In vivo rate-determining steps of tau seed accumulation in Alzheimer’s disease

The cortical origin and initial spread of medial temporal tauopathy in Alzheimer’s disease assessed with positron emission tomography

(2021) Justin S. Sanchez et al.   Science Translational Medicine

Scaling analysis reveals the mechanism and rates of prion replication in vivo

(2021) Georg Meisl et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Functional brain architecture is associated with the rate of tau accumulation in Alzheimer’s disease

(2020) Nicolai Franzmeier et al.   Nature Communications

Tau molecular diversity contributes to clinical heterogeneity in Alzheimer’s disease

(2020) Simon Dujardin et al.   NATURE MEDICINE

The role of age on tau PET uptake and gray matter atrophy in atypical Alzheimer's disease

(2019) Jennifer L. Whitwell et al.   Alzheimers & Dementia

Aβ and tau prion-like activities decline with longevity in the Alzheimer’s disease human brain

(2019) Atsushi Aoyagi et al.   Science Translational Medicine

Association of Amyloid and Tau With Cognition in Preclinical Alzheimer Disease

(2019) Bernard J. Hanseeuw et al.   JAMA Neurology

Measurement of Tau Filament Fragmentation Provides Insights into Prion-like Spreading

(2018) Franziska Kundel et al.   ACS Chemical Neuroscience

Tau seeding activity begins in the transentorhinal/entorhinal regions and anticipates phospho-tau pathology in Alzheimer’s disease and PART

(2018) Sarah K. Kaufman et al.   ACTA NEUROPATHOLOGICA

Tau burden and the functional connectome in Alzheimer’s disease and progressive supranuclear palsy

(2018) Thomas E Cope et al.   BRAIN

Tau protein liquid–liquid phase separation can initiate tau aggregation

(2018) Susanne Wegmann et al.   EMBO JOURNAL

Extracellular Monomeric and Aggregated Tau Efficiently Enter Human Neurons through Overlapping but Distinct Pathways

(2018) Lewis D. Evans et al.   Cell Reports

Synaptic Tau Seeding Precedes Tau Pathology in Human Alzheimer's Disease Brain

(2018) Sarah L. DeVos et al.   Frontiers in Neuroscience

Direct Observation of Murine Prion Protein Replication in Vitro

(2018) Jason C. Sang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Multiphysics of Prionlike Diseases: Progression and Atrophy

(2018) Johannes Weickenmeier et al.   PHYSICAL REVIEW LETTERS

Spatiotemporal Distribution of β-Amyloid in Alzheimer Disease Is the Result of Heterogeneous Regional Carrying Capacities

(2017) Alex Whittington et al.   JOURNAL OF NUCLEAR MEDICINE

Cryo-EM structures of tau filaments from Alzheimer’s disease

(2017) Anthony W. P. Fitzpatrick et al.   NATURE

Cytosolic Fc receptor TRIM21 inhibits seeded tau aggregation

(2017) William A. McEwan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modulation of electrostatic interactions to reveal a reaction network unifying the aggregation behaviour of the Aβ42 peptide and its variants

(2017) Georg Meisl et al.   Chemical Science

Neurofibrillary Tangle Stage and the Rate of Progression of Alzheimer Symptoms

(2017) Jing Qian et al.   JAMA Neurology

Widespread tau seeding activity at early Braak stages

(2016) Jennifer L. Furman et al.   ACTA NEUROPATHOLOGICA

Short Fibrils Constitute the Major Species of Seed-Competent Tau in the Brains of Mice Transgenic for Human P301S Tau

(2016) S. J. Jackson et al.   JOURNAL OF NEUROSCIENCE

3D Visualization of the Temporal and Spatial Spread of Tau Pathology Reveals Extensive Sites of Tau Accumulation Associated with Neuronal Loss and Recognition Memory Deficit in Aged Tau Transgenic Mice

(2016) Hongjun Fu et al.   PLoS One

Removing endogenous tau does not prevent tau propagation yet reduces its neurotoxicity

(2015) S. Wegmann et al.   EMBO JOURNAL

A novel in vivo model of tau propagation with rapid and progressive neurofibrillary tangle pathology: the pattern of spread is determined by connectivity, not proximity

(2014) Zeshan Ahmed et al.   ACTA NEUROPATHOLOGICA

The amyloid state and its association with protein misfolding diseases

(2014) Tuomas P. J. Knowles et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Spatial Propagation of Protein Polymerization

(2014) S. I. A. Cohen et al.   PHYSICAL REVIEW LETTERS

Proteopathic tau seeding predicts tauopathy in vivo

(2014) B. B. Holmes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synthetic Tau Fibrils Mediate Transmission of Neurofibrillary Tangles in a Transgenic Mouse Model of Alzheimer's-Like Tauopathy

(2013) M. Iba et al.   JOURNAL OF NEUROSCIENCE

Brain homogenates from human tauopathies induce tau inclusions in mouse brain

(2013) Florence Clavaguera et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuropathological Alterations in Alzheimer Disease

(2013) A. Serrano-Pozo et al.   Cold Spring Harbor Perspectives in Medicine

Propagation of Tau Pathology in a Model of Early Alzheimer's Disease

(2012) Alix de Calignon et al.   NEURON

Trans-Synaptic Spread of Tau Pathology In Vivo

(2012) Li Liu et al.   PLoS One

Stages of the Pathologic Process in Alzheimer Disease: Age Categories From 1 to 100 Years

(2011) Heiko Braak et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Transmission and spreading of tauopathy in transgenic mouse brain

(2009) Florence Clavaguera et al.   NATURE CELL BIOLOGY

An Analytical Solution to the Kinetics of Breakable Filament Assembly

(2009) T. P. J. Knowles et al.   SCIENCE