Effects of LRRK2 Inhibitors in Nonhuman Primates

Characterization of Lipopolysaccharide Effects on LRRK2 Signaling in RAW Macrophages

(2023) Asmaa Oun et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The impact of the lung environment on macrophage development, activation and function: diversity in the face of adversity

(2022) Calum C. Bain et al.   Mucosal Immunology

The Roc domain of LRRK2 as a hub for protein-protein interactions: a focus on PAK6 and its impact on RAB phosphorylation

(2022) Susanna Cogo et al.   BRAIN RESEARCH

From the tyrosine hydroxylase hypothesis of Parkinson’s disease to modern strategies: a short historical overview

(2022) Wolf-Dieter Rausch et al.   JOURNAL OF NEURAL TRANSMISSION

LRRK2 and idiopathic Parkinson’s disease

(2022) Emily M. Rocha et al.   TRENDS IN NEUROSCIENCES

A step forward for LRRK2 inhibitors in Parkinson’s disease

(2022) Patrick A. Lewis   Science Translational Medicine

Distinct profiles of LRRK2 activation and Rab GTPase phosphorylation in clinical samples from different PD cohorts

(2022) Lilian Petropoulou-Vathi et al.   npj Parkinsons Disease

Discovery and Optimization of Potent, Selective, and Brain-Penetrant 1-Heteroaryl-1H-Indazole LRRK2 Kinase Inhibitors for the Treatment of Parkinson’s Disease

(2022) David A. Candito et al.   Journal of Medicinal Chemistry

LRRK2; a dynamic regulator of cellular trafficking

(2021) Jordan Follett et al.   BRAIN RESEARCH

The History and Mystery of Alveolar Epithelial Type II Cells: Focus on Their Physiologic and Pathologic Role in Lung

(2021) Barbara Ruaro et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Characterization of the onset, progression, and reversibility of morphological changes in mouse lung following pharmacological inhibition of LRRK2 kinase activity

(2021) Dianne Bryce et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

LRRK2 is required for CD38-mediated NAADP-Ca2+ signaling and the downstream activation of TFEB (transcription factor EB) in immune cells

(2021) Neel R. Nabar et al.   Autophagy

The development of inhibitors of leucine‐rich repeat kinase 2 (LRRK2) as a therapeutic strategy for Parkinson's disease: the current state of play

(2021) Sonia Azeggagh et al.   BRITISH JOURNAL OF PHARMACOLOGY

BORCS6 is involved in the enlargement of lung lamellar bodies in Lrrk2 knockout mice

(2021) Miho Araki et al.   HUMAN MOLECULAR GENETICS

Structure-Guided Discovery of Aminoquinazolines as Brain-Penetrant and Selective LRRK2 Inhibitors

(2021) Mitchell H. Keylor et al.   JOURNAL OF MEDICINAL CHEMISTRY

LRRK2 inhibitors induce reversible changes in nonhuman primate lungs without measurable pulmonary deficits

(2020) Marco A. S. Baptista et al.   Science Translational Medicine

LRRK2 Is Recruited to Phagosomes and Co-recruits RAB8 and RAB10 in Human Pluripotent Stem Cell-Derived Macrophages

(2020) Heyne Lee et al.   Stem Cell Reports

Contributions of alveolar epithelial cell quality control to pulmonary fibrosis

(2020) Jeremy Katzen et al.   JOURNAL OF CLINICAL INVESTIGATION

An in vitro alveolar epithelial cell model recapitulates LRRK2 inhibitor-induced increases in lamellar body size observed in preclinical models

(2020) Julie Harney et al.   TOXICOLOGY IN VITRO

Roco Proteins: GTPases with a Baroque Structure and Mechanism

(2019) Lina Wauters et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

LRRK2 links genetic and sporadic Parkinson's disease

(2019) Jillian H. Kluss et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The road to lysosome‐related organelles: Insights from Hermansky‐Pudlak syndrome and other rare diseases

(2019) Shanna L. Bowman et al.   TRAFFIC

The genetic architecture of Parkinson's disease

(2019) Cornelis Blauwendraat et al.   LANCET NEUROLOGY

LRRK2 Biology from structure to dysfunction: research progresses, but the themes remain the same

(2019) Daniel C. Berwick et al.   Molecular Neurodegeneration

The interstitial macrophage: A long-neglected piece in the puzzle of lung immunity

(2018) Maude Liegeois et al.   CELLULAR IMMUNOLOGY

Alveolar Macrophages

(2018) Nikita Joshi et al.   CELLULAR IMMUNOLOGY

Rab38 Mutation and the Lung Phenotype

(2018) Kazuhiro Osanai   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

LRRK2 activation in idiopathic Parkinson’s disease

(2018) Roberto Di Maio et al.   Science Translational Medicine

Achieving neuroprotection with LRRK2 kinase inhibitors in Parkinson disease

(2017) Andrew B. West   EXPERIMENTAL NEUROLOGY

Discovery of a 3-(4-Pyrimidinyl) Indazole (MLi-2), an Orally Available and Selective Leucine-Rich Repeat Kinase 2 (LRRK2) Inhibitor that Reduces Brain Kinase Activity

(2017) Jack D. Scott et al.   JOURNAL OF MEDICINAL CHEMISTRY

LRRK2 at the interface of autophagosomes, endosomes and lysosomes

(2016) Dorien A. Roosen et al.   Molecular Neurodegeneration

Defects in trafficking bridge Parkinson's disease pathology and genetics

(2016) Asa Abeliovich et al.   NATURE

Structural model of the dimeric Parkinson’s protein LRRK2 reveals a compact architecture involving distant interdomain contacts

(2016) Giambattista Guaitoli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Macrophage-epithelial interactions in pulmonary alveoli

(2016) Jahar Bhattacharya et al.   Seminars in Immunopathology

LRRK2 contributes to monocyte dysregulation in Parkinson’s disease

(2016) Corinna Bliederhaeuser et al.   Acta Neuropathologica Communications

Lost after translation: insights from pulmonary surfactant for understanding the role of alveolar epithelial dysfunction and cellular quality control in fibrotic lung disease

(2015) Surafel Mulugeta et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Effect of selective LRRK2 kinase inhibition on nonhuman primate lung

(2015) Reina N. Fuji et al.   Science Translational Medicine

Surfactant Secretion in LRRK2 Knock-Out Rats: Changes in Lamellar Body Morphology and Rate of Exocytosis

(2014) Pika Miklavc et al.   PLoS One

Type 2 alveolar cells are stem cells in adult lung

(2013) Christina E. Barkauskas et al.   JOURNAL OF CLINICAL INVESTIGATION

Discovery of Highly Potent, Selective, and Brain-Penetrant Aminopyrazole Leucine-Rich Repeat Kinase 2 (LRRK2) Small Molecule Inhibitors

(2013) Anthony A. Estrada et al.   JOURNAL OF MEDICINAL CHEMISTRY

Rab38 targets to lamellar bodies and normalizes their sizes in lung alveolar type II epithelial cells

(2011) Linghui Zhang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

LRRK2 protein levels are determined by kinase function and are crucial for kidney and lung homeostasis in mice

(2011) Martin C. Herzig et al.   HUMAN MOLECULAR GENETICS

Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of  -synuclein, and apoptotic cell death in aged mice

(2010) Y. Tong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Altered lung surfactant system in a Rab38-deficient rat model of Hermansky-Pudlak syndrome

(2009) Kazuhiro Osanai et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

A Mutation in Rab38 Small GTPase Causes Abnormal Lung Surfactant Homeostasis and Aberrant Alveolar Structure in Mice

(2008) Kazuhiro Osanai et al.   AMERICAN JOURNAL OF PATHOLOGY