Cell-Autonomous Cxcl1 Sustains Tolerogenic Circuitries and Stromal Inflammation via Neutrophil-Derived TNF in Pancreatic Cancer

Entinostat Decreases Immune Suppression to Promote Antitumor Responses in a HER2+ Breast Tumor Microenvironment

(2022) Dimitrios N. Sidiropoulos et al.   Cancer Immunology Research

Tumor Necrosis Factor α: Taking a Personalized Road in Cancer Therapy

(2022) Adit Ben-Baruch   Frontiers in Immunology

Combined MEK and STAT3 inhibition uncovers stromal plasticity by enriching for cancer-associated fibroblasts with mesenchymal stem cell-like features to overcome immunotherapy resistance in pancreatic cancer

(2022) Jashodeep Datta et al.   GASTROENTEROLOGY

Single-nucleus and spatial transcriptome profiling of pancreatic cancer identifies multicellular dynamics associated with neoadjuvant treatment

(2022) William L. Hwang et al.   NATURE GENETICS

Sotigalimab and/or nivolumab with chemotherapy in first-line metastatic pancreatic cancer: clinical and immunologic analyses from the randomized phase 2 PRINCE trial

(2022) Lacey J. Padrón et al.   NATURE MEDICINE

Distinct mechanisms of innate and adaptive immune regulation underlie poor oncologic outcomes associated with KRAS-TP53 co-alteration in pancreatic cancer

(2022) Jashodeep Datta et al.   ONCOGENE

Neutrophil-mediated fibroblast-tumor cell il-6/stat-3 signaling underlies the association between neutrophil-to-lymphocyte ratio dynamics and chemotherapy response in localized pancreatic cancer: A hybrid clinical-preclinical study

(2022) Iago de Castro Silva et al.   eLife

Analysis of classical neutrophils and polymorphonuclear myeloid-derived suppressor cells in cancer patients and tumor-bearing mice

(2021) Filippo Veglia et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Inference and analysis of cell-cell communication using CellChat

(2021) Suoqin Jin et al.   Nature Communications

Neutrophil-derived TNF drives fungal acute lung injury in chronic granulomatous disease

(2021) R Elaine Cagnina et al.   JOURNAL OF INFECTIOUS DISEASES

Oncogenic KRAS recruits an expansive transcriptional network through mutant p53 to drive pancreatic cancer metastasis

(2021) Michael P Kim et al.   Cancer Discovery

Targeting tumor-stromal IL-6/STAT3 signaling through IL-1 receptor inhibition in pancreatic cancer

(2021) Austin R Dosch et al.   MOLECULAR CANCER THERAPEUTICS

TP53 missense mutations in PDAC are associated with enhanced fibrosis and an immunosuppressive microenvironment

(2021) Martino Maddalena et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ras-p53 genomic cooperativity as a model to investigate mechanisms of innate immune regulation in gastrointestinal cancers

(2021) Austin R. Dosch et al.   Oncotarget

TNFR2 blockade alone or in combination with PD‐1 blockade shows therapeutic efficacy in murine cancer models

(2020) Katherine Case et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Squamous trans-differentiation of pancreatic cancer cells promotes stromal inflammation

(2020) Tim DD Somerville et al.   eLife

Therapeutic resistance of pancreatic cancer: Roadmap to its reversal

(2020) Sen Yu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Cross-Species Single-Cell Analysis of Pancreatic Ductal Adenocarcinoma Reveals Antigen-Presenting Cancer-Associated Fibroblasts

(2019) Ela Elyada et al.   Cancer Discovery

The TNF Paradox in Cancer Progression and Immunotherapy

(2019) Anne Montfort et al.   Frontiers in Immunology

Immunosuppression by monocytic myeloid-derived suppressor cells in patients with pancreatic ductal carcinoma is orchestrated by STAT3

(2019) Rosalinda Trovato et al.   Journal for ImmunoTherapy of Cancer

Single-cell RNA sequencing reveals compartmental remodeling of tumor-infiltrating immune cells induced by anti-CD47 targeting in pancreatic cancer

(2019) Yu Pan et al.   Journal of Hematology & Oncology

NicheNet: modeling intercellular communication by linking ligands to target genes

(2019) Robin Browaeys et al.   NATURE METHODS

Emerging trends in the immunotherapy of pancreatic cancer

(2018) Kasturi Banerjee et al.   CANCER LETTERS

Tumor Cell-Intrinsic Factors Underlie Heterogeneity of Immune Cell Infiltration and Response to Immunotherapy

(2018) Jinyang Li et al.   IMMUNITY

Inverse Correlation of STAT3 and MEK Signaling Mediates Resistance to RAS Pathway Inhibition in Pancreatic Cancer

(2018) Nagaraj S Nagathihalli et al.   CANCER RESEARCH

Urolithin A, a novel natural compound to target PI3K/AKT/mTOR pathway in pancreatic cancer

(2018) Tulasigeri M Totiger et al.   MOLECULAR CANCER THERAPEUTICS

Addendum: The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

(2018) Jordi Barretina et al.   NATURE

IL-1-induced JAK/STAT signaling is antagonized by TGF-beta to shape CAF heterogeneity in pancreatic ductal adenocarcinoma

(2018) Giulia Biffi et al.   Cancer Discovery

Targeting both tumour-associated CXCR2+neutrophils and CCR2+macrophages disrupts myeloid recruitment and improves chemotherapeutic responses in pancreatic ductal adenocarcinoma

(2017) Timothy M Nywening et al.   GUT

Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer

(2017) Daniel Öhlund et al.   JOURNAL OF EXPERIMENTAL MEDICINE

PI3K pathway regulates ER-dependent transcription in breast cancer through the epigenetic regulator KMT2D

(2017) Eneda Toska et al.   SCIENCE

Targeting TNFR2 with antagonistic antibodies inhibits proliferation of ovarian cancer cells and tumor-associated Tregs

(2017) Heather Torrey et al.   Science Signaling

TNFα blockade overcomes resistance to anti-PD-1 in experimental melanoma

(2017) Florie Bertrand et al.   Nature Communications

Adiponectin receptor agonists inhibit leptin induced pSTAT3 and in vivo pancreatic tumor growth

(2017) Fanuel Messaggio et al.   Oncotarget

Targeting TNFR2 with antagonistic antibodies inhibits proliferation of ovarian cancer cells and tumor-associated Tregs

(2017) Heather Torrey et al.   Science Signaling

Tumor-necrosis factor is a master of T cell exhaustion

(2016) Amy E Baxter et al.   NATURE IMMUNOLOGY

Pancreatic cancer

(2016) Jorg Kleeff et al.   Nature Reviews Disease Primers

Exclusion of T Cells From Pancreatic Carcinomas in Mice Is Regulated by Ly6Clow F4/80+ Extratumoral Macrophages

(2015) Gregory L. Beatty et al.   GASTROENTEROLOGY

Signal Transducer and Activator of Transcription 3, Mediated Remodeling of the Tumor Microenvironment Results in Enhanced Tumor Drug Delivery in a Mouse Model of Pancreatic Cancer

(2015) Nagaraj S. Nagathihalli et al.   GASTROENTEROLOGY

limma powers differential expression analyses for RNA-sequencing and microarray studies

(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

Improved vectors and genome-wide libraries for CRISPR screening

(2014) Neville E Sanjana et al.   NATURE METHODS

Cooperativity of Oncogenic K-Ras and Downregulated p16/INK4A in Human Pancreatic Tumorigenesis

(2014) Zhe Chang et al.   PLoS One

Impaired Th1 immunity in ovarian cancer patients is mediated by TNFR2+ Tregs within the tumor microenvironment

(2013) Chindu Govindaraj et al.   CLINICAL IMMUNOLOGY

Induction of cancer cell stemness by chemotherapy

(2012) Xingwang Hu et al.   CELL CYCLE

BAY 11-7082 Is a Broad-Spectrum Inhibitor with Anti-Inflammatory Activity against Multiple Targets

(2012) Jaehwi Lee et al.   MEDIATORS OF INFLAMMATION

Combined Blockade of Src Kinase and Epidermal Growth Factor Receptor with Gemcitabine Overcomes STAT3-Mediated Resistance of Inhibition of Pancreatic Tumor Growth

(2011) N. S. Nagaraj et al.   CLINICAL CANCER RESEARCH

Tumor Progression Locus 2 Mediates Signal-Induced Increases in Cytoplasmic Calcium and Cell Migration

(2011) M. Hatziapostolou et al.   Science Signaling

Targeted Inhibition of Src Kinase Signaling Attenuates Pancreatic Tumorigenesis

(2010) Nagathihalli S. Nagaraj et al.   MOLECULAR CANCER THERAPEUTICS

Selective death of autoreactive T cells in human diabetes by TNF or TNF receptor 2 agonism

(2008) L. Ban et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA