Identification of genomic alterations with clinical impact in canine splenic hemangiosarcoma

Analyses of canine cancer mutations and treatment outcomes using real-world clinico-genomics data of 2119 dogs

(2023) Kevin Wu et al.   npj Precision Oncology

Leveraging base-pair mammalian constraint to understand genetic variation and human disease

(2023) Patrick F. Sullivan et al.   SCIENCE

Histopathological Grading, Clinical Staging and CD 31 Expression of Canine Splenic Hemangiosarcoma

(2023) Ka-To Chu et al.   Veterinary Sciences

Ancestry-inclusive dog genomics challenges popular breed stereotypes

(2022) Kathleen Morrill et al.   SCIENCE

Genomic landscapes of canine splenic angiosarcoma (hemangiosarcoma) contain extensive heterogeneity within and between patients

(2022) Shukmei Wong et al.   PLoS One

The impact of rare germline variants on human somatic mutation processes

(2022) Mischan Vali-Pour et al.   Nature Communications

Pilot safety evaluation of doxorubicin chemotherapy combined with non-specific immunotherapy (Immunocidin®) for canine splenic hemangiosarcoma

(2022) Margaret L. Musser et al.   PLoS One

Genomically Complex Human Angiosarcoma and Canine Hemangiosarcoma Establish Convergent Angiogenic Transcriptional Programs Driven by Novel Gene Fusions

(2021) Jong Hyuk Kim et al.   MOLECULAR CANCER RESEARCH

Combined VEGFR and MAPK pathway inhibition in angiosarcoma

(2021) Michael J. Wagner et al.   Scientific Reports

Comparison of the oncogenomic landscape of canine and feline hemangiosarcoma shows novel parallels with human angiosarcoma

(2021) Kim Wong et al.   Disease Models & Mechanisms

Adjuvant carboplatin for treatment of splenic hemangiosarcoma in dogs: Retrospective evaluation of 18 cases (2011‐2016) and comparison with doxorubicin‐based chemotherapy

(2021) Erica A. Faulhaber et al.   JOURNAL OF VETERINARY INTERNAL MEDICINE

Canine and feline haemangiosarcoma

(2021) Maureen A. Griffin et al.   VETERINARY RECORD

Canine tumor mutational burden is correlated with TP53 mutation across tumor types and breeds

(2021) Burair A. Alsaihati et al.   Nature Communications

Investigation of Prognostic Value of Claudin-5, PSMA, and Ki67 Expression in Canine Splenic Hemangiosarcoma

(2021) Juliana Moreira Rozolen et al.   Animals

Genome-Wide Analyses for Osteosarcoma in Leonberger Dogs Reveal the CDKN2A/B Gene Locus as a Major Risk Locus

(2021) Anna Letko et al.   Genes

The Angiosarcoma Project: enabling genomic and clinical discoveries in a rare cancer through patient-partnered research

(2020) Corrie A. Painter et al.   NATURE MEDICINE

Refining the “double two‐thirds” rule: Genotype‐based breed grouping and clinical presentation help predict the diagnosis of canine splenic mass lesions in 288 dogs

(2020) Owen Davies et al.   Veterinary and Comparative Oncology

Molecular subtypes in canine hemangiosarcoma reveal similarities with human angiosarcoma

(2020) Guannan Wang et al.   PLoS One

Evaluation of intrinsic and extrinsic risk factors for dog visceral hemangiosarcoma: A retrospective case-control study register-based in Lazio region, Italy

(2020) Azzurra Carnio et al.   PREVENTIVE VETERINARY MEDICINE

Loss of Setd2 promotes Kras-induced acinar-to-ductal metaplasia and epithelia–mesenchymal transition during pancreatic carcinogenesis

(2019) Ningning Niu et al.   GUT

Adjuvant anthracycline‐based vs metronomic chemotherapy vs no medical treatment for dogs with metastatic splenic hemangiosarcoma: A multi‐institutional retrospective study of the Italian Society of Veterinary Oncology

(2019) Laura Marconato et al.   Veterinary and Comparative Oncology

Whole genome sequencing of canids reveals genomic regions under selection and variants influencing morphology

(2019) Jocelyn Plassais et al.   Nature Communications

Comparative genomics reveals shared mutational landscape in canine hemangiosarcoma and human angiosarcoma

(2019) Kate Megquier et al.   MOLECULAR CANCER RESEARCH

SETD2 indicates favourable prognosis in gastric cancer and suppresses cancer cell proliferation, migration, and invasion

(2018) Ziyi Chen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

SETD2 is recurrently mutated in whole-exome sequenced canine osteosarcoma.

(2018) Sharadha Sakthikumar et al.   CANCER RESEARCH

Maftools: efficient and comprehensive analysis of somatic variants in cancer

(2018) Anand Mayakonda et al.   GENOME RESEARCH

COSMIC: the Catalogue Of Somatic Mutations In Cancer

(2018) John G Tate et al.   NUCLEIC ACIDS RESEARCH

Evaluation of clinical and histologic factors associated with survival time in dogs with stage II splenic hemangiosarcoma treated by splenectomy and adjuvant chemotherapy: 30 cases (2011–2014)

(2017) Antony S. Moore et al.   JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION

Actionable mutations in canine hemangiosarcoma

(2017) Guannan Wang et al.   PLoS One

Lollipops in the Clinic: Information Dense Mutation Plots for Precision Medicine

(2016) Jeremy J. Jay et al.   PLoS One

Survival time of dogs with splenic hemangiosarcoma treated by splenectomy with or without adjuvant chemotherapy: 208 cases (2001–2012)

(2015) Kristin M. Wendelburg et al.   JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION

Genome-wide Association Study Identifies Shared Risk Loci Common to Two Malignancies in Golden Retrievers

(2015) Noriko Tonomura et al.   PLoS Genetics

An Improved Canine Genome and a Comprehensive Catalogue of Coding Genes and Non-Coding Transcripts

(2014) Marc P. Hoeppner et al.   PLoS One

Loss of p53 induces cell proliferation via Ras-independent activation of the Raf/Mek/Erk signaling pathway

(2014) Matthias Drosten et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hemangiosarcoma and its cancer stem cell subpopulation are effectively killed by a toxin targeted through epidermal growth factor and urokinase receptors

(2013) Jill T. Schappa et al.   INTERNATIONAL JOURNAL OF CANCER

Epidemiological, Clinical and Pathological Features of Primary Cardiac Hemangiosarcoma in Dogs: A Review of 51 Cases

(2013) Shinya YAMAMOTO et al.   JOURNAL OF VETERINARY MEDICAL SCIENCE

Combined targeting of MEK and PI3K/mTOR effector pathways is necessary to effectively inhibit NRAS mutant melanoma in vitro and in vivo

(2013) C. Posch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genome-wide analyses implicate 33 loci in heritable dog osteosarcoma, including regulatory variants near CDKN2A/B

(2013) Elinor K Karlsson et al.   GENOME BIOLOGY

The class I PI3K/Akt pathway is critical for cancer cell survival in dogs and offers an opportunity for therapeutic intervention

(2012) Yu-Ting Chen et al.   BMC Veterinary Research

Alterations of the p53 and PIK3CA/AKT/mTOR pathways in angiosarcomas

(2012) Antoine Italiano et al.   CANCER

VarScan 2: Somatic mutation and copy number alteration discovery in cancer by exome sequencing

(2012) D. C. Koboldt et al.   GENOME RESEARCH

The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1.

(2012) Ethan Cerami et al.   Cancer Discovery

BamTools: a C++ API and toolkit for analyzing and managing BAM files

(2011) D. W. Barnett et al.   BIOINFORMATICS

A statistical framework for SNP calling, mutation discovery, association mapping and population genetical parameter estimation from sequencing data

(2011) H. Li   BIOINFORMATICS

Angiosarcoma

(2010) Guy Lahat et al.   ANNALS OF SURGERY

Detection of nonneutral substitution rates on mammalian phylogenies

(2009) K. S. Pollard et al.   GENOME RESEARCH

Gene Expression Profiles of Sporadic Canine Hemangiosarcoma Are Uniquely Associated with Breed

(2009) Beth A. Tamburini et al.   PLoS One

Single-Nucleotide-Polymorphism-Based Association Mapping of Dog Stereotypes

(2008) Paul Jones et al.   GENETICS