Deletions of singular U1 snRNA gene significantly interfere with transcription and 3’-end mRNA formation

U1 snRNP increases RNA Pol II elongation rate to enable synthesis of long genes

(2023) Claudia A. Mimoso et al.   MOLECULAR CELL

ChIP-Atlas 2021 update: a data-mining suite for exploring epigenomic landscapes by fully integrating ChIP-seq, ATAC-seq and Bisulfite-seq data

(2022) Zhaonan Zou et al.   NUCLEIC ACIDS RESEARCH

AnimalTFDB 4.0: a comprehensive animal transcription factor database updated with variation and expression annotations

(2022) Wen-Kang Shen et al.   NUCLEIC ACIDS RESEARCH

Structure of a transcribing RNA polymerase II–U1 snRNP complex

(2021) Suyang Zhang et al.   SCIENCE

Human spliceosomal snRNA sequence variants generate variant spliceosomes

(2021) Justin W. Mabin et al.   RNA

Two oppositely-charged sf3b1 mutations cause defective development, impaired immune response, and aberrant selection of intronic branch sites in Drosophila

(2021) Bei Zhang et al.   PLoS Genetics

U1 snRNP regulates cancer cell migration and invasion in vitro

(2020) Jung-Min Oh et al.   Nature Communications

Genetic Control of Expression and Splicing in Developing Human Brain Informs Disease Mechanisms

(2020) Rebecca L. Walker et al.   CELL

U1 snRNP regulates chromatin retention of noncoding RNAs

(2020) Yafei Yin et al.   NATURE

Competition between maturation and degradation drives human snRNA 3′ end quality control

(2020) Rea M. Lardelli et al.   GENES & DEVELOPMENT

Graph-based genome alignment and genotyping with HISAT2 and HISAT-genotype

(2019) Daehwan Kim et al.   NATURE BIOTECHNOLOGY

Recurrent noncoding U1 snRNA mutations drive cryptic splicing in SHH medulloblastoma

(2019) Hiromichi Suzuki et al.   NATURE

Tau-Mediated Disruption of the Spliceosome Triggers Cryptic RNA Splicing and Neurodegeneration in Alzheimer’s Disease

(2019) Yi-Chen Hsieh et al.   Cell Reports

The role of SAGA coactivator complex in snRNA transcription

(2018) D. V. Kopytova et al.   CELL CYCLE

Minor spliceosome and disease

(2018) Bhupendra Verma et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

RNA Polymerase II Phosphorylated on CTD Serine 5 Interacts with the Spliceosome during Co-transcriptional Splicing

(2018) Takayuki Nojima et al.   MOLECULAR CELL

Overexpression of U1 snRNA induces decrease of U1 spliceosome function associated with Alzheimer’s disease

(2017) Zhi Cheng et al.   JOURNAL OF NEUROGENETICS

The conserved AU dinucleotide at the 5′ end of nascent U1 snRNA is optimized for the interaction with nuclear cap-binding-complex

(2017) Chung-Shu Yeh et al.   NUCLEIC ACIDS RESEARCH

Variant snRNPs: New players within the spliceosome system

(2017) Pilar Vazquez-Arango et al.   RNA Biology

Regulation of expression of human RNA polymerase II-transcribed snRNA genes

(2017) Joana Guiro et al.   Open Biology

A U1 snRNP–specific assembly pathway reveals the SMN complex as a versatile hub for RNP exchange

(2016) Byung Ran So et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Variant U1 snRNAs are implicated in human pluripotent stem cell maintenance and neuromuscular disease

(2016) Pilar Vazquez-Arango et al.   NUCLEIC ACIDS RESEARCH

A U1 snRNP–specific assembly pathway reveals the SMN complex as a versatile hub for RNP exchange

(2016) Byung Ran So et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A conserved intronic U1 snRNP-binding sequence promotestrans-splicing inDrosophila

(2015) Jun-Li Gao et al.   GENES & DEVELOPMENT

U6 snRNA Pseudogenes: Markers of Retrotransposition Dynamics in Mammals

(2015) Aurélien J. Doucet et al.   MOLECULAR BIOLOGY AND EVOLUTION

Trimmomatic: a flexible trimmer for Illumina sequence data

(2014) Anthony M. Bolger et al.   BIOINFORMATICS

Positive and negative gustatory inputs affect Drosophila lifespan partly in parallel to dFOXO signaling

(2014) I. Ostojic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The human splicing code reveals new insights into the genetic determinants of disease

(2014) H. Y. Xiong et al.   SCIENCE

Dynamic analyses of alternative polyadenylation from RNA-seq reveal a 3′-UTR landscape across seven tumour types

(2014) Zheng Xia et al.   Nature Communications

Developmental Analysis of Spliceosomal snRNA Isoform Expression

(2014) Zhipeng Lu et al.   G3-Genes Genomes Genetics

featureCounts: an efficient general purpose program for assigning sequence reads to genomic features

(2013) Y. Liao et al.   BIOINFORMATICS

snRNA Catalysts in the Spliceosome’s Ancient Core

(2013) Hiten D. Madhani   CELL

Rbfox3-regulated alternative splicing of Numb promotes neuronal differentiation during development

(2013) Kee K. Kim et al.   JOURNAL OF CELL BIOLOGY

RNA catalyses nuclear pre-mRNA splicing

(2013) Sebastian M. Fica et al.   NATURE

U1 small nuclear ribonucleoprotein complex and RNA splicing alterations in Alzheimer's disease

(2013) B. Bai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutation of a U2 snRNA Gene Causes Global Disruption of Alternative Splicing and Neurodegeneration

(2012) Yichang Jia et al.   CELL

U1 snRNP Determines mRNA Length and Regulates Isoform Expression

(2012) Michael G. Berg et al.   CELL

Differentially expressed, variant U1 snRNAs regulate gene expression in human cells

(2012) D. O'Reilly et al.   GENOME RESEARCH

clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters

(2012) Guangchuang Yu et al.   OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY

New connections between splicing and human disease

(2012) Richard A. Padgett   TRENDS IN GENETICS

Mutations in U4atac snRNA, a Component of the Minor Spliceosome, in the Developmental Disorder MOPD I

(2011) H. He et al.   SCIENCE

U1 snRNP protects pre-mRNAs from premature cleavage and polyadenylation

(2010) Daisuke Kaida et al.   NATURE

Regulation of Vertebrate Nervous System Alternative Splicing and Development by an SR-Related Protein

(2009) John A. Calarco et al.   CELL

The Spliceosome: Design Principles of a Dynamic RNP Machine

(2009) Markus C. Wahl et al.   CELL

U2 snRNA variants are differentially incorporated into spliceosomes

(2009) Jason A. SOMARELLI et al.   ENTOMOLOGICAL RESEARCH