Simvastatin Preferentially Targets FLT3/ITD Acute Myeloid Leukemia by Inhibiting MEK/ERK and p38-MAPK Signaling Pathways
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Title
Simvastatin Preferentially Targets FLT3/ITD Acute Myeloid Leukemia by Inhibiting MEK/ERK and p38-MAPK Signaling Pathways
Authors
Keywords
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Journal
DRUGS IN R&D
Volume -, Issue -, Pages -
Publisher
Springer Science and Business Media LLC
Online
2023-10-17
DOI
10.1007/s40268-023-00442-6
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- (2021) Rebecca L. Siegel et al. CA-A CANCER JOURNAL FOR CLINICIANS
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- (2018) Seema Shah et al. SEMINARS IN CANCER BIOLOGY
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- Acute Myeloid Leukemia, Version 3.2017, NCCN Clinical Practice Guidelines in Oncology
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- (2008) Susan D. P. W. M. de Jonge-Peeters et al. ANNALS OF HEMATOLOGY
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