEUROEPIDEMIOLOGY

Hippocampal tau pathology is related to neuroanatomical connections: an ageing population-based study

(2009) G. Lace et al.   BRAIN

Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade

(2009) Clifford R Jack et al.   LANCET NEUROLOGY

Predicting human resting-state functional connectivity from structural connectivity

(2009) C. J. Honey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

APOE ε4 lowers age at onset and is a high risk factor for Alzheimer's disease; A case control study from central Norway

(2008) Sigrid B Sando et al.   BMC Neurology