The impact of nanoparticle protein corona on cytotoxicity, immunotoxicity and target drug delivery

Monoclonal Antibody-Functionalized Multilayered Particles: Targeting Cancer Cells in the Presence of Protein Coronas

(2015) Qiong Dai et al.   ACS Nano

The “Sweet” Side of the Protein Corona: Effects of Glycosylation on Nanoparticle–Cell Interactions

(2015) Sha Wan et al.   ACS Nano

In Vivo Biomolecule Corona around Blood-Circulating, Clinically Used and Antibody-Targeted Lipid Bilayer Nanoscale Vesicles

(2015) Marilena Hadjidemetriou et al.   ACS Nano

Protein Corona of Nanoparticles: Distinct Proteins Regulate the Cellular Uptake

(2015) Sandra Ritz et al.   BIOMACROMOLECULES

A plasma protein corona enhances the biocompatibility of Au@Fe3O4 Janus particles

(2015) Lisa Landgraf et al.   BIOMATERIALS

Balancing the effect of corona on therapeutic efficacy and macrophage uptake of lipid nanocapsules

(2015) P. Sánchez-Moreno et al.   BIOMATERIALS

The nanoparticle biomolecule corona: lessons learned – challenge accepted?

(2015) D. Docter et al.   CHEMICAL SOCIETY REVIEWS

Proteomic Profiling of a Biomimetic Drug Delivery Platform

(2015) Claudia Corbo et al.   CURRENT DRUG TARGETS

Comparative examination of adsorption of serum proteins on HSA- and PLGA-based nanoparticles using SDS–PAGE and LC–MS

(2015) R. Gossmann et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Protein corona hampers targeting potential of MUC1 aptamer functionalized SN-38 core–shell nanoparticles

(2015) Behrang Shiri Varnamkhasti et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Review, Evaluation, and Discussion of the Challenges of Missing Value Imputation for Mass Spectrometry-Based Label-Free Global Proteomics

(2015) Bobbie-Jo M. Webb-Robertson et al.   JOURNAL OF PROTEOME RESEARCH

Surface chemistry and serum type both determine the nanoparticle–protein corona

(2015) Daniela Pozzi et al.   Journal of Proteomics

No king without a crown – impact of the nanomaterial-protein corona on nanobiomedicine

(2015) Dominic Docter et al.   Nanomedicine

What are the biological and therapeutic implications of biomolecule corona formation on the surface of inhaled nanomedicines?

(2015) Abhinav Kumar et al.   Nanomedicine

Enabling cytoplasmic delivery and organelle targeting by surface modification of nanocarriers

(2015) Alessandro Parodi et al.   Nanomedicine

Crucial role of the protein corona for the specific targeting of nanoparticles

(2015) Morteza Mahmoudi et al.   Nanomedicine

Personalized disease-specific protein corona influences the therapeutic impact of graphene oxide

(2015) Mohammad Javad Hajipour et al.   Nanoscale

Protein corona composition of gold nanoparticles/nanorods affects amyloid beta fibrillation process

(2015) Somayeh Mirsadeghi et al.   Nanoscale

Nanoparticle biointerfacing by platelet membrane cloaking

(2015) Che-Ming J. Hu et al.   NATURE

Principles of nanoparticle design for overcoming biological barriers to drug delivery

(2015) Elvin Blanco et al.   NATURE BIOTECHNOLOGY

Trojan horses and guided missiles: targeted therapies in the war on arthritis

(2015) Mathieu Ferrari et al.   Nature Reviews Rheumatology

Active targeting of chemotherapy to disseminated tumors using nanoparticle-carrying T cells

(2015) Bonnie Huang et al.   Science Translational Medicine

Cancer nanomedicine: from targeted delivery to combination therapy

(2015) Xiaoyang Xu et al.   TRENDS IN MOLECULAR MEDICINE

Reducing the cytotoxicity of ZnO nanoparticles by a pre-formed protein corona in a supplemented cell culture medium

(2015) Hong Yin et al.   RSC Advances

Mild Hyperthermia Enhances Transport of Liposomal Gemcitabine and Improves In Vivo Therapeutic Response

(2015) Dickson K. Kirui et al.   Advanced Healthcare Materials

Merging Worlds of Nanomaterials and Biological Environment: Factors Governing Protein Corona Formation on Nanoparticles and Its Biological Consequences

(2015) Parisa Foroozandeh et al.   Nanoscale Research Letters

Nanoparticles for Imaging, Sensing, and Therapeutic Intervention

(2014) Lara K. Bogart et al.   ACS Nano

Modulation of Complement Activation and Amplification on Nanoparticle Surfaces by Glycopolymer Conformation and Chemistry

(2014) Kai Yu et al.   ACS Nano

Protein Corona Fingerprinting Predicts the Cellular Interaction of Gold and Silver Nanoparticles

(2014) Carl D. Walkey et al.   ACS Nano

The effect of multistage nanovector targeting of VEGFR2 positive tumor endothelia on cell adhesion and local payload accumulation

(2014) Jonathan O. Martinez et al.   BIOMATERIALS

The effect of protein corona composition on the interaction of carbon nanotubes with human blood platelets

(2014) Silvia H. De Paoli et al.   BIOMATERIALS

The nano-plasma interface: Implications of the protein corona

(2014) Joy Wolfram et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Physicochemical features and transfection properties of chitosan/poloxamer 188/poly(D,L-lactide-co-glycolide) nanoplexes

(2014) Donato Cosco et al.   International Journal of Nanomedicine

Secondary Structure of Corona Proteins Determines the Cell Surface Receptors Used by Nanoparticles

(2014) Candace C. Fleischer et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Cancer Cell Membrane-Coated Nanoparticles for Anticancer Vaccination and Drug Delivery

(2014) Ronnie H. Fang et al.   NANO LETTERS

Protein corona composition does not accurately predict hematocompatibility of colloidal gold nanoparticles

(2014) Marina A. Dobrovolskaia et al.   Nanomedicine-Nanotechnology Biology and Medicine

Ex situ evaluation of the composition of protein corona of intravenously injected superparamagnetic nanoparticles in rats

(2014) Usawadee Sakulkhu et al.   Nanoscale

Multifunctional, stimuli-sensitive nanoparticulate systems for drug delivery

(2014) Vladimir P. Torchilin   NATURE REVIEWS DRUG DISCOVERY

Plasma Protein Corona Modulates the Vascular Wall Interaction of Drug Carriers in a Material and Donor Specific Manner

(2014) Daniel J. Sobczynski et al.   PLoS One

Formation of a Protein Corona on Silver Nanoparticles Mediates Cellular Toxicity via Scavenger Receptors

(2014) Jonathan H. Shannahan et al.   TOXICOLOGICAL SCIENCES

Protein Corona Composition of Superparamagnetic Iron Oxide Nanoparticles with Various Physico-Chemical Properties and Coatings

(2014) Usawadee Sakulkhu et al.   Scientific Reports

Personalized protein coronas: a “key” factor at the nanobiointerface

(2014) Mohammad J. Hajipour et al.   Biomaterials Science

The liposome–protein corona in mice and humans and its implications for in vivo delivery

(2014) G. Caracciolo et al.   Journal of Materials Chemistry B

Differential Roles of the Protein Corona in the Cellular Uptake of Nanoporous Polymer Particles by Monocyte and Macrophage Cell Lines

(2013) Yan Yan et al.   ACS Nano

Temperature: The “Ignored” Factor at the NanoBio Interface

(2013) Morteza Mahmoudi et al.   ACS Nano

Cancer nanotechnology: The impact of passive and active targeting in the era of modern cancer biology

(2013) Nicolas Bertrand et al.   ADVANCED DRUG DELIVERY REVIEWS

Polyethylenimine and chitosan carriers for the delivery of RNA interference effectors

(2013) Roberto Molinaro et al.   Expert Opinion on Drug Delivery

Reconstructed Stem Cell Nanoghosts: A Natural Tumor Targeting Platform

(2013) Naama E. Toledano Furman et al.   NANO LETTERS

Interview: Nanomedicine: past, present and future

(2013) Thomas J Webster   Nanomedicine

The biomolecular corona is retained during nanoparticle uptake and protects the cells from the damage induced by cationic nanoparticles until degraded in the lysosomes

(2013) Fengjuan Wang et al.   Nanomedicine-Nanotechnology Biology and Medicine

Effect of polyethyleneglycol (PEG) chain length on the bio–nano-interactions between PEGylated lipid nanoparticles and biological fluids: from nanostructure to uptake in cancer cells

(2013) Daniela Pozzi et al.   Nanoscale

Tracking protein corona over time

(2013) Martin Lundqvist   Nature Nanotechnology

Transferrin-functionalized nanoparticles lose their targeting capabilities when a biomolecule corona adsorbs on the surface

(2013) Anna Salvati et al.   Nature Nanotechnology

Rapid formation of plasma protein corona critically affects nanoparticle pathophysiology

(2013) Stefan Tenzer et al.   Nature Nanotechnology

Silver Nanoparticle Protein Corona Composition in Cell Culture Media

(2013) Jonathan H. Shannahan et al.   PLoS One

A Liposomal Drug Platform Overrides Peptide Ligand Targeting to a Cancer Biomarker, Irrespective of Ligand Affinity or Density

(2013) Bethany Powell Gray et al.   PLoS One

Minimal "Self" Peptides That Inhibit Phagocytic Clearance and Enhance Delivery of Nanoparticles

(2013) P. L. Rodriguez et al.   SCIENCE

Comparison of Nanotube-Protein Corona Composition in Cell Culture Media

(2013) Jonathan H. Shannahan et al.   Small

High levels of reactive oxygen species in gold nanoparticle-targeted cancer cells following femtosecond pulse irradiation

(2013) Limor Minai et al.   Scientific Reports

Mechanisms of Nanoparticle-Induced Oxidative Stress and Toxicity

(2013) Amruta Manke et al.   Biomed Research International

Interaction of nanoparticles with proteins: relation to bio-reactivity of the nanoparticle

(2013) Shruti R Saptarshi et al.   JOURNAL OF NANOBIOTECHNOLOGY

Exploiting the Protein Corona around Gold Nanorods for Loading and Triggered Release

(2012) James Chen Yong Kah et al.   ACS Nano

Reversible versus Irreversible Binding of Transferrin to Polystyrene Nanoparticles: Soft and Hard Corona

(2012) Silvia Milani et al.   ACS Nano

Effects of the Presence or Absence of a Protein Corona on Silica Nanoparticle Uptake and Impact on Cells

(2012) Anna Lesniak et al.   ACS Nano

Liposomal drug delivery systems: From concept to clinical applications

(2012) Theresa M. Allen et al.   ADVANCED DRUG DELIVERY REVIEWS

Label-free quantitative analysis for studying the interactions between nanoparticles and plasma proteins

(2012) Anna Laura Capriotti et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Nanotechnology-based combinational drug delivery: an emerging approach for cancer therapy

(2012) Priyambada Parhi et al.   DRUG DISCOVERY TODAY

Do plasma proteins distinguish between liposomes of varying charge density?

(2012) Anna Laura Capriotti et al.   Journal of Proteomics

A Chemical Approach for Cell-Specific Targeting of Nanomaterials: Small-Molecule-Initiated Misfolding of Nanoparticle Corona Proteins

(2012) Kanlaya Prapainop et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Intravenous Delivery of Hydrophobin-Functionalized Porous Silicon Nanoparticles: Stability, Plasma Protein Adsorption and Biodistribution

(2012) Mirkka Sarparanta et al.   MOLECULAR PHARMACEUTICS

Biomolecular coronas provide the biological identity of nanosized materials

(2012) Marco P. Monopoli et al.   Nature Nanotechnology

Synthetic nanoparticles functionalized with biomimetic leukocyte membranes possess cell-like functions

(2012) Alessandro Parodi et al.   Nature Nanotechnology

The Interplay of Lung Surfactant Proteins and Lipids Assimilates the Macrophage Clearance of Nanoparticles

(2012) Christian A. Ruge et al.   PLoS One

Proteomic Characterization of Engineered Nanomaterial–Protein Interactions in Relation to Surface Reactivity

(2011) Jukka Sund et al.   ACS Nano

Nanoparticle Size Is a Critical Physicochemical Determinant of the Human Blood Plasma Corona: A Comprehensive Quantitative Proteomic Analysis

(2011) Stefan Tenzer et al.   ACS Nano

Comprehensive proteomic analysis of mineral nanoparticles derived from human body fluids and analyzed by liquid chromatography–tandem mass spectrometry

(2011) Jan Martel et al.   ANALYTICAL BIOCHEMISTRY

Inhibition of Amyloid Peptide Fibrillation by Inorganic Nanoparticles: Functional Similarities with Proteins

(2011) Seong Il Yoo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The effects of aggregation and protein corona on the cellular internalization of iron oxide nanoparticles

(2011) M. Safi et al.   BIOMATERIALS

Understanding and controlling the interaction of nanomaterials with proteins in a physiological environment

(2011) Carl D. Walkey et al.   CHEMICAL SOCIETY REVIEWS

Immune complement activation is attenuated by surface nanotopography

(2011) Mats Hulander et al.   International Journal of Nanomedicine

Multifunctional PEGylated 2C5-immunoliposomes containing pH-sensitive bonds and TAT peptide for enhanced tumor cell internalization and cytotoxicity

(2011) Erez Koren et al.   JOURNAL OF CONTROLLED RELEASE

Physical−Chemical Aspects of Protein Corona: Relevance toin Vitroandin VivoBiological Impacts of Nanoparticles

(2011) Marco P. Monopoli et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nanoparticle Size and Surface Chemistry Determine Serum Protein Adsorption and Macrophage Uptake

(2011) Carl D. Walkey et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Evolution of the Protein Corona of Lipid Gene Vectors as a Function of Plasma Concentration

(2011) Giulio Caracciolo et al.   LANGMUIR

Elucidation of the Contribution of Active Site and Exosite Interactions to Affinity and Specificity of Peptidylic Serine Protease Inhibitors Using Non-Natural Arginine Analogs

(2011) M. Hosseini et al.   MOLECULAR PHARMACOLOGY

Uptake of nanoparticles by alveolar macrophages is triggered by surfactant protein A

(2011) Christian A. Ruge et al.   Nanomedicine-Nanotechnology Biology and Medicine

Respiratory epithelial cytotoxicity and membrane damage (holes) caused by amine-modified nanoparticles

(2011) Pakatip Ruenraroengsak et al.   Nanotoxicology

The targeted delivery of multicomponent cargos to cancer cells by nanoporous particle-supported lipid bilayers

(2011) Carlee E. Ashley et al.   NATURE MATERIALS

Binding of blood proteins to carbon nanotubes reduces cytotoxicity

(2011) C. Ge et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Erythrocyte membrane-camouflaged polymeric nanoparticles as a biomimetic delivery platform

(2011) C.-M. J. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quantitative proteomics analysis of adsorbed plasma proteins classifies nanoparticles with different surface properties and size

(2011) Haizhen Zhang et al.   PROTEOMICS

Hardening of the Nanoparticle-Protein Corona in Metal (Au, Ag) and Oxide (Fe3O4, CoO, and CeO2) Nanoparticles

(2011) Eudald Casals et al.   Small

Effects of Cell Culture Media on the Dynamic Formation of Protein−Nanoparticle Complexes and Influence on the Cellular Response

(2010) Gabriele Maiorano et al.   ACS Nano

Time Evolution of the Nanoparticle Protein Corona

(2010) Eudald Casals et al.   ACS Nano

Toxicity and interaction of titanium dioxide nanoparticles with microtubule protein

(2010) Z. N. Gheshlaghi et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Analysis of plasma protein adsorption onto DC-Chol-DOPE cationic liposomes by HPLC-CHIP coupled to a Q-TOF mass spectrometer

(2010) Anna Laura Capriotti et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Surface chemistry and aspect ratio mediated cellular uptake of Au nanorods

(2010) Yang Qiu et al.   BIOMATERIALS

Toxicity of Silver Nanoparticles Increases during Storage Because of Slow Dissolution under Release of Silver Ions

(2010) S. Kittler et al.   CHEMISTRY OF MATERIALS

Interaction of metal oxide nanoparticles with lung surfactant protein A

(2010) Christine Schulze et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Drug delivery by red blood cells: vascular carriers designed by mother nature

(2010) Vladimir R Muzykantov   Expert Opinion on Drug Delivery

To exploit the tumor microenvironment: Passive and active tumor targeting of nanocarriers for anti-cancer drug delivery

(2010) Fabienne Danhier et al.   JOURNAL OF CONTROLLED RELEASE

High performance in vivo near-IR (>1 μm) imaging and photothermal cancer therapy with carbon nanotubes

(2010) Joshua T. Robinson et al.   Nano Research

Rapid translocation of nanoparticles from the lung airspaces to the body

(2010) Hak Soo Choi et al.   NATURE BIOTECHNOLOGY

Nanoparticle-induced unfolding of fibrinogen promotes Mac-1 receptor activation and inflammation

(2010) Zhou J. Deng et al.   Nature Nanotechnology

Modeling the Time Evolution of the Nanoparticle-Protein Corona in a Body Fluid

(2010) Daniele Dell'Orco et al.   PLoS One

Blood Interactions with Noble Metals: Coagulation and Immune Complement Activation

(2009) Mats Hulander et al.   ACS Applied Materials & Interfaces

Nanoparticle interaction with plasma proteins as it relates to particle biodistribution, biocompatibility and therapeutic efficacy

(2009) Parag Aggarwal et al.   ADVANCED DRUG DELIVERY REVIEWS

Surface adsorption of protein corona controls the cell internalization mechanism of DC-Chol–DOPE/DNA lipoplexes in serum

(2009) Giulio Caracciolo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Complete high-density lipoproteins in nanoparticle corona

(2009) Erik Hellstrand et al.   FEBS Journal

Quantitative analysis of the protein corona on FePt nanoparticles formed by transferrin binding

(2009) X. Jiang et al.   Journal of the Royal Society Interface

The First Targeted Delivery of siRNA in Humans via a Self-Assembling, Cyclodextrin Polymer-Based Nanoparticle: From Concept to Clinic

(2009) Mark E. Davis   MOLECULAR PHARMACEUTICS

Differential plasma protein binding to metal oxide nanoparticles

(2009) Zhou J Deng et al.   NANOTECHNOLOGY

Surface hydrophobin prevents immune recognition of airborne fungal spores

(2009) Vishukumar Aimanianda et al.   NATURE

Materials engineering for immunomodulation

(2009) Jeffrey A. Hubbell et al.   NATURE

Understanding biophysicochemical interactions at the nano–bio interface

(2009) Andre E. Nel et al.   NATURE MATERIALS

Evaluation of nanoparticle immunotoxicity

(2009) Marina A. Dobrovolskaia et al.   Nature Nanotechnology

Mechanism of active targeting in solid tumors with transferrin-containing gold nanoparticles

(2009) C. H. J. Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Active targeting schemes for nanoparticle systems in cancer therapeutics

(2008) James D. Byrne et al.   ADVANCED DRUG DELIVERY REVIEWS

Interaction of gold nanoparticles with protein: A spectroscopic study to monitor protein conformational changes

(2008) Nishima Wangoo et al.   APPLIED PHYSICS LETTERS

Drug Delivery with Carbon Nanotubes for In vivo Cancer Treatment

(2008) Z. Liu et al.   CANCER RESEARCH

Drug Loaded Erythrocytes: As Novel Drug Delivery System

(2008) R. Hirlekar et al.   CURRENT PHARMACEUTICAL DESIGN

Interaction of colloidal gold nanoparticles with human blood: effects on particle size and analysis of plasma protein binding profiles

(2008) Marina A. Dobrovolskaia et al.   Nanomedicine-Nanotechnology Biology and Medicine

The long and short of carbon nanotube toxicity

(2008) Kostas Kostarelos   NATURE BIOTECHNOLOGY

Are carbon nanotubes safe?

(2008) Yuliang Zhao et al.   Nature Nanotechnology

Nanoparticle size and surface properties determine the protein corona with possible implications for biological impacts

(2008) M. Lundqvist et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Limitations and relative utility of screening assays to assess engineered nanoparticle toxicity in a human cell line

(2008) N.A. Monteiro-Riviere et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY