The interdependence of isoprenoid synthesis and apicoplast biogenesis in malaria parasites

The Plasmodium falciparum apicoplast cysteine desulfurase provides sulfur for both iron-sulfur cluster assembly and tRNA modification

(2023) Russell P Swift et al.   eLife

Critical role for isoprenoids in apicoplast biogenesis by malaria parasites

(2022) Megan Okada et al.   eLife

Roles of the apicoplast across the life cycles of rodent and human malaria parasites

(2022) Hayley D. Buchanan et al.   JOURNAL OF EUKARYOTIC MICROBIOLOGY

The Heptaprenyl Diphosphate Synthase (Coq1) Is the Target of a Lipophilic Bisphosphonate That Protects Mice against Toxoplasma gondii Infection

(2022) Melissa A. Sleda et al.   mBio

New insights into apicoplast metabolism in blood-stage malaria parasites

(2022) Rubayet Elahi et al.   CURRENT OPINION IN MICROBIOLOGY

Dephospho‐CoA kinase, a nuclear‐encoded apicoplast protein, remains active and essential after Plasmodium falciparum apicoplast disruption

(2021) Russell P Swift et al.   EMBO JOURNAL

Toxoplasma gondii apicoplast-resident ferredoxin is an essential electron transfer protein for the MEP isoprenoid-biosynthetic pathway

(2021) Stephanie Henkel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Plastid biogenesis in malaria parasites requires the interactions and catalytic activity of the Clp proteolytic system

(2020) Anat Florentin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Comprehensive Subcellular Atlas of the Toxoplasma Proteome via hyperLOPIT Provides Spatial Context for Protein Functions

(2020) Konstantin Barylyuk et al.   Cell Host & Microbe

The NTP generating activity of pyruvate kinase II is critical for apicoplast maintenance in Plasmodium falciparum

(2020) Russell P Swift et al.   eLife

Recent Advances in the [Fe–S] Cluster Biogenesis (SUF) Pathway Functional in the Apicoplast of Plasmodium

(2018) Zarna Rajeshkumar Pala et al.   TRENDS IN PARASITOLOGY

Factors mediating plastid dependency and the origins of parasitism in apicomplexans and their close relatives

(2015) Jan Janouškovec et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sulfur Mobilization for Fe-S Cluster Assembly by the Essential SUF Pathway in the Plasmodium falciparum Apicoplast and Its Inhibition

(2014) Manish Charan et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Isoprenoid Biosynthesis in Plasmodium falciparum

(2014) Ann M. Guggisberg et al.   EUKARYOTIC CELL

Isoprenoid Precursor Biosynthesis Is the Essential Metabolic Role of the Apicoplast during Gametocytogenesis in Plasmodium falciparum

(2014) Jessica D. Wiley et al.   EUKARYOTIC CELL

Identification of Vital and Dispensable Sulfur Utilization Factors in the Plasmodium Apicoplast

(2014) Joana M. Haussig et al.   PLoS One

Ycf93 (Orf105), a Small Apicoplast-Encoded Membrane Protein in the Relict Plastid of the Malaria Parasite Plasmodium falciparum That Is Conserved in Apicomplexa

(2014) Christopher D. Goodman et al.   PLoS One

Antiapicoplast and Gametocytocidal Screening To Identify the Mechanisms of Action of Compounds within the Malaria Box

(2013) Jessica D. Bowman et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Type II Fatty Acid Biosynthesis Is Essential for Plasmodium falciparum Sporozoite Development in the Midgut of Anopheles Mosquitoes

(2013) Ben C. L. van Schaijk et al.   EUKARYOTIC CELL

Kinetic Flux Profiling Elucidates Two Independent Acetyl-CoA Biosynthetic Pathways inPlasmodium falciparum

(2013) Simon A. Cobbold et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

At the membrane frontier: A prospectus on the remarkable evolutionary conservation of polyprenols and polyprenyl-phosphates

(2011) Meredith D. Hartley et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Apicoplast isoprenoid precursor synthesis and the molecular basis of fosmidomycin resistance inToxoplasma gondii

(2011) Sethu C. Nair et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Chemical Rescue of Malaria Parasites Lacking an Apicoplast Defines Organelle Function in Blood-Stage Plasmodium falciparum

(2011) Ellen Yeh et al.   PLOS BIOLOGY