SNX27-driven membrane localisation of OTULIN antagonises linear ubiquitination and NF-κB signalling activation

Emerging Roles and Research Tools of Atypical Ubiquitination

(2020) Qiuling Huang et al.   PROTEOMICS

Immune Dysregulation in Children With Down Syndrome

(2020) Dean Huggard et al.   Frontiers in Pediatrics

Linear ubiquitination at a glance

(2019) Maureen Spit et al.   JOURNAL OF CELL SCIENCE

Regulation of the endosomal SNX27-retromer by OTULIN

(2019) Aurelia Stangl et al.   Nature Communications

Cholera toxin inhibits SNX27-retromer mediated delivery of cargo proteins to the plasma membrane

(2018) Varsha Singh et al.   JOURNAL OF CELL SCIENCE

Proteome-wide identification of ubiquitin interactions using UbIA-MS

(2018) Xiaofei Zhang et al.   Nature Protocols

An Interaction Landscape of Ubiquitin Signaling

(2017) Xiaofei Zhang et al.   MOLECULAR CELL

The Met1-Linked Ubiquitin Machinery: Emerging Themes of (De)regulation

(2017) Matous Hrdinka et al.   MOLECULAR CELL

Internally tagged ubiquitin: a tool to identify linear polyubiquitin-modified proteins by mass spectrometry

(2017) Katarzyna Kliza et al.   NATURE METHODS

The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity

(2016) Rune Busk Damgaard et al.   CELL

SNX27, a protein involved in down syndrome, regulates GPR17 trafficking and oligodendrocyte differentiation

(2016) Veronica Meraviglia et al.   GLIA

Atypical parkinsonism–associated retromer mutant alters endosomal sorting of specific cargo proteins

(2016) Kirsty J. McMillan et al.   JOURNAL OF CELL BIOLOGY

Biallelic hypomorphic mutations in a linear deubiquitinase define otulipenia, an early-onset autoinflammatory disease

(2016) Qing Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

FAM21 directs SNX27–retromer cargoes to the plasma membrane by preventing transport to the Golgi apparatus

(2016) Seongju Lee et al.   Nature Communications

Retromer and sorting nexins in endosomal sorting

(2015) Matthew Gallon et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The retromer complex in development and disease

(2015) S. Wang et al.   DEVELOPMENT

Human HOIP and LUBAC deficiency underlies autoinflammation, immunodeficiency, amylopectinosis, and lymphangiectasia

(2015) Bertrand Boisson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Sorting nexin 27 regulates basal and stimulated brush border trafficking of NHE3

(2015) Varsha Singh et al.   MOLECULAR BIOLOGY OF THE CELL

Cell Fate Decisions Regulated by K63 Ubiquitination of Tumor Necrosis Factor Receptor 1

(2014) J. Fritsch et al.   MOLECULAR AND CELLULAR BIOLOGY

Binding of OTULIN to the PUB Domain of HOIP Controls NF-κB Signaling

(2014) Veronique Schaeffer et al.   MOLECULAR CELL

Linear ubiquitin chains: NF-κB signalling, cell death and beyond

(2014) Kazuhiro Iwai et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A role for sorting nexin 27 in AMPA receptor trafficking

(2014) Li Shen Loo et al.   Nature Communications

OTULIN Antagonizes LUBAC Signaling by Specifically Hydrolyzing Met1-Linked Polyubiquitin

(2013) Kirstin Keusekotten et al.   CELL

OTULIN Restricts Met1-Linked Ubiquitination to Control Innate Immune Signaling

(2013) Berthe Katrine Fiil et al.   MOLECULAR CELL

Loss of sorting nexin 27 contributes to excitatory synaptic dysfunction by modulating glutamate receptor recycling in Down's syndrome

(2013) Xin Wang et al.   NATURE MEDICINE

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

SHARPIN is a key regulator of immune and inflammatory responses

(2012) Zhe Wang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis

(2011) Fumiyo Ikeda et al.   NATURE

Linear ubiquitination prevents inflammation and regulates immune signalling

(2011) Björn Gerlach et al.   NATURE

Caspase-8 and caspase-7 sequentially mediate proteolytic activation of acid sphingomyelinase in TNF-R1 receptosomes

(2010) Bärbel Edelmann et al.   EMBO JOURNAL

Endosomal sorting and signalling: an emerging role for sorting nexins

(2008) Peter J. Cullen   NATURE REVIEWS MOLECULAR CELL BIOLOGY