Receptor for advanced glycation end‐products: Biological significance and imaging applications

Affinity probes based on small-molecule inhibitors for tumor imaging

(2022) Xinzeyu Yi et al.   Frontiers in Oncology

Molecularly targeted nanoparticles: an emerging tool for evaluation of expression of the receptor for advanced glycation end products in a murine model of peripheral artery disease

(2021) Marcin Woźniak et al.   CELLULAR & MOLECULAR BIOLOGY LETTERS

Impact of HMGB1, RAGE, and TLR4 in Alzheimer’s Disease (AD): From Risk Factors to Therapeutic Targeting

(2020) Yam Nath Paudel et al.   Cells

Quantitative imaging of the receptor for advanced glycation end-products in prostate cancer

(2020) Christian J. Konopka et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Correlated Multimodal Imaging in Life Sciences: Expanding the Biomedical Horizon

(2020) Andreas Walter et al.   Frontiers in Physics

Strategies for PET Imaging of the Receptor for Advanced Glycation Endproducts (RAGE)

(2020) Lindsey R. Drake et al.   Journal of Pharmaceutical Analysis

Inhalable gene delivery system using a cationic RAGE-antagonist peptide for gene delivery to inflammatory lung cells

(2019) Chunxian Piao et al.   ACS Biomaterials-Science & Engineering

Assessment of Azeliragon QTc Liability Through Integrated, Model‐Based Concentration QTc Analysis

(2019) Aaron H. Burstein et al.   Clinical Pharmacology in Drug Development

Effect of advanced glycation end‐products (AGE) lowering drug ALT‐711 on biochemical, vascular, and bone parameters in a rat model of CKD‐MBD

(2019) Neal X. Chen et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Antibody drug conjugates against the receptor for advanced glycation end products (RAGE), a novel therapeutic target in endometrial cancer

(2019) Gareth D. Healey et al.   Journal for ImmunoTherapy of Cancer

Evidence of extensive atherosclerosis, coronary artery disease and myocardial infarction in the ApoE −/− : Ins2 +/Akita mouse fed a western diet

(2018) Daniel E. Venegas-Pino et al.   ATHEROSCLEROSIS

Production and application of HMGB1 derived recombinant RAGE-antagonist peptide for anti-inflammatory therapy in acute lung injury

(2018) Seonyeong Lee et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

High mobility group box 1 promotes the epithelial-to-mesenchymal transition in prostate cancer PC3 cells via the RAGE/NF-κB signaling pathway

(2018) Jingliang Zhang et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

RAGE and Its Ligands: Molecular Interplay Between Glycation, Inflammation, and Hallmarks of Cancer—a Review

(2018) Gowri Palanissami et al.   Hormones & Cancer

HMGB1 promotes ERK-mediated mitochondrial Drp1 phosphorylation for chemoresistance through RAGE in colorectal cancer

(2018) Chih-Yang Huang et al.   Cell Death & Disease

Diaphanous-1 affects the nanoscale clustering and lateral diffusion of receptor for advanced glycation endproducts (RAGE)

(2018) Qiaochu Zhu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Therapeutic options to reduce advanced glycation end products in patients with diabetes mellitus: A review

(2018) Philipp Jud et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Targeting the Receptor for Advanced Glycation Endproducts (RAGE): A Medicinal Chemistry Perspective

(2017) Salvatore Bongarzone et al.   JOURNAL OF MEDICINAL CHEMISTRY

HMGB1/Advanced Glycation End Products (RAGE) does not aggravate inflammation but promote endogenous neural stem cells differentiation in spinal cord injury

(2017) Hongyu Wang et al.   Scientific Reports

Entorhinal Cortex dysfunction can be rescued by inhibition of microglial RAGE in an Alzheimer’s disease mouse model

(2017) Chiara Criscuolo et al.   Scientific Reports

Synthesis and Evaluation of [18F]RAGER: A First Generation Small-Molecule PET Radioligand Targeting the Receptor for Advanced Glycation Endproducts

(2016) Brian P. Cary et al.   ACS Chemical Neuroscience

The receptor for advanced glycation end products is required for β-catenin stabilization in a chemical-induced asthma model

(2016) Lihong Yao et al.   BRITISH JOURNAL OF PHARMACOLOGY

High plasma level of soluble RAGE is independently associated with a low recurrence of atrial fibrillation after catheter ablation in diabetic patient

(2016) Pil-Sung Yang et al.   EUROPACE

Blockade of receptor for advanced glycation end products protects against systolic overload-induced heart failure after transverse aortic constriction in mice

(2016) Yu Liu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Glycation & the RAGE axis: targeting signal transduction through DIAPH1

(2016) Alexander Shekhtman et al.   Expert Review of Proteomics

Low Endogenous Secretory Receptor for Advanced Glycation End-Products Levels Are Associated With Inflammation and Carotid Atherosclerosis in Prediabetes

(2016) Antonino Di Pino et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Polyethylenimine: A versatile, multifunctional non-viral vector for nucleic acid delivery

(2016) Abhijeet P. Pandey et al.   Materials Science & Engineering C-Materials for Biological Applications

Tumor-Associated Macrophages and Neutrophils in Tumor Microenvironment

(2016) Jaehong Kim et al.   MEDIATORS OF INFLAMMATION

Effects of RAGE-Specific Inhibitor FPS-ZM1 on Amyloid-β Metabolism and AGEs-Induced Inflammation and Oxidative Stress in Rat Hippocampus

(2016) Yan Hong et al.   NEUROCHEMICAL RESEARCH

RAGE axis in neuroinflammation, neurodegeneration and its emerging role in the pathogenesis of amyotrophic lateral sclerosis

(2016) Rashmi Ray et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Targeting of RAGE-ligand signaling impairs breast cancer cell invasion and metastasis

(2016) T Kwak et al.   ONCOGENE

M2-like tumor-associated macrophages drive vasculogenic mimicry through amplification of IL-6 expression in glioma cells

(2016) Lin Zhang et al.   Oncotarget

Overexpression of soluble RAGE in mesenchymal stem cells enhances their immunoregulatory potential for cellular therapy in autoimmune arthritis

(2016) Min-Jung Park et al.   Scientific Reports

Positron Emission Tomography: Current Challenges and Opportunities for Technological Advances in Clinical and Preclinical Imaging Systems

(2015) Juan José Vaquero et al.   Annual Review of Biomedical Engineering

Role of receptor for advanced glycation end products in the complication and progression of various types of cancers

(2015) Parth Malik et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Advanced glycation endproducts increase proliferation, migration and invasion of the breast cancer cell line MDA-MB-231

(2015) Hana Sharaf et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Fine tuning of 4,6-bisphenyl-2-(3-alkoxyanilino)pyrimidine focusing on the activity-sensitive aminoalkoxy moiety for a therapeutically useful inhibitor of receptor for advanced glycation end products (RAGE)

(2015) Young Taek Han et al.   BIOORGANIC & MEDICINAL CHEMISTRY

The receptor for advanced glycation end products (RAGE) enhances autophagy and neutrophil extracellular traps in pancreatic cancer

(2015) B A Boone et al.   CANCER GENE THERAPY

RAGE Mediates S100A7-Induced Breast Cancer Growth and Metastasis by Modulating the Tumor Microenvironment

(2015) M. W. Nasser et al.   CANCER RESEARCH

Multiscale Imaging of Nanoparticle Drug Delivery

(2015) Lawrence Dobrucki et al.   CURRENT DRUG TARGETS

Amyloid-beta mediates the receptor of advanced glycation end product-induced pro-inflammatory response via toll-like receptor 4 signaling pathway in retinal ganglion cell line RGC-5

(2015) Jong-Jer Lee et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

RAGE siRNA-mediated gene silencing provides cardioprotection against ventricular arrhythmias in acute ischemia and reperfusion

(2015) Hyelim Park et al.   JOURNAL OF CONTROLLED RELEASE

PAMAM Dendrimers: Destined for Success or Doomed to Fail? Plain and Modified PAMAM Dendrimers in the Context of Biomedical Applications

(2015) Magdalena Labieniec-Watala et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Enhanced Cytoplasmic Delivery of RAGE siRNA Using Bioreducible Polyethylenimine-based Nanocarriers for Myocardial Gene Therapy

(2015) Min Jung Yang et al.   MACROMOLECULAR BIOSCIENCE

Autophagy-mediated HMGB1 release promotes gastric cancer cell survival via RAGE activation of extracellular signal-regulated kinases 1/2

(2015) QIU-YU ZHANG et al.   ONCOLOGY REPORTS

Receptor for advanced glycation end-products in neurodegenerative diseases

(2015) Judyta Juranek et al.   REVIEWS IN THE NEUROSCIENCES

Current perspectives on the health risks associated with the consumption of advanced glycation end products: recommendations for dietary management

(2015) Evanthia Diamanti-Kandarakis et al.   Diabetes Metabolic Syndrome and Obesity-Targets and Therapy

Tumor cell-produced matrix metalloproteinase 9 (MMP-9) drives malignant progression and metastasis of basal-like triple negative breast cancer

(2015) Christine Mehner et al.   Oncotarget

RAGE overexpression confers a metastatic phenotype to the WM115 human primary melanoma cell line

(2014) Varsha Meghnani et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Cardiac RNAi therapy using RAGE siRNA/deoxycholic acid-modified polyethylenimine complexes for myocardial infarction

(2014) Jueun Hong et al.   BIOMATERIALS

Effect of TTP488 in patients with mild to moderate Alzheimer’s disease

(2014) Aaron H Burstein et al.   BMC Neurology

RAGE Expression in Tumor-Associated Macrophages Promotes Angiogenesis in Glioma

(2014) X. Chen et al.   CANCER RESEARCH

Role of bone-marrow- and non-bone-marrow-derived receptor for advanced glycation end-products (RAGE) in a mouse model of diabetes-associated atherosclerosis

(2014) Christine Koulis et al.   CLINICAL SCIENCE

Role of AGEs-RAGE System in Cardiovascular Disease

(2014) Kei Fukami et al.   CURRENT PHARMACEUTICAL DESIGN

Pyrazole-5-carboxamides, novel inhibitors of receptor for advanced glycation end products (RAGE)

(2014) Young Taek Han et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Advanced Glycation End Products and Diabetic Complications

(2014) Varun Parkash Singh et al.   KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY

Anti-fibrotic effects of specific-siRNA targeting of the receptor for advanced glycation end products in a rat model of experimental hepatic fibrosis

(2014) XIAO-GANG CAI et al.   Molecular Medicine Reports

Cutaneous activation of rage in nonsystemic vasculitic and diabetic neuropathy

(2014) Can Ebru Bekircan-Kurt et al.   MUSCLE & NERVE

Clinical trial of an inhibitor of RAGE-A  interactions in Alzheimer disease

(2014) D. Galasko et al.   NEUROLOGY

Imaging RAGE expression in atherosclerotic plaques in hyperlipidemic pigs

(2014) Lynne L Johnson et al.   EJNMMI Research

Role of advanced glycation end products in cellular signaling

(2014) Christiane Ott et al.   Redox Biology

RAGE-binding S100A8/A9 promotes the migration and invasion of human breast cancer cells through actin polymerization and epithelial–mesenchymal transition

(2013) Chonggao Yin et al.   BREAST CANCER RESEARCH AND TREATMENT

Low molecular weight heparin suppresses receptor for advanced glycation end products-mediated expression of malignant phenotype in human fibrosarcoma cells

(2013) Akihiko Takeuchi et al.   CANCER SCIENCE

Structural insights into the oligomerization mode of the human receptor for advanced glycation end-products

(2013) Laure Yatime et al.   FEBS Journal

The many faces of HMGB1: molecular structure-functional activity in inflammation, apoptosis, and chemotaxis

(2013) Huan Yang et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Delivery materials for siRNA therapeutics

(2013) Rosemary Kanasty et al.   NATURE MATERIALS

Circulating levels of soluble receptor for advanced glycation end product are inversely associated with vascular calcification in patients on haemodialysis independent of S100A12 (EN-RAGE) levels

(2013) Hyung Soo Kim et al.   NEPHROLOGY

Imaging receptor for advanced glycation end product expression in mouse model of hind limb ischemia

(2013) Yared Tekabe et al.   EJNMMI Research

64Cu Core-Labeled Nanoparticles with High Specific Activity via Metal-Free Click Chemistry

(2012) Dexing Zeng et al.   ACS Nano

Antibody-Drug Conjugates in Cancer Therapy

(2012) Eric L. Sievers et al.   Annual Review of Medicine

Synthesis and structure–activity relationships of tri-substituted thiazoles as RAGE antagonists for the treatment of Alzheimer’s disease

(2012) Yun Suk Lee et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Pinocembrin protects against β-amyloid-induced toxicity in neurons through inhibiting receptor for advanced glycation end products (RAGE)-independent signaling pathways and regulating mitochondrion-mediated apoptosis

(2012) Rui Liu et al.   BMC Medicine

S100P-Derived RAGE Antagonistic Peptide Reduces Tumor Growth and Metastasis

(2012) T. Arumugam et al.   CLINICAL CANCER RESEARCH

Metformin Inhibits Advanced Glycation End Products (AGEs)-induced Growth and VEGF Expression in MCF-7 Breast Cancer Cells by Suppressing AGEs Receptor Expression via AMP-activated Protein Kinase

(2012) Y. Ishibashi et al.   HORMONE AND METABOLIC RESEARCH

A multimodal RAGE-specific inhibitor reduces amyloid β–mediated brain disorder in a mouse model of Alzheimer disease

(2012) Rashid Deane et al.   JOURNAL OF CLINICAL INVESTIGATION

Ligand-Based Design, Synthesis, and Biological Evaluation of 2-Aminopyrimidines, a Novel Series of Receptor for Advanced Glycation End Products (RAGE) Inhibitors

(2012) Young Taek Han et al.   JOURNAL OF MEDICINAL CHEMISTRY

Receptor for advanced glycation endproducts (RAGE) deficiency protects against MPTP toxicity

(2012) Peter Teismann et al.   NEUROBIOLOGY OF AGING

Copper-64 radiolabeling and biological evaluation of bifunctional chelators for radiopharmaceutical development

(2012) Ravindra A. De Silva et al.   NUCLEAR MEDICINE AND BIOLOGY

Induction of RAGE Shedding by Activation of G Protein-Coupled Receptors

(2012) Verena V. Metz et al.   PLoS One

Potential Clinical Utility of Advanced Glycation End Product Cross-Link Breakers in Age- and Diabetes-Associated Disorders

(2012) Sho-ichi Yamagishi   REJUVENATION RESEARCH

Applications for Preclinical PET/MRI

(2012) Martin S. Judenhofer et al.   SEMINARS IN NUCLEAR MEDICINE

Imaging of Receptors for Advanced Glycation End Products in Experimental Myocardial Ischemia and Reperfusion Injury

(2012) Yared Tekabe et al.   JACC-Cardiovascular Imaging

Fundamentals of PET and PET/CT imaging

(2011) Sandip Basu et al.   Annals of the New York Academy of Sciences

Immunohistochemical localization of receptor for advanced glycation end (RAGE) products in the R6/2 mouse model of Huntington's disease

(2011) Serenella Anzilotti et al.   BRAIN RESEARCH BULLETIN

Knockdown of RAGE expression inhibits colorectal cancer cell invasion and suppresses angiogenesis in vitro and in vivo

(2011) Huasheng Liang et al.   CANCER LETTERS

Advanced Glycation End Products Are Direct Modulators of  -Cell Function

(2011) M. T. Coughlan et al.   DIABETES

Effects of alagebrium, an advanced glycation endproduct breaker, on exercise tolerance and cardiac function in patients with chronic heart failure

(2011) Jasper W.L. Hartog et al.   EUROPEAN JOURNAL OF HEART FAILURE

S100B alters neuronal survival and dendrite extension via RAGE-mediated NF-κB signaling

(2011) Alejandro Villarreal et al.   JOURNAL OF NEUROCHEMISTRY

Targeted reduction of advanced glycation improves renal function in obesity

(2011) Brooke E. Harcourt et al.   KIDNEY INTERNATIONAL

Toll-like receptor signaling in amyotrophic lateral sclerosis spinal cord tissue

(2011) M. Casula et al.   NEUROSCIENCE

TIRAP, an Adaptor Protein for TLR2/4, Transduces a Signal from RAGE Phosphorylated upon Ligand Binding

(2011) Masakiyo Sakaguchi et al.   PLoS One

Advanced Glycation End Product Recognition by the Receptor for AGEs

(2011) Jing Xue et al.   STRUCTURE

RAGE: a single receptor fits multiple ligands

(2011) Günter Fritz   TRENDS IN BIOCHEMICAL SCIENCES

HMGB1 and RAGE in Inflammation and Cancer

(2010) Gary P. Sims et al.   Annual Review of Immunology

Matrix Metalloproteinases: Regulators of the Tumor Microenvironment

(2010) Kai Kessenbrock et al.   CELL

Activation of the ROCK1 Branch of the Transforming Growth Factor-β Pathway Contributes to RAGE-Dependent Acceleration of Atherosclerosis in Diabetic ApoE-Null Mice

(2010) De-xiu Bu et al.   CIRCULATION RESEARCH

Delayed intervention with AGE inhibitors attenuates the progression of diabetes-accelerated atherosclerosis in diabetic apolipoprotein E knockout mice

(2010) A. M. D. Watson et al.   DIABETOLOGIA

A review on the clinical uses of SPECT/CT

(2010) Giuliano Mariani et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Advanced glycation end-products induce vascular dysfunction via resistance to nitric oxide and suppression of endothelial nitric oxide synthase

(2010) Aino Soro-Paavonen et al.   JOURNAL OF HYPERTENSION

Noninvasive monitoring the biology of atherosclerotic plaque development with radiolabeled annexin V and matrix metalloproteinase inhibitor in spontaneous atherosclerotic mice

(2010) Yared Tekabe et al.   JOURNAL OF NUCLEAR CARDIOLOGY

Approaches to Multimodality Imaging of Angiogenesis

(2010) L. W. Dobrucki et al.   JOURNAL OF NUCLEAR MEDICINE

Advanced Glycation End Products in Foods and a Practical Guide to Their Reduction in the Diet

(2010) Jaime Uribarri et al.   JOURNAL OF THE AMERICAN DIETETIC ASSOCIATION

RAGE Modulates Hypoxia/Reoxygenation Injury in Adult Murine Cardiomyocytes via JNK and GSK-3β Signaling Pathways

(2010) Linshan Shang et al.   PLoS One

The receptor for advanced glycation end products (RAGE) sustains autophagy and limits apoptosis, promoting pancreatic tumor cell survival

(2009) R Kang et al.   CELL DEATH AND DIFFERENTIATION

S100B Interaction With the Receptor for Advanced Glycation End Products (RAGE)

(2009) J.N. Tsoporis et al.   CIRCULATION RESEARCH

Multimodality Cardiovascular Molecular Imaging, Part II

(2009) Matthias Nahrendorf et al.   Circulation-Cardiovascular Imaging

Phase I Clinical Studies of the Advanced Glycation End-product (AGE)-Breaker TRC4186

(2009) Kumar P. Chandra et al.   CLINICAL DRUG INVESTIGATION

RAGE-dependent signaling in microglia contributes to neuroinflammation, Aβ accumulation, and impaired learning/memory in a mouse model of Alzheimer’s disease

(2009) Fang Fang et al.   FASEB JOURNAL

TRC4186, a Novel AGE-breaker, Improves Diabetic Cardiomyopathy and Nephropathy in Ob-ZSF1 Model of Type 2 Diabetes

(2009) Deepa Joshi et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

A Novel Monoclonal Antibody for RAGE-Directed Imaging Identifies Accelerated Atherosclerosis in Diabetes

(2009) Y. Tekabe et al.   JOURNAL OF NUCLEAR MEDICINE

Clinical Cardiovascular Molecular Imaging

(2009) F. M. Bengel   JOURNAL OF NUCLEAR MEDICINE

RAGE (Receptor for Advanced Glycation Endproducts), RAGE Ligands, and their role in Cancer and Inflammation

(2009) Louis J Sparvero et al.   Journal of Translational Medicine

PET and SPECT in cardiovascular molecular imaging

(2009) Lawrence W. Dobrucki et al.   Nature Reviews Cardiology

Development of Receptor for Advanced Glycation End Products–Directed Imaging of Atherosclerotic Plaque in a Murine Model of Spontaneous Atherosclerosis

(2008) Yared Tekabe et al.   Circulation-Cardiovascular Imaging

Multimodality Cardiovascular Molecular Imaging, Part I

(2008) Albert J. Sinusas et al.   Circulation-Cardiovascular Imaging

RAGE and Modulation of Ischemic Injury in the Diabetic Myocardium

(2008) L. G. Bucciarelli et al.   DIABETES

Specific siRNA Targeting the Receptor for Advanced Glycation End Products Inhibits Experimental Hepatic Fibrosis in Rats

(2008) Jin-Rong Xia et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Structural Basis for Pattern Recognition by the Receptor for Advanced Glycation End Products (RAGE)

(2008) Jingjing Xie et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Receptor for Advanced Glycation End Products Is Subjected to Protein Ectodomain Shedding by Metalloproteinases

(2008) Ling Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Vascular and inflammatory stresses mediate atherosclerosis via RAGE and its ligands in apoE–/– mice

(2008) Evis Harja et al.   JOURNAL OF CLINICAL INVESTIGATION

Reversal of chaperone activity loss of glycated αA-crystallin by a crosslink breaker

(2008) Poppy Datta et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

V domain of RAGE interacts with AGEs on prostate carcinoma cells

(2008) Edith Uetz-von Allmen et al.   PROSTATE

Receptor for advanced glycation end products (RAGE) mediates neuronal differentiation and neurite outgrowth

(2007) Lingyan Wang et al.   JOURNAL OF NEUROSCIENCE RESEARCH