Competition between maturation and degradation drives human snRNA 3′ end quality control

Disruption of Telomerase RNA Maturation Kinetics Precipitates Disease

(2019) Caitlin M. Roake et al.   MOLECULAR CELL

Nuclear Pre-snRNA Export Is an Essential Quality Assurance Mechanism for Functional Spliceosomes

(2019) Daniel Becker et al.   Cell Reports

PNLDC1, mouse pre‐piRNA Trimmer, is required for meiotic and post‐meiotic male germ cell development

(2018) Toru Nishimura et al.   EMBO REPORTS

Controlling nuclear RNA levels

(2018) Manfred Schmid et al.   NATURE REVIEWS GENETICS

PARN and TOE1 Constitute a 3′ End Maturation Module for Nuclear Non-coding RNAs

(2018) Ahyeon Son et al.   Cell Reports

TOE1 acts as a 3′ exonuclease for telomerase RNA and regulates telomere maintenance

(2018) Tingting Deng et al.   NUCLEIC ACIDS RESEARCH

Targeting RNA for processing or destruction by the eukaryotic RNA exosome and its cofactors

(2017) John C. Zinder et al.   GENES & DEVELOPMENT

PARN Modulates Y RNA Stability and Its 3′-End Formation

(2017) Siddharth Shukla et al.   MOLECULAR AND CELLULAR BIOLOGY

Biallelic mutations in the 3′ exonuclease TOE1 cause pontocerebellar hypoplasia and uncover a role in snRNA processing

(2017) Rea M Lardelli et al.   NATURE GENETICS

PNLDC1 is essential for piRNA 3′ end trimming and transposon silencing during spermatogenesis in mice

(2017) Deqiang Ding et al.   Nature Communications

Human mutations in integrator complex subunits link transcriptome integrity to brain development

(2017) Renske Oegema et al.   PLoS Genetics

TUT‐DIS3L2 is a mammalian surveillance pathway for aberrant structured non‐coding RNAs

(2016) Dmytro Ustianenko et al.   EMBO JOURNAL

Identification of a Nuclear Exosome Decay Pathway for Processed Transcripts

(2016) Nicola Meola et al.   MOLECULAR CELL

Inhibition of telomerase RNA decay rescues telomerase deficiency caused by dyskerin or PARN defects

(2016) Siddharth Shukla et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Perlman syndrome nuclease DIS3L2 controls cytoplasmic non-coding RNAs and provides surveillance pathway for maturing snRNAs

(2016) Anna Łabno et al.   NUCLEIC ACIDS RESEARCH

Inhibition of telomerase RNA decay rescues telomerase deficiency caused by dyskerin or PARN defects

(2016) Siddharth Shukla et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Dis3l2-Mediated Decay Is a Quality Control Pathway for Noncoding RNAs

(2016) Mehdi Pirouz et al.   Cell Reports

Poly(A)-specific ribonuclease deficiency impacts telomere biology and causes dyskeratosis congenita

(2015) Hemanth Tummala et al.   JOURNAL OF CLINICAL INVESTIGATION

Bone marrow failure and developmental delay caused by mutations in poly(A)-specific ribonuclease (PARN)

(2015) Santhosh Dhanraj et al.   JOURNAL OF MEDICAL GENETICS

Exome sequencing links mutations in PARN and RTEL1 with familial pulmonary fibrosis and telomere shortening

(2015) Bridget D Stuart et al.   NATURE GENETICS

Poly(A)-specific ribonuclease (PARN) mediates 3′-end maturation of the telomerase RNA component

(2015) Diane H Moon et al.   NATURE GENETICS

RBM7 subunit of the NEXT complex binds U-rich sequences and targets 3′-end extended forms of snRNAs

(2015) Dominika Hrossova et al.   NUCLEIC ACIDS RESEARCH

Human Telomerase RNA Processing and Quality Control

(2015) Chi-Kang Tseng et al.   Cell Reports

Crystal structure of human U1 snRNP, a small nuclear ribonucleoprotein particle, reveals the mechanism of 5′ splice site recognition

(2015) Yasushi Kondo et al.   eLife

CLP1 Founder Mutation Links tRNA Splicing and Maturation to Cerebellar Development and Neurodegeneration

(2014) Ashleigh E. Schaffer et al.   CELL

Quality control of assembly-defective U1 snRNAs by decapping and 5'-to-3' exonucleolytic digestion

(2014) S. Shukla et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

EXOSC8 mutations alter mRNA metabolism and cause hypomyelination with spinal muscular atrophy and cerebellar hypoplasia

(2014) Veronika Boczonadi et al.   Nature Communications

Whole-genome screening identifies proteins localized to distinct nuclear bodies

(2013) Ka-wing Fong et al.   JOURNAL OF CELL BIOLOGY

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

CBC–ARS2 stimulates 3′-end maturation of multiple RNA families and favors cap-proximal processing

(2013) Marie Hallais et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Poly(A)-Specific Ribonuclease Mediates 3′-End Trimming of Argonaute2-Cleaved Precursor MicroRNAs

(2013) Mayuko Yoda et al.   Cell Reports

Mutation of a U2 snRNA Gene Causes Global Disruption of Alternative Splicing and Neurodegeneration

(2012) Yichang Jia et al.   CELL

Differentially expressed, variant U1 snRNAs regulate gene expression in human cells

(2012) D. O'Reilly et al.   GENOME RESEARCH

Mutations in the RNA exosome component gene EXOSC3 cause pontocerebellar hypoplasia and spinal motor neuron degeneration

(2012) Jijun Wan et al.   NATURE GENETICS

Maturation of mammalian H/ACA box snoRNAs: PAPD5-dependent adenylation and PARN-dependent trimming

(2012) H. Berndt et al.   RNA

A homozygous mutation in RNU4ATAC as a cause of microcephalic osteodysplastic primordial dwarfism type I (MOPD I) with associated pigmentary disorder

(2011) Ghada M.H. Abdel-Salam et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Mutations in U4atac snRNA, a Component of the Minor Spliceosome, in the Developmental Disorder MOPD I

(2011) H. He et al.   SCIENCE

An auxin-based degron system for the rapid depletion of proteins in nonplant cells

(2009) Kohei Nishimura et al.   NATURE METHODS

Decapping is preceded by 3′ uridylation in a novel pathway of bulk mRNA turnover

(2009) Olivia S Rissland et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Evolution of Spliceosomal snRNA Genes in Metazoan Animals

(2008) Manuela Marz et al.   JOURNAL OF MOLECULAR EVOLUTION

RNA recognition by 3′-to-5′ exonucleases: The substrate perspective

(2007) Hend Ibrahim et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms