Prospects for Anti-Tumor Mechanism and Potential Clinical Application Based on Glutathione Peroxidase 4 Mediated Ferroptosis

Bufotalin induces ferroptosis in non-small cell lung cancer cells by facilitating the ubiquitination and degradation of GPX4

(2022) Wen Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Molecular mechanisms of ferroptosis and its role in prostate cancer therapy

(2022) Shaokun Wang et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Ferroptosis: A Potential Therapeutic Target in Acute Kidney Injury

(2022) Keiko Hosohata et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

System Xc−/GSH/GPX4 axis: An important antioxidant system for the ferroptosis in drug-resistant solid tumor therapy

(2022) Feng-Jiao Li et al.   Frontiers in Pharmacology

The Role of Programmed Necrosis in Colorectal Cancer

(2022) Yu-Qiang Yu et al.   Cancers

Ferroptosis: mechanisms, biology and role in disease

(2021) Xuejun Jiang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Global Research Trends of Ferroptosis: A Rapidly Evolving Field With Enormous Potential

(2021) Haiyang Wu et al.   Frontiers in Cell and Developmental Biology

Insight into the Double-Edged Role of Ferroptosis in Disease

(2021) Lei Zhang et al.   Biomolecules

Natural medicinal ingredients induce tumor ferroptosis and related mechanisms

(2021) Zixue XUAN et al.   Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences

The role of ferroptosis in ionizing radiation-induced cell death and tumor suppression

(2020) Guang Lei et al.   CELL RESEARCH

Directly targeting glutathione peroxidase 4 may be more effective than disrupting glutathione on ferroptosis-based cancer therapy

(2020) Yunpeng Wei et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Lipid peroxidation and ferroptosis: The role of GSH and GPx4

(2020) Fulvio Ursini et al.   FREE RADICAL BIOLOGY AND MEDICINE

Ferroptosis and Cancer: Mitochondria Meet the “Iron Maiden” Cell Death

(2020) Anna Martina Battaglia et al.   Cells

Mitochondria-dependent ferroptosis plays a pivotal role in doxorubicin cardiotoxicity

(2020) Tomonori Tadokoro et al.   JCI Insight

CircIL4R facilitates the tumorigenesis and inhibits ferroptosis in hepatocellular carcinoma by regulating the miR‐541‐3p/GPX4 axis

(2020) Qinhong Xu et al.   CELL BIOLOGY INTERNATIONAL

Ferroptosis: molecular mechanisms and health implications

(2020) Daolin Tang et al.   CELL RESEARCH

GPX4 at the Crossroads of Lipid Homeostasis and Ferroptosis

(2019) Giovanni C. Forcina et al.   PROTEOMICS

Targeting Ferroptosis to Iron Out Cancer

(2019) Behrouz Hassannia et al.   CANCER CELL

Selenium Drives a Transcriptional Adaptive Program to Block Ferroptosis and Treat Stroke

(2019) Ishraq Alim et al.   CELL

Inhibition of tumor propellant glutathione peroxidase 4 induces ferroptosis in cancer cells and enhances anticancer effect of cisplatin

(2019) Xuefei Zhang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Recent Progress in Ferroptosis Inducers for Cancer Therapy

(2019) Chen Liang et al.   ADVANCED MATERIALS

A Compendium of Genetic Modifiers of Mitochondrial Dysfunction Reveals Intra-organelle Buffering

(2019) Tsz-Leung To et al.   CELL

FSP1 is a glutathione-independent ferroptosis suppressor

(2019) Sebastian Doll et al.   NATURE

Regulatory Phenomena in the Glutathione Peroxidase Superfamily

(2019) Regina Brigelius-Flohé et al.   ANTIOXIDANTS & REDOX SIGNALING

Lysosome-associated membrane protein-2 deficiency increases the risk of reactive oxygen species-induced ferroptosis in retinal pigment epithelial cells

(2019) Jong-Jer Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

GPx4, Lipid Peroxidation, and Cell Death: Discoveries, Rediscoveries, and Open Issues

(2018) Matilde Maiorino et al.   ANTIOXIDANTS & REDOX SIGNALING

Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis

(2018) Irina Ingold et al.   CELL

Selenium and GPX4, a vital symbiosis

(2018) José Pedro Friedmann Angeli et al.   FREE RADICAL BIOLOGY AND MEDICINE

FINO2 initiates ferroptosis through GPX4 inactivation and iron oxidation

(2018) Michael M. Gaschler et al.   Nature Chemical Biology

Unsolved mysteries: How does lipid peroxidation cause ferroptosis?

(2018) Huizhong Feng et al.   PLOS BIOLOGY

Role of GPX4 in ferroptosis and its pharmacological implication

(2018) Tobias M. Seibt et al.   FREE RADICAL BIOLOGY AND MEDICINE

Selenium-sensitive miRNA-181a-5p targeting SBP2 regulates selenoproteins expression in cartilage

(2018) Zixin Min et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Iron and ferroptosis: A still ill-defined liaison

(2017) Sebastian Doll et al.   IUBMB LIFE

Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition

(2017) Matthew J. Hangauer et al.   NATURE

Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway

(2017) Vasanthi S. Viswanathan et al.   NATURE

Five-Membered Ring Peroxide Selectively Initiates Ferroptosis in Cancer Cells

(2016) Rachel P. Abrams et al.   ACS Chemical Biology

Ferroptosis, a new form of cell death, and its relationships with tumourous diseases

(2016) Haitao Yu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis

(2016) Kenichi Shimada et al.   Nature Chemical Biology

The cellular origins of drug resistance in cancer

(2016) Geoffrey R Oxnard   NATURE MEDICINE

Tumor cells can follow distinct evolutionary paths to become resistant to epidermal growth factor receptor inhibition

(2016) Aaron N Hata et al.   NATURE MEDICINE

Ferroptosis: Death by Lipid Peroxidation

(2016) Wan Seok Yang et al.   TRENDS IN CELL BIOLOGY

Selenite inhibits glutamine metabolism and induces apoptosis by regulating GLS1 protein degradation via APC/C-CDH1 pathway in colorectal cancer cells

(2016) Junzhang Zhao et al.   Oncotarget

Selenium compounds as therapeutic agents in cancer

(2015) Aristi P. Fernandes et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Cystathionine Is a Novel Substrate of Cystine/Glutamate Transporter

(2015) Sho Kobayashi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selenium and Human Health: Witnessing a Copernican Revolution?

(2015) Ewa Jablonska et al.   JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART C-ENVIRONMENTAL CARCINOGENESIS & ECOTOXICOLOGY REVIEWS

Selenite-Induced Toxicity in Cancer Cells Is Mediated by Metabolic Generation of Endogenous Selenium Nanoparticles

(2015) Peng Bao et al.   JOURNAL OF PROTEOME RESEARCH

Absence of Glutathione Peroxidase 4 Affects Tumor Angiogenesis through Increased 12/15-Lipoxygenase Activity

(2015) Manuela Schneider et al.   NEOPLASIA

Plasma Tocopherols and Risk of Prostate Cancer in the Selenium and Vitamin E Cancer Prevention Trial (SELECT)

(2014) D. Albanes et al.   Cancer Prevention Research

Regulation of Ferroptotic Cancer Cell Death by GPX4

(2014) Wan Seok Yang et al.   CELL

Selective up-regulation of human selenoproteins in response to oxidative stress

(2014) Touat-Hamici Zahia et al.   FREE RADICAL BIOLOGY AND MEDICINE

Characterization and structural analysis of human selenium-dependent glutathione peroxidase 4 mutant expressed in Escherichia coli

(2014) Yang Yu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mutations in the enzyme glutathione peroxidase 4 cause Sedaghatian-type spondylometaphyseal dysplasia

(2014) Amanda C Smith et al.   JOURNAL OF MEDICAL GENETICS

Drug resistance to targeted therapies: Déjà vu all over again

(2014) Floris H. Groenendijk et al.   Molecular Oncology

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

(2014) Jose Pedro Friedmann Angeli et al.   NATURE CELL BIOLOGY

The Effect of Selenium Therapy on Mortality in Patients With Sepsis Syndrome

(2013) Xavier Forceville   CRITICAL CARE MEDICINE

Glutathione synthesis

(2012) Shelly C. Lu   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Glutathione peroxidases

(2012) Regina Brigelius-Flohé et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Selenium and human health

(2012) Margaret P Rayman   LANCET

The unfolded protein response: controlling cell fate decisions under ER stress and beyond

(2012) Claudio Hetz   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Toxicology and pharmacology of selenium: emphasis on synthetic organoselenium compounds

(2011) Cristina W. Nogueira et al.   ARCHIVES OF TOXICOLOGY

Development of small-molecule probes that selectively kill cells induced to express mutant RAS

(2011) Michel Weïwer et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Cysteine mutant of mammalian GPx4 rescues cell death induced by disruption of the wild-type selenoenzyme

(2011) Alexander M. Mannes et al.   FASEB JOURNAL

Vitamin E and the Risk of Prostate Cancer

(2011) Eric A. Klein et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

A Comparison of Thiol Peroxidase Mechanisms

(2010) Leopold Flohé et al.   ANTIOXIDANTS & REDOX SIGNALING

A Chromatin-Mediated Reversible Drug-Tolerant State in Cancer Cell Subpopulations

(2010) Sreenath V. Sharma et al.   CELL

Targeted insertion of cysteine by decoding UGA codons with mammalian selenocysteine machinery

(2010) X.-M. Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Selenium and Selenoproteins in Health and Disease

(2009) Laura V. Papp et al.   ANTIOXIDANTS & REDOX SIGNALING

The selenium to selenoprotein pathway in eukaryotes: More molecular partners than anticipated

(2009) Christine Allmang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Selenium and Vitamin E Supplementation for Cancer Prevention

(2009) Margaret P. Rayman   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Synthetic Lethal Screening Identifies Compounds Activating Iron-Dependent, Nonapoptotic Cell Death in Oncogenic-RAS-Harboring Cancer Cells

(2008) Wan Seok Yang et al.   CHEMISTRY & BIOLOGY

Translational regulation of glutathione peroxidase 4 expression through guanine-rich sequence-binding factor 1 is essential for embryonic brain development

(2008) C. Ufer et al.   GENES & DEVELOPMENT

Effect of Selenium and Vitamin E on Risk of Prostate Cancer and Other Cancers

(2008) Scott M. Lippman et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION