How caffeic acid and its derivatives combat diabetes and its complications: A systematic review

Caffeic acid attenuates neuroinflammation and cognitive impairment in streptozotocin-induced diabetic rats: Pivotal role of the cholinergic and purinergic signaling pathways

(2023) Milagros Fanny Vera Castro et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Potential of Caffeic Acid and 10-Dehydrogingerdione as Lipid Regulators Relevant to Their Inhibitory Effect on miR-122 and ATP Citrate Lyase Activity in Diabetic Hyperlipidemic Rats

(2023) Mohamed M. Elseweidy et al.   Biomedicines

Metformin beyond an anti-diabetic agent: A comprehensive and mechanistic review on its effects against natural and chemical toxins

(2023) Amirhossein Malaekeh-Nikouei et al.   BIOMEDICINE & PHARMACOTHERAPY

Promising influences of caffeic acid and caffeic acid phenethyl ester against natural and chemical toxins: A comprehensive and mechanistic review

(2023) Sajjad Ehtiati et al.   Journal of Functional Foods

Caffeic acid regulates glucose homeostasis and inhibits purinergic and cholinergic activities while abating oxidative stress and dyslipidaemia in fructose-streptozotocin-induced diabetic rats

(2022) Veronica F Salau et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Effects of caffeic acid on the growth performance, growth genes, digestive enzyme activity, and serum immune parameters of beluga ( Huso huso )

(2022) Ehsan Ahmadifar et al.   Journal of Experimental Zoology Part A-Ecological and Integrative Physiology

Antioxidant Polyphenols of Antirhea borbonica Medicinal Plant and Caffeic Acid Reduce Cerebrovascular, Inflammatory and Metabolic Disorders Aggravated by High-Fat Diet-Induced Obesity in a Mouse Model of Stroke

(2022) Janice Taïlé et al.   Antioxidants

N-Octyl Caffeamide, a Caffeic Acid Amide Derivative, Prevents Progression of Diabetes and Hepatic Steatosis in High-Fat Diet Induced Obese Mice

(2022) Miao-Yi Wu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Novel Caffeic Acid - Zinc Acetate Complex: Studies on Promising Antidiabetic and Antioxidant Synergism Through Complexation

(2022) Godfrey R. Matowane et al.   Medicinal Chemistry

Binding Studies of Caffeic and p-Coumaric Acid with α-Amylase: Multispectroscopic and Computational Approaches Deciphering the Effect on Advanced Glycation End Products (AGEs)

(2022) Mohd Shahnawaz Khan et al.   MOLECULES

Burden of diabetes and hyperglycaemia in adults in the Americas, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019

(2022) Ewerton Cousin et al.   Lancet Diabetes & Endocrinology

Protective Effect of Portulaca oleracea on Streptozotocin-Induced Type I Diabetes-Associated Reproductive System Dysfunction and Inflammation

(2022) Hassan Rakhshandeh et al.   MOLECULES

Caffeic Acid Phenethyl Ester Loaded PEG–PLGA Nanoparticles Enhance Wound Healing in Diabetic Rats

(2022) Mohammed Z. Nasrullah   Antioxidants

Redox changes in obesity, metabolic syndrome, and diabetes

(2021) Bato Korac et al.   Redox Biology

Standardised pomegranate peel extract lavage prevents postoperative peritoneal adhesion by regulating TGF-β and VEGF levels

(2021) Mobarakeh Ghadiri et al.   INFLAMMOPHARMACOLOGY

The effects of caffeic acid phenethyl ester on retina in a diabetic rat model

(2021) Alparslan Şahin et al.   Cutaneous and Ocular Toxicology

Modulatory effects of caffeic acid on purinergic and cholinergic systems and oxi-inflammatory parameters of streptozotocin-induced diabetic rats

(2021) Milagros Fanny Vera Castro et al.   LIFE SCIENCES

Efficacy of Caffeic Acid on Diabetes and Its Complications in the Mouse

(2021) Nada Oršolić et al.   MOLECULES

Colchicine effectively attenuates inflammatory biomarker high-sensitivity C-reactive protein (hs-CRP) in patients with non-ST-segment elevation myocardial infarction: a randomised, double-blind, placebo-controlled clinical trial

(2021) Arash Gholoobi et al.   INFLAMMOPHARMACOLOGY

Novel insights into the genetically obese (ob/ob) and diabetic (db/db) mice: two sides of the same coin

(2021) Francesco Suriano et al.   Microbiome

A biochemical and immunohistochemical study of the effects of caffeic acid phenethyl ester on alveolar bone loss and oxidative stress in diabetic rats with experimental periodontitis

(2020) Alper Kızıldağ et al.   BIOTECHNIC & HISTOCHEMISTRY

The Diabetes Mellitus–Atherosclerosis Connection: The Role of Lipid and Glucose Metabolism and Chronic Inflammation

(2020) Anastasia Poznyak et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Evaluation of the Effects of Peritoneal Lavage with Rosmarinus officinalis Extract against the Prevention of Postsurgical-Induced Peritoneal Adhesion

(2020) Yasamin Roohbakhsh et al.   PLANTA MEDICA

Genetics of diabetes mellitus and diabetes complications

(2020) Joanne B. Cole et al.   Nature Reviews Nephrology

Precision medicine in diabetes: a Consensus Report from the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)

(2020) Wendy K. Chung et al.   DIABETOLOGIA

Newboulasides A and B, two new caffeic acid glycosides from Newbouldia laevis with α-amylase inhibitory activity

(2020) Ikechukwu Sonne Mbagwu et al.   NATURAL PRODUCT RESEARCH

Vascular Complication in Adolescents With Diabetes Mellitus

(2020) Lara E. Graves et al.   Frontiers in Endocrinology

Evaluation of the anti-oxidant and anti-inflammatory effects of the methanolic extract of Ferula szowitsiana root on PHA-induced inflammation in human lymphocytes

(2019) Vahid Reza Askari et al.   DRUG AND CHEMICAL TOXICOLOGY

Protective Effects of Caffeic Acid Phenethyl Ester (CAPE) and Novel Cape Analogue as Inducers of Heme Oxygenase-1 in Streptozotocin-Induced Type 1 Diabetic Rats

(2019) Valeria Sorrenti et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Caffeic Acid Inhibits the Formation of Advanced Glycation End Products (AGEs) and Mitigates the AGEs‐Induced Oxidative Stress and Inflammation Reaction in Human Umbilical Vein Endothelial Cells (HUVECs)

(2019) Xiangyu Cao et al.   CHEMISTRY & BIODIVERSITY

WITHDRAWN: Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: results from the International Diabetes Federation Diabetes Atlas, 9th edition

(2019) Pouya Saeedi et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Caffeic acid reduces oxidative stress and microglial activation in the mouse hippocampus

(2019) Minori Koga et al.   TISSUE & CELL

Antimicrobial Potential of Caffeic Acid against Staphylococcus aureus Clinical Strains

(2018) Małgorzata Kępa et al.   Biomed Research International

Global trends in diabetes complications: a review of current evidence

(2018) Jessica L. Harding et al.   DIABETOLOGIA

Metabolomics study of cadmium-induced diabetic nephropathy and protective effect of caffeic acid phenethyl ester using UPLC–Q-TOF-MS combined with pattern recognition

(2017) Pin Gong et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Caffeic Acid Phenethyl Ester (Propolis Extract) Ameliorates Insulin Resistance by Inhibiting JNK and NF-κB Inflammatory Pathways in Diabetic Mice and HepG2 Cell Models

(2017) Jiarui Nie et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Antioxidant, Antidiabetic, and Antihypertensive Properties of Echinacea purpurea Flower Extract and Caffeic Acid Derivatives Using In Vitro Models

(2017) Shiow-Ying Chiou et al.   JOURNAL OF MEDICINAL FOOD

Caffeic Acid Attenuates Diabetic Kidney Disease via Modulation of Autophagy in a High-Fat Diet/Streptozotocin- Induced Diabetic Rat

(2017) Marwa Matboli et al.   Scientific Reports

Low nanomolar caffeic acid attenuates high glucose-induced endothelial dysfunction in primary human umbilical-vein endothelial cells by affecting NF-κB and Nrf2 pathways

(2016) Deborah Fratantonio et al.   BIOFACTORS

Risk of Cause-Specific Death in Individuals With Diabetes: A Competing Risks Analysis

(2016) Jose Miguel Baena-Díez et al.   DIABETES CARE

Plausible anti-inflammatory mechanism of resveratrol and caffeic acid against chronic stress-induced insulin resistance in mice

(2016) Suprithi Choudhary et al.   INFLAMMOPHARMACOLOGY

Caffeic acid improves memory impairment and brain glucose metabolism via ameliorating cerebral insulin and leptin signaling pathways in high-fat diet-induced hyperinsulinemic rats

(2015) Wen-Chang Chang et al.   FOOD RESEARCH INTERNATIONAL

Antidiabetic Effects of Simple Phenolic Acids: A Comprehensive Review

(2015) Ramachandran Vinayagam et al.   PHYTOTHERAPY RESEARCH

Caffeic acid phenethyl amide ameliorates ischemia/reperfusion injury and cardiac dysfunction in streptozotocin-induced diabetic rats

(2014) Yi-Jin Ho et al.   Cardiovascular Diabetology

Caffeic acid phenethyl ester, a 5-lipoxygenase enzyme inhibitor, alleviates diabetic atherosclerotic manifestations: Effect on vascular reactivity and stiffness

(2014) Noura Ahmed Hassan et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Antihypertensive effect of caffeic acid and its analogs through dual renin–angiotensin–aldosterone system inhibition

(2014) Khushwant S. Bhullar et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Caffeic Acid Phenethyl Ester and Therapeutic Potentials

(2014) Ghulam Murtaza et al.   Biomed Research International

Caffeic acid phenethyl amide improves glucose homeostasis and attenuates the progression of vascular dysfunction in Streptozotocin-induced diabetic rats

(2013) Yi-Jin Ho et al.   Cardiovascular Diabetology

Caffeic acid, naringenin and quercetin enhance glucose-stimulated insulin secretion and glucose sensitivity in INS-1E cells

(2013) S. Bhattacharya et al.   DIABETES OBESITY & METABOLISM

Protective and anti-angiopathy effects of caffeic acid phenethyl ester against induced type 1 diabetes in vivo

(2013) Soha H. Abduljawad et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Caffeic Acid Phenylethyl Amide Protects against the Metabolic Consequences in Diabetes Mellitus Induced by Diet and Streptozocin

(2012) Yi-Chun Weng et al.   Evidence-based Complementary and Alternative Medicine

Protective Effect of Caffeic Acid Phenethyl Ester on Oxidative Stress in Diabetic Rat Sciatic Nerve

(2012) Yavuz Yucel et al.   International Journal of Pharmacology

Caffeic acid phenethyl ester reduces the activation of the nuclear factor κB pathway by high-fat diet-induced obesity in mice

(2012) Rosângela Maria Neves Bezerra et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Caffeic acid and cinnamic acid ameliorate glucose metabolism via modulating glycogenesis and gluconeogenesis in insulin-resistant mouse hepatocytes

(2012) Da-Wei Huang et al.   Journal of Functional Foods

The molecular basis of working mechanism of natural polyphenolic antioxidants

(2010) Monica Leopoldini et al.   FOOD CHEMISTRY

The proglycation effect of caffeic acid leads to the elevation of oxidative stress and inflammation in monocytes, macrophages and vascular endothelial cells

(2010) Chi-Hao Wu et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Caffeic and chlorogenic acids in Ilex paraguariensis extracts are the main inhibitors of AGE generation by methylglyoxal in model proteins

(2009) A. Gugliucci et al.   FITOTERAPIA

Effects of Caffeic Acid and Cinnamic Acid on Glucose Uptake in Insulin-Resistant Mouse Hepatocytes

(2009) Da-Wei Huang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Anti-glycative and anti-inflammatory effects of caffeic acid and ellagic acid in kidney of diabetic mice

(2009) Che-yi Chao et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Anti-inflammatory and anti-coagulatory activities of caffeic acid and ellagic acid in cardiac tissue of diabetic mice

(2009) Pei-chun Chao et al.   Nutrition & Metabolism

Caffeic acid phenethyl ester (CAPE) exhibits significant potential as an antidiabetic and liver-protective agent in streptozotocin-induced diabetic rats

(2009) Sefa Celik et al.   PHARMACOLOGICAL RESEARCH

Caffeic acid phenethyl ester (CAPE) protects brain against oxidative stress and inflammation induced by diabetes in rats

(2008) Sefa Celik et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY