Sequence elements within the PEXEL motif and its downstream region modulate PTEX‐dependent protein export in Plasmodium falciparum

A revised mechanism for how Plasmodium falciparum recruits and exports proteins into its erythrocytic host cell

(2022) Mikha Gabriela et al.   PLoS Pathogens

The Medicines for Malaria Venture Malaria Box contains inhibitors of protein secretion in Plasmodium falciparum blood stage parasites

(2022) Oliver Looker et al.   TRAFFIC

Defining the Essential Exportome of the Malaria Parasite

(2021) Thorey K. Jonsdottir et al.   TRENDS IN PARASITOLOGY

Transport mechanisms at the malaria parasite-host cell interface

(2021) Josh R. Beck et al.   PLoS Pathogens

Crossing the Vacuolar Rubicon: Structural Insights into Effector Protein Trafficking in Apicomplexan Parasites

(2020) Pascal F. Egea   Microorganisms

Uncoupling the Threading and Unfoldase Actions of Plasmodium HSP101 Reveals Differences in Export between Soluble and Insoluble Proteins

(2019) Kathryn M. Matthews et al.   mBio

Spatial organization of protein export in malaria parasite blood stages

(2018) Sarah C. Charnaud et al.   TRAFFIC

Malaria parasite translocon structure and mechanism of effector export

(2018) Chi-Min Ho et al.   NATURE

Plasmepsin V cleaves malaria effector proteins in a distinct endoplasmic reticulum translocation interactome for export to the erythrocyte

(2018) Danushka S. Marapana et al.   Nature Microbiology

EXP2 is a nutrient-permeable channel in the vacuolar membrane of Plasmodium and is essential for protein export via PTEX

(2018) Matthias Garten et al.   Nature Microbiology

Ticket to ride: export of proteins to thePlasmodium falciparum-infected erythrocyte

(2016) Jude M. Przyborski et al.   MOLECULAR MICROBIOLOGY

BiPPred: Combined sequence- and structure-based prediction of peptide binding to the Hsp70 chaperone BiP

(2016) Markus Schneider et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Export of malaria proteins requires co-translational processing of the PEXEL motif independent of phosphatidylinositol-3-phosphate binding

(2016) Justin A. Boddey et al.   Nature Communications

Stable Translocation Intermediates Jam Global Protein Export in Plasmodium falciparum Parasites and Link the PTEX Component EXP2 with Translocation Activity

(2016) Paolo Mesén-Ramírez et al.   PLoS Pathogens

Understanding the structural basis of substrate recognition by Plasmodium falciparum plasmepsin V to aid in the design of potent inhibitors

(2016) Rajiv K. Bedi et al.   Scientific Reports

ThePlasmodium falciparumexportome contains non-canonical PEXEL/HT proteins

(2015) Jana Schulze et al.   MOLECULAR MICROBIOLOGY

Structural basis for plasmepsin V inhibition that blocks export of malaria proteins to human erythrocytes

(2015) Anthony N Hodder et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Critical Steps in Protein Export of Plasmodium falciparum Blood Stages

(2015) Tobias Spielmann et al.   TRENDS IN PARASITOLOGY

Structural basis for plasmepsin V inhibition that blocks export of malaria proteins to human erythrocytes

(2015) Anthony N Hodder et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Stochastic but Highly Coordinated Protein Unfolding and Translocation by the ClpXP Proteolytic Machine

(2014) Juan Carlos Cordova et al.   CELL

PTEX is an essential nexus for protein export in malaria parasites

(2014) Brendan Elsworth et al.   NATURE

PTEX component HSP101 mediates export of diverse malaria effectors into host erythrocytes

(2014) Josh R. Beck et al.   NATURE

Inhibition of Plasmepsin V Activity Demonstrates Its Essential Role in Protein Export, PfEMP1 Display, and Survival of Malaria Parasites

(2014) Brad E. Sleebs et al.   PLOS BIOLOGY

The Exported Protein PbCP1 Localises to Cleft-Like Structures in the Rodent Malaria Parasite Plasmodium berghei

(2013) Silvia Haase et al.   PLoS One

Role of Plasmepsin V in Export of Diverse Protein Families from thePlasmodium falciparumExportome

(2013) Justin A. Boddey et al.   TRAFFIC

Spatial association with PTEX complexes defines regions for effector export into Plasmodium falciparum-infected erythrocytes

(2013) David T. Riglar et al.   Nature Communications

Aggregate reactivation mediated by the Hsp100 chaperones

(2012) Michal Zolkiewski et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Uncovering Common Principles in Protein Export of Malaria Parasites

(2012) Christof Grüring et al.   Cell Host & Microbe

Biosynthesis, Localization, and Macromolecular Arrangement of thePlasmodium falciparumTranslocon of Exported Proteins (PTEX)

(2012) Hayley E. Bullen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Comparison of the absolute and relative efficiencies of electroporation-based transfection protocols for Plasmodium falciparum

(2012) Sandra Hasenkamp et al.   MALARIA JOURNAL

The C-terminal portion of the cleaved HT motif is necessary and sufficient to mediate export of proteins from the malaria parasite into its host cell

(2012) Sarah J. Tarr et al.   MOLECULAR MICROBIOLOGY

The elusive middle domain of Hsp104 and ClpB: Location and function

(2011) Morgan E. DeSantis et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Identification of a role for the PfEMP1 semi-conserved head structure in protein trafficking to the surface of Plasmodium falciparum infected red blood cells

(2010) Martin Melcher et al.   CELLULAR MICROBIOLOGY

Protein export in Plasmodium parasites: From the endoplasmic reticulum to the vacuolar export machine

(2010) Brendan S. Crabb et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

An aspartyl protease directs malaria effector proteins to the host cell

(2010) Justin A. Boddey et al.   NATURE

Plasmepsin V licenses Plasmodium proteins for export into the host erythrocyte

(2010) Ilaria Russo et al.   NATURE

A newly discovered protein export machine in malaria parasites

(2009) Tania F. de Koning-Ward et al.   NATURE

Protein export in malaria parasites: do multiple export motifs add up to multiple export pathways?

(2009) Tobias Spielmann et al.   TRENDS IN PARASITOLOGY

Peptide and Protein Binding in the Axial Channel of Hsp104

(2008) Ronnie Lum et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

N-terminal processing of proteins exported by malaria parasites

(2008) Henry H. Chang et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Sequence requirements for the export of thePlasmodium falciparumMaurer's clefts protein REX2

(2008) Silvia Haase et al.   MOLECULAR MICROBIOLOGY

Protein unfolding is an essential requirement for transport across the parasitophorous vacuolar membrane ofPlasmodium falciparum

(2008) Nina Gehde et al.   MOLECULAR MICROBIOLOGY

Targeting of the Ring Exported Protein 1 to the Maurers Clefts is Mediated by a Two-Phase Process

(2008) Matthew W. A. Dixon et al.   TRAFFIC

Role of thePlasmodiumExport Element in Trafficking Parasite Proteins to the Infected Erythrocyte

(2008) Justin A Boddey et al.   TRAFFIC

The Malaria Secretome: From Algorithms to Essential Function in Blood Stage Infection

(2008) Christiaan van Ooij et al.   PLoS Pathogens