Ferroptosis of immune cells in the tumor microenvironment

Prospects for Anti-Tumor Mechanism and Potential Clinical Application Based on Glutathione Peroxidase 4 Mediated Ferroptosis

(2023) Mingliang Chen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

LPCAT3 Inhibitors Remodel the Polyunsaturated Phospholipid Content of Human Cells and Protect from Ferroptosis

(2022) Alex Reed et al.   ACS Chemical Biology

Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications

(2022) Brent R. Stockwell   CELL

Cancer cells dying from ferroptosis impede dendritic cell-mediated anti-tumor immunity

(2022) Bartosz Wiernicki et al.   Nature Communications

PKCβII–ACSL4 pathway mediating ferroptosis execution and anti‐tumor immunity

(2022) Guang Lei et al.   Cancer Communications

p53 Promotes Ferroptosis in Macrophages Treated with Fe3O4 Nanoparticles

(2022) Cong Wu et al.   ACS Applied Materials & Interfaces

Ferroptosis of tumour neutrophils causes immune suppression in cancer

(2022) Rina Kim et al.   NATURE

Prognostic prediction and immune infiltration analysis based on ferroptosis and EMT state in hepatocellular carcinoma

(2022) Zhaochen Liu et al.   Frontiers in Immunology

Oxygenated phosphatidylethanolamine navigates phagocytosis of ferroptotic cells by interacting with TLR2

(2021) Xiang Luo et al.   CELL DEATH AND DIFFERENTIATION

CD36-mediated ferroptosis dampens intratumoral CD8+ T cell effector function and impairs their antitumor ability

(2021) Xingzhe Ma et al.   Cell Metabolism

Phospholipase iPLA2β averts ferroptosis by eliminating a redox lipid death signal

(2021) Wan-Yang Sun et al.   Nature Chemical Biology

Anti-ferroptotic mechanism of IL4i1-mediated amino acid metabolism

(2021) Leonie Zeitler et al.   eLife

Metabolic flexibility determines human NK cell functional fate in the tumor microenvironment

(2021) Sophie M. Poznanski et al.   Cell Metabolism

DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer

(2021) Chao Mao et al.   NATURE

A mitochondrial gatekeeper that helps cells escape death by ferroptosis

(2021) Javier Garcia-Bermudez et al.   NATURE

Ferroptotic cell death triggered by conjugated linolenic acids is mediated by ACSL1

(2021) Alexander Beatty et al.   Nature Communications

Uptake of oxidized lipids by the scavenger receptor CD36 promotes lipid peroxidation and dysfunction in CD8+ T cells in tumors

(2021) Shihao Xu et al.   IMMUNITY

Sorafenib fails to trigger ferroptosis across a wide range of cancer cell lines

(2021) Jiashuo Zheng et al.   Cell Death & Disease

The glutathione peroxidase Gpx4 prevents lipid peroxidation and ferroptosis to sustain Treg cell activation and suppression of antitumor immunity

(2021) Chengxian Xu et al.   Cell Reports

Ferroptosis: a cell death connecting oxidative stress, inflammation and cardiovascular diseases

(2021) Yi Yu et al.   Cell Death Discovery

PPARG-mediated ferroptosis in dendritic cells limits antitumor immunity

(2021) Leng Han et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Hepcidin Promoted Ferroptosis through Iron Metabolism which Is Associated with DMT1 Signaling Activation in Early Brain Injury following Subarachnoid Hemorrhage

(2021) Hongxia Zhang et al.   Oxidative Medicine and Cellular Longevity

Phospholipase iPLA2β acts as a guardian against ferroptosis

(2021) Chao Mao et al.   Cancer Communications

Redox lipid reprogramming commands susceptibility of macrophages and microglia to ferroptotic death

(2020) Alexandr A. Kapralov et al.   Nature Chemical Biology

Cytochrome P450 oxidoreductase contributes to phospholipid peroxidation in ferroptosis

(2020) Yilong Zou et al.   Nature Chemical Biology

Ferroptosis: past, present and future

(2020) Jie Li et al.   Cell Death & Disease

Transferrin Receptor Is a Specific Ferroptosis Marker

(2020) Huizhong Feng et al.   Cell Reports

Metabolic determinants of cancer cell sensitivity to canonical ferroptosis inducers

(2020) Mariluz Soula et al.   Nature Chemical Biology

Oxidative Damage and Antioxidant Defense in Ferroptosis

(2020) Feimei Kuang et al.   Frontiers in Cell and Developmental Biology

Non-canonical Glutamate-Cysteine Ligase Activity Protects against Ferroptosis

(2020) Yun Pyo Kang et al.   Cell Metabolism

Ferroptosis: molecular mechanisms and health implications

(2020) Daolin Tang et al.   CELL RESEARCH

Distinct Populations of Immune-Suppressive Macrophages Differentiate from Monocytic Myeloid-Derived Suppressor Cells in Cancer

(2020) Taekyoung Kwak et al.   Cell Reports

Pharmacologic Screening Identifies Metabolic Vulnerabilities of CD8+ T Cells

(2020) Jefte M. Drijvers et al.   Cancer Immunology Research

Eicosanoids in Cancer: New Roles in Immunoregulation

(2020) Amber M. Johnson et al.   Frontiers in Pharmacology

CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy

(2019) Weimin Wang et al.   NATURE

Fatty acid transport protein 2 reprograms neutrophils in cancer

(2019) Filippo Veglia et al.   NATURE

Targeting Tumor-Associated Macrophages in Cancer

(2019) Paulina Pathria et al.   TRENDS IN IMMUNOLOGY

A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis

(2019) Yilong Zou et al.   Nature Communications

FSP1 is a glutathione-independent ferroptosis suppressor

(2019) Sebastian Doll et al.   NATURE

The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis

(2019) Kirill Bersuker et al.   NATURE

B1 and Marginal Zone B Cells but Not Follicular B2 Cells Require Gpx4 to Prevent Lipid Peroxidation and Ferroptosis

(2019) Jonathan Muri et al.   Cell Reports

Triggered ferroptotic polymer micelles for reversing multidrug resistance to chemotherapy

(2019) Min Gao et al.   BIOMATERIALS

Single-cell transcriptome analysis reveals tumor immune microenvironment heterogenicity and granulocytes enrichment in colorectal cancer liver metastases

(2019) Yunbin Zhang et al.   CANCER LETTERS

GTP Cyclohydrolase 1/Tetrahydrobiopterin Counteract Ferroptosis through Lipid Remodeling

(2019) Vanessa A. N. Kraft et al.   ACS Central Science

Combination Therapy with Sulfasalazine and Valproic Acid Promotes Human Glioblastoma Cell Death Through Imbalance of the Intracellular Oxidative Response

(2018) Carlos Gustavo Garcia et al.   MOLECULAR NEUROBIOLOGY

Resolving the Role of Lipoxygenases in the Initiation and Execution of Ferroptosis

(2018) Ron Shah et al.   ACS Central Science

Emerging role of 12/15-Lipoxygenase (ALOX15) in human pathologies

(2018) Nikhlesh K. Singh et al.   PROGRESS IN LIPID RESEARCH

Enhanced Cisplatin Chemotherapy by Iron Oxide Nanocarrier-Mediated Generation of Highly Toxic Reactive Oxygen Species

(2017) Ping’an Ma et al.   NANO LETTERS

Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway

(2017) Vasanthi S. Viswanathan et al.   NATURE

Lipid bodies containing oxidatively truncated lipids block antigen cross-presentation by dendritic cells in cancer

(2017) Filippo Veglia et al.   Nature Communications

On the Mechanism of Cytoprotection by Ferrostatin-1 and Liproxstatin-1 and the Role of Lipid Peroxidation in Ferroptotic Cell Death

(2017) Omkar Zilka et al.   ACS Central Science

Five-Membered Ring Peroxide Selectively Initiates Ferroptosis in Cancer Cells

(2016) Rachel P. Abrams et al.   ACS Chemical Biology

Autophagy promotes ferroptosis by degradation of ferritin

(2016) Wen Hou et al.   Autophagy

Ferroptosis is an autophagic cell death process

(2016) Minghui Gao et al.   CELL RESEARCH

Selective Targeting of Myeloid-Derived Suppressor Cells in Cancer Patients Using DS-8273a, an Agonistic TRAIL-R2 Antibody

(2016) George A. Dominguez et al.   CLINICAL CANCER RESEARCH

ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

(2016) Sebastian Doll et al.   Nature Chemical Biology

Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis

(2016) Wan Seok Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human Haploid Cell Genetics Reveals Roles for Lipid Metabolism Genes in Nonapoptotic Cell Death

(2015) Scott J. Dixon et al.   ACS Chemical Biology

The retinoblastoma (Rb) protein regulates ferroptosis induced by sorafenib in human hepatocellular carcinoma cells

(2015) Christophe Louandre et al.   CANCER LETTERS

Activation of the p62-Keap1-NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells

(2015) Xiaofang Sun et al.   HEPATOLOGY

12/15-lipoxygenase–mediated enzymatic lipid oxidation regulates DC maturation and function

(2015) Tobias Rothe et al.   JOURNAL OF CLINICAL INVESTIGATION

Glutaminolysis and Transferrin Regulate Ferroptosis

(2015) Minghui Gao et al.   MOLECULAR CELL

Regulation of Ferroptotic Cancer Cell Death by GPX4

(2014) Wan Seok Yang et al.   CELL

Tumor-Associated Macrophages: From Mechanisms to Therapy

(2014) Roy Noy et al.   IMMUNITY

Oxidized Lipids Block Antigen Cross-Presentation by Dendritic Cells in Cancer

(2014) W. Cao et al.   JOURNAL OF IMMUNOLOGY

Pharmacological inhibition of cystine–glutamate exchange induces endoplasmic reticulum stress and ferroptosis

(2014) Scott J Dixon et al.   eLife

The Multifaceted Functions of Neutrophils

(2013) Tanya N. Mayadas et al.   Annual Review of Pathology-Mechanisms of Disease

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Mechanisms of Oxidative Glutamate Toxicity: The Glutamate/Cystine Antiporter System xc¯ as a Neuroprotective Drug Target

(2012) Philipp Albrecht et al.   CNS & Neurological Disorders-Drug Targets

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Lipid accumulation and dendritic cell dysfunction in cancer

(2010) Donna L Herber et al.   NATURE MEDICINE

Development of Monocytes, Macrophages, and Dendritic Cells

(2010) F. Geissmann et al.   SCIENCE

Early termination of ISRCTN45828668, a phase 1/2 prospective, randomized study of Sulfasalazine for the treatment of progressing malignant gliomas in adults

(2009) Pierre A Robe et al.   BMC CANCER

Synthetic Lethal Screening Identifies Compounds Activating Iron-Dependent, Nonapoptotic Cell Death in Oncogenic-RAS-Harboring Cancer Cells

(2008) Wan Seok Yang et al.   CHEMISTRY & BIOLOGY

NK cells and cancer immunosurveillance

(2008) I Waldhauer et al.   ONCOGENE