Mind the GAP: RASA2 and RASA3 GTPase-activating proteins as gatekeepers of T cell activation and adhesion

Genome-wide CRISPR/Cas9 screens reveal shared and cell-specific mechanisms of resistance to SHP2 inhibition

(2023) Wei Wei et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Immunological Proteome Resource

(2023) Alejandro J. Brenes et al.   NATURE IMMUNOLOGY

Distinct bidirectional regulation of LFA1 and α4β7 by Rap1 and integrin adaptors in T cells under shear flow

(2023) Yuji Kamioka et al.   Cell Reports

The critical role of Rap1-GAPs Rasa3 and Sipa1 in T cells for pulmonary transit and egress from the lymph nodes

(2023) Shunsuke Horitani et al.   Frontiers in Immunology

Rap1 organizes lymphocyte front-back polarity via RhoA signaling and talin1

(2023) Yoshihiro Ueda et al.   iScience

The RASopathies: from pathogenetics to therapeutics

(2022) Katie E. Hebron et al.   Disease Models & Mechanisms

Molecular Mechanisms of Leukocyte β2 Integrin Activation

(2022) Lai Wen et al.   BLOOD

LFA1 Activation: Insights from a Single-Molecule Approach

(2022) Naoyuki Kondo et al.   Cells

A CRISPR screen targeting PI3K effectors identifies RASA3 as a negative regulator of LFA-1–mediated adhesion in T cells

(2022) Kristoffer H. Johansen et al.   Science Signaling

The 2022 Update of IUIS Phenotypical Classification for Human Inborn Errors of Immunity

(2022) Aziz Bousfiha et al.   JOURNAL OF CLINICAL IMMUNOLOGY

An αvβ3 integrin checkpoint is critical for efficient TH2 cell cytokine polarization and potentiation of antigen-specific immunity

(2022) Aydan C. H. Szeto et al.   NATURE IMMUNOLOGY

The ERK mitogen-activated protein kinase signaling network: the final frontier in RAS signal transduction

(2021) Jennifer E. Klomp et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Homeostasis of Naive and Memory T Lymphocytes

(2021) Takeshi Kawabe et al.   Cold Spring Harbor Perspectives in Biology

Highly accurate protein structure prediction with AlphaFold

(2021) John Jumper et al.   NATURE

Emerging therapeutic opportunities for integrin inhibitors

(2021) R. J. Slack et al.   NATURE REVIEWS DRUG DISCOVERY

LFA-1 in T cell priming, differentiation, and effector functions

(2021) Audrey Gérard et al.   TRENDS IN IMMUNOLOGY

PI3K in T Cell Adhesion and Trafficking

(2021) Kristoffer H. Johansen et al.   Frontiers in Immunology

GTPase-activating protein Rasal1 associates with ZAP-70 of the TCR and negatively regulates T-cell tumor immunity

(2019) Youg Raj Thaker et al.   Nature Communications

Engineered T Cell Therapy for Cancer in the Clinic

(2019) Lijun Zhao et al.   Frontiers in Immunology

ICAMs Are Not Obligatory for Functional Immune Synapses between Naive CD4 T Cells and Lymph Node DCs

(2018) Sara W. Feigelson et al.   Cell Reports

Shared and Unique Features Distinguishing Follicular T Helper and Regulatory Cells of Peripheral Lymph Node and Peyer’s Patches

(2018) Hristo Georgiev et al.   Frontiers in Immunology

Genome-wide CRISPR Screens in Primary Human T Cells Reveal Key Regulators of Immune Function

(2018) Eric Shifrut et al.   CELL

α4β7 integrin inhibitors: a patent review

(2018) Hao Li et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

RAS P21 Protein Activator 3 (RASA3) Specifically Promotes Pathogenic T Helper 17 Cell Generation by Repressing T-Helper-2-Cell-Biased Programs

(2018) Bing Wu et al.   IMMUNITY

ICAMs support B cell interactions with T follicular helper cells and promote clonal selection

(2017) Irina Zaretsky et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Integrin LFA-1 Controls T Follicular Helper Cell Generation and Maintenance

(2016) Alexandre P. Meli et al.   IMMUNITY

PI3Kδ promotes CD4+ T-cell interactions with antigen-presenting cells by increasing LFA-1 binding to ICAM-1

(2016) Fabien Garçon et al.   IMMUNOLOGY AND CELL BIOLOGY

The Phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P3) Binder Rasa3 Regulates Phosphoinositide 3-kinase (PI3K)-dependent Integrin αIIbβ3Outside-in Signaling

(2016) Anthony M. Battram et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RASA3 is a critical inhibitor of RAP1-dependent platelet activation

(2015) Lucia Stefanini et al.   JOURNAL OF CLINICAL INVESTIGATION

CD28 Inhibits T Cell Adhesion by Recruiting CAPRI to the Plasma Membrane

(2015) Marianne Strazza et al.   JOURNAL OF IMMUNOLOGY

Recurrent inactivating RASA2 mutations in melanoma

(2015) Rand Arafeh et al.   NATURE GENETICS

The Ras GTPase-Activating Protein Rasal3 Supports Survival of Naive T Cells

(2015) Ryunosuke Muro et al.   PLoS One

Next-generation sequencing identifies rare variants associated with Noonan syndrome

(2014) P.-C. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Specificity and Commonality of the Phosphoinositide-Binding Proteome Analyzed by Quantitative Mass Spectrometry

(2014) Stephanie Jungmichel et al.   Cell Reports

Rasa3 Controls Megakaryocyte Rap1 Activation, Integrin Signaling and Differentiation into Proplatelet

(2014) Patricia Molina-Ortiz et al.   PLoS Genetics

Regulation of Ras Exchange Factors and Cellular Localization of Ras Activation by Lipid Messengers in T Cells

(2013) Jesse E. Jun et al.   Frontiers in Immunology

A Comprehensive Survey of Ras Mutations in Cancer

(2012) I. A. Prior et al.   CANCER RESEARCH

Structural specializations of α4β7, an integrin that mediates rolling adhesion

(2012) Yamei Yu et al.   JOURNAL OF CELL BIOLOGY

Rap1 Can Bypass the FAK-Src-Paxillin Cascade to Induce Cell Spreading and Focal Adhesion Formation

(2012) Sarah H. Ross et al.   PLoS One

Critical function for the Ras-GTPase activating protein RASA3 in vertebrate erythropoiesis and megakaryopoiesis

(2012) Lionel Blanc et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Integrin inside-out signaling and the immunological synapse

(2011) Timothy A Springer et al.   CURRENT OPINION IN CELL BIOLOGY

A Two-Dimensional ERK-AKT Signaling Code for an NGF-Triggered Cell-Fate Decision

(2011) Jia-Yun Chen et al.   MOLECULAR CELL

A genetically selective inhibitor demonstrates a function for the kinase Zap70 in regulatory T cells independent of its catalytic activity

(2010) Byron B Au-Yeung et al.   NATURE IMMUNOLOGY

CalDAG-GEFI is at the nexus of calcium-dependent platelet activation

(2009) L. Stefanini et al.   BLOOD

Crystal Structure of the GTPase-activating Protein-related Domain from IQGAP1

(2009) Vinodh B. Kurella et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Ability of GAP1IP4BP To Function as a Rap1 GTPase-Activating Protein (GAP) Requires Its Ras GAP-Related Domain and an Arginine Finger Rather than an Asparagine Thumb

(2009) S. Kupzig et al.   MOLECULAR AND CELLULAR BIOLOGY