CXCR2 chemokine receptor – a master regulator in cancer and physiology
Published 2023 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
CXCR2 chemokine receptor – a master regulator in cancer and physiology
Authors
Keywords
-
Journal
TRENDS IN MOLECULAR MEDICINE
Volume -, Issue -, Pages -
Publisher
Elsevier BV
Online
2023-10-21
DOI
10.1016/j.molmed.2023.09.003
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- A phase I/II study of the CXCR2 inhibitor, AZD5069, in combination with durvalumab, in patients (pts) with advanced hepatocellular carcinoma (HCC).
- (2023) T.R. Jeffry Evans et al. JOURNAL OF CLINICAL ONCOLOGY
- Expanding role of CXCR2 and therapeutic potential of CXCR2 antagonists in inflammatory diseases and cancers
- (2023) Yishi Xie et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- CXCR2 expression during melanoma tumorigenesis controls transcriptional programs that facilitate tumor growth
- (2023) J. Yang et al. Molecular Cancer
- Platelet-derived chemokines promote skeletal muscle regeneration by guiding neutrophil recruitment to injured muscles
- (2023) Flavia A. Graca et al. Nature Communications
- Cell-Autonomous Cxcl1 Sustains Tolerogenic Circuitries and Stromal Inflammation via Neutrophil-Derived TNF in Pancreatic Cancer
- (2023) Anna Bianchi et al. Cancer Discovery
- Driver Mutations Dictate the Immunologic Landscape and Response to Checkpoint Immunotherapy of Glioblastoma
- (2023) Alan T. Yeo et al. Cancer Immunology Research
- Post hoc analysis of a randomized, double-blind, prospective trial evaluating a CXCR1/2 inhibitor in new-onset type 1 diabetes: endo-metabolic features at baseline identify a subgroup of responders
- (2023) Valeria Sordi et al. Frontiers in Endocrinology
- Aortic valve calcification is promoted by interleukin-8 and restricted through antagonizing CXC motif chemokine receptor 2
- (2023) Kawthar Dhayni et al. CARDIOVASCULAR RESEARCH
- Neutrophil aging exacerbates high fat diet induced metabolic alterations
- (2023) Andrea Baragetti et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- Ladarixin, an inhibitor of IL ‐8 receptors CXCR1 and CXCR2 , in new‐onset type 1 diabetes: a multicenter, randomized, double‐blind, placebo‐controlled trial
- (2022) Lorenzo Piemonti et al. DIABETES OBESITY & METABOLISM
- Targeting myeloid derived suppressor cells reverts immune suppression and sensitizes BRAF-mutant papillary thyroid cancer to MAPK inhibitors
- (2022) Peitao Zhang et al. Nature Communications
- Murine bone marrow macrophages and human monocytes do not express atypical chemokine receptor 1
- (2022) Antal Rot et al. Cell Stem Cell
- Targeting HIC1/TGF-β axis-shaped prostate cancer microenvironment restrains its progression
- (2022) Tianqi Wu et al. Cell Death & Disease
- KDM6A Loss Recruits Tumor-Associated Neutrophils and Promotes Neutrophil Extracellular Trap Formation in Pancreatic Cancer
- (2022) Jing Yang et al. CANCER RESEARCH
- CXCR2 intrinsically drives the maturation and function of neutrophils in mice
- (2022) Pauline Delobel et al. Frontiers in Immunology
- Disease modification and symptom relief in osteoarthritis using a mutated GCP ‐2/ CXCL6 chemokine
- (2022) Sara Caxaria et al. EMBO Molecular Medicine
- ARID1A loss induces polymorphonuclear myeloid-derived suppressor cell chemotaxis and promotes prostate cancer progression
- (2022) Ni Li et al. Nature Communications
- Transcriptional reprogramming of infiltrating neutrophils drives lung disease in severe COVID-19 despite low viral load
- (2022) Devon J. Eddins et al. Blood Advances
- Hyperactive immature state and differential CXCR2 expression of neutrophils in severe COVID-19
- (2022) Christopher M Rice et al. Life Science Alliance
- Structural Basis of a Chemokine Heterodimer Binding to Glycosaminoglycans
- (2021) Krishna Mohan Sepuru et al. BIOCHEMICAL JOURNAL
- Type I collagen deletion in αSMA+ myofibroblasts augments immune suppression and accelerates progression of pancreatic cancer
- (2021) Yang Chen et al. CANCER CELL
- Astrocytes lure CXCR2-expressing CD4+ T cells to gray matter via TAK1-mediated chemokine production in a mouse model of multiple sclerosis
- (2021) Yee Ming Khaw et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Blocking Migration of Polymorphonuclear Myeloid-Derived Suppressor Cells Inhibits Mouse Melanoma Progression
- (2021) Christopher Groth et al. Cancers
- Differential Interleukin‐8 thresholds for chemotaxis and netosis in human neutrophils
- (2021) Alvaro Teijeira et al. EUROPEAN JOURNAL OF IMMUNOLOGY
- Targeting CXCR2 inhibits the progression of lung cancer and promotes therapeutic effect of cisplatin
- (2021) Yuan Cheng et al. Molecular Cancer
- CXCR2 Levels Correlate with Immune Infiltration and a Better Prognosis of Triple-Negative Breast Cancers
- (2021) Florence Boissière-Michot et al. Cancers
- Latest update on chemokine receptors as therapeutic targets
- (2021) Wing Yee Lai et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- Integrated analysis of multimodal single-cell data
- (2021) Yuhan Hao et al. CELL
- Combined Inhibition of SHP2 and CXCR1/2 Promotes Anti-Tumor T Cell Response in NSCLC
- (2021) Kwan Ho Tang et al. Cancer Discovery
- Pivotal Role for Cxcr2 in Regulating Tumor-Associated Neutrophil in Breast Cancer
- (2021) Colin Timaxian et al. Cancers
- The relationship between cytokine and neutrophil gene network distinguishes SARS-CoV-2–infected patients by sex and age
- (2021) Paula P. Freire et al. JCI Insight
- Targeting CXCR1/2 Does Not Improve Insulin Secretion After Pancreatic Islet Transplantation: A Phase 3, Double-Blind, Randomized, Placebo-Controlled Trial in Type 1 Diabetes
- (2020) Paola Maffi et al. DIABETES CARE
- Neutrophil-selective deletion of Cxcr2 protects against CNS neurodegeneration in a mouse model of multiple sclerosis
- (2020) Yee Ming Khaw et al. Journal of Neuroinflammation
- Epigenetic therapy inhibits metastases by disrupting premetastatic niches
- (2020) Zhihao Lu et al. NATURE
- C-X-C motif chemokine receptor type 2 correlates with higher disease stages and predicts worse prognosis, and its downregulation enhances chemotherapy sensitivity in triple-negative breast cancer
- (2020) Huimin Chu et al. Translational Cancer Research
- CXCR1 and CXCR2 Chemokine Receptor Agonists Produced by Tumors Induce Neutrophil Extracellular Traps that Interfere with Immune Cytotoxicity
- (2020) Álvaro Teijeira et al. IMMUNITY
- Development and Validation of a Clinical Risk Score to Predict the Occurrence of Critical Illness in Hospitalized Patients With COVID-19
- (2020) Wenhua Liang et al. JAMA Internal Medicine
- Targeting Chemokine—Glycosaminoglycan Interactions to Inhibit Inflammation
- (2020) Helena Crijns et al. Frontiers in Immunology
- Structural Insights Into How Proteoglycans Determine Chemokine-CXCR1/CXCR2 Interactions: Progress and Challenges
- (2020) Krishna Rajarathnam et al. Frontiers in Immunology
- Lung adenocarcinoma‐related TNF‐α‐dependent inflammation upregulates MHC‐II on alveolar type II cells through CXCR‐2 to contribute to Treg expansion
- (2020) Ningfei Guo et al. FASEB JOURNAL
- Single-cell transcriptome profiling reveals neutrophil heterogeneity in homeostasis and infection
- (2020) Xuemei Xie et al. NATURE IMMUNOLOGY
- Chronic circadian disruption modulates breast cancer stemness and immune microenvironment to drive metastasis in mice
- (2020) Eva Hadadi et al. Nature Communications
- Immunological and inflammatory profiles in mild and severe cases of COVID-19
- (2020) Jin-Wen Song et al. Nature Communications
- Prognostic Value of CXCR2 in Breast Cancer
- (2020) Florence Boissière-Michot et al. Cancers
- Neutrophil recruitment by chemokines Cxcl1/KC and Cxcl2/MIP2: Role of Cxcr2 activation and glycosaminoglycan interactions
- (2020) Kirti V. Sawant et al. JOURNAL OF LEUKOCYTE BIOLOGY
- Sex differences in immune responses that underlie COVID-19 disease outcomes
- (2020) Takehiro Takahashi et al. NATURE
- Gut microbiome directs hepatocytes to recruit MDSC and promote cholangiocarcinoma
- (2020) Qianfei Zhang et al. Cancer Discovery
- A Neutrophil Timer Coordinates Immune Defense and Vascular Protection
- (2019) José M. Adrover et al. IMMUNITY
- Potential roles and targeted therapy of the CXCLs/CXCR2 axis in cancer and inflammatory diseases
- (2019) Yuan Cheng et al. BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
- Secreted nuclear protein DEK regulates hematopoiesis through CXCR2 signaling
- (2019) Maegan L. Capitano et al. JOURNAL OF CLINICAL INVESTIGATION
- Efficacy and Safety of Danirixin (GSK1325756) Co-administered With Standard-of-Care Antiviral (Oseltamivir): A Phase 2b, Global, Randomized Study of Adults Hospitalized With Influenza
- (2019) Anuradha Madan et al. Open Forum Infectious Diseases
- Randomized, Double-Blind, Placebo-Controlled Study of the Safety, Tolerability, and Clinical Effect of Danirixin in Adults With Acute, Uncomplicated Influenza
- (2019) Grace Roberts et al. Open Forum Infectious Diseases
- Targeting VLA4 integrin and CXCR2 mobilizes serially repopulating hematopoietic stem cells
- (2019) Darja Karpova et al. JOURNAL OF CLINICAL INVESTIGATION
- Disrupted CXCR2 signaling in oligodendroglia lineage cells enhances myelin repair in a viral model of multiple sclerosis
- (2019) Brett S. Marro et al. JOURNAL OF VIROLOGY
- Re-education of Tumor-Associated Macrophages by CXCR2 Blockade Drives Senescence and Tumor Inhibition in Advanced Prostate Cancer
- (2019) Diletta Di Mitri et al. Cell Reports
- Phase I trial of HuMax-IL8 (BMS-986253), an anti-IL-8 monoclonal antibody, in patients with metastatic or unresectable solid tumors
- (2019) Marijo Bilusic et al. Journal for ImmunoTherapy of Cancer
- Structural basis of chemokine interactions with heparan sulfate, chondroitin sulfate, and dermatan sulfate
- (2019) Krishna Mohan Sepuru et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The CXCL5/CXCR2 axis is sufficient to promote breast cancer colonization during bone metastasis
- (2019) Ricardo Romero-Moreno et al. Nature Communications
- Chemokine receptor trafficking coordinates neutrophil clustering and dispersal at wounds in zebrafish
- (2019) Caroline Coombs et al. Nature Communications
- Targeting cellular heterogeneity with CXCR2 blockade for the treatment of therapy-resistant prostate cancer
- (2019) Yanjing Li et al. Science Translational Medicine
- Developmental Analysis of Bone Marrow Neutrophils Reveals Populations Specialized in Expansion, Trafficking, and Effector Functions
- (2018) Maximilien Evrard et al. IMMUNITY
- Glycosaminoglycan Interactions Fine-Tune Chemokine-Mediated Neutrophil Trafficking: Structural Insights and Molecular Mechanisms
- (2018) Krishna Rajarathnam et al. JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY
- Pharmacokinetics of the Oral Selective CXCR2 Antagonist AZD5069: A Summary of Eight Phase I Studies in Healthy Volunteers
- (2018) Marie Cullberg et al. Drugs in research & development
- Effect of the CXCR2 antagonist danirixin on symptoms and health status in COPD
- (2018) Aili L. Lazaar et al. EUROPEAN RESPIRATORY JOURNAL
- Structural basis, stoichiometry, and thermodynamics of binding of the chemokines KC and MIP2 to the glycosaminoglycan heparin
- (2018) Krishna Mohan Sepuru et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The role of CXCR2 in acute inflammatory responses and its antagonists as anti-inflammatory therapeutics
- (2018) Xiaoyu Zhang et al. CURRENT OPINION IN HEMATOLOGY
- The chemokine receptor CXCR2 contributes to murine adipocyte development
- (2018) Douglas P. Dyer et al. JOURNAL OF LEUKOCYTE BIOLOGY
- Getting TANned: How the tumor microenvironment drives neutrophil recruitment
- (2018) Shuvasree SenGupta et al. JOURNAL OF LEUKOCYTE BIOLOGY
- How do chemokines navigate neutrophils to the target site: Dissecting the structural mechanisms and signaling pathways
- (2018) Krishna Rajarathnam et al. CELLULAR SIGNALLING
- Glycosaminoglycan-Mediated Downstream Signaling of CXCL8 Binding to Endothelial Cells
- (2017) Rupert Derler et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Chemokine CXCL7 Heterodimers: Structural Insights, CXCR2 Receptor Function, and Glycosaminoglycan Interactions
- (2017) Aaron Brown et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Beyond Chemoattraction: Multifunctionality of Chemokine Receptors in Leukocytes
- (2017) Pilar López-Cotarelo et al. TRENDS IN IMMUNOLOGY
- CXCR2 Inhibition – a novel approach to treating CoronAry heart DiseAse (CICADA): study protocol for a randomised controlled trial
- (2017) Jubin P. Joseph et al. Trials
- Role of the CXCL8-CXCR1/2 Axis in Cancer and Inflammatory Diseases
- (2017) Helen Ha et al. Theranostics
- Heparin-bound chemokine CXCL8 monomer and dimer are impaired for CXCR1 and CXCR2 activation: implications for gradients and neutrophil trafficking
- (2017) Prem Raj B. Joseph et al. Open Biology
- CXCL3 positively regulates adipogenic differentiation
- (2016) Joji Kusuyama et al. JOURNAL OF LIPID RESEARCH
- The effects of a CXCR1/CXCR2 antagonist on neutrophil migration in mild atopic asthmatic subjects
- (2016) Candice M. Todd et al. PULMONARY PHARMACOLOGY & THERAPEUTICS
- CXCR1-mediated neutrophil degranulation and fungal killing promote Candida clearance and host survival
- (2016) Muthulekha Swamydas et al. Science Translational Medicine
- Efficacy and safety of a CXCR2 antagonist, AZD5069, in patients with uncontrolled persistent asthma: a randomised, double-blind, placebo-controlled trial
- (2016) Paul M O'Byrne et al. Lancet Respiratory Medicine
- CXCR2 Antagonist MK-7123. A Phase 2 Proof-of-Concept Trial for Chronic Obstructive Pulmonary Disease
- (2015) Stephen I. Rennard et al. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
- A pilot study on reparixin, a CXCR1/2 antagonist, to assess safety and efficacy in attenuating ischaemia-reperfusion injury and inflammation after on-pump coronary artery bypass graft surgery
- (2015) P. Opfermann et al. CLINICAL AND EXPERIMENTAL IMMUNOLOGY
- The effects of the CXCR2 antagonist, MK-7123, on bone marrow functions in healthy subjects
- (2015) Nina Hastrup et al. CYTOKINE
- Functional defect of peripheral neutrophils in mice with induced deletion of CXCR2
- (2013) LiPing Liu et al. GENESIS
- Targeting CXCR2 Enhances Chemotherapeutic Response, Inhibits Mammary Tumor Growth, Angiogenesis, and Lung Metastasis
- (2013) B. Sharma et al. MOLECULAR CANCER THERAPEUTICS
- A CXCL1 Paracrine Network Links Cancer Chemoresistance and Metastasis
- (2012) Swarnali Acharyya et al. CELL
- Chemokines and chemokine receptors: new insights into cancer-related inflammation
- (2010) Gwendal Lazennec et al. TRENDS IN MOLECULAR MEDICINE
- CXC Ligand 5 Is an Adipose-Tissue Derived Factor that Links Obesity to Insulin Resistance
- (2009) Carine Chavey et al. Cell Metabolism
- Emerging roles of chemokines in prostate cancer
- (2009) David Vindrieux et al. ENDOCRINE-RELATED CANCER
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationFind the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
Search