A Liposomal Drug Platform Overrides Peptide Ligand Targeting to a Cancer Biomarker, Irrespective of Ligand Affinity or Density

Abstract P5-18-09: A Phase I Study of MM-302, a HER2-targeted Liposomal Doxorubicin, in Patients with Advanced, HER2- Positive Breast Cancer

(2014) T Wickham et al.   CANCER RESEARCH

Cancer statistics, 2013

(2013) Rebecca Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

From Phage Display to Nanoparticle Delivery: Functionalizing Liposomes with Multivalent Peptides Improves Targeting to a Cancer Biomarker

(2012) Bethany Powell Gray et al.   BIOCONJUGATE CHEMISTRY

Pericyte-Coverage of Human Tumor Vasculature and Nanoparticle Permeability

(2012) Liuzhe Zhang et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Analysis on the current status of targeted drug delivery to tumors

(2012) Il Keun Kwon et al.   JOURNAL OF CONTROLLED RELEASE

Synthesis and biological evaluation of a peptide–paclitaxel conjugate which targets the integrin αvβ6

(2011) Shunzi Li et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Influence of Affinity and Antigen Internalization on the Uptake and Penetration of Anti-HER2 Antibodies in Solid Tumors

(2011) S. I. Rudnick et al.   CANCER RESEARCH

Pegylated Liposomal Doxorubicin

(2011) Sean T. Duggan et al.   DRUGS

Effective tumor targeting and enhanced anti-tumor effect of liposomes engrafted with peptides specific for tumor lymphatics and vasculature

(2011) Thomas P. Herringson et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Tumour necrosis factor-alpha increases extravasation of virus particles into tumour tissue by activating the Rho A/Rho kinase pathway

(2011) Takahiro Seki et al.   JOURNAL OF CONTROLLED RELEASE

Drug targeting to tumors: Principles, pitfalls and (pre-) clinical progress

(2011) Twan Lammers et al.   JOURNAL OF CONTROLLED RELEASE

Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on size

(2011) H. Cabral et al.   Nature Nanotechnology

Delivery of Molecular and Nanoscale Medicine to Tumors: Transport Barriers and Strategies

(2011) Vikash P. Chauhan et al.   Annual Review of Chemical and Biomolecular Engineering

Efficacy, Biodistribution, and Pharmacokinetics of CD22-Targeted Pegylated Liposomal Doxorubicin in a B-cell Non-Hodgkin's Lymphoma Xenograft Mouse Model

(2010) J. M. Tuscano et al.   CLINICAL CANCER RESEARCH

Cancer antineovascular therapy with liposome drug delivery systems targeted to BiP/GRP78

(2010) Yasufumi Katanasaka et al.   INTERNATIONAL JOURNAL OF CANCER

Tumor-targeted delivery of liposome-encapsulated doxorubicin by use of a peptide that selectively binds to irradiated tumors

(2010) Amanda Lowery et al.   JOURNAL OF CONTROLLED RELEASE

Increasing the antitumor efficacy of doxorubicin-loaded liposomes with peptides anchored via a chelator lipid

(2010) Thomas P. Herringson et al.   JOURNAL OF DRUG TARGETING

Antiangiogenic Targeting Liposomes Increase Therapeutic Efficacy for Solid Tumors

(2009) De-Kuan Chang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nanosystem drug targeting: Facing up to complex realities

(2009) Pakatip Ruenraroengsak et al.   JOURNAL OF CONTROLLED RELEASE

Epithelial-to-mesenchymal transition in the development and progression of adenocarcinoma and squamous cell carcinoma of the lung

(2009) Ludmila Prudkin et al.   MODERN PATHOLOGY

Synthesis and characterization of a high-affinity  v 6-specific ligand for in vitro and in vivo applications

(2009) S. Li et al.   MOLECULAR CANCER THERAPEUTICS

A modeling analysis of the effects of molecular size and binding affinity on tumor targeting

(2009) M. M. Schmidt et al.   MOLECULAR CANCER THERAPEUTICS

Mediating Tumor Targeting Efficiency of Nanoparticles Through Design

(2009) Steven D. Perrault et al.   NANO LETTERS

A Novel Peptide Enhances Therapeutic Efficacy of Liposomal Anti-Cancer Drugs in Mice Models of Human Lung Cancer

(2009) De-Kuan Chang et al.   PLoS One

Cooperative nanomaterial system to sensitize, target, and treat tumors

(2009) J.-H. Park et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antibody tumor penetration: Transport opposed by systemic and antigen-mediated clearance

(2008) Greg M. Thurber et al.   ADVANCED DRUG DELIVERY REVIEWS

Enhanced Antitumor Efficacy of Clinical-Grade Vasculature-Targeted Liposomal Doxorubicin

(2008) F. Pastorino et al.   CLINICAL CANCER RESEARCH

Peptide ligand-mediated liposome distribution and targeting to EGFR expressing tumor in vivo

(2008) Shuxian Song et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Hepatocellular carcinoma cell-specific peptide ligand for targeted drug delivery

(2008) A. Lo et al.   MOLECULAR CANCER THERAPEUTICS

Does a targeting ligand influence nanoparticle tumor localization or uptake?

(2008) Kathleen F. Pirollo et al.   TRENDS IN BIOTECHNOLOGY

Overexpression of the αvβ6 Integrin in Endometrial Cancer

(2008) Jonathan L. Hecht et al.   APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY