Review
Biochemistry & Molecular Biology
Duygu Sari-Ak, Alvaro Torres-Gomez, Yavuz-Furkan Yazicioglu, Anthos Christofides, Nikolaos Patsoukis, Esther M. Lafuente, Vassiliki A. Boussiotis
Summary: This review discusses the structural and molecular properties of RIAM and the functional role of the Rap1/RIAM module in hematopoietic cells.
BIOMEDICAL JOURNAL
(2022)
Review
Biochemistry & Molecular Biology
Shiela C. C. Samson, Akib M. M. Khan, Michelle C. C. Mendoza
Summary: The RAS-ERK pathway is crucial in promoting cell migration and invasion, with steady-state ERK activity playing a role in promoting both single cell and collective migration and invasion. ERK drives actin polymerization and adhesion turnover for edge protrusion, while cell contraction stimulates cell movement in epithelial sheets.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Oncology
Elisavet Lioulia, Panagiotis Mokos, Emmanuel Panteris, Dimitra Dafou
Summary: This study demonstrates the UBE2T/MAPK-ERK/beta-catenin axis as a critical regulator of cell state transition and EMT in HCC.
MOLECULAR ONCOLOGY
(2022)
Article
Pharmacology & Pharmacy
Chao Zhang, Shutao Zhao, Yuen Tan, Siwei Pan, Wen An, Qingchuan Chen, Xudong Wang, Huimian Xu
Summary: The high expression of SKA3 in gastric cancer is negatively correlated with the low expression of DUSP2, and is associated with the malignant degree, peritoneal metastasis, and poor prognosis. Further experiments showed that silencing SKA3 expression can inhibit the proliferation, migration, invasion, and epithelial-mesenchymal transition of gastric cancer. Mechanistically, SKA3 negatively regulates DUSP2 and activates the MAPK/ERK pathway to promote gastric cancer progression.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Longfei Xiao, Huahong Peng, Mo Yan, Saipeng Chen
Summary: The study identified ACTG1 as a potential biomarker for metastatic prostate cancer, which may regulate the metastasis of PCa through the MAPK/ERK signaling pathway.
DNA AND CELL BIOLOGY
(2021)
Review
Oncology
Eunus S. Ali, Shamima Akter, Sarker Ramproshad, Banani Mondal, Thoufiqul Alam Riaz, Muhammad Torequl Islam, Ishaq N. Khan, Anca Oana Docea, Daniela Calina, Javad Sharifi-Rad, William C. Cho
Summary: The MAPK pathway plays a crucial role in transmitting signals from outside the cell to inside, and is associated with cancer treatment response, normal cell pathway maintenance, and compensatory pathway activation. MAPK inhibitors often activate compensatory feedback loops, leading to resistance in tumor cells and microenvironment. Therefore, innovative combination therapies are needed to limit alternate pathway initiation.
CANCER CELL INTERNATIONAL
(2022)
Article
Oncology
Lina Shan, Wenqian Zheng, Bingjun Bai, Jinghui Hu, Yiming Lv, Kangke Chen, Xiaowei Wang, Yangtao Pan, Xuefeng Huang, Hongbo Zhu, Sheng Dai
Summary: This study found that over expression of BMAL1 is closely related to poor prognosis of CRC. BMAL1 overexpression promotes proliferation and migration of CRC and regulates its metastasis through the activation of EMT and MAPK pathways. These findings are important for understanding the relationship between BMAL1 and tumorigenic phenotypes and may serve as a potential therapeutic target for BMAL1 overexpressing CRC.
Article
Food Science & Technology
Xiao-Li Li, Qi Yin, Wei Wang, Run-Hui Ma, Zhi-Jing Ni, Kiran Thakur, Jian-Guo Zhang, Zhao-Jun Wei
Summary: Ginsenoside (G-CK) and DDP inhibit the proliferation of HeLa cells, and their combination blocks cell growth and colony-forming ability, inhibits cell migration and EMT processes. This is achieved through inhibition of the RAS/MEK/ERK and PI3K/AKT signaling pathways, resulting in up-regulation of E-cadherin, down-regulation of N-cadherin and vimentin, and impaired cell migration. G-CK also protects HEK293 cells from oxidative stress damage induced by DDP.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Medicine, Research & Experimental
Hao Wang, Zhenzhen Lin, Zhe Nian, Wei Zhang, Wenxu Liu, Fei Yan, Zengtuan Xiao, Xia Wang, Zhenfa Zhang, Zhenyi Ma, Zhe Liu
Summary: The study identifies GFI1 as a critical regulator of anchorage independence in lung cancer cells, revealing a mechanism by which carcinoma cells hijack a hematopoietic factor for gaining anchorage independence. This could lead to ERK signaling dependency in tumor cells, suggesting potential interventions for suppressing metastasis and improving therapeutic outcomes in cancer.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Biochemistry & Molecular Biology
Jiayu Guo, Shuai Ke, Qi Chen, Jiangqiao Zhou, Jia Guo, Tao Qiu
Summary: NCOA7 is downregulated in various cancers, but its expression and prognostic significance in clear cell renal cell carcinoma (ccRCC) are unknown. In this study, NCOA7 expression in ccRCC tissues was analyzed, and its inhibitory role in ccRCC progression was demonstrated. Mechanistically, NCOA7 inhibited the MAPK/ERK pathway to regulate EMT and apoptosis, thus inhibiting ccRCC progression. These findings suggest that NCOA7 could serve as a prognostic marker and therapeutic target for ccRCC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biology
Chaitra Rao, Danielle E. Frodyma, Siddesh Southekal, Robert A. Svoboda, Adrian R. Black, Chittibabu Guda, Tomohiro Mizutani, Hans Clevers, Keith R. Johnson, Kurt W. Fisher, Robert E. Lewis
Summary: The research demonstrates that KSR1 and ERK promote EMT-like phenotype by preferentially translating EPSTI1, which plays a crucial role in human colorectal cancer cells, affecting cell migration and invasion behavior.
Article
Biochemistry & Molecular Biology
Byeong Hyeok Choi, Ziyue Kou, Tania Marlyn Colon, Chih-Hong Chen, Yuan Chen, Wei Dai
Summary: Radil, a downstream effector of Ras, interacts strongly with KRas and GTP-bound Ras, suggesting a role in Ras activation. Overexpression of Radil leads to transient activation of MAPK signaling, while Radil knockdown weakens downstream Ras signaling, affecting cell proliferation, invasion, and migration. Radil plays a vital role in regulating Ras signaling, cell adhesion, and the epithelial-mesenchymal transition, potentially offering new opportunities for Ras-related anticancer drug development.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Biology
Manuel Jurado, Oscar Castano, Antonio Zorzano
Summary: PRMT5 modulates the MAPK pathway by methylating Raf kinase, reducing the activation of ERK in time and amplitude, thereby avoiding aberrant behavior.
COMPUTERS IN BIOLOGY AND MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Yujin Wang, Xiaoyan Shen, Qingwen Wang, Zixin Guo, Liwen Hu, Zhe Dong, Weidong Hu
Summary: The study found that the levels of RBJ protein were increased in tumor tissue of non-small cell lung cancer (NSCLC) and correlated positively with clinical stage. Silencing RBJ inhibited the growth, invasion, and migration of NSCLC cells, while overexpression of RBJ accelerated tumor formation. The results suggest that RBJ promotes the progression of NSCLC by activating the epithelial-mesenchymal transition (EMT) signaling pathway.
CURRENT PHARMACEUTICAL DESIGN
(2022)
Article
Multidisciplinary Sciences
Ethan J. Brock, Ryan M. Jackson, Julie L. Boerner, Quanwen Li, Meredith A. Tennis, Bonnie F. Sloane, Raymond R. Mattingly
Summary: Research on breast ductal carcinoma in situ (DCIS) suggests that Sprouty4 plays a crucial role in controlling ERK/MAPK signaling, thereby limiting the progression of these lesions towards invasive ductal carcinoma (IDC).
Review
Chemistry, Medicinal
Ethan J. Brock, Kyungmin Ji, John J. Reiners, Raymond R. Mattingly
MINI-REVIEWS IN MEDICINAL CHEMISTRY
(2016)
Review
Oncology
Ethan J. Brock, Kyungmin Ji, Seema Shah, Raymond R. Mattingly, Bonnie F. Sloane
JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA
(2019)
Article
Oncology
Seema Shah, Ethan J. Brock, Ryan M. Jackson, Kyungmin Ji, Julie L. Boerner, Bonnie F. Sloane, Raymond R. Mattingly
Article
Multidisciplinary Sciences
Ethan J. Brock, Ryan M. Jackson, Julie L. Boerner, Quanwen Li, Meredith A. Tennis, Bonnie F. Sloane, Raymond R. Mattingly
Summary: Research on breast ductal carcinoma in situ (DCIS) suggests that Sprouty4 plays a crucial role in controlling ERK/MAPK signaling, thereby limiting the progression of these lesions towards invasive ductal carcinoma (IDC).