MARCH7-mediated ubiquitination decreases the solubility of ATG14 to inhibit autophagy

S-Nitrosylation of p62 Inhibits Autophagic Flux to Promote α-Synuclein Secretion and Spread in Parkinson’s Disease and Lewy Body Dementia

(2022) Chang-ki Oh et al.   JOURNAL OF NEUROSCIENCE

Structure of human chromatin-remodelling PBAF complex bound to a nucleosome

(2022) Junjie Yuan et al.   NATURE

K48/K63-linked polyubiquitination of ATG9A by TRAF6 E3 ligase regulates oxidative stress-induced autophagy

(2022) Yi-Ting Wang et al.   Cell Reports

Emerging functions of branched ubiquitin chains

(2021) Michael E. French et al.   Cell Discovery

USP5 attenuates NLRP3 inflammasome activation by promoting autophagic degradation of NLRP3

(2021) Baoshan Cai et al.   Autophagy

Autophagy in major human diseases

(2021) Daniel J Klionsky et al.   EMBO JOURNAL

Deubiquitinating enzymes (DUBs): Regulation, homeostasis, and oxidative stress response

(2021) Nathan A. Snyder et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SNX27-driven membrane localisation of OTULIN antagonises linear ubiquitination and NF-κB signalling activation

(2021) Ruona Shi et al.   Cell and Bioscience

Activation Mechanisms of the VPS34 Complexes

(2021) Yohei Ohashi   Cells

Autophagy and disease: unanswered questions

(2020) Ying Yang et al.   CELL DEATH AND DIFFERENTIATION

Structure-Mediated RNA Decay by UPF1 and G3BP1

(2020) Joseph W. Fischer et al.   MOLECULAR CELL

NEDD4L downregulates autophagy and cell growth by modulating ULK1 and a glutamine transporter

(2020) Dong-Eun Lee et al.   Cell Death & Disease

Targeting E3 Ubiquitin Ligases and Deubiquitinases in Ciliopathy and Cancer

(2020) Takashi Shiromizu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Reconstitution of autophagosome nucleation defines Atg9 vesicles as seeds for membrane formation

(2020) Justyna Sawa-Makarska et al.   SCIENCE

The Roles of Ubiquitin in Mediating Autophagy

(2020) Zhangyuan Yin et al.   Cells

Ubiquitin signaling in neurodegenerative diseases: an autophagy and proteasome perspective

(2020) François Le Guerroué et al.   CELL DEATH AND DIFFERENTIATION

Ubiquitin Signaling and Degradation of Aggregate-Prone Proteins

(2019) Margarita Galves et al.   TRENDS IN BIOCHEMICAL SCIENCES

The ubiquitin-specific protease USP8 directly deubiquitinates SQSTM1/p62 to suppress its autophagic activity

(2019) Hong Peng et al.   Autophagy

The Membrane-Associated MARCH E3 Ligase Family: Emerging Roles in Immune Regulation

(2019) Heng Lin et al.   Frontiers in Immunology

Autophagosome-Lysosome Fusion

(2019) Péter Lőrincz et al.   JOURNAL OF MOLECULAR BIOLOGY

Structural pathway for allosteric activation of the autophagic PI 3-kinase complex I

(2019) Lindsey N. Young et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cellular quality control by the ubiquitin-proteasome system and autophagy

(2019) Christian Pohl et al.   SCIENCE

Negative regulation of autophagy by UBA6-BIRC6–mediated ubiquitination of LC3

(2019) Rui Jia et al.   eLife

Regulation of the Mdm2–p53 pathway by the ubiquitin E3 ligase MARCH7

(2018) Kailiang Zhao et al.   EMBO REPORTS

Proteome-wide identification of ubiquitin interactions using UbIA-MS

(2018) Xiaofei Zhang et al.   Nature Protocols

Identifying ubiquitinated proteins and aggregates

(2018) Nathan Basisty et al.   Aging-US

Monitoring and Measuring Autophagy

(2017) Saori R. Yoshii et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

An Interaction Landscape of Ubiquitin Signaling

(2017) Xiaofei Zhang et al.   MOLECULAR CELL

Phosphorylated Presenilin 1 decreases β-amyloid by facilitating autophagosome–lysosome fusion

(2017) Victor Bustos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

USP9X counteracts differential ubiquitination of NPHP5 by MARCH7 and BBS11 to regulate ciliogenesis

(2017) Arindam Das et al.   PLoS Genetics

ATG14 controls SNARE-mediated autophagosome fusion with a lysosome

(2015) Rong Liu et al.   Autophagy

Dopamine Controls Systemic Inflammation through Inhibition of NLRP3 Inflammasome

(2015) Yiqing Yan et al.   CELL

Regulation of translesion DNA synthesis: Posttranslational modification of lysine residues in key proteins

(2015) Justyna McIntyre et al.   DNA REPAIR

ATG14 promotes membrane tethering and fusion of autophagosomes to endolysosomes

(2015) Jiajie Diao et al.   NATURE

Deubiquitinase-based analysis of ubiquitin chain architecture using Ubiquitin Chain Restriction (UbiCRest)

(2015) Manuela K Hospenthal et al.   Nature Protocols

G-protein-coupled receptors regulate autophagy by ZBTB16-mediated ubiquitination and proteasomal degradation of Atg14L

(2015) Tao Zhang et al.   eLife

OTU Deubiquitinases Reveal Mechanisms of Linkage Specificity and Enable Ubiquitin Chain Restriction Analysis

(2013) Tycho E.T. Mevissen et al.   CELL

UBE2O negatively regulates TRAF6-mediated NF-κB activation by inhibiting TRAF6 polyubiquitination

(2013) Xiaofei Zhang et al.   CELL RESEARCH

mTOR inhibits autophagy by controlling ULK1 ubiquitylation, self-association and function through AMBRA1 and TRAF6

(2013) Francesca Nazio et al.   NATURE CELL BIOLOGY

Autophagy in Human Health and Disease

(2013) Augustine M.K. Choi et al.   NEW ENGLAND JOURNAL OF MEDICINE

K48-linked ubiquitination and protein degradation regulate 53BP1 recruitment at DNA damage sites

(2012) Frédérick A Mallette et al.   CELL RESEARCH

AMPK and mTOR coordinate the regulation of Ulk1 and mammalian autophagy initiation

(2011) Libin Shang et al.   Autophagy

p62/SQSTM1 and ALFY interact to facilitate the formation of p62 bodies/ALIS and their degradation by autophagy

(2010) Terje Høyvarde Clausen et al.   Autophagy

Regulation of autophagy by phosphatidylinositol 3-phosphate

(2010) Chloe Burman et al.   FEBS LETTERS

Ubiquitin accumulation in autophagy-deficient mice is dependent on the Nrf2-mediated stress response pathway: a potential role for protein aggregation in autophagic substrate selection

(2010) Brigit E. Riley et al.   JOURNAL OF CELL BIOLOGY

Regulation of membrane biogenesis in autophagy via PI3P dynamics

(2010) Takeshi Noda et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Atypical ubiquitin chains: new molecular signals. ‘Protein Modifications: Beyond the Usual Suspects’ Review Series

(2008) Fumiyo Ikeda et al.   EMBO REPORTS

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

(2008) Jürgen Cox et al.   NATURE BIOTECHNOLOGY

Identification of Barkor as a mammalian autophagy-specific factor for Beclin 1 and class III phosphatidylinositol 3-kinase

(2008) Q. Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Ubiquitin E3 Ligase MARCH7 is Differentially Regulated by the Deubiquitylating Enzymes USP7 and USP9X

(2008) James A. Nathan et al.   TRAFFIC